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The map label for this gene is ilvD

Identifier: 78189861

GI number: 78189861

Start: 2425075

End: 2426754

Strand: Reverse

Name: ilvD

Synonym: Cag_1906

Alternate gene names: 78189861

Gene position: 2426754-2425075 (Counterclockwise)

Preceding gene: 78189868

Following gene: 78189860

Centisome position: 94.35

GC content: 49.29

Gene sequence:

>1680_bases
ATGAGATCCGACACCATAAAATCGGGCTTTGAAAAAGCTCCCCATCGTAGCCTTTTAAAAGCTACAGGCGCAATCCGCTC
AAGCAGCGATTACCGCAAGCCGTTTATTGGCATCTGCAATTCATATAATGAGTTAATTCCCGGTCATACCCATTTGCAAG
AGCTGGGACGCATTGCGAAAGAGGCGGTACGCGAAGCGGGCGGTGTGCCTTTTGAGTTCAACACCATTGGCGTTTGTGAT
GGCATTGCTATGGGGCATATTGGGATGCGCTACTCGCTTGCAAGCCGTGAGTTAATTGCTGATAGCGTTGAAACCGTTGC
CGAAGCGCATCGGCTTGATGGCTTAGTCTGTATTCCAAATTGTGATAAAATCACCCCGGGTATGATGATGGCTGCACTAC
GCATTAACATTCCTGTGATTTTTGTTTCAGGCGGACCAATGAAAGCTGGTCATACTCCCGAAGGTAAAACGGTGGACTTA
ATTTCGGTTTTTGAAGCGGTTGGGCAATGCAGCAACGGCTCAATAACAGAAGGTGAACTGCAAAATATTGAGGAGCATGC
CTGCCCGGGTTGCGGCTCATGCTCAGGCATGTTTACCGCAAATTCCATGAACTGCTTAAGCGAAGCGCTTGGTTTTGCCT
TACCGGGTAACGGCACCATTGTCGCTGAAGATCCTCGTCGGCTGGAGTTAGTAAAAGCTGCCTCACGCCGCATTGTGGAT
TTAGTAGAGAACAATGTGCGTCCACGCGATATTTTAACGCGCCAAGCGTTGCTCAATGCCTTTGCGCTCGATTTTGCTAT
GGGCGGCAGCACCAACACTATTTTGCATACGCTTGCCATTGCGAATGAAGCGGGTTTGAGTTTCGACTTTAGCGAGTTAA
ACGCTCTTTCAGCGAAAACGCCTTACATCTGCCAAGTAAGCCCGGCTACTATGGCGGTGCATATTGAGGACGTTGATCGT
GCGGGTGGCATTTCCGCTATTTTAAAAGAGTTAAGCTCGATTGATGGGTTGCTTGATCTTTCAGCAATAACGGTAACAGG
TAAAACGTTAGGCGAAAATATTGCCAACGCCGAAGTGCTCGACCGCAGCGTTATTCGCAGCATCAGCGATCCCTATTCCG
CAACGGGTGGCTTGGCGGTGCTTTATGGCAATTTAGCGCCACAAGGTGCGGTGGTAAAAACGGGTGCGGTAAGCCCACAA
ATGATGCAGCATAGCGGTCCCGCTAAAGTGTATAATGCTCAAGATGATGCTATTAAAGGCATTATGGAGGGTGATGTAAA
AGCTGGCGATGTGGTGGTAATTCGCTACGAAGGTCCAAAAGGAGGTCCAGGAATGCCTGAAATGCTCTCGCCAACCAGCG
CCATTATGGGGCGCGGACTTGGTGATTCTGTTGCACTCATTACCGATGGACGCTTTTCAGGCGGATCACGAGGAGCTTGC
ATTGGGCACGTTTCCCCTGAAGCGGCAGAACGTGGACCAATTGCCGCCCTGCAAAATGGCGATATTATCACCATTGATAT
TCCTGCACGCACCATGTCGGTTGCGTTGAGCGAATCAACTATCAAGGAACGCTTAGCACAATTGCCGCCATTTGAACCTA
AAATTAAACGAGGCTATTTAGCTCGCTATGCGCAATTAGTAACCTCAGCCAACACGGGTGCAATTTTAGGGCACCTCTAA

Upstream 100 bases:

>100_bases
GAAAGATAAACATACTGGTACTCTCGGAAACGGTTATCTCCGAAAGTATTGCTAAGAGTAAGAGCATTTGCTCATATTTC
GCCATTTATTTGATACCCTT

Downstream 100 bases:

>100_bases
AAATCTACTACGCGCCTTGATAGCTGCGTTGGGCGGTGCTCAAAATCCTCATGTACTACGTGTACATTCCGGTTTTTGCG
CTCCGTCCGCCTTGCTCTCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MRSDTIKSGFEKAPHRSLLKATGAIRSSSDYRKPFIGICNSYNELIPGHTHLQELGRIAKEAVREAGGVPFEFNTIGVCD
GIAMGHIGMRYSLASRELIADSVETVAEAHRLDGLVCIPNCDKITPGMMMAALRINIPVIFVSGGPMKAGHTPEGKTVDL
ISVFEAVGQCSNGSITEGELQNIEEHACPGCGSCSGMFTANSMNCLSEALGFALPGNGTIVAEDPRRLELVKAASRRIVD
LVENNVRPRDILTRQALLNAFALDFAMGGSTNTILHTLAIANEAGLSFDFSELNALSAKTPYICQVSPATMAVHIEDVDR
AGGISAILKELSSIDGLLDLSAITVTGKTLGENIANAEVLDRSVIRSISDPYSATGGLAVLYGNLAPQGAVVKTGAVSPQ
MMQHSGPAKVYNAQDDAIKGIMEGDVKAGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
IGHVSPEAAERGPIAALQNGDIITIDIPARTMSVALSESTIKERLAQLPPFEPKIKRGYLARYAQLVTSANTGAILGHL

Sequences:

>Translated_559_residues
MRSDTIKSGFEKAPHRSLLKATGAIRSSSDYRKPFIGICNSYNELIPGHTHLQELGRIAKEAVREAGGVPFEFNTIGVCD
GIAMGHIGMRYSLASRELIADSVETVAEAHRLDGLVCIPNCDKITPGMMMAALRINIPVIFVSGGPMKAGHTPEGKTVDL
ISVFEAVGQCSNGSITEGELQNIEEHACPGCGSCSGMFTANSMNCLSEALGFALPGNGTIVAEDPRRLELVKAASRRIVD
LVENNVRPRDILTRQALLNAFALDFAMGGSTNTILHTLAIANEAGLSFDFSELNALSAKTPYICQVSPATMAVHIEDVDR
AGGISAILKELSSIDGLLDLSAITVTGKTLGENIANAEVLDRSVIRSISDPYSATGGLAVLYGNLAPQGAVVKTGAVSPQ
MMQHSGPAKVYNAQDDAIKGIMEGDVKAGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
IGHVSPEAAERGPIAALQNGDIITIDIPARTMSVALSESTIKERLAQLPPFEPKIKRGYLARYAQLVTSANTGAILGHL
>Mature_559_residues
MRSDTIKSGFEKAPHRSLLKATGAIRSSSDYRKPFIGICNSYNELIPGHTHLQELGRIAKEAVREAGGVPFEFNTIGVCD
GIAMGHIGMRYSLASRELIADSVETVAEAHRLDGLVCIPNCDKITPGMMMAALRINIPVIFVSGGPMKAGHTPEGKTVDL
ISVFEAVGQCSNGSITEGELQNIEEHACPGCGSCSGMFTANSMNCLSEALGFALPGNGTIVAEDPRRLELVKAASRRIVD
LVENNVRPRDILTRQALLNAFALDFAMGGSTNTILHTLAIANEAGLSFDFSELNALSAKTPYICQVSPATMAVHIEDVDR
AGGISAILKELSSIDGLLDLSAITVTGKTLGENIANAEVLDRSVIRSISDPYSATGGLAVLYGNLAPQGAVVKTGAVSPQ
MMQHSGPAKVYNAQDDAIKGIMEGDVKAGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
IGHVSPEAAERGPIAALQNGDIITIDIPARTMSVALSESTIKERLAQLPPFEPKIKRGYLARYAQLVTSANTGAILGHL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=607, Percent_Identity=47.2817133443163, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1788157, Length=523, Percent_Identity=32.1223709369025, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI2367371, Length=507, Percent_Identity=33.5305719921105, Blast_Score=215, Evalue=7e-57,
Organism=Escherichia coli, GI1786464, Length=504, Percent_Identity=32.7380952380952, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322476, Length=550, Percent_Identity=40.9090909090909, Blast_Score=398, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_CHLCH (Q3APB9)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_380199.1
- ProteinModelPortal:   Q3APB9
- SMR:   Q3APB9
- STRING:   Q3APB9
- GeneID:   3747651
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1906
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK00911
- BioCyc:   CCHL340177:CAG_1906-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58692; Mature: 58692

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDTIKSGFEKAPHRSLLKATGAIRSSSDYRKPFIGICNSYNELIPGHTHLQELGRIAK
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHCCCHHHHHHHHHHHH
EAVREAGGVPFEFNTIGVCDGIAMGHIGMRYSLASRELIADSVETVAEAHRLDGLVCIPN
HHHHHHCCCCEEECEEECCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEECCC
CDKITPGMMMAALRINIPVIFVSGGPMKAGHTPEGKTVDLISVFEAVGQCSNGSITEGEL
CCCCCHHHHHHHEEECCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCHHHH
QNIEEHACPGCGSCSGMFTANSMNCLSEALGFALPGNGTIVAEDPRRLELVKAASRRIVD
HHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCEEEECCCHHHHHHHHHHHHHHH
LVENNVRPRDILTRQALLNAFALDFAMGGSTNTILHTLAIANEAGLSFDFSELNALSAKT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEECHHHHHHHCCCC
PYICQVSPATMAVHIEDVDRAGGISAILKELSSIDGLLDLSAITVTGKTLGENIANAEVL
CEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEEEECHHHHCCHHHHHHH
DRSVIRSISDPYSATGGLAVLYGNLAPQGAVVKTGAVSPQMMQHSGPAKVYNAQDDAIKG
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEECCCCCHHHHHCCCCCEEECCCHHHHHH
IMEGDVKAGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
HHCCCCCCCCEEEEEECCCCCCCCCCHHCCCHHHHHCCCCCCCEEEEECCCCCCCCCCEE
IGHVSPEAAERGPIAALQNGDIITIDIPARTMSVALSESTIKERLAQLPPFEPKIKRGYL
EECCCCHHHCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ARYAQLVTSANTGAILGHL
HHHHHHHHCCCCCEEECCC
>Mature Secondary Structure
MRSDTIKSGFEKAPHRSLLKATGAIRSSSDYRKPFIGICNSYNELIPGHTHLQELGRIAK
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHCCCHHHHHHHHHHHH
EAVREAGGVPFEFNTIGVCDGIAMGHIGMRYSLASRELIADSVETVAEAHRLDGLVCIPN
HHHHHHCCCCEEECEEECCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEECCC
CDKITPGMMMAALRINIPVIFVSGGPMKAGHTPEGKTVDLISVFEAVGQCSNGSITEGEL
CCCCCHHHHHHHEEECCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCHHHH
QNIEEHACPGCGSCSGMFTANSMNCLSEALGFALPGNGTIVAEDPRRLELVKAASRRIVD
HHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCEEEECCCHHHHHHHHHHHHHHH
LVENNVRPRDILTRQALLNAFALDFAMGGSTNTILHTLAIANEAGLSFDFSELNALSAKT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEECHHHHHHHCCCC
PYICQVSPATMAVHIEDVDRAGGISAILKELSSIDGLLDLSAITVTGKTLGENIANAEVL
CEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEEEECHHHHCCHHHHHHH
DRSVIRSISDPYSATGGLAVLYGNLAPQGAVVKTGAVSPQMMQHSGPAKVYNAQDDAIKG
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEECCCCCHHHHHCCCCCEEECCCHHHHHH
IMEGDVKAGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
HHCCCCCCCCEEEEEECCCCCCCCCCHHCCCHHHHHCCCCCCCEEEEECCCCCCCCCCEE
IGHVSPEAAERGPIAALQNGDIITIDIPARTMSVALSESTIKERLAQLPPFEPKIKRGYL
EECCCCHHHCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ARYAQLVTSANTGAILGHL
HHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA