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The map label for this gene is hemN [H]

Identifier: 78189762

GI number: 78189762

Start: 2327595

End: 2328719

Strand: Reverse

Name: hemN [H]

Synonym: Cag_1806

Alternate gene names: 78189762

Gene position: 2328719-2327595 (Counterclockwise)

Preceding gene: 78189763

Following gene: 78189758

Centisome position: 90.54

GC content: 46.67

Gene sequence:

>1125_bases
GTGAGCCTCTCTCTTTACCTGCACATTCCTTTCTGCCGAGAGCGCTGCCCTTACTGCGATTTTTATTTAATAACAGGCAC
AGGTCAGGTTGAGCCATTTTTTGCAGCTTTAGCGCGTGAAACCGCTTTTCGTGCAGATGAGCTACAAGGAGCCACGATCA
GCGCTATCCATATTGGTGGTGGAACGCCATCGTTAGTGCCTGTTGCCATGCTCTCGCGCTGGCTTGAGCAACTTGCTTGT
TATGCAACCTTTGCGCCTACTATGGAGCTGGCGCTTGAAGCAAATCCCGAAGATATAACGCCTGCGTTGTTAGACGAGTT
ACAATCGCTTGGCGTTAATCGTTTAAGCATTGGCGTACAATCATTCTCCATTCAAAAGCTCACCGTGCTGGGGCGAAAGC
ATAGTGCCACTGATGCCTTACGGGTAACGGAGATGGCGCTTGAGCGTTTTGCTTCTGTAAGCCTTGACTTAATGTGCGGC
TTGCCACATGAAACGCTTGCCGTATGGGAAGGTGATTTGTCCACAGCGTTAGCACTTCAGCCGCATCACCTCTCTGTTTA
TATGCTTTCTATTGAGCCAAAAACGCGCTTTCATTGGCTTGTGGCGCGTGGAGAATTGCCTGCGCCAATGGAGGCAGAGC
AAGCACTCTTTTATGAAACCGCAATCCATACCATAAAGCTGCAAGGCTATCAGCATTACGAAGTATCGAACTTTTGCTTG
CCTAACTTTCATTCACGCTACAATCTTGCAAGCTGGGAGCGCAAACCATATCTCGGTTTTGGGGCAGCAGCTCATAGCTT
TATTGTGCAACAAAACCGTGAAATTCGTCAAGCTAATATTGAAAGCTTAAGCCGTTATCTTGCCCATCCCGAAAATGCTG
TAGCTTTTCGTGAAGAGCTTGGCTGCAATGAGCGTTTTACGGAGGAGCTTTTTTTAACCTTGCGTTTAAATCGAGGATTA
TCAAGGAGCTTTTTTAGTCGAACAGCTTCGAGGGATGTGGTAGAAACCTTGTTTGCTACTTTTCAAGAGCAAGGCTGGAT
GTATGAGGACAATGAACGTTTTTATTTAACGGAGCGAGGTTTTCTTTTTGCCGATTATATTGCTGAGGAGTTGCTTGCAA
AGTAA

Upstream 100 bases:

>100_bases
TCCTGCTTTTGTTGCTGACGATCTTTATCAAGCCATTACGGAATTTATTTTGCCCCATTCGCAAGAATAGGGGGCATTGT
AATAACTTTCTTCTCCGCAT

Downstream 100 bases:

>100_bases
TTATAGTGCTTTAGAATCTTAACATTTTCTTTAGGGATACATACGACATGCGTCCCTAAAGAAATGTGCTTTCATTCTTA
TCCTATTTCCCCAACTTCTC

Product: putative oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSLSLYLHIPFCRERCPYCDFYLITGTGQVEPFFAALARETAFRADELQGATISAIHIGGGTPSLVPVAMLSRWLEQLAC
YATFAPTMELALEANPEDITPALLDELQSLGVNRLSIGVQSFSIQKLTVLGRKHSATDALRVTEMALERFASVSLDLMCG
LPHETLAVWEGDLSTALALQPHHLSVYMLSIEPKTRFHWLVARGELPAPMEAEQALFYETAIHTIKLQGYQHYEVSNFCL
PNFHSRYNLASWERKPYLGFGAAAHSFIVQQNREIRQANIESLSRYLAHPENAVAFREELGCNERFTEELFLTLRLNRGL
SