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The map label for this gene is ald [H]

Identifier: 78189833

GI number: 78189833

Start: 2386923

End: 2388056

Strand: Reverse

Name: ald [H]

Synonym: Cag_1878

Alternate gene names: 78189833

Gene position: 2388056-2386923 (Counterclockwise)

Preceding gene: 78189834

Following gene: 78189832

Centisome position: 92.85

GC content: 44.97

Gene sequence:

>1134_bases
ATGAATATTGTGCTTGGCATTCCAAAAGAGCGAGCGCAAGATGAACGGCGCGTGGCGCTTTCGCCTGCTGGTGTGCAAAT
TTTAGGAGAGCATGGTATTCAGGTGATTATTGAAAGCAATGCGGGCATGTACTGTAACTTTACCGATCTTGCCTATAGTG
ATGCTGGAGCCTCAATTGCTACTTCACCTGAAGAGTTGTATGAACAAAGCAACGTTATTGTAAAAGTTTCACCCCCAACA
CTTGAAGAGCTGCCACTTTTTCAGCATGGGCAACTCTTACTTTCAGCACTCCATCTTGGTACCATTACCCCCCACCTTAT
TGAGCTTCTTATTGAAAAAAACATCACTGCACTTGCTTTTGAATTTATTGAAACGCGTGATGGTGAGCTGCCAATTGTGC
GAACGCTCAGTGAAATTGCAGGCTCTTTAGCCATTCAAACCGCCGCAAAATATCTTGAAACCAATTATGGCGGCAGTGGC
ATTTTGCTTGGCGGTATTGCGGGCGTGCCGCCAGCTCACGTTACCATTATTGGAGCTGGAACGGTAGGACTTTTTGCGGC
ACAAGATGCTCTTGGCTTAGGCGCACAAGTTACCGTGCTCGATAAAGAAATTAATCGCCTTCGTCGTTTTGAAGCCTTTT
TTAATCGCCATCTTGTTACCGCTATTGCTAACGAGCACTACATTGCTGAACTTGCAAAAAAGTCGGATGTGGTGATTGGT
GCTTTAAGTCCTAAACAAAAAGTTATTAAGCCGTTAGTAAGCGAGCAAGTAGTACAATCCATGAAGACAGGTTCAGTAAT
TATTGATGTTTCTATTGATCAAGGAGCCTGTTTTGCTACCAGCCGCCATACCTCCCACTCCAATCCCATCTACGTAAAGC
ACGGGGTTACCCATTACTGTGTGCCCAATATTCCTTCAGCCGTTGCCAAAACGGCTTCGTTTGCATTAACCAATACCCTT
CTACCATTCCTTCTTAAACTTTCGGGGCATGAAACCATGTCGGCAATTCTCTGGAAAAGCCATAGCTTGCGGCGTGGTAC
CTATATTTTTAGAGGATATGTTACTCAAAAAGTAGTCGCCGAGCTGACGGGTGCACCTTTTCGTGAAATTGAAATGTTGC
TTGCGGCAAGTTGA

Upstream 100 bases:

>100_bases
ATTCCCCATGGCTATTGAATACTCTCCCGACTTTGGAGCTGTTGCTTTTGAGCTTGGCGCTAAAACGCTGGAACGTTGGC
TACTCAAGCCCGAAAAGCCC

Downstream 100 bases:

>100_bases
TAGTGCTGGGTAACTTATTATCTGCACTTTTTCAAATATCTCCCTCCCTCCACCAACTCATATCACGGGAACTCACATAA
GGATGCCATTGTTAGTCAGC

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MNIVLGIPKERAQDERRVALSPAGVQILGEHGIQVIIESNAGMYCNFTDLAYSDAGASIATSPEELYEQSNVIVKVSPPT
LEELPLFQHGQLLLSALHLGTITPHLIELLIEKNITALAFEFIETRDGELPIVRTLSEIAGSLAIQTAAKYLETNYGGSG
ILLGGIAGVPPAHVTIIGAGTVGLFAAQDALGLGAQVTVLDKEINRLRRFEAFFNRHLVTAIANEHYIAELAKKSDVVIG
ALSPKQKVIKPLVSEQVVQSMKTGSVIIDVSIDQGACFATSRHTSHSNPIYVKHGVTHYCVPNIPSAVAKTASFALTNTL
LPFLLKLSGHETMSAILWKSHSLRRGTYIFRGYVTQKVVAELTGAPFREIEMLLAAS

Sequences:

>Translated_377_residues
MNIVLGIPKERAQDERRVALSPAGVQILGEHGIQVIIESNAGMYCNFTDLAYSDAGASIATSPEELYEQSNVIVKVSPPT
LEELPLFQHGQLLLSALHLGTITPHLIELLIEKNITALAFEFIETRDGELPIVRTLSEIAGSLAIQTAAKYLETNYGGSG
ILLGGIAGVPPAHVTIIGAGTVGLFAAQDALGLGAQVTVLDKEINRLRRFEAFFNRHLVTAIANEHYIAELAKKSDVVIG
ALSPKQKVIKPLVSEQVVQSMKTGSVIIDVSIDQGACFATSRHTSHSNPIYVKHGVTHYCVPNIPSAVAKTASFALTNTL
LPFLLKLSGHETMSAILWKSHSLRRGTYIFRGYVTQKVVAELTGAPFREIEMLLAAS
>Mature_377_residues
MNIVLGIPKERAQDERRVALSPAGVQILGEHGIQVIIESNAGMYCNFTDLAYSDAGASIATSPEELYEQSNVIVKVSPPT
LEELPLFQHGQLLLSALHLGTITPHLIELLIEKNITALAFEFIETRDGELPIVRTLSEIAGSLAIQTAAKYLETNYGGSG
ILLGGIAGVPPAHVTIIGAGTVGLFAAQDALGLGAQVTVLDKEINRLRRFEAFFNRHLVTAIANEHYIAELAKKSDVVIG
ALSPKQKVIKPLVSEQVVQSMKTGSVIIDVSIDQGACFATSRHTSHSNPIYVKHGVTHYCVPNIPSAVAKTASFALTNTL
LPFLLKLSGHETMSAILWKSHSLRRGTYIFRGYVTQKVVAELTGAPFREIEMLLAAS

Specific function: This enzyme is a key factor in the assimilation of L- alanine as an energy source through the tricarboxylic acid cycle during sporulation [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=426, Percent_Identity=28.4037558685446, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI122939153, Length=426, Percent_Identity=28.4037558685446, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI1787887, Length=350, Percent_Identity=30.5714285714286, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17550456, Length=368, Percent_Identity=29.0760869565217, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 40593; Mature: 40593

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVLGIPKERAQDERRVALSPAGVQILGEHGIQVIIESNAGMYCNFTDLAYSDAGASIA
CCEEECCCHHHCCCCCEEEECCCCEEEEECCCEEEEEECCCCEEEEEHHCEECCCCCCCC
TSPEELYEQSNVIVKVSPPTLEELPLFQHGQLLLSALHLGTITPHLIELLIEKNITALAF
CCHHHHHHHCCEEEEECCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHH
EFIETRDGELPIVRTLSEIAGSLAIQTAAKYLETNYGGSGILLGGIAGVPPAHVTIIGAG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEECC
TVGLFAAQDALGLGAQVTVLDKEINRLRRFEAFFNRHLVTAIANEHYIAELAKKSDVVIG
CHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEE
ALSPKQKVIKPLVSEQVVQSMKTGSVIIDVSIDQGACFATSRHTSHSNPIYVKHGVTHYC
ECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCCEEEECCCCEEE
VPNIPSAVAKTASFALTNTLLPFLLKLSGHETMSAILWKSHSLRRGTYIFRGYVTQKVVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHHHHHHH
ELTGAPFREIEMLLAAS
HHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MNIVLGIPKERAQDERRVALSPAGVQILGEHGIQVIIESNAGMYCNFTDLAYSDAGASIA
CCEEECCCHHHCCCCCEEEECCCCEEEEECCCEEEEEECCCCEEEEEHHCEECCCCCCCC
TSPEELYEQSNVIVKVSPPTLEELPLFQHGQLLLSALHLGTITPHLIELLIEKNITALAF
CCHHHHHHHCCEEEEECCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHH
EFIETRDGELPIVRTLSEIAGSLAIQTAAKYLETNYGGSGILLGGIAGVPPAHVTIIGAG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEECC
TVGLFAAQDALGLGAQVTVLDKEINRLRRFEAFFNRHLVTAIANEHYIAELAKKSDVVIG
CHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEE
ALSPKQKVIKPLVSEQVVQSMKTGSVIIDVSIDQGACFATSRHTSHSNPIYVKHGVTHYC
ECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCCEEEECCCCEEE
VPNIPSAVAKTASFALTNTLLPFLLKLSGHETMSAILWKSHSLRRGTYIFRGYVTQKVVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHHHHHHH
ELTGAPFREIEMLLAAS
HHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2340274 [H]