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The map label for this gene is lysA [H]

Identifier: 78221443

GI number: 78221443

Start: 250957

End: 252276

Strand: Reverse

Name: lysA [H]

Synonym: Gmet_0219

Alternate gene names: 78221443

Gene position: 252276-250957 (Counterclockwise)

Preceding gene: 304570566

Following gene: 78221415

Centisome position: 6.31

GC content: 63.94

Gene sequence:

>1320_bases
ATGACAATGACTTCTTTTGGTCCGACCGGACTCGACGCAACGCTTATCCCGAAGATCGCCGGGGAATGGGGAACCCCTAT
TTACCTCCACGATCAGCAGTACATCGAGAACAGCTGCGACCAGCTGCTTGCCATGCCCAATGCCTACGGCCTGCACGTCC
GCTACGCCATCAAGGCCAACTCTGACCGCACCGTCCTGCGCATTGTCACCGGCAAGGGGCTGGACCTGGACTGCTCATCC
CTGGACGAGGCCGCCCGGGCCCATGCCGCCGGCATCCCCTACAGCCGCATGATGCTCACCACCCAGGAGGTCCCCACCGG
CGAGGAGCGGACCGAACTGGAAGCCATGATCAAGGTCGGCCTCAAGTACAATGTCTGCTCCACGCTGCAGTACCAGCTCA
TCGCCGACTTTGCCGCCCAGAACAAGATCGACCTTTCCATGAGGGTCCATCCGGGCGCCGCCGGCGGCGGCGAGAGCGCC
ACCCGCGACACCGGCAGCGAGTACTCCTGCTTCGGCGTCCACCTGCGCGACGTCCCGACCGTGAAGGCCCTGGCCGACGA
GAAAGGGCTCCGCTTCACCCAGGTCCACGTCCATATCGGCTCCGGCGGCGCCCCGGAGAAGTGGCAAGAGAACATCGACC
GGGAGCTCGGCTTCATCAAAACCTACTTCCCGGATGCAGTCACCGTCAGCTTCGGCGGCGGCCTCAAGGTGGCCCGCATG
CCGGGCGAGAAGCAGGCCGACATCGCCACCCTGGGAGCCTATGCAAAGCAGCGGATCGAAGAGTTCAAGGCCGCCACCGG
CCGCGAACTGATGATGGAGATCGAGCCGGGGACCTTTGTGGTGGCCAACTCGGGGCACATCGTCACTCGCATCATCGACA
AGAAGTTCACCAACGAGATGAACTTCCTCATCGTCGACGGCGGCATGGAGCTACTGACCCGGCCGCTCCTCTACGGCTCC
GAGCATCCCATCGCCATCGTCCGCCAGGACGGGACGCTCCTCTCCAGCGAGTACGACCAGACCCCCACGGCGGGGCTGAA
GCCCTTCGGCATCGTCGGCCGCTGCTGCGAAAGCGGCGACTCGGTCCGCCTGGACAAGGAGGGGAACATCGTGCCGGTCA
TGATCGTTGAGCCGGAGATCGGCGACTACGTCGTCATCGGCGGCACCGGCGCCTACTCCGAGAGCATGTCGCCGGAGAAC
TACAACTCCCACCGCAAGCCGGGAGCCGTCATGAGGACCAAAACCGGCGAACTGGTGCTCATCCGGAAGAAGCAGGTACG
GGAGCAACTGACCCAGAACGAACTGGACGTGACGCTGTAA

Upstream 100 bases:

>100_bases
GCAACCATGGAAAATGCTAGAAAAGTAAATTAACATTTACATGCCGCCGTGACGGCATCTTGGAACCAAACATCACCATC
ACATCCATGAGGTTGATCGA

Downstream 100 bases:

>100_bases
TTCATTGTCACATATGCTCAGGAAACAGAAAAGGCGGCCATTTGGCCGCCTTTCGAATTATGCATAATGTCCTCGGAATT
CCCTGCCAATTAAGTAAGGT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTMTSFGPTGLDATLIPKIAGEWGTPIYLHDQQYIENSCDQLLAMPNAYGLHVRYAIKANSDRTVLRIVTGKGLDLDCSS
LDEAARAHAAGIPYSRMMLTTQEVPTGEERTELEAMIKVGLKYNVCSTLQYQLIADFAAQNKIDLSMRVHPGAAGGGESA
TRDTGSEYSCFGVHLRDVPTVKALADEKGLRFTQVHVHIGSGGAPEKWQENIDRELGFIKTYFPDAVTVSFGGGLKVARM
PGEKQADIATLGAYAKQRIEEFKAATGRELMMEIEPGTFVVANSGHIVTRIIDKKFTNEMNFLIVDGGMELLTRPLLYGS
EHPIAIVRQDGTLLSSEYDQTPTAGLKPFGIVGRCCESGDSVRLDKEGNIVPVMIVEPEIGDYVVIGGTGAYSESMSPEN
YNSHRKPGAVMRTKTGELVLIRKKQVREQLTQNELDVTL

Sequences:

>Translated_439_residues
MTMTSFGPTGLDATLIPKIAGEWGTPIYLHDQQYIENSCDQLLAMPNAYGLHVRYAIKANSDRTVLRIVTGKGLDLDCSS
LDEAARAHAAGIPYSRMMLTTQEVPTGEERTELEAMIKVGLKYNVCSTLQYQLIADFAAQNKIDLSMRVHPGAAGGGESA
TRDTGSEYSCFGVHLRDVPTVKALADEKGLRFTQVHVHIGSGGAPEKWQENIDRELGFIKTYFPDAVTVSFGGGLKVARM
PGEKQADIATLGAYAKQRIEEFKAATGRELMMEIEPGTFVVANSGHIVTRIIDKKFTNEMNFLIVDGGMELLTRPLLYGS
EHPIAIVRQDGTLLSSEYDQTPTAGLKPFGIVGRCCESGDSVRLDKEGNIVPVMIVEPEIGDYVVIGGTGAYSESMSPEN
YNSHRKPGAVMRTKTGELVLIRKKQVREQLTQNELDVTL
>Mature_438_residues
TMTSFGPTGLDATLIPKIAGEWGTPIYLHDQQYIENSCDQLLAMPNAYGLHVRYAIKANSDRTVLRIVTGKGLDLDCSSL
DEAARAHAAGIPYSRMMLTTQEVPTGEERTELEAMIKVGLKYNVCSTLQYQLIADFAAQNKIDLSMRVHPGAAGGGESAT
RDTGSEYSCFGVHLRDVPTVKALADEKGLRFTQVHVHIGSGGAPEKWQENIDRELGFIKTYFPDAVTVSFGGGLKVARMP
GEKQADIATLGAYAKQRIEEFKAATGRELMMEIEPGTFVVANSGHIVTRIIDKKFTNEMNFLIVDGGMELLTRPLLYGSE
HPIAIVRQDGTLLSSEYDQTPTAGLKPFGIVGRCCESGDSVRLDKEGNIVPVMIVEPEIGDYVVIGGTGAYSESMSPENY
NSHRKPGAVMRTKTGELVLIRKKQVREQLTQNELDVTL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=419, Percent_Identity=30.5489260143198, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47952; Mature: 47821

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTSFGPTGLDATLIPKIAGEWGTPIYLHDQQYIENSCDQLLAMPNAYGLHVRYAIKAN
CCCCCCCCCCCCCEEHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEEEEEEEEEC
SDRTVLRIVTGKGLDLDCSSLDEAARAHAAGIPYSRMMLTTQEVPTGEERTELEAMIKVG
CCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEEEECCCCCCCHHHHHHHHHHHC
LKYNVCSTLQYQLIADFAAQNKIDLSMRVHPGAAGGGESATRDTGSEYSCFGVHLRDVPT
CEECHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCC
VKALADEKGLRFTQVHVHIGSGGAPEKWQENIDRELGFIKTYFPDAVTVSFGGGLKVARM
HHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCEEECCCEEEEEECCCEEEEEC
PGEKQADIATLGAYAKQRIEEFKAATGRELMMEIEPGTFVVANSGHIVTRIIDKKFTNEM
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCEEEEEHHHHHCCCC
NFLIVDGGMELLTRPLLYGSEHPIAIVRQDGTLLSSEYDQTPTAGLKPFGIVGRCCESGD
CEEEECCCHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHCCCC
SVRLDKEGNIVPVMIVEPEIGDYVVIGGTGAYSESMSPENYNSHRKPGAVMRTKTGELVL
CEEECCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
IRKKQVREQLTQNELDVTL
EEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TMTSFGPTGLDATLIPKIAGEWGTPIYLHDQQYIENSCDQLLAMPNAYGLHVRYAIKAN
CCCCCCCCCCCCEEHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEEEEEEEEEC
SDRTVLRIVTGKGLDLDCSSLDEAARAHAAGIPYSRMMLTTQEVPTGEERTELEAMIKVG
CCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEEEECCCCCCCHHHHHHHHHHHC
LKYNVCSTLQYQLIADFAAQNKIDLSMRVHPGAAGGGESATRDTGSEYSCFGVHLRDVPT
CEECHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCC
VKALADEKGLRFTQVHVHIGSGGAPEKWQENIDRELGFIKTYFPDAVTVSFGGGLKVARM
HHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCEEECCCEEEEEECCCEEEEEC
PGEKQADIATLGAYAKQRIEEFKAATGRELMMEIEPGTFVVANSGHIVTRIIDKKFTNEM
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCEEEEEHHHHHCCCC
NFLIVDGGMELLTRPLLYGSEHPIAIVRQDGTLLSSEYDQTPTAGLKPFGIVGRCCESGD
CEEEECCCHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHCCCC
SVRLDKEGNIVPVMIVEPEIGDYVVIGGTGAYSESMSPENYNSHRKPGAVMRTKTGELVL
CEEECCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
IRKKQVREQLTQNELDVTL
EEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]