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The map label for this gene is phoR [H]

Identifier: 78221421

GI number: 78221421

Start: 227447

End: 229579

Strand: Direct

Name: phoR [H]

Synonym: Gmet_0197

Alternate gene names: 78221421

Gene position: 227447-229579 (Clockwise)

Preceding gene: 78221420

Following gene: 78221422

Centisome position: 5.69

GC content: 62.03

Gene sequence:

>2133_bases
ATGTCTTCACCAAACCATCGGATATGCCTCGTTGTCGGCTGGGGGGGCGCCGTTCTGCTCTTCCTGGGGCTTGTCGGCAC
GTTCGTCGCCTACCGCATCCATAACGCCTCTATCTTCGGCGTTCTCCCCCATGTTCTCGTCTTTCTCATGCTCTGTTTCA
TATTCATGGCCGTAAGCTATCGCCGCATGAAGAGCGAGGAAGCCCTGGCCCATGTCAAGGAACTGATGCAGGTCCAGCGG
GAACTGGACAAGACCGCGCGCCGTTACCGCAGTCTCATGGAGGGGGCGGGTACGGCCATCTTCGTCTTCAATGCCGATAC
GGGGATGCTGGTGGAGGTGAATCGCCGCGGAACCGAACTCTTCGGCTACGACAAGGAGGAGATGATCCCGTTGCGGGGGA
AGGACCTGGTCCTTGAGGAGGACCAGGAGAAATTCATCTCCCTCGTTCACCGAGTGGCCCGGCGGGGGAGGGGACGCTCC
GACGGGATCACGTTTCGCCGCAAGGGTGGTGAGTGCTTCCTGGGTCAGGTCGATGCCCGTCTCATCGACCTGGGGGACGA
GAAGGTGGTTCATGCCGTGGTTCGCGACATCACCTTCAAGCACCGGGCCGAACGGGAGGTCCGCCAGCGCAACCGGGAAC
TCTCCACCCTTGTCGGCATCATTACCCGGGCCAACCAGGAGACGGAGCTGGAGACGGTGCTCGACGTGACGCTTCGCGAG
ACCATCGAGGCCTTCGGCGCCAATGGCGGCGGGATACACCTTGGCAATCAGGACGGGAAGCTGAGGCCAACGGCATCAAT
CAACGTTCCCGAGCAACTCCGGTTCCTCCTTGCCCGGCGGGATGAGGCAGGCCCCCTGGAGCGGATCGCCGACTCCGGCA
CCAGCCTCAGTCTGGCGAACCTGGAAACGGAGTGCCGTTTCGGCTCGTCGCCGGCCGTCCAGGGGTGGAAGGGATTCGTC
GGGGTTCCCCTTTCGGCCCGCAACCGCGTCACCGGCGTCATGTACCTCCTGTGCAGGAAGGAACGTCGCTTCGGGGATGA
CGAGGTGGCCCTCTTGCTTTCCATCGCCGGCCAGGTGGGGATCGTGATCGACAACGCCCGCCTCTTCGATGAACTCAAGT
GGAAGAGCGATGAGCTCATGGGCTCCCTCCGCCTCCTGGAACGGAGCAGCCACGAACTCTCCTTCTCCCAGCACCGGCTC
CGCACCAACCTGATGCTCGTGGAACGGGCCAACCAGGAACTGGAGCGGATCGACCGGATGAAGTCCAACTTCCTCGGCAT
GATTTCCCACGAGTTCCGCACCCCCCTGACGAGCATCATCAGCGGCACCGAGTTTCTCCTCTCGTCCCCCTCCTTTCAGA
TTGGAAGCGATGCGCGCCGGGTCCTTGACATGATCAATCAGGGGGGAGAACGCCTTTCCGAAATCGTCAGCGATATCCTC
AAGGTGGCGAAGCTGGAGGCCAACAGCACTCCGGTCACCCGCTCGACCCTCCACATTTCCCAGGTTTTCGAAGAGGTCCT
TGAGGCGCTGGAACCCCTGCGGGCCGAACGGGACCTCACGATTTCCTTCGCCGACCTGGAGAGGCTTCCCCACTGCAACG
GCGACCGGGAGTGCTTCAAGGATATCTTCACCGAACTGCTGGAAAATTCCATCAAATTCACCCCCGACGGCGGTACCATC
ATGGTTGACGCCCGGATTGTGGACAGGGATCGGCTCTCGCCGAGGGGAGACATCCTCAACCGCTTCAATTCCCGGTTCCT
TGCCCAGTCGGGTGGGGGGTGCTACCTGGAGGTGGAGGTCCGGGACAGCGGCATCGGCGTGAGTCATGATGAGCAGGTGA
AGATCTTCGACAAGTTCTACGAGGTGGGTGATATCCGTCATCACTCCAGCGGCAAGAACAAGTTCCAGGGGAAGGGGACC
GGGTTGGGGCTCGCCATCGTCAAGGGGATGGTGGAAGCCCATGGGGGCATGGTCTGGGTCGAGAGTCCGGGAGAAAGTTC
CGATGGCCGTCTCGGCAGCGCCTTCTTCGTGCTTCTCCCCCTGGAGGAGAGTGCCTGCCAGCCCCAACTCCCCCTCTCCG
GAGCCGGCATGTCCCGTTCCCATGACGACCTTCCCGATGAGGGGGGCGGATAG

Upstream 100 bases:

>100_bases
GACCGCGACAGGATCAGGACGATCACCGCGGTTACGGCCATGGATTGGCTGAGAAGGCGGCTTTTATCACATTAGTCCTT
GGCGGGATGGATAGGTAGTC

Downstream 100 bases:

>100_bases
CCGCCGCGGCGGTGGCGCAGGTCCCGAAGATACCCGTTGAAAAAGACGAAACACCTGTGCTATCTCTGTTCAACTATACC
GGTCAGTGGCGATTTTTCGC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 710; Mature: 709

Protein sequence:

>710_residues
MSSPNHRICLVVGWGGAVLLFLGLVGTFVAYRIHNASIFGVLPHVLVFLMLCFIFMAVSYRRMKSEEALAHVKELMQVQR
ELDKTARRYRSLMEGAGTAIFVFNADTGMLVEVNRRGTELFGYDKEEMIPLRGKDLVLEEDQEKFISLVHRVARRGRGRS
DGITFRRKGGECFLGQVDARLIDLGDEKVVHAVVRDITFKHRAEREVRQRNRELSTLVGIITRANQETELETVLDVTLRE
TIEAFGANGGGIHLGNQDGKLRPTASINVPEQLRFLLARRDEAGPLERIADSGTSLSLANLETECRFGSSPAVQGWKGFV
GVPLSARNRVTGVMYLLCRKERRFGDDEVALLLSIAGQVGIVIDNARLFDELKWKSDELMGSLRLLERSSHELSFSQHRL
RTNLMLVERANQELERIDRMKSNFLGMISHEFRTPLTSIISGTEFLLSSPSFQIGSDARRVLDMINQGGERLSEIVSDIL
KVAKLEANSTPVTRSTLHISQVFEEVLEALEPLRAERDLTISFADLERLPHCNGDRECFKDIFTELLENSIKFTPDGGTI
MVDARIVDRDRLSPRGDILNRFNSRFLAQSGGGCYLEVEVRDSGIGVSHDEQVKIFDKFYEVGDIRHHSSGKNKFQGKGT
GLGLAIVKGMVEAHGGMVWVESPGESSDGRLGSAFFVLLPLEESACQPQLPLSGAGMSRSHDDLPDEGGG

Sequences:

>Translated_710_residues
MSSPNHRICLVVGWGGAVLLFLGLVGTFVAYRIHNASIFGVLPHVLVFLMLCFIFMAVSYRRMKSEEALAHVKELMQVQR
ELDKTARRYRSLMEGAGTAIFVFNADTGMLVEVNRRGTELFGYDKEEMIPLRGKDLVLEEDQEKFISLVHRVARRGRGRS
DGITFRRKGGECFLGQVDARLIDLGDEKVVHAVVRDITFKHRAEREVRQRNRELSTLVGIITRANQETELETVLDVTLRE
TIEAFGANGGGIHLGNQDGKLRPTASINVPEQLRFLLARRDEAGPLERIADSGTSLSLANLETECRFGSSPAVQGWKGFV
GVPLSARNRVTGVMYLLCRKERRFGDDEVALLLSIAGQVGIVIDNARLFDELKWKSDELMGSLRLLERSSHELSFSQHRL
RTNLMLVERANQELERIDRMKSNFLGMISHEFRTPLTSIISGTEFLLSSPSFQIGSDARRVLDMINQGGERLSEIVSDIL
KVAKLEANSTPVTRSTLHISQVFEEVLEALEPLRAERDLTISFADLERLPHCNGDRECFKDIFTELLENSIKFTPDGGTI
MVDARIVDRDRLSPRGDILNRFNSRFLAQSGGGCYLEVEVRDSGIGVSHDEQVKIFDKFYEVGDIRHHSSGKNKFQGKGT
GLGLAIVKGMVEAHGGMVWVESPGESSDGRLGSAFFVLLPLEESACQPQLPLSGAGMSRSHDDLPDEGGG
>Mature_709_residues
SSPNHRICLVVGWGGAVLLFLGLVGTFVAYRIHNASIFGVLPHVLVFLMLCFIFMAVSYRRMKSEEALAHVKELMQVQRE
LDKTARRYRSLMEGAGTAIFVFNADTGMLVEVNRRGTELFGYDKEEMIPLRGKDLVLEEDQEKFISLVHRVARRGRGRSD
GITFRRKGGECFLGQVDARLIDLGDEKVVHAVVRDITFKHRAEREVRQRNRELSTLVGIITRANQETELETVLDVTLRET
IEAFGANGGGIHLGNQDGKLRPTASINVPEQLRFLLARRDEAGPLERIADSGTSLSLANLETECRFGSSPAVQGWKGFVG
VPLSARNRVTGVMYLLCRKERRFGDDEVALLLSIAGQVGIVIDNARLFDELKWKSDELMGSLRLLERSSHELSFSQHRLR
TNLMLVERANQELERIDRMKSNFLGMISHEFRTPLTSIISGTEFLLSSPSFQIGSDARRVLDMINQGGERLSEIVSDILK
VAKLEANSTPVTRSTLHISQVFEEVLEALEPLRAERDLTISFADLERLPHCNGDRECFKDIFTELLENSIKFTPDGGTIM
VDARIVDRDRLSPRGDILNRFNSRFLAQSGGGCYLEVEVRDSGIGVSHDEQVKIFDKFYEVGDIRHHSSGKNKFQGKGTG
LGLAIVKGMVEAHGGMVWVESPGESSDGRLGSAFFVLLPLEESACQPQLPLSGAGMSRSHDDLPDEGGG

