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The map label for this gene is nth [C]

Identifier: 78221297

GI number: 78221297

Start: 84643

End: 85314

Strand: Reverse

Name: nth [C]

Synonym: Gmet_0070

Alternate gene names: 78221297

Gene position: 85314-84643 (Counterclockwise)

Preceding gene: 78221298

Following gene: 78221292

Centisome position: 2.13

GC content: 65.33

Gene sequence:

>672_bases
ATGCTCGACGCGGTCCTGCAGGAGATCTTCGACATCCTCCATGCCGCCTACGGACCCCGCCACTGGTGGCCCGCCGACAC
CCCCTTCGAGGTCTGCGTCGGCGCAATCCTGACCCAGAACACCAACTGGGGAAACGTGGAAAAAGCCATCTCAAACCTGA
AGCGTGAGAGCCTCCTCTCCCCCGAAGCCCTCCGCGACGTGCCGGCCGCCTCCCTGGCGGAGGCCATCCGGCCGGCCGGG
TACTTCAATGTGAAGAGCCTCCGGCTCAAGGATTTCGCGGGGTATCTCTGGGAACGGCACGGGGGAAGCCTGGAGCGGAT
GTTCGCAGGGGATTGGCACGCGTTGCGGGAGGAACTGCTGGGGGTGCGGGGGATCGGCCCGGAGACCGCTGATTCGATCC
TTCTCTACGCGGGGGGGAAACCGACCTTCGTGGTGGATGCCTACACGAAGCGTCTCTTCGCGGCCCTGGGGATTCTGAAC
GGGTCGGCCGGCTACGATGAGGTGCGAGATCTCTTCATGGCCAACCTGCCGCCCGACGTCCGGCTCTTCAACGAGTACCA
CGCCCTCATCGTGGAGCACGGCAAGCGCCACTGCCGCAAGCGCCCCCTCTGCCCCGGCTGTGGCCTCCACCTCTTCTGTC
GAAGCCACGTTACGGAACGGCCGGCATCATAA

Upstream 100 bases:

>100_bases
CGGGAGATCTTCTCATGCGGGAGTACGAGGAGACCACCGAGGCGGTGCGGCGGATCTACGAGCGGATTATGGGGGGAGAC
TCCCCCGGCGGGACGGCCTG

Downstream 100 bases:

>100_bases
TTCCGTCAGTCAGAAACGAGCACCTGAGCGCCTTAAGGCACCCCTTTTTCAATGCTTGCCCCTGCCATGAGCTCAACGCG
GTTGCGTCCCCCCTGTTTGG

Product: DNA-3-methyladenine glycosylase III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MLDAVLQEIFDILHAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVEKAISNLKRESLLSPEALRDVPAASLAEAIRPAG
YFNVKSLRLKDFAGYLWERHGGSLERMFAGDWHALREELLGVRGIGPETADSILLYAGGKPTFVVDAYTKRLFAALGILN
GSAGYDEVRDLFMANLPPDVRLFNEYHALIVEHGKRHCRKRPLCPGCGLHLFCRSHVTERPAS

Sequences:

>Translated_223_residues
MLDAVLQEIFDILHAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVEKAISNLKRESLLSPEALRDVPAASLAEAIRPAG
YFNVKSLRLKDFAGYLWERHGGSLERMFAGDWHALREELLGVRGIGPETADSILLYAGGKPTFVVDAYTKRLFAALGILN
GSAGYDEVRDLFMANLPPDVRLFNEYHALIVEHGKRHCRKRPLCPGCGLHLFCRSHVTERPAS
>Mature_223_residues
MLDAVLQEIFDILHAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVEKAISNLKRESLLSPEALRDVPAASLAEAIRPAG
YFNVKSLRLKDFAGYLWERHGGSLERMFAGDWHALREELLGVRGIGPETADSILLYAGGKPTFVVDAYTKRLFAALGILN
GSAGYDEVRDLFMANLPPDVRLFNEYHALIVEHGKRHCRKRPLCPGCGLHLFCRSHVTERPAS

Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da

COG id: COG2231

COG function: function code L; Uncharacterized protein related to Endonuclease III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 4.2.99.18

Molecular weight: Translated: 24866; Mature: 24866

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDAVLQEIFDILHAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVEKAISNLKRESLLS
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
PEALRDVPAASLAEAIRPAGYFNVKSLRLKDFAGYLWERHGGSLERMFAGDWHALREELL
CHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHH
GVRGIGPETADSILLYAGGKPTFVVDAYTKRLFAALGILNGSAGYDEVRDLFMANLPPDV
CCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCH
RLFNEYHALIVEHGKRHCRKRPLCPGCGLHLFCRSHVTERPAS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLDAVLQEIFDILHAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVEKAISNLKRESLLS
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
PEALRDVPAASLAEAIRPAGYFNVKSLRLKDFAGYLWERHGGSLERMFAGDWHALREELL
CHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHH
GVRGIGPETADSILLYAGGKPTFVVDAYTKRLFAALGILNGSAGYDEVRDLFMANLPPDV
CCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCH
RLFNEYHALIVEHGKRHCRKRPLCPGCGLHLFCRSHVTERPAS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]