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The map label for this gene is msrA

Identifier: 78221491

GI number: 78221491

Start: 298880

End: 299368

Strand: Direct

Name: msrA

Synonym: Gmet_0268

Alternate gene names: 78221491

Gene position: 298880-299368 (Clockwise)

Preceding gene: 78221490

Following gene: 78221492

Centisome position: 7.48

GC content: 61.55

Gene sequence:

>489_bases
ATGGACGAAACACCAGAACTTGAAAAGGCAACCTTCGGTGCCGGGTGCTTCTGGCACGTGGAGGCCGAATTCCGGCGGGT
GTCGGGGGTGGTAGCCACTCACGCCGGGTACATGGGGGGATGGAAGGACCATCCCACCTACGAGGAGGTCTGCTCCAAGG
AAACGGGGCATGCGGAGGTGGTGGAGGTGGTCTACGATCCCGCGCGGGTCTCCTATGACGAGCTTCTCCGGATTTTCTGG
ACAATCCACGATCCAACCCAGCTGAACCGCCAGGGGCCGGATATCGGTACCAACTACCGCTCGGTCATCTTTTTTCATAC
CCCGGAGCAGGAGCAGGCCGCCCGGCTCTCGATGGAGAAAGAAGGGGGTTCCGGCCGCTACTCCCGGCCAATCGTTACCG
AAATTGCTTCCGCCTCCGCCTTCTGGTGGGCCGAGGAGTACCATCAGCAGTACCTGGAGAAGCGCGGCGGCGGAAGCTGC
AACTGGTGA

Upstream 100 bases:

>100_bases
AAAAAGCATGGCTGGGGAGGAGATGCAAACGAGACAGCGGATTTCTCCTGTGCTACCTTTGTTGTAGTATCGATACAGTG
TTGACAGGGAGGTTCACATC

Downstream 100 bases:

>100_bases
AGAGAAAGGAGCTATTAATGACAGCAAGAGGATGGCTTGTAGGGATGGTCGTCGCGGCGGCTGCGGCGGTCTGCGGCGTG
GGAAACGCCGGCGCCGAGGT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MDETPELEKATFGAGCFWHVEAEFRRVSGVVATHAGYMGGWKDHPTYEEVCSKETGHAEVVEVVYDPARVSYDELLRIFW
TIHDPTQLNRQGPDIGTNYRSVIFFHTPEQEQAARLSMEKEGGSGRYSRPIVTEIASASAFWWAEEYHQQYLEKRGGGSC
NW

Sequences:

>Translated_162_residues
MDETPELEKATFGAGCFWHVEAEFRRVSGVVATHAGYMGGWKDHPTYEEVCSKETGHAEVVEVVYDPARVSYDELLRIFW
TIHDPTQLNRQGPDIGTNYRSVIFFHTPEQEQAARLSMEKEGGSGRYSRPIVTEIASASAFWWAEEYHQQYLEKRGGGSC
NW
>Mature_162_residues
MDETPELEKATFGAGCFWHVEAEFRRVSGVVATHAGYMGGWKDHPTYEEVCSKETGHAEVVEVVYDPARVSYDELLRIFW
TIHDPTQLNRQGPDIGTNYRSVIFFHTPEQEQAARLSMEKEGGSGRYSRPIVTEIASASAFWWAEEYHQQYLEKRGGGSC
NW

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=49.0566037735849, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=49.0566037735849, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI208609993, Length=114, Percent_Identity=49.1228070175439, Blast_Score=103, Evalue=6e-23,
Organism=Escherichia coli, GI1790665, Length=159, Percent_Identity=51.5723270440252, Blast_Score=161, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=31.5436241610738, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=39.1025641025641, Blast_Score=102, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=42.0689655172414, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=41.3793103448276, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=40.7142857142857, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_GEOMG (Q39Z11)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383238.1
- ProteinModelPortal:   Q39Z11
- SMR:   Q39Z11
- STRING:   Q39Z11
- GeneID:   3738640
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0268
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   NYRSVIF
- PhylomeDB:   Q39Z11
- ProtClustDB:   PRK14054
- BioCyc:   GMET269799:GMET_0268-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 18481; Mature: 18481

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: ACT_SITE 16-16

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDETPELEKATFGAGCFWHVEAEFRRVSGVVATHAGYMGGWKDHPTYEEVCSKETGHAEV
CCCCCCCCHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCHHH
VEVVYDPARVSYDELLRIFWTIHDPTQLNRQGPDIGTNYRSVIFFHTPEQEQAARLSMEK
HHHHHCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHC
EGGSGRYSRPIVTEIASASAFWWAEEYHQQYLEKRGGGSCNW
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDETPELEKATFGAGCFWHVEAEFRRVSGVVATHAGYMGGWKDHPTYEEVCSKETGHAEV
CCCCCCCCHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCHHH
VEVVYDPARVSYDELLRIFWTIHDPTQLNRQGPDIGTNYRSVIFFHTPEQEQAARLSMEK
HHHHHCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHC
EGGSGRYSRPIVTEIASASAFWWAEEYHQQYLEKRGGGSCNW
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA