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The map label for this gene is pyrC

Identifier: 304570571

GI number: 304570571

Start: 1984949

End: 1986223

Strand: Direct

Name: pyrC

Synonym: NA

Alternate gene names: 304570571

Gene position: 1984949-1986223 (Clockwise)

Preceding gene: 78222978

Following gene: 78222980

Centisome position: 49.66

GC content: 59.76

Gene sequence:

>1275_bases
ATGAATTTGTTGATACAGGGAGGGCGGGTAATCGACCCGTCGCAGGGAATTGATGAAGTGCTCGATATACTCGTCGAGAA
CGGGGCCGTCAAAGAGCTGGGCAAAGGGGTGAAGGCACCCTCCGGAACCGAAACCATCGACGCTTCCGGCCTCATCGTAA
CGCCGGGACTCATCGACATGCACGTTCACCTTCGGGACCCGGGCCACGAGTACAAGGAAGACATCGTCAGCGGCACAAAG
GCGGCAGCGGCCGGCGGGTTCACTTCGGTGGCCTGCATGCCCAACACCAAGCCGGTAAACGACAACAAGGCGGTGACCAG
CTACATTATCGCCAAGGCCAAGGCAGAAGGATCAGTCAACGTCTTCCCGGTGGGCTCCATCACCCAGGGGTCCAAAGGCG
AGCTTCTCTCCGAGATGGGCGAGCTGAAGGAGTCGGGTTGCGTGGCCGTTTCCGATGACGGGCATCCGGTGACGAACTCG
GAGCTCATGCGCCGGGCACTGGAGTATGCCAAGGGAATGGGGATCATGGTCATCTCCCATGCCGAGGACCTGTCACTGGT
GGGGGCAGGGGTCATGAACGAGGGGTTCGTCTCCACTGAGTTGGGCCTCAAGGGGATTCCGTGGGCCGCCGAAGACGCGG
CAACCGCCCGCGACGTCTACCTGGCCGAGTTCACCGATTCTCCGCTCCACATCGCCCATGTTTCCACCAAGGGGTCCCTC
CGCATCATCCGCAATGCCAAGGCTCGGGGCGTGAAAGTCACCTGCGAAACCGCGCCGCACTATTTCAGCCTTACGGATGA
TGCGGTGCGGGGGTACGACACCAATGCCAAGATGAACCCGCCGCTTCGCACGGCCGATGACGTGACAGCGGTAAAGGAGG
CATTGAAGGACGGAACCATCGATGCCATCGCCACCGACCATGCTCCCCACCATATCGACGAAAAGGACCTGGAGTTCAAC
GAGGCCCTGAACGGCATCGTCGGGTTGGAAACGTCCCTGACGTTGTCACTCCGGTTGGTGGAAGAAGGGGTTTTGACCCT
TCCGGTTCTGGTTGATAAAATGGCATGCAACCCTGCAAAAATCCTCGGGATTGACCGCGGAACCCTGAAGCCTGGCTCTG
TTGCCGACATCACCGTCATCGATCCGAAGGCTACGTGGACTGTGGATGCCGACAAGCTCGCCAGCAAATCCAAGAACTCT
CCCTTCCTCGGGTGGGAGGTGAAGGGGGCCGCGGCGTTCACCATTGTCGGCGGAAAGGTTGTGTATAAACGTTGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:
NA

Sequences:

>Translated_424_residues
MNLLIQGGRVIDPSQGIDEVLDILVENGAVKELGKGVKAPSGTETIDASGLIVTPGLIDMHVHLRDPGHEYKEDIVSGTK
AAAAGGFTSVACMPNTKPVNDNKAVTSYIIAKAKAEGSVNVFPVGSITQGSKGELLSEMGELKESGCVAVSDDGHPVTNS
ELMRRALEYAKGMGIMVISHAEDLSLVGAGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTDSPLHIAHVSTKGSL
RIIRNAKARGVKVTCETAPHYFSLTDDAVRGYDTNAKMNPPLRTADDVTAVKEALKDGTIDAIATDHAPHHIDEKDLEFN
EALNGIVGLETSLTLSLRLVEEGVLTLPVLVDKMACNPAKILGIDRGTLKPGSVADITVIDPKATWTVDADKLASKSKNS
PFLGWEVKGAAAFTIVGGKVVYKR
>Mature_424_residues
MNLLIQGGRVIDPSQGIDEVLDILVENGAVKELGKGVKAPSGTETIDASGLIVTPGLIDMHVHLRDPGHEYKEDIVSGTK
AAAAGGFTSVACMPNTKPVNDNKAVTSYIIAKAKAEGSVNVFPVGSITQGSKGELLSEMGELKESGCVAVSDDGHPVTNS
ELMRRALEYAKGMGIMVISHAEDLSLVGAGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTDSPLHIAHVSTKGSL
RIIRNAKARGVKVTCETAPHYFSLTDDAVRGYDTNAKMNPPLRTADDVTAVKEALKDGTIDAIATDHAPHHIDEKDLEFN
EALNGIVGLETSLTLSLRLVEEGVLTLPVLVDKMACNPAKILGIDRGTLKPGSVADITVIDPKATWTVDADKLASKSKNS
PFLGWEVKGAAAFTIVGGKVVYKR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=409, Percent_Identity=32.2738386308068, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4503375, Length=452, Percent_Identity=28.9823008849558, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4503051, Length=448, Percent_Identity=26.1160714285714, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI190194363, Length=448, Percent_Identity=27.6785714285714, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI62422571, Length=448, Percent_Identity=26.1160714285714, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=27.1929824561404, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI4503379, Length=446, Percent_Identity=24.8878923766816, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4503377, Length=448, Percent_Identity=25.4464285714286, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1786722, Length=440, Percent_Identity=29.3181818181818, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI87082175, Length=445, Percent_Identity=26.9662921348315, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI193204318, Length=415, Percent_Identity=28.1927710843373, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71989490, Length=449, Percent_Identity=26.9487750556793, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17539558, Length=456, Percent_Identity=25.6578947368421, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI86575075, Length=431, Percent_Identity=25.5220417633411, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=423, Percent_Identity=26.4775413711584, Blast_Score=116, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24642586, Length=397, Percent_Identity=31.7380352644836, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17137462, Length=448, Percent_Identity=26.5625, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI221377917, Length=454, Percent_Identity=27.3127753303965, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18859883, Length=453, Percent_Identity=27.5938189845475, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644287, Length=306, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_GEOMG (Q39US3)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384726.2
- ProteinModelPortal:   Q39US3
- SMR:   Q39US3
- STRING:   Q39US3
- GeneID:   3741446
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1770
- NMPDR:   fig|269799.3.peg.2087
- eggNOG:   COG0044
- HOGENOM:   HBG724623
- ProtClustDB:   CLSK828273
- BioCyc:   GMET269799:GMET_1770-MONOMER
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 44713; Mature: 44713

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIQGGRVIDPSQGIDEVLDILVENGAVKELGKGVKAPSGTETIDASGLIVTPGLIDM
CCEEEECCEEECCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCEECCCCEEECCCEEEE
HVHLRDPGHEYKEDIVSGTKAAAAGGFTSVACMPNTKPVNDNKAVTSYIIAKAKAEGSVN
EEEECCCCHHHHHHHHCCCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHEEEECCCCCEE
VFPVGSITQGSKGELLSEMGELKESGCVAVSDDGHPVTNSELMRRALEYAKGMGIMVISH
EEECCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
AEDLSLVGAGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTDSPLHIAHVSTKGSL
CCCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCE
RIIRNAKARGVKVTCETAPHYFSLTDDAVRGYDTNAKMNPPLRTADDVTAVKEALKDGTI
EEEECCCCCCEEEEEECCCCEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCE
DAIATDHAPHHIDEKDLEFNEALNGIVGLETSLTLSLRLVEEGVLTLPVLVDKMACNPAK
EEEECCCCCCCCCCCCCCHHHHHCCEEECCCEEEEEEEEECCCCEEHHHHHHHHCCCCEE
ILGIDRGTLKPGSVADITVIDPKATWTVDADKLASKSKNSPFLGWEVKGAAAFTIVGGKV
EEECCCCCCCCCCEEEEEEECCCCEEEECHHHHHHCCCCCCEEEEEECCEEEEEEECCEE
VYKR
EEEC
>Mature Secondary Structure
MNLLIQGGRVIDPSQGIDEVLDILVENGAVKELGKGVKAPSGTETIDASGLIVTPGLIDM
CCEEEECCEEECCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCEECCCCEEECCCEEEE
HVHLRDPGHEYKEDIVSGTKAAAAGGFTSVACMPNTKPVNDNKAVTSYIIAKAKAEGSVN
EEEECCCCHHHHHHHHCCCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHEEEECCCCCEE
VFPVGSITQGSKGELLSEMGELKESGCVAVSDDGHPVTNSELMRRALEYAKGMGIMVISH
EEECCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
AEDLSLVGAGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTDSPLHIAHVSTKGSL
CCCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCE
RIIRNAKARGVKVTCETAPHYFSLTDDAVRGYDTNAKMNPPLRTADDVTAVKEALKDGTI
EEEECCCCCCEEEEEECCCCEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCE
DAIATDHAPHHIDEKDLEFNEALNGIVGLETSLTLSLRLVEEGVLTLPVLVDKMACNPAK
EEEECCCCCCCCCCCCCCHHHHHCCEEECCCEEEEEEEEECCCCEEHHHHHHHHCCCCEE
ILGIDRGTLKPGSVADITVIDPKATWTVDADKLASKSKNSPFLGWEVKGAAAFTIVGGKV
EEECCCCCCCCCCEEEEEEECCCCEEEECHHHHHHCCCCCCEEEEEECCEEEEEEECCEE
VYKR
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA