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The map label for this gene is 78221371

Identifier: 78221371

GI number: 78221371

Start: 173599

End: 175206

Strand: Direct

Name: 78221371

Synonym: Gmet_0144

Alternate gene names: NA

Gene position: 173599-175206 (Clockwise)

Preceding gene: 78221370

Following gene: 78221372

Centisome position: 4.34

GC content: 66.23

Gene sequence:

>1608_bases
ATGAGACACCCCGAATTCACTCCCCGAAGAGTCTACGTCGCCGCCTCGTACATGGCCCCAGTGGGGCGCTACGACGGCAA
GCACCGGGAACAGCTCTCCTTCCTCGACCTGGCCGAAAAGGCCAAGTCGGTCTTCAACGATTCACCGGTGAAACCCCGCG
CCATCGAGGCGGTGGTGGTCGGCTCCCAGAGCCCCGTGGCCTTTTCCGGCGTCGACAACACCGCCGCCAAGATCGCCGGG
GTCGTGGGGGTCTCGGGGGCCAAGTCGGTCCTCATCGACACCGCCTCCTCCTCGGGCGCCTCGGCCTTCGAGAACGCCTA
CCTCCAGATCGCCTCGGGCCGCTGCGACCATGTGCTCGCCATCGGCATCCAGAAAATGAGCGACGCCCCCACCACCGAGG
CGACCCGCATTGTCGCCGGGGTCATCGACAAAGACGAGGCTGAATTCGGCCTCAGCATGCCCGCCTGTGGGGCACTGGTG
GCCCGGGCGCTCATGGAGCGGCACGGCCTCTCCATTGACGAATGGACCGCCTTCTCGGCCCTCCTCACCCAGCGGGCCCA
CCGCTACGCCGCCAGGAACCCGGACGCGCATTTGAACAGGGAAATCCCCTTGGAGGAGTACTACCGCCAGATCATCAACG
GGAAAAACTACCGCTACTGGTGGCCCCTGCGCTACCACGACTTCTGCCCCATGTCCGATGGCGTGGCCGCCGTGATCCTC
ACCGCCGCCCCCCAGGAGGTGATGGTCTCCGGCGTGGGGAGCGCCACCGATATCCCCACCATCGCCGACCGCAACTACTT
CCACTCCTTCCCCGCCACCGTGGCCGCCGCCGCCGAGGCCTACGGCATGGCCGGCATCAGGGACATCCGCGCCTTCGCCG
GGAAGATCCACGTGAACATGCACGACCCCTTCAACGGCTTCGGCCCCATCAACATGGTGGATCTCGGCTTCGTCCCCCGG
GGGCGCATCCTCGACGCCCTCCTGGACGACGCTTGCACCGGGGAGAACGGCATGTTCCCCACCAACCTCACTGGCGGCCT
CAAGGGACGGGGCCACCCCCTGGGGGCCACCGGCATGATCCAGGTGGTGGAGAACCACCGGATGATTCTCGAAGGGCGCT
TCCAGGCCGGCGTCTCCCACTCCATCGGCGGCCCCATCAACAACAACATCGTCACCCTCCTGGAGCGGAGCGACCACTAC
GAGCGCCGTCCCCACGAACCCTACAAGCCGTGGGGGCTCCCCTCCCTGGGCCGGCTCAAGCCGAAGGAAGTGACCGTTGA
CGCCCTCCTGGCGGAAACCGGCGTCGTGGAAGGGACCTTCGTCACCGCCACCACCCGCTTCGACTACAGGAGCGGCGACC
CCGAGGGAATCATCACCATCGTTTCCTGCCGGGCACAAAGCGGCAAAAGTTACCGCTTCCTCTTCGGCATCGCCGGCGAG
AACTACCAGCAACTCATCAAGCTCCTCCCCGGCGACCGGATCAGCCTGGAGCGGAGCGACGGCCAGATCCTCCTCAACCG
GATGCCGGTGAAGAAGTTCTACCAGCGCACCATCGACGGGCTGGTGGATCTGGCAGGGAGCGGGTGGAAGAGGCTGACGG
GGTGGTAA

Upstream 100 bases:

>100_bases
AGCCCGAAAGGTTCGGGCTTTTTGCTGCCGGTTGCTCAACGGCAATCCTCGTTTACACTACAGAGACAGGGTCACAAATC
TCCCCGTAAACGGAGCCCCC

Downstream 100 bases:

>100_bases
CCTGCGCCGGAGGAATGGTGAAGAAACCTTTTTATACATGGGATGGTGATACCCTGGTGCTTAATATCCTCGGCACGCCC
AATGCCAAACGGGACGCCAT

Product: thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MRHPEFTPRRVYVAASYMAPVGRYDGKHREQLSFLDLAEKAKSVFNDSPVKPRAIEAVVVGSQSPVAFSGVDNTAAKIAG
VVGVSGAKSVLIDTASSSGASAFENAYLQIASGRCDHVLAIGIQKMSDAPTTEATRIVAGVIDKDEAEFGLSMPACGALV
ARALMERHGLSIDEWTAFSALLTQRAHRYAARNPDAHLNREIPLEEYYRQIINGKNYRYWWPLRYHDFCPMSDGVAAVIL
TAAPQEVMVSGVGSATDIPTIADRNYFHSFPATVAAAAEAYGMAGIRDIRAFAGKIHVNMHDPFNGFGPINMVDLGFVPR
GRILDALLDDACTGENGMFPTNLTGGLKGRGHPLGATGMIQVVENHRMILEGRFQAGVSHSIGGPINNNIVTLLERSDHY
ERRPHEPYKPWGLPSLGRLKPKEVTVDALLAETGVVEGTFVTATTRFDYRSGDPEGIITIVSCRAQSGKSYRFLFGIAGE
NYQQLIKLLPGDRISLERSDGQILLNRMPVKKFYQRTIDGLVDLAGSGWKRLTGW

Sequences:

>Translated_535_residues
MRHPEFTPRRVYVAASYMAPVGRYDGKHREQLSFLDLAEKAKSVFNDSPVKPRAIEAVVVGSQSPVAFSGVDNTAAKIAG
VVGVSGAKSVLIDTASSSGASAFENAYLQIASGRCDHVLAIGIQKMSDAPTTEATRIVAGVIDKDEAEFGLSMPACGALV
ARALMERHGLSIDEWTAFSALLTQRAHRYAARNPDAHLNREIPLEEYYRQIINGKNYRYWWPLRYHDFCPMSDGVAAVIL
TAAPQEVMVSGVGSATDIPTIADRNYFHSFPATVAAAAEAYGMAGIRDIRAFAGKIHVNMHDPFNGFGPINMVDLGFVPR
GRILDALLDDACTGENGMFPTNLTGGLKGRGHPLGATGMIQVVENHRMILEGRFQAGVSHSIGGPINNNIVTLLERSDHY
ERRPHEPYKPWGLPSLGRLKPKEVTVDALLAETGVVEGTFVTATTRFDYRSGDPEGIITIVSCRAQSGKSYRFLFGIAGE
NYQQLIKLLPGDRISLERSDGQILLNRMPVKKFYQRTIDGLVDLAGSGWKRLTGW
>Mature_535_residues
MRHPEFTPRRVYVAASYMAPVGRYDGKHREQLSFLDLAEKAKSVFNDSPVKPRAIEAVVVGSQSPVAFSGVDNTAAKIAG
VVGVSGAKSVLIDTASSSGASAFENAYLQIASGRCDHVLAIGIQKMSDAPTTEATRIVAGVIDKDEAEFGLSMPACGALV
ARALMERHGLSIDEWTAFSALLTQRAHRYAARNPDAHLNREIPLEEYYRQIINGKNYRYWWPLRYHDFCPMSDGVAAVIL
TAAPQEVMVSGVGSATDIPTIADRNYFHSFPATVAAAAEAYGMAGIRDIRAFAGKIHVNMHDPFNGFGPINMVDLGFVPR
GRILDALLDDACTGENGMFPTNLTGGLKGRGHPLGATGMIQVVENHRMILEGRFQAGVSHSIGGPINNNIVTLLERSDHY
ERRPHEPYKPWGLPSLGRLKPKEVTVDALLAETGVVEGTFVTATTRFDYRSGDPEGIITIVSCRAQSGKSYRFLFGIAGE
NYQQLIKLLPGDRISLERSDGQILLNRMPVKKFYQRTIDGLVDLAGSGWKRLTGW

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=389, Percent_Identity=24.6786632390745, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI302344760, Length=311, Percent_Identity=24.7588424437299, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: NA

Molecular weight: Translated: 58306; Mature: 58306

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHPEFTPRRVYVAASYMAPVGRYDGKHREQLSFLDLAEKAKSVFNDSPVKPRAIEAVVV
CCCCCCCCCEEEEEEHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
GSQSPVAFSGVDNTAAKIAGVVGVSGAKSVLIDTASSSGASAFENAYLQIASGRCDHVLA
CCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCEEEEECCCCCEEEE
IGIQKMSDAPTTEATRIVAGVIDKDEAEFGLSMPACGALVARALMERHGLSIDEWTAFSA
EEHHHHCCCCCCHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
LLTQRAHRYAARNPDAHLNREIPLEEYYRQIINGKNYRYWWPLRYHDFCPMSDGVAAVIL
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEE
TAAPQEVMVSGVGSATDIPTIADRNYFHSFPATVAAAAEAYGMAGIRDIRAFAGKIHVNM
ECCCHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHCEEEEEE
HDPFNGFGPINMVDLGFVPRGRILDALLDDACTGENGMFPTNLTGGLKGRGHPLGATGMI
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
QVVENHRMILEGRFQAGVSHSIGGPINNNIVTLLERSDHYERRPHEPYKPWGLPSLGRLK
HHHHCCEEEEEEHHHCCCCCCCCCCCCCCEEEEEECCCCHHCCCCCCCCCCCCCCCCCCC
PKEVTVDALLAETGVVEGTFVTATTRFDYRSGDPEGIITIVSCRAQSGKSYRFLFGIAGE
CCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEEECCC
NYQQLIKLLPGDRISLERSDGQILLNRMPVKKFYQRTIDGLVDLAGSGWKRLTGW
CHHHHHHHCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MRHPEFTPRRVYVAASYMAPVGRYDGKHREQLSFLDLAEKAKSVFNDSPVKPRAIEAVVV
CCCCCCCCCEEEEEEHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
GSQSPVAFSGVDNTAAKIAGVVGVSGAKSVLIDTASSSGASAFENAYLQIASGRCDHVLA
CCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCEEEEECCCCCEEEE
IGIQKMSDAPTTEATRIVAGVIDKDEAEFGLSMPACGALVARALMERHGLSIDEWTAFSA
EEHHHHCCCCCCHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
LLTQRAHRYAARNPDAHLNREIPLEEYYRQIINGKNYRYWWPLRYHDFCPMSDGVAAVIL
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEE
TAAPQEVMVSGVGSATDIPTIADRNYFHSFPATVAAAAEAYGMAGIRDIRAFAGKIHVNM
ECCCHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHCEEEEEE
HDPFNGFGPINMVDLGFVPRGRILDALLDDACTGENGMFPTNLTGGLKGRGHPLGATGMI
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
QVVENHRMILEGRFQAGVSHSIGGPINNNIVTLLERSDHYERRPHEPYKPWGLPSLGRLK
HHHHCCEEEEEEHHHCCCCCCCCCCCCCCEEEEEECCCCHHCCCCCCCCCCCCCCCCCCC
PKEVTVDALLAETGVVEGTFVTATTRFDYRSGDPEGIITIVSCRAQSGKSYRFLFGIAGE
CCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEEECCC
NYQQLIKLLPGDRISLERSDGQILLNRMPVKKFYQRTIDGLVDLAGSGWKRLTGW
CHHHHHHHCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]