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The map label for this gene is cysG [H]

Identifier: 78189895

GI number: 78189895

Start: 2473799

End: 2474794

Strand: Reverse

Name: cysG [H]

Synonym: Cag_1942

Alternate gene names: 78189895

Gene position: 2474794-2473799 (Counterclockwise)

Preceding gene: 78189896

Following gene: 78189894

Centisome position: 96.22

GC content: 49.0

Gene sequence:

>996_bases
ATGAGTGCAAGCAAACAAGGTATGGAAAGTAATGGCTATGTGTATCTCATTGGGGCTGGTCCCGGTGATCCTGAATTGCT
GACGTTAAAGGCTGACCGTGTGCTGCGTGAAGCGGATGTGATTCTTTACGATGATTTAGTAAGCAGCGATATTCTTGCAC
GTTACCATGCGGAGAAAATTTTTACGGGTAAACGTAAAGATAACCACCATTTTGAGCAGGATGCCATTAATGATGAGTTA
GTGCGCCAAGCCAAAGAGGGGAAGCGCGTGGCGCGTTTAAAAGGTGGCGATCCCTTTATTTTTGGGCGTGGTGGCGAAGA
GCTTGAAACGTTACGCCAGCACGGTATCCGTTACGAAATTGTGCCGGGCATTACCGCTGCGCACGGAGCGGCATCGTATG
CTGAAATTCCCTTAACCATGCGAAAACTCTCCTCATCGGTAGCGTTTTGCACAGGGCATCCCGTTACAAAAATTCAAGTT
CCCAGCGCTGATACGTTAGTCTATTACATGGTTGCTTCCAGCGCTCACGCCGTACTTGAGGCGGTTGCCGCAAGCGGGCG
CCCCGACTCAACGCCTGTAGCATTGGTACACAATGCTACTCGCTACAACCAAAAAGCGCTTTTCGGTACACTTGGCGAGT
GGCTGCGTGGTGAGCGTGCCGTGTATTCTCCTGCACTGCTCATTATTGGCGAAAGCATTTCACTTGCAGTGGCAGATAAT
TGGTTTCAAGCGAAGCCAAAAGTGCTGCTTGTGGGTGACGATCCCGCCTTAATGTTATTGAGCGATGCTTTTTTTGTTTC
ATTTACCAAAGCAGCACAACGAGAAACCCTTGTAGCCGAACCCTTAGAACTCCATCTGTTTGATGCTCTCCATTTTGCTT
CCGTTGCAGATGTAGAGGCATTTGTTGAGCATTATCCCTCACTGCCATCAACCCTTCGCGTTACTTGTGCCACTGATCAA
GTAATGGCGCTTTATCGGCAATACTACGGTGGATGA

Upstream 100 bases:

>100_bases
GGCGAGGATGTAAAGCGCACGGTGGCACTGCGTAACGCCATAAAAGCCATGGTTGAAAGTCCTGATTGGTCTCTTGAGAA
GTAAGATTTGATAAAACGGT

Downstream 100 bases:

>100_bases
GCCGTATGCCACAAGCCAACCGCTTTTTGATACGTTTCAACGCCAAATAACGTATGCGCGCTTAGCGGTTACCTCAGCTT
GTAACTTGCGCTGCGGCTAC

Product: uroporphyrin-III C-methyltransferase-like

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSASKQGMESNGYVYLIGAGPGDPELLTLKADRVLREADVILYDDLVSSDILARYHAEKIFTGKRKDNHHFEQDAINDEL
VRQAKEGKRVARLKGGDPFIFGRGGEELETLRQHGIRYEIVPGITAAHGAASYAEIPLTMRKLSSSVAFCTGHPVTKIQV
PSADTLVYYMVASSAHAVLEAVAASGRPDSTPVALVHNATRYNQKALFGTLGEWLRGERAVYSPALLIIGESISLAVADN
WFQAKPKVLLVGDDPALMLLSDAFFVSFTKAAQRETLVAEPLELHLFDALHFASVADVEAFVEHYPSLPSTLRVTCATDQ
VMALYRQYYGG

Sequences:

>Translated_331_residues
MSASKQGMESNGYVYLIGAGPGDPELLTLKADRVLREADVILYDDLVSSDILARYHAEKIFTGKRKDNHHFEQDAINDEL
VRQAKEGKRVARLKGGDPFIFGRGGEELETLRQHGIRYEIVPGITAAHGAASYAEIPLTMRKLSSSVAFCTGHPVTKIQV
PSADTLVYYMVASSAHAVLEAVAASGRPDSTPVALVHNATRYNQKALFGTLGEWLRGERAVYSPALLIIGESISLAVADN
WFQAKPKVLLVGDDPALMLLSDAFFVSFTKAAQRETLVAEPLELHLFDALHFASVADVEAFVEHYPSLPSTLRVTCATDQ
VMALYRQYYGG
>Mature_330_residues
SASKQGMESNGYVYLIGAGPGDPELLTLKADRVLREADVILYDDLVSSDILARYHAEKIFTGKRKDNHHFEQDAINDELV
RQAKEGKRVARLKGGDPFIFGRGGEELETLRQHGIRYEIVPGITAAHGAASYAEIPLTMRKLSSSVAFCTGHPVTKIQVP
SADTLVYYMVASSAHAVLEAVAASGRPDSTPVALVHNATRYNQKALFGTLGEWLRGERAVYSPALLIIGESISLAVADNW
FQAKPKVLLVGDDPALMLLSDAFFVSFTKAAQRETLVAEPLELHLFDALHFASVADVEAFVEHYPSLPSTLRVTCATDQV
MALYRQYYGG

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=243, Percent_Identity=46.0905349794239, Blast_Score=208, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6322922, Length=247, Percent_Identity=29.5546558704453, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 36169; Mature: 36037

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASKQGMESNGYVYLIGAGPGDPELLTLKADRVLREADVILYDDLVSSDILARYHAEKI
CCCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHCCEEEEHHHHHHHHHHHHHHHHH
FTGKRKDNHHFEQDAINDELVRQAKEGKRVARLKGGDPFIFGRGGEELETLRQHGIRYEI
HCCCCCCCCCCHHHCCCHHHHHHHHCCCEEEEECCCCEEEECCCCHHHHHHHHCCCEEEE
VPGITAAHGAASYAEIPLTMRKLSSSVAFCTGHPVTKIQVPSADTLVYYMVASSAHAVLE
ECCCCHHCCCCCHHHCCHHHHHHCCCEEEECCCCEEEEECCCCCEEEEEEECCCHHHHHH
AVAASGRPDSTPVALVHNATRYNQKALFGTLGEWLRGERAVYSPALLIIGESISLAVADN
HHHHCCCCCCCCEEEEECCHHHCHHHHHHHHHHHHCCCCHHCCCEEEEEECCEEEEEECC
WFQAKPKVLLVGDDPALMLLSDAFFVSFTKAAQRETLVAEPLELHLFDALHFASVADVEA
CCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FVEHYPSLPSTLRVTCATDQVMALYRQYYGG
HHHHCCCCCCEEEEEECHHHHHHHHHHHHCC
>Mature Secondary Structure 
SASKQGMESNGYVYLIGAGPGDPELLTLKADRVLREADVILYDDLVSSDILARYHAEKI
CCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHCCEEEEHHHHHHHHHHHHHHHHH
FTGKRKDNHHFEQDAINDELVRQAKEGKRVARLKGGDPFIFGRGGEELETLRQHGIRYEI
HCCCCCCCCCCHHHCCCHHHHHHHHCCCEEEEECCCCEEEECCCCHHHHHHHHCCCEEEE
VPGITAAHGAASYAEIPLTMRKLSSSVAFCTGHPVTKIQVPSADTLVYYMVASSAHAVLE
ECCCCHHCCCCCHHHCCHHHHHHCCCEEEECCCCEEEEECCCCCEEEEEEECCCHHHHHH
AVAASGRPDSTPVALVHNATRYNQKALFGTLGEWLRGERAVYSPALLIIGESISLAVADN
HHHHCCCCCCCCEEEEECCHHHCHHHHHHHHHHHHCCCCHHCCCEEEEEECCEEEEEECC
WFQAKPKVLLVGDDPALMLLSDAFFVSFTKAAQRETLVAEPLELHLFDALHFASVADVEA
CCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FVEHYPSLPSTLRVTCATDQVMALYRQYYGG
HHHHCCCCCCEEEEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA