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The map label for this gene is yhfN [H]

Identifier: 78221336

GI number: 78221336

Start: 135784

End: 137049

Strand: Reverse

Name: yhfN [H]

Synonym: Gmet_0109

Alternate gene names: 78221336

Gene position: 137049-135784 (Counterclockwise)

Preceding gene: 78221337

Following gene: 78221335

Centisome position: 3.43

GC content: 64.14

Gene sequence:

>1266_bases
ATGACCGCCGTCATCATCCTTTTCTACCTCATTACCCTTGGCGCCGGCTTTTTCCTTCGGACGCTGAATCTCCGCCATCT
GAAACGGTACGGCTCCACCGTCCCCTCCGGTTTCGAGGGGGCGGTGGAGCCGGAAACCCTCCGCAAAACGGTTGCCTATA
CCCTTGACCAGAGCCGCCTGGGGCTCGCCGAGTCCCTCTTCGACGCGGCGCTCCTCCTCATTTTTCTCTTCGGGCTTCTG
CCGGCCTATGACCGGTGGCTCGCCTCCCTGGGAGGCTCCTTCGTCCTCTCGGGTGTCCTCTTCTTCCTGGGTCTCACCCT
CATCCAGACGTTCCTCGGCATCCCCTTCGACCTTTACGGGACCTTTCGCCTCGAAGTCCGCTACGGCTTCAACACCACGA
CTCCCGGCCTCTGGCTCTCGGACCTGGCAAAGTCGACCCTCATCGCGGTGGTGCTGACCGGGCTCCTGGTGGCCGGGGCC
TTTGCCCTCGTGGCGTGGAGTCCCCGCTTCTGGTGGCTCTGGGTCTGGGGGTTCTTCGCCATGGTCTCCCTCTTCCTCAT
GTACCTCTCCCCCTACGTCATCGAACCCCTCTTCAACCGGTTCGAGCCGGTCGCCGAGGAGGGGCTGGAGGAGGAGATCC
GCGCCTTGTGTGAACGGGCCGGGCTGCGGGTCAGCCGGGTCATGCAGGTGGACGCCTCCCGGCGCAGCCGCCACTCCAAT
GCCTACTTCACCGGCATCGGCCGGGTAAAGCGTATCGTCCTTTACGACACCCTCATCCGCCAGATGAGCCACCGGGAGAT
CCTGGCGGTCCTTGCCCACGAGATCGGCCACTGGAAGAAGGGGCATATCCGCCGGCGGTTGATCCTCACGGAAGCCGGTG
CCCTGGCCGGCTCGTGGTTTGCCTGGAAACTCACGGGATGGGAGGGATTTCCGGGGCTCATCGGCCTGACGGACGCCTCC
TTCGCGGCGCGACTCGTCATCCTCGGTTTCCTGGGCTCCATCGTTTCCTTCCCCTTCACCCCCCTTTCCAGTTGGCTCTC
CCGCCGCCACGAGCGGGAGGCGGACCGTTTCGCCACCGACATTACGGGGGATGCGGAGGCCTTGGCCTCAGCCCTCGTGA
AGCTCTCCACGGAGAATCTCTCCAATCTCCACCCTCATCCCCTTTATGCGGCGTTCTACTATTCCCATCCTCCCGTGGTT
GAGCGGGTGGGCAGGCTGAGGGCCGCCATGCCTCCGGCAGGAAAAGCGGGAGAGACCACGATGTAA

Upstream 100 bases:

>100_bases
CCACCGGCACCCTCCGCAAGGACAAGGATTTCGGCGGCGGCTACCGGTATCAGGTCATCATCGAGGAAGGGACCGTGAAG
CGCTGACGCTCTCCTCCTCC

Downstream 100 bases:

>100_bases
TCGGAAATTTTTTCATAATTCAGGTCCCTGGCGAGTCGTCACTGCCGTGGTTGAATGAATCTCTAACGATCTGCCATTCA
CTGTGGCTAATTATGATTTT

Product: peptidase M48, Ste24p

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTAVIILFYLITLGAGFFLRTLNLRHLKRYGSTVPSGFEGAVEPETLRKTVAYTLDQSRLGLAESLFDAALLLIFLFGLL
PAYDRWLASLGGSFVLSGVLFFLGLTLIQTFLGIPFDLYGTFRLEVRYGFNTTTPGLWLSDLAKSTLIAVVLTGLLVAGA
FALVAWSPRFWWLWVWGFFAMVSLFLMYLSPYVIEPLFNRFEPVAEEGLEEEIRALCERAGLRVSRVMQVDASRRSRHSN
AYFTGIGRVKRIVLYDTLIRQMSHREILAVLAHEIGHWKKGHIRRRLILTEAGALAGSWFAWKLTGWEGFPGLIGLTDAS
FAARLVILGFLGSIVSFPFTPLSSWLSRRHEREADRFATDITGDAEALASALVKLSTENLSNLHPHPLYAAFYYSHPPVV
ERVGRLRAAMPPAGKAGETTM

Sequences:

>Translated_421_residues
MTAVIILFYLITLGAGFFLRTLNLRHLKRYGSTVPSGFEGAVEPETLRKTVAYTLDQSRLGLAESLFDAALLLIFLFGLL
PAYDRWLASLGGSFVLSGVLFFLGLTLIQTFLGIPFDLYGTFRLEVRYGFNTTTPGLWLSDLAKSTLIAVVLTGLLVAGA
FALVAWSPRFWWLWVWGFFAMVSLFLMYLSPYVIEPLFNRFEPVAEEGLEEEIRALCERAGLRVSRVMQVDASRRSRHSN
AYFTGIGRVKRIVLYDTLIRQMSHREILAVLAHEIGHWKKGHIRRRLILTEAGALAGSWFAWKLTGWEGFPGLIGLTDAS
FAARLVILGFLGSIVSFPFTPLSSWLSRRHEREADRFATDITGDAEALASALVKLSTENLSNLHPHPLYAAFYYSHPPVV
ERVGRLRAAMPPAGKAGETTM
>Mature_420_residues
TAVIILFYLITLGAGFFLRTLNLRHLKRYGSTVPSGFEGAVEPETLRKTVAYTLDQSRLGLAESLFDAALLLIFLFGLLP
AYDRWLASLGGSFVLSGVLFFLGLTLIQTFLGIPFDLYGTFRLEVRYGFNTTTPGLWLSDLAKSTLIAVVLTGLLVAGAF
ALVAWSPRFWWLWVWGFFAMVSLFLMYLSPYVIEPLFNRFEPVAEEGLEEEIRALCERAGLRVSRVMQVDASRRSRHSNA
YFTGIGRVKRIVLYDTLIRQMSHREILAVLAHEIGHWKKGHIRRRLILTEAGALAGSWFAWKLTGWEGFPGLIGLTDASF
AARLVILGFLGSIVSFPFTPLSSWLSRRHEREADRFATDITGDAEALASALVKLSTENLSNLHPHPLYAAFYYSHPPVVE
RVGRLRAAMPPAGKAGETTM

Specific function: Unknown

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=439, Percent_Identity=29.6127562642369, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17505484, Length=427, Percent_Identity=30.6791569086651, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322577, Length=417, Percent_Identity=30.6954436450839, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19922414, Length=419, Percent_Identity=30.5489260143198, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI78707252, Length=424, Percent_Identity=26.8867924528302, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI78707254, Length=424, Percent_Identity=26.8867924528302, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24654305, Length=254, Percent_Identity=27.1653543307087, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: NA

Molecular weight: Translated: 47029; Mature: 46898

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure 
TAVIILFYLITLGAGFFLRTLNLRHLKRYGSTVPSGFEGAVEPETLRKTVAYTLDQSRL
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCHHHH
GLAESLFDAALLLIFLFGLLPAYDRWLASLGGSFVLSGVLFFLGLTLIQTFLGIPFDLYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEECE
TFRLEVRYGFNTTTPGLWLSDLAKSTLIAVVLTGLLVAGAFALVAWSPRFWWLWVWGFFA
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MVSLFLMYLSPYVIEPLFNRFEPVAEEGLEEEIRALCERAGLRVSRVMQVDASRRSRHSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
AYFTGIGRVKRIVLYDTLIRQMSHREILAVLAHEIGHWKKGHIRRRLILTEAGALAGSWF
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCE
AWKLTGWEGFPGLIGLTDASFAARLVILGFLGSIVSFPFTPLSSWLSRRHEREADRFATD
EEEECCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
ITGDAEALASALVKLSTENLSNLHPHPLYAAFYYSHPPVVERVGRLRAAMPPAGKAGETT
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCC
M
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]