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=272, Percent_Identity=30.8823529411765, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1786783, Length=283, Percent_Identity=28.9752650176678, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1789149, Length=285, Percent_Identity=27.719298245614, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87081816, Length=277, Percent_Identity=29.6028880866426, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=259, Percent_Identity=29.3436293436293, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790436, Length=302, Percent_Identity=24.1721854304636, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786912, Length=273, Percent_Identity=25.6410256410256, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=259, Percent_Identity=23.9382239382239, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788713, Length=271, Percent_Identity=25.830258302583, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=26.7399267399267, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790861, Length=236, Percent_Identity=24.1525423728814, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 79072; Mature: 78940

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPNHRICLVVGWGGAVLLFLGLVGTFVAYRIHNASIFGVLPHVLVFLMLCFIFMAVSY
CCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RRMKSEEALAHVKELMQVQRELDKTARRYRSLMEGAGTAIFVFNADTGMLVEVNRRGTEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCEE
FGYDKEEMIPLRGKDLVLEEDQEKFISLVHRVARRGRGRSDGITFRRKGGECFLGQVDAR
CCCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCE
LIDLGDEKVVHAVVRDITFKHRAEREVRQRNRELSTLVGIITRANQETELETVLDVTLRE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TIEAFGANGGGIHLGNQDGKLRPTASINVPEQLRFLLARRDEAGPLERIADSGTSLSLAN
HHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEC
LETECRFGSSPAVQGWKGFVGVPLSARNRVTGVMYLLCRKERRFGDDEVALLLSIAGQVG
CCHHCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEE
IVIDNARLFDELKWKSDELMGSLRLLERSSHELSFSQHRLRTNLMLVERANQELERIDRM
EEEECHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSNFLGMISHEFRTPLTSIISGTEFLLSSPSFQIGSDARRVLDMINQGGERLSEIVSDIL
HHHHHHHHHHHHHCHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
KVAKLEANSTPVTRSTLHISQVFEEVLEALEPLRAERDLTISFADLERLPHCNGDRECFK
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCHHHHH
DIFTELLENSIKFTPDGGTIMVDARIVDRDRLSPRGDILNRFNSRFLAQSGGGCYLEVEV
HHHHHHHHCCCEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEE
RDSGIGVSHDEQVKIFDKFYEVGDIRHHSSGKNKFQGKGTGLGLAIVKGMVEAHGGMVWV
ECCCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEE
ESPGESSDGRLGSAFFVLLPLEESACQPQLPLSGAGMSRSHDDLPDEGGG
ECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSPNHRICLVVGWGGAVLLFLGLVGTFVAYRIHNASIFGVLPHVLVFLMLCFIFMAVSY
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RRMKSEEALAHVKELMQVQRELDKTARRYRSLMEGAGTAIFVFNADTGMLVEVNRRGTEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCEE
FGYDKEEMIPLRGKDLVLEEDQEKFISLVHRVARRGRGRSDGITFRRKGGECFLGQVDAR
CCCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCE
LIDLGDEKVVHAVVRDITFKHRAEREVRQRNRELSTLVGIITRANQETELETVLDVTLRE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TIEAFGANGGGIHLGNQDGKLRPTASINVPEQLRFLLARRDEAGPLERIADSGTSLSLAN
HHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEC
LETECRFGSSPAVQGWKGFVGVPLSARNRVTGVMYLLCRKERRFGDDEVALLLSIAGQVG
CCHHCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEE
IVIDNARLFDELKWKSDELMGSLRLLERSSHELSFSQHRLRTNLMLVERANQELERIDRM
EEEECHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSNFLGMISHEFRTPLTSIISGTEFLLSSPSFQIGSDARRVLDMINQGGERLSEIVSDIL
HHHHHHHHHHHHHCHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
KVAKLEANSTPVTRSTLHISQVFEEVLEALEPLRAERDLTISFADLERLPHCNGDRECFK
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCHHHHH
DIFTELLENSIKFTPDGGTIMVDARIVDRDRLSPRGDILNRFNSRFLAQSGGGCYLEVEV
HHHHHHHHCCCEECCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEE
RDSGIGVSHDEQVKIFDKFYEVGDIRHHSSGKNKFQGKGTGLGLAIVKGMVEAHGGMVWV
ECCCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEE
ESPGESSDGRLGSAFFVLLPLEESACQPQLPLSGAGMSRSHDDLPDEGGG
ECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]