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The map label for this gene is gpsA

Identifier: 78221236

GI number: 78221236

Start: 12343

End: 13350

Strand: Direct

Name: gpsA

Synonym: Gmet_0008

Alternate gene names: 78221236

Gene position: 12343-13350 (Clockwise)

Preceding gene: 78221234

Following gene: 78221237

Centisome position: 0.31

GC content: 67.96

Gene sequence:

>1008_bases
ATGGGCGAAAAGATCGGAGTCATCGGCGCGGGGAGTTGGGGAACAACCCTGGCAAATCTTCTGGCAAAGAAGGGGCTGGA
TGTCACCCTCTGGGCCTATGAGCCGGAGCTGGTGGCGGAGATGCGGGCCACGCGGGTCAACACCCTCTTTCTCCCTGGCA
CGGAACTCGCTGCCGGCCTCGCCTTCACCAACTCTCTTGAGGAGGCGGCAGCGGGGAAAGATGTGCTGGTTCTCGTCTCC
CCCTCCCAGGTCATGCGGAGCGTCCTGACGCAGCTCGCTCCCCTCCTGAAGCCCGGGGTGACGCTGGTGAACGCTTCCAA
GGGGATTGAGCTCGATACCCTCATGACCATGGACCAGGTATGCGGCGCCGTCCTCCCCCCCGCAGTCGCCGGACGCTTCT
GCGTCCTCTCGGGCCCAAGCTTTGCCCGGGAAGTGGCCCAGGAGATGCCGACGGCGGTGGTGGCGGCCTCCGCCGACCTC
GAGGCTGCGGCCCAGGTCCAGCGCCTCTTCACCGCTCCCTATTTCCGGGTCTACACCAACAGCGACGTGGTGGGGGTCGA
GATCGGCGGGGCCCTCAAGAACGTCATCGCCCTGGCCGCGGGGATCTCCGACGGCCTGGGGCTCGGCCACAACACCCGGG
CCGCCCTCATCACCCGGGGGCTCGCCGAGATGAACCGCCTCGGCCGCGCCATGGGGGCGGATCCGGCCACCTTCGCCGGG
CTTGCCGGCATGGGGGACCTGGTCCTCACCTGCACCGGCGACCTCTCCCGCAACCGGACCGTGGGGATGAAGCTGGGCCA
GGGGATGCGCCTTGCGGAGATCCTCGGTGAGATGCGGATGGTGGCCGAGGGGGTGAAGACCGCCGAGTCGGCCTGGCGTC
TTGCCAGCCAGATGGGGGTCGACATGCCCATCACCGAGAAGGTCTACCAGGTGCTCTACGAGGACAAGCCGGCACGGCAG
GCGGTCCTTGAACTCATGACCCGCGACCCGAAGGCCGAGCGGGGGTAG

Upstream 100 bases:

>100_bases
TTCGATTGTCAGAGAACTTTGTCTACGATGTGCTGGCACATTTTTCTGTCCACGATGTCGTGGCACTCAACAGTTAACAA
ACATGAGCGAGGGACTGTCC

Downstream 100 bases:

>100_bases
GAACCCGAGTCCCCACACCCGTCGGAGGGTATGCCATGAACCTGCGCCTCACGATCAGGAACAAGCTTTTTCTGGCTACC
CTCCTCATTCTCTTCATCTC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MGEKIGVIGAGSWGTTLANLLAKKGLDVTLWAYEPELVAEMRATRVNTLFLPGTELAAGLAFTNSLEEAAAGKDVLVLVS
PSQVMRSVLTQLAPLLKPGVTLVNASKGIELDTLMTMDQVCGAVLPPAVAGRFCVLSGPSFAREVAQEMPTAVVAASADL
EAAAQVQRLFTAPYFRVYTNSDVVGVEIGGALKNVIALAAGISDGLGLGHNTRAALITRGLAEMNRLGRAMGADPATFAG
LAGMGDLVLTCTGDLSRNRTVGMKLGQGMRLAEILGEMRMVAEGVKTAESAWRLASQMGVDMPITEKVYQVLYEDKPARQ
AVLELMTRDPKAERG

Sequences:

