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The map label for this gene is ctaD [H]

Identifier: 78221472

GI number: 78221472

Start: 279719

End: 281344

Strand: Direct

Name: ctaD [H]

Synonym: Gmet_0249

Alternate gene names: 78221472

Gene position: 279719-281344 (Clockwise)

Preceding gene: 78221471

Following gene: 78221473

Centisome position: 7.0

GC content: 63.1

Gene sequence:

>1626_bases
ATGAAACCCACTGACCAGACCATGACCCCCGCCGCCAGCTTCTGGAACGACACCGGCAGGAGCGGCATCGCCTCCTGGAT
CTTTTCCACCGACCACAAGCGGATCGGTCTCCTCTACTTCTTCTCGGTGTTCGGCTTTTTCCTCGTGGGCGTCGTGCTCG
GCCTTCTGATCCGCATCGAGCTGATGGCGCCGGGCCGGACCATCATGGGCCCCCAGACCTACAACGCCCTCTTCACCGTC
CACGGGGTGGTGATGGTCTTTCTCTTCATCATCCCCGGATTCCAGGGCTCCTTCGGCAACCTCATCATGCCGATCCAGAT
CGGCGCCCGGGACGTGGCCTTTCCCCGCCTGAACCTCTTTTCGTGGTGGCTCTACATGGCAGGCGCGGCAATCATCCTCA
CGTCGCTCTTCACCGGCGGCGGCCCCCCCGACACCGGCTGGACCTTCTACCTCCCCTTCAGCGGCCGGACCGGGACCAAC
GTCTCCCTGGCGGTGTTCGGCGTCTTCGTCGTGGGGTTCTCGTCCATCGCCACCGGGGTCAATTTCGTCACCACCATCCA
CCGCCTGCGGGCCGAGGGGATGACCTGGGGACGGCTGCCGCTTTTTGTCTGGTCCCTCTACGCCACCGCCTGGGTGCAGA
TTCTGGCGACCCCCATCCTCGGCATCACCCTGGTGCTGATCATCGCCGAACGGCTCCTCGGAACCGGCCTCTTCGACCCG
GGGCGAGGGGGAGATCCCCTCATGTACCAGCACCTCTTCTGGATCTACTCCCATCCCGCGGTCTACATCATGATCCTGCC
GGCCATGGGGGTGATCTCGGAGATTATCCCGGTCTTTGCCCGCAAGCCGGTCTTCGGCTACAAGATGATCGCCTTTTCCA
GCCTCGCCATCGCCGCGGCCGGTTCCCTGGTCTGGGGGCACCACATGTTCACCAGCGGCATGAGCGATACGGCGGTCCTG
GTATTCTCCTTTCTTACCTTCGTCGTCGCCATCCCGTCGGCCATCAAGGTCTTCAACTGGGTCTCCACCCTCTACAAGGG
GTCCATCTCCCTGGAAGCACCCATGCTCTTCTCCCTCTCCTTCATCTTCCTCTTCTCCATCGGGGGGCTGACCGGACTGA
TCCAGGGGGCGGCGGCAACCGACATCCATGTCCACGACACCCAGTTCGTGGTGGGGCATTTCCACTATGTCATCTTCGGC
GGCTCGGGATTCGCCTTCTTCGCCGCCATGCACTACTGGCTCCCCAAGTTCTATGGCCGCCGCTACGCCGAAAAACCGGC
GATTATCGCCTGGGCGCTCATGTCCGTCGGTTTCAACATCCTCTACTTCTCCATGATCGTGCTGGGGCTGGAGGGGATGC
CACGGCGCTACTACGACTATCTCCCCGAATTCGCCCCCCTCAACCTGGTCTCCACCATCGGGAGCTGGATCCTGGCCTCC
GGTCTCGTGCTGCTCTTGGTGAACCTGGTCCGGGGGCTGAGGAGCGGGGAGCGGGTCGGGAAAAATCCGTGGGGAGCGGC
GACCTTGGAGTGGAGCATCCCGACGCCCCCACCCACGGAGAATTTCGAGGAGGAGCCGGTGGTCACTCACGGCCCCTATG
ATTACCGGGGAGCCGGCATCCCATGA

Upstream 100 bases:

>100_bases
CTGCGGGTGAGCGCCACCATCGTCATCATAAGCACGGGGGCCTTTCTCGCCTTCCTGTTCCTGACCGGGAAAAAACGCCC
CGCGTCTCCCCGAGGTGGCC

Downstream 100 bases:

>100_bases
GTCATCAGACCCGAAAAGACCCAGCCGGCGCCAAGCTCGGCATGTGGCTCTTCCTCTTTACCGAGCTGTTCCTGTTCGGG
GGGCTGTTCCTTCTTTACGG

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MKPTDQTMTPAASFWNDTGRSGIASWIFSTDHKRIGLLYFFSVFGFFLVGVVLGLLIRIELMAPGRTIMGPQTYNALFTV
HGVVMVFLFIIPGFQGSFGNLIMPIQIGARDVAFPRLNLFSWWLYMAGAAIILTSLFTGGGPPDTGWTFYLPFSGRTGTN
VSLAVFGVFVVGFSSIATGVNFVTTIHRLRAEGMTWGRLPLFVWSLYATAWVQILATPILGITLVLIIAERLLGTGLFDP
GRGGDPLMYQHLFWIYSHPAVYIMILPAMGVISEIIPVFARKPVFGYKMIAFSSLAIAAAGSLVWGHHMFTSGMSDTAVL
VFSFLTFVVAIPSAIKVFNWVSTLYKGSISLEAPMLFSLSFIFLFSIGGLTGLIQGAAATDIHVHDTQFVVGHFHYVIFG
GSGFAFFAAMHYWLPKFYGRRYAEKPAIIAWALMSVGFNILYFSMIVLGLEGMPRRYYDYLPEFAPLNLVSTIGSWILAS
GLVLLLVNLVRGLRSGERVGKNPWGAATLEWSIPTPPPTENFEEEPVVTHGPYDYRGAGIP

Sequences:

>Translated_541_residues
MKPTDQTMTPAASFWNDTGRSGIASWIFSTDHKRIGLLYFFSVFGFFLVGVVLGLLIRIELMAPGRTIMGPQTYNALFTV
HGVVMVFLFIIPGFQGSFGNLIMPIQIGARDVAFPRLNLFSWWLYMAGAAIILTSLFTGGGPPDTGWTFYLPFSGRTGTN
VSLAVFGVFVVGFSSIATGVNFVTTIHRLRAEGMTWGRLPLFVWSLYATAWVQILATPILGITLVLIIAERLLGTGLFDP
GRGGDPLMYQHLFWIYSHPAVYIMILPAMGVISEIIPVFARKPVFGYKMIAFSSLAIAAAGSLVWGHHMFTSGMSDTAVL
VFSFLTFVVAIPSAIKVFNWVSTLYKGSISLEAPMLFSLSFIFLFSIGGLTGLIQGAAATDIHVHDTQFVVGHFHYVIFG
GSGFAFFAAMHYWLPKFYGRRYAEKPAIIAWALMSVGFNILYFSMIVLGLEGMPRRYYDYLPEFAPLNLVSTIGSWILAS
GLVLLLVNLVRGLRSGERVGKNPWGAATLEWSIPTPPPTENFEEEPVVTHGPYDYRGAGIP
>Mature_541_residues
MKPTDQTMTPAASFWNDTGRSGIASWIFSTDHKRIGLLYFFSVFGFFLVGVVLGLLIRIELMAPGRTIMGPQTYNALFTV
HGVVMVFLFIIPGFQGSFGNLIMPIQIGARDVAFPRLNLFSWWLYMAGAAIILTSLFTGGGPPDTGWTFYLPFSGRTGTN
VSLAVFGVFVVGFSSIATGVNFVTTIHRLRAEGMTWGRLPLFVWSLYATAWVQILATPILGITLVLIIAERLLGTGLFDP
GRGGDPLMYQHLFWIYSHPAVYIMILPAMGVISEIIPVFARKPVFGYKMIAFSSLAIAAAGSLVWGHHMFTSGMSDTAVL
VFSFLTFVVAIPSAIKVFNWVSTLYKGSISLEAPMLFSLSFIFLFSIGGLTGLIQGAAATDIHVHDTQFVVGHFHYVIFG
GSGFAFFAAMHYWLPKFYGRRYAEKPAIIAWALMSVGFNILYFSMIVLGLEGMPRRYYDYLPEFAPLNLVSTIGSWILAS
GLVLLLVNLVRGLRSGERVGKNPWGAATLEWSIPTPPPTENFEEEPVVTHGPYDYRGAGIP

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=505, Percent_Identity=40.1980198019802, Blast_Score=357, Evalue=2e-98,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=36.1867704280156, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6226519, Length=532, Percent_Identity=37.781954887218, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6226524, Length=324, Percent_Identity=37.6543209876543, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=35.0806451612903, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59490; Mature: 59490

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTDQTMTPAASFWNDTGRSGIASWIFSTDHKRIGLLYFFSVFGFFLVGVVLGLLIRIE
CCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEH
LMAPGRTIMGPQTYNALFTVHGVVMVFLFIIPGFQGSFGNLIMPIQIGARDVAFPRLNLF
EECCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHH
SWWLYMAGAAIILTSLFTGGGPPDTGWTFYLPFSGRTGTNVSLAVFGVFVVGFSSIATGV
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
NFVTTIHRLRAEGMTWGRLPLFVWSLYATAWVQILATPILGITLVLIIAERLLGTGLFDP
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GRGGDPLMYQHLFWIYSHPAVYIMILPAMGVISEIIPVFARKPVFGYKMIAFSSLAIAAA
CCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GSLVWGHHMFTSGMSDTAVLVFSFLTFVVAIPSAIKVFNWVSTLYKGSISLEAPMLFSLS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FIFLFSIGGLTGLIQGAAATDIHVHDTQFVVGHFHYVIFGGSGFAFFAAMHYWLPKFYGR
HHHHHHHCCHHHHHCCCCCCEEEECCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
RYAEKPAIIAWALMSVGFNILYFSMIVLGLEGMPRRYYDYLPEFAPLNLVSTIGSWILAS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
GLVLLLVNLVRGLRSGERVGKNPWGAATLEWSIPTPPPTENFEEEPVVTHGPYDYRGAGI
HHHHHHHHHHHHHCCCHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCC
P
C
>Mature Secondary Structure
MKPTDQTMTPAASFWNDTGRSGIASWIFSTDHKRIGLLYFFSVFGFFLVGVVLGLLIRIE
CCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEH
LMAPGRTIMGPQTYNALFTVHGVVMVFLFIIPGFQGSFGNLIMPIQIGARDVAFPRLNLF
EECCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHH
SWWLYMAGAAIILTSLFTGGGPPDTGWTFYLPFSGRTGTNVSLAVFGVFVVGFSSIATGV
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
NFVTTIHRLRAEGMTWGRLPLFVWSLYATAWVQILATPILGITLVLIIAERLLGTGLFDP
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GRGGDPLMYQHLFWIYSHPAVYIMILPAMGVISEIIPVFARKPVFGYKMIAFSSLAIAAA
CCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GSLVWGHHMFTSGMSDTAVLVFSFLTFVVAIPSAIKVFNWVSTLYKGSISLEAPMLFSLS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FIFLFSIGGLTGLIQGAAATDIHVHDTQFVVGHFHYVIFGGSGFAFFAAMHYWLPKFYGR
HHHHHHHCCHHHHHCCCCCCEEEECCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
RYAEKPAIIAWALMSVGFNILYFSMIVLGLEGMPRRYYDYLPEFAPLNLVSTIGSWILAS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
GLVLLLVNLVRGLRSGERVGKNPWGAATLEWSIPTPPPTENFEEEPVVTHGPYDYRGAGI
HHHHHHHHHHHHHCCCHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8399373 [H]