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The map label for this gene is dspA [H]

Identifier: 78221240

GI number: 78221240

Start: 18680

End: 20365

Strand: Direct

Name: dspA [H]

Synonym: Gmet_0012

Alternate gene names: 78221240

Gene position: 18680-20365 (Clockwise)

Preceding gene: 78221239

Following gene: 78221241

Centisome position: 0.47

GC content: 63.35

Gene sequence:

>1686_bases
ATGGACGATTTGCACCTGAGGATACTGCTGGCGGAGGACTCCGAGGAGGATGCCTTTCTGCTTCTGCGGGAGCTGGAACG
GGGGGGATACACGGTGGAGTGCGAGCGGGTGCAGACCCGCTCCGCCATGAAAAAGGCCCTGGTCTCCCGGCAATGGGACA
TGGTCATTTCCGACTACCGGATGCCCCGGTTCTCCGCGCCCCAGGCCCTGGAAACCCTCAAGGAGAGCGGTCTCGACCTC
CCCTTCATCATCGTCTCCGGCAAGATCGCCGAGGATATGCTCGTGGATGCCATGCGGGCCGGCGCCAACGACTACTTCAT
GAAGGGGAACCTGTCGCGGCTCATTCCTGCCATCGAGCGGGAGCTGCGGGAGGCTGCCGAGCGGCGCATCCGGCGCCGGG
CCGAGCGGGCCATCCGCCAGGGGAAAATGGAGTGGGAGGCGGCTTTCGACGCCGTGTCGGACCTGGTCCTTCTCACCGAC
CTCTACAGCACGGTCATCCGCTGCAACAACCGGGTCATCGAGGCCTTCAACGCCACCTACAGCGACATCCTGGGGAGGAA
CATCACCGAGCTTTTCTACGGCAGCCCCGACGCCGGGGAGAGCATTTTCGATCAGTGCACCGATCTGAAGGCCGATAACG
GCGATGTCCGCTTTCCCAAACTCACGGGATGGTACAAGGCCTCCTGCTTTCCCATGCACCCTACCGAAAACGAACACGGC
TTCGTCTACGTCATCAAGGACGTCACCAAGCGGAAAAAGATGGAGGAAGAGAAGGAGCTGGCCACCCTGGAGCTTCTCCG
GAGCCGCCAGGCCCTCAGGGAGAATCTGGAGGAGATGAAGCGGGCCAACATGGAGCTGGGGCGCCTGAACGCCGCCAAGA
ACACCGTCATCGGCATGGCCTCCCATGAACTGAAGACCCCGCTTACCTCCATCATCGGTGGGCTCCAGTTTCTCTTCCAC
TACAGCGGCCTGGAGATGACCCCGGAGCAGAAGGAGATGATGGAGTCGGTCTACGAGGGGGTGACCCAGCTGCGGGGGAT
CGTGGACGATCTCCTCTCCATCTCCCGCATCGAGACCAAGGGATTCGCCGTCACCAAGCGGATGGTGAACCTCCTCAATC
TCTGCCGGGAGGTGCGCCATACCCTGCTCCTTCCCCTGTCGGAGCGGGACATCGAGCTCTCCATTGCCGAGGACACCTGC
AGCATTCCGGCCGACGAGGGGTTCTGCCGGCTCGTGACCCGGAACCTCCTGGAGAACGCCATCAAGTTCACCGCCGACGG
GGGACGGATCACCATCAGCGGCGAGCTCACCTCCCTGGACGACCTCCTCCCCCAGGCCGATTCGCTCCGCTGCTTCTACC
GGGAGTTCCCCTCCAACATCGAGGGGCACCCTGCCTTCTATCGCCTCGACATCGCCGACACGGGAATCGGCATCCCCCCC
GAGGAGCGGGTGCGGATCTTCGAGAAATTCTACGGCGTCGGCGACCTCGCCTACCACTCCTCCGGCAAGACCGGCTTCAT
GTCCAAGGGGTCAGGGCTCGGCCTCTCCATCGTCAAGGGGATCATGGACGCCCACGGCGGCATGGTCTGGGTGGGGCCCG
GGGAAAACGGCTCGGGAAGCGTCTTCTCCCTCCTCTTCCCCATGGACAACACCTGTGTCATCCCGCCCCGCGAAGGGAGA
CGGTAG

Upstream 100 bases:

>100_bases
CGGGCGGGCCTGGGCCGAAGGGACAATCGGCGCCGGCGCCACCTTTTACTTTACCCTGGGAGAATCTCACCGCCTTGCGG
AGGGCGACGAAGGATAAGCG

Downstream 100 bases:

>100_bases
ACACCATGGCATCGGCCCTTTCGCTTCGCGGCCTCACCAAGCGCTTCGGCTCCCTCACGGCCGTGGATTCCTTCTCCCTG
GAGGTGGAGCGGGGGACCAT

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MDDLHLRILLAEDSEEDAFLLLRELERGGYTVECERVQTRSAMKKALVSRQWDMVISDYRMPRFSAPQALETLKESGLDL
PFIIVSGKIAEDMLVDAMRAGANDYFMKGNLSRLIPAIERELREAAERRIRRRAERAIRQGKMEWEAAFDAVSDLVLLTD
LYSTVIRCNNRVIEAFNATYSDILGRNITELFYGSPDAGESIFDQCTDLKADNGDVRFPKLTGWYKASCFPMHPTENEHG
FVYVIKDVTKRKKMEEEKELATLELLRSRQALRENLEEMKRANMELGRLNAAKNTVIGMASHELKTPLTSIIGGLQFLFH
YSGLEMTPEQKEMMESVYEGVTQLRGIVDDLLSISRIETKGFAVTKRMVNLLNLCREVRHTLLLPLSERDIELSIAEDTC
SIPADEGFCRLVTRNLLENAIKFTADGGRITISGELTSLDDLLPQADSLRCFYREFPSNIEGHPAFYRLDIADTGIGIPP
EERVRIFEKFYGVGDLAYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVGPGENGSGSVFSLLFPMDNTCVIPPREGR
R

Sequences:

>Translated_561_residues
MDDLHLRILLAEDSEEDAFLLLRELERGGYTVECERVQTRSAMKKALVSRQWDMVISDYRMPRFSAPQALETLKESGLDL
PFIIVSGKIAEDMLVDAMRAGANDYFMKGNLSRLIPAIERELREAAERRIRRRAERAIRQGKMEWEAAFDAVSDLVLLTD
LYSTVIRCNNRVIEAFNATYSDILGRNITELFYGSPDAGESIFDQCTDLKADNGDVRFPKLTGWYKASCFPMHPTENEHG
FVYVIKDVTKRKKMEEEKELATLELLRSRQALRENLEEMKRANMELGRLNAAKNTVIGMASHELKTPLTSIIGGLQFLFH
YSGLEMTPEQKEMMESVYEGVTQLRGIVDDLLSISRIETKGFAVTKRMVNLLNLCREVRHTLLLPLSERDIELSIAEDTC
SIPADEGFCRLVTRNLLENAIKFTADGGRITISGELTSLDDLLPQADSLRCFYREFPSNIEGHPAFYRLDIADTGIGIPP
EERVRIFEKFYGVGDLAYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVGPGENGSGSVFSLLFPMDNTCVIPPREGR
R
>Mature_561_residues
MDDLHLRILLAEDSEEDAFLLLRELERGGYTVECERVQTRSAMKKALVSRQWDMVISDYRMPRFSAPQALETLKESGLDL
PFIIVSGKIAEDMLVDAMRAGANDYFMKGNLSRLIPAIERELREAAERRIRRRAERAIRQGKMEWEAAFDAVSDLVLLTD
LYSTVIRCNNRVIEAFNATYSDILGRNITELFYGSPDAGESIFDQCTDLKADNGDVRFPKLTGWYKASCFPMHPTENEHG
FVYVIKDVTKRKKMEEEKELATLELLRSRQALRENLEEMKRANMELGRLNAAKNTVIGMASHELKTPLTSIIGGLQFLFH
YSGLEMTPEQKEMMESVYEGVTQLRGIVDDLLSISRIETKGFAVTKRMVNLLNLCREVRHTLLLPLSERDIELSIAEDTC
SIPADEGFCRLVTRNLLENAIKFTADGGRITISGELTSLDDLLPQADSLRCFYREFPSNIEGHPAFYRLDIADTGIGIPP
EERVRIFEKFYGVGDLAYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVGPGENGSGSVFSLLFPMDNTCVIPPREGR
R

Specific function: Member Of The Two-Component Regulatory System Kdpd/Kdpe Involved In The Regulation Of The Kdp Operon. Kdpd May Function As A Membrane-Associated Protein Kinase That Phosphorylates Kdpe In Response To Environmental Signals. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=325, Percent_Identity=27.0769230769231, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=274, Percent_Identity=26.6423357664234, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788713, Length=266, Percent_Identity=25.187969924812, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693157, Length=319, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=26.7206477732794, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082128, Length=262, Percent_Identity=26.7175572519084, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1789149, Length=290, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786600, Length=264, Percent_Identity=25.7575757575758, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=289, Percent_Identity=27.3356401384083, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790861, Length=229, Percent_Identity=26.6375545851528, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=27.7056277056277, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63158; Mature: 63158

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDLHLRILLAEDSEEDAFLLLRELERGGYTVECERVQTRSAMKKALVSRQWDMVISDYR
CCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
MPRFSAPQALETLKESGLDLPFIIVSGKIAEDMLVDAMRAGANDYFMKGNLSRLIPAIER
CCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHH
ELREAAERRIRRRAERAIRQGKMEWEAAFDAVSDLVLLTDLYSTVIRCNNRVIEAFNATY
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHH
SDILGRNITELFYGSPDAGESIFDQCTDLKADNGDVRFPKLTGWYKASCFPMHPTENEHG
HHHHCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCEECCEEECCCCCCCCC
FVYVIKDVTKRKKMEEEKELATLELLRSRQALRENLEEMKRANMELGRLNAAKNTVIGMA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEC
SHELKTPLTSIIGGLQFLFHYSGLEMTPEQKEMMESVYEGVTQLRGIVDDLLSISRIETK
HHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFAVTKRMVNLLNLCREVRHTLLLPLSERDIELSIAEDTCSIPADEGFCRLVTRNLLENA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
IKFTADGGRITISGELTSLDDLLPQADSLRCFYREFPSNIEGHPAFYRLDIADTGIGIPP
HEEECCCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCC
EERVRIFEKFYGVGDLAYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVGPGENGSGS
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCC
VFSLLFPMDNTCVIPPREGRR
EEEEEECCCCEEEECCCCCCC
>Mature Secondary Structure
MDDLHLRILLAEDSEEDAFLLLRELERGGYTVECERVQTRSAMKKALVSRQWDMVISDYR
CCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
MPRFSAPQALETLKESGLDLPFIIVSGKIAEDMLVDAMRAGANDYFMKGNLSRLIPAIER
CCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHH
ELREAAERRIRRRAERAIRQGKMEWEAAFDAVSDLVLLTDLYSTVIRCNNRVIEAFNATY
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHH
SDILGRNITELFYGSPDAGESIFDQCTDLKADNGDVRFPKLTGWYKASCFPMHPTENEHG
HHHHCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCEECCEEECCCCCCCCC
FVYVIKDVTKRKKMEEEKELATLELLRSRQALRENLEEMKRANMELGRLNAAKNTVIGMA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEC
SHELKTPLTSIIGGLQFLFHYSGLEMTPEQKEMMESVYEGVTQLRGIVDDLLSISRIETK
HHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFAVTKRMVNLLNLCREVRHTLLLPLSERDIELSIAEDTCSIPADEGFCRLVTRNLLENA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
IKFTADGGRITISGELTSLDDLLPQADSLRCFYREFPSNIEGHPAFYRLDIADTGIGIPP
HEEECCCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCC
EERVRIFEKFYGVGDLAYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVGPGENGSGS
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCC
VFSLLFPMDNTCVIPPREGRR
EEEEEECCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8535519; 8905231; 3141423 [H]