>Translated_335_residues
MGEKIGVIGAGSWGTTLANLLAKKGLDVTLWAYEPELVAEMRATRVNTLFLPGTELAAGLAFTNSLEEAAAGKDVLVLVS
PSQVMRSVLTQLAPLLKPGVTLVNASKGIELDTLMTMDQVCGAVLPPAVAGRFCVLSGPSFAREVAQEMPTAVVAASADL
EAAAQVQRLFTAPYFRVYTNSDVVGVEIGGALKNVIALAAGISDGLGLGHNTRAALITRGLAEMNRLGRAMGADPATFAG
LAGMGDLVLTCTGDLSRNRTVGMKLGQGMRLAEILGEMRMVAEGVKTAESAWRLASQMGVDMPITEKVYQVLYEDKPARQ
AVLELMTRDPKAERG
>Mature_334_residues
GEKIGVIGAGSWGTTLANLLAKKGLDVTLWAYEPELVAEMRATRVNTLFLPGTELAAGLAFTNSLEEAAAGKDVLVLVSP
SQVMRSVLTQLAPLLKPGVTLVNASKGIELDTLMTMDQVCGAVLPPAVAGRFCVLSGPSFAREVAQEMPTAVVAASADLE
AAAQVQRLFTAPYFRVYTNSDVVGVEIGGALKNVIALAAGISDGLGLGHNTRAALITRGLAEMNRLGRAMGADPATFAGL
AGMGDLVLTCTGDLSRNRTVGMKLGQGMRLAEILGEMRMVAEGVKTAESAWRLASQMGVDMPITEKVYQVLYEDKPARQA
VLELMTRDPKAERG

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=348, Percent_Identity=30.4597701149425, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI24307999, Length=351, Percent_Identity=29.9145299145299, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI1790037, Length=330, Percent_Identity=49.0909090909091, Blast_Score=294, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI32564403, Length=353, Percent_Identity=30.5949008498584, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193210136, Length=353, Percent_Identity=30.5949008498584, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32564399, Length=344, Percent_Identity=30.8139534883721, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17507425, Length=335, Percent_Identity=27.4626865671642, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193210134, Length=341, Percent_Identity=30.2052785923754, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324513, Length=344, Percent_Identity=28.7790697674419, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320181, Length=348, Percent_Identity=29.8850574712644, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI22026922, Length=353, Percent_Identity=27.4787535410765, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17136204, Length=332, Percent_Identity=29.2168674698795, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17136200, Length=332, Percent_Identity=29.2168674698795, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17136202, Length=332, Percent_Identity=29.2168674698795, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45551945, Length=235, Percent_Identity=30.6382978723404, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281362270, Length=235, Percent_Identity=30.6382978723404, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648969, Length=205, Percent_Identity=30.7317073170732, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_GEOMG (Q39ZR6)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_382983.1
- ProteinModelPortal:   Q39ZR6
- SMR:   Q39ZR6
- STRING:   Q39ZR6
- GeneID:   3739910
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0008
- NMPDR:   fig|269799.3.peg.72
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   SQTLRGN
- PhylomeDB:   Q39ZR6
- ProtClustDB:   PRK00094
- BioCyc:   GMET269799:GMET_0008-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 35175; Mature: 35044

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 193-193 BINDING 107-107 BINDING 107-107 BINDING 142-142 BINDING 257-257 BINDING 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEKIGVIGAGSWGTTLANLLAKKGLDVTLWAYEPELVAEMRATRVNTLFLPGTELAAGL
CCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCEEEECCHHHHHHH
AFTNSLEEAAAGKDVLVLVSPSQVMRSVLTQLAPLLKPGVTLVNASKGIELDTLMTMDQV
HHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHH
CGAVLPPAVAGRFCVLSGPSFAREVAQEMPTAVVAASADLEAAAQVQRLFTAPYFRVYTN
HHHHCCHHHHCCEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEC
SDVVGVEIGGALKNVIALAAGISDGLGLGHNTRAALITRGLAEMNRLGRAMGADPATFAG
CCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LAGMGDLVLTCTGDLSRNRTVGMKLGQGMRLAEILGEMRMVAEGVKTAESAWRLASQMGV
HCCCCCEEEEECCCCCCCCEECHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DMPITEKVYQVLYEDKPARQAVLELMTRDPKAERG
CCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GEKIGVIGAGSWGTTLANLLAKKGLDVTLWAYEPELVAEMRATRVNTLFLPGTELAAGL
CCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCEEEECCHHHHHHH
AFTNSLEEAAAGKDVLVLVSPSQVMRSVLTQLAPLLKPGVTLVNASKGIELDTLMTMDQV
HHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHH
CGAVLPPAVAGRFCVLSGPSFAREVAQEMPTAVVAASADLEAAAQVQRLFTAPYFRVYTN
HHHHCCHHHHCCEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEC
SDVVGVEIGGALKNVIALAAGISDGLGLGHNTRAALITRGLAEMNRLGRAMGADPATFAG
CCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LAGMGDLVLTCTGDLSRNRTVGMKLGQGMRLAEILGEMRMVAEGVKTAESAWRLASQMGV
HCCCCCEEEEECCCCCCCCEECHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DMPITEKVYQVLYEDKPARQAVLELMTRDPKAERG
CCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA