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The map label for this gene is msrAB [H]

Identifier: 304570566

GI number: 304570566

Start: 253138

End: 254169

Strand: Reverse

Name: msrAB [H]

Synonym: NA

Alternate gene names: 304570566

Gene position: 254169-253138 (Counterclockwise)

Preceding gene: 78221448

Following gene: 78221443

Centisome position: 6.36

GC content: 64.05

Gene sequence:

>1032_bases
TTGACGATTCTGGTATTTGTTGTTGCCTGCCTGATACTGGCAGTTGTTGCCAGGCCCCCCCGCTTCGGCGGCCGAACAGC
AGAAAAGGAGACGACGATGACAGCGAGGAAATACTCTGACGAAGAGCTGAAGCAGCGCCTCACTCCGCTGCAGTACCGCG
TGACGAGGAAATCGGGGACCGAGCCCCCCTTCGACAATACCTACTGGAACGAGCACCGCGAAGGGCTCTATGTGGACATC
GTCAGCGGTGAGCCGCTCTTCTCATCCAGGGACAAGTTCGATTCCGGCACCGGCTGGCCCAGCTTCACCCGGCCGGTCGC
CCCGAACAGCGTGAAGGAGGAGACCGACATCGGCTTCGGCACGGTCCGGACCGAGGTCCGCTCCAAAGAAGCCGACTCCC
ACCTGGGGCATCTCTTCACCGACGGGCCGCGGGACAAGGGGGGGCTGCGTTACTGCGTCAACTCCGCGGCGCTCCGCTTC
ATCCCGGTGGACGACCTGGAGAAGGAAGGGTATGGCTCGTATCTCCCCCTCTTCGGCCGGAAGGCGCCGGCAGCGGCAGT
AAAGCAGGTGGCGACCCTGGCCGGAGGCTGTTTCTGGGGAATGCAGGACCTGCTGCGCAAGCAGCCGGGGGTGATCGCCA
CGGAGGTGGGCTACACCGGCGGCAGCGTGCCCAACGCCACCTACGAAAACCACGAGGGGCACGCCGAAGCGGTGCGGATC
GAATTCGACCCGACGAAGACCAGCTACGAGGCCCTGTTGCGGTTCTTCTTCCGGATGCACGACCCGACCACCTTGAACCG
CCAGGGGAACGACATCGGCAGCAGCTACCGGAGCGCCATCTTCTACCATGACGCCGAGCAGAAGCGGATCGCGGAAAAGG
TCAAGGCCGAGGTGGACGCCAGCGGCAAGTGGAAGCGGCCTGTCGTCACCGAGATCGTCCCGGCCGGCCCCTGGTGGCGG
GCCGAGGAGTATCATCAGGATTACCTGGTGAAGAACCCGGGAGGGTATACCTGCCACTGGGTACGGGAGTAG

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:
NA

Sequences:

>Translated_343_residues
MTILVFVVACLILAVVARPPRFGGRTAEKETTMTARKYSDEELKQRLTPLQYRVTRKSGTEPPFDNTYWNEHREGLYVDI
VSGEPLFSSRDKFDSGTGWPSFTRPVAPNSVKEETDIGFGTVRTEVRSKEADSHLGHLFTDGPRDKGGLRYCVNSAALRF
IPVDDLEKEGYGSYLPLFGRKAPAAAVKQVATLAGGCFWGMQDLLRKQPGVIATEVGYTGGSVPNATYENHEGHAEAVRI
EFDPTKTSYEALLRFFFRMHDPTTLNRQGNDIGSSYRSAIFYHDAEQKRIAEKVKAEVDASGKWKRPVVTEIVPAGPWWR
AEEYHQDYLVKNPGGYTCHWVRE
>Mature_342_residues
TILVFVVACLILAVVARPPRFGGRTAEKETTMTARKYSDEELKQRLTPLQYRVTRKSGTEPPFDNTYWNEHREGLYVDIV
SGEPLFSSRDKFDSGTGWPSFTRPVAPNSVKEETDIGFGTVRTEVRSKEADSHLGHLFTDGPRDKGGLRYCVNSAALRFI
PVDDLEKEGYGSYLPLFGRKAPAAAVKQVATLAGGCFWGMQDLLRKQPGVIATEVGYTGGSVPNATYENHEGHAEAVRIE
FDPTKTSYEALLRFFFRMHDPTTLNRQGNDIGSSYRSAIFYHDAEQKRIAEKVKAEVDASGKWKRPVVTEIVPAGPWWRA
EEYHQDYLVKNPGGYTCHWVRE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=151, Percent_Identity=44.3708609271523, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI301336162, Length=151, Percent_Identity=44.3708609271523, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI73089054, Length=151, Percent_Identity=44.3708609271523, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI37620216, Length=151, Percent_Identity=44.3708609271523, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI117606353, Length=131, Percent_Identity=43.5114503816794, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=41.5584415584416, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=41.5584415584416, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI208609993, Length=106, Percent_Identity=44.3396226415094, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=46.4052287581699, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1788077, Length=126, Percent_Identity=48.4126984126984, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI115532676, Length=124, Percent_Identity=41.9354838709677, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17553450, Length=124, Percent_Identity=41.9354838709677, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17533973, Length=133, Percent_Identity=38.3458646616541, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=173, Percent_Identity=40.4624277456647, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319816, Length=138, Percent_Identity=34.0579710144928, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24645799, Length=145, Percent_Identity=40, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI221378664, Length=122, Percent_Identity=45.9016393442623, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553335, Length=125, Percent_Identity=44, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356369, Length=125, Percent_Identity=44, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221378662, Length=129, Percent_Identity=43.4108527131783, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24645801, Length=156, Percent_Identity=37.1794871794872, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24645804, Length=138, Percent_Identity=39.8550724637681, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24664627, Length=149, Percent_Identity=36.9127516778523, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=37.410071942446, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24664631, Length=149, Percent_Identity=36.241610738255, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 38578; Mature: 38447

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVFVVACLILAVVARPPRFGGRTAEKETTMTARKYSDEELKQRLTPLQYRVTRKSGT
CCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCC
EPPFDNTYWNEHREGLYVDIVSGEPLFSSRDKFDSGTGWPSFTRPVAPNSVKEETDIGFG
CCCCCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCH
TVRTEVRSKEADSHLGHLFTDGPRDKGGLRYCVNSAALRFIPVDDLEKEGYGSYLPLFGR
HHHHHHHHHHHHHHHCHHCCCCCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCC
KAPAAAVKQVATLAGGCFWGMQDLLRKQPGVIATEVGYTGGSVPNATYENHEGHAEAVRI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEE
EFDPTKTSYEALLRFFFRMHDPTTLNRQGNDIGSSYRSAIFYHDAEQKRIAEKVKAEVDA
EECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHCCC
SGKWKRPVVTEIVPAGPWWRAEEYHQDYLVKNPGGYTCHWVRE
CCCCCCCHHHHEECCCCCCCCHHHCCCCEEECCCCCEEEEECC
>Mature Secondary Structure 
TILVFVVACLILAVVARPPRFGGRTAEKETTMTARKYSDEELKQRLTPLQYRVTRKSGT
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCC
EPPFDNTYWNEHREGLYVDIVSGEPLFSSRDKFDSGTGWPSFTRPVAPNSVKEETDIGFG
CCCCCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCH
TVRTEVRSKEADSHLGHLFTDGPRDKGGLRYCVNSAALRFIPVDDLEKEGYGSYLPLFGR
HHHHHHHHHHHHHHHCHHCCCCCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCC
KAPAAAVKQVATLAGGCFWGMQDLLRKQPGVIATEVGYTGGSVPNATYENHEGHAEAVRI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEE
EFDPTKTSYEALLRFFFRMHDPTTLNRQGNDIGSSYRSAIFYHDAEQKRIAEKVKAEVDA
EECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHCCC
SGKWKRPVVTEIVPAGPWWRAEEYHQDYLVKNPGGYTCHWVRE
CCCCCCCHHHHEECCCCCCCCHHHCCCCEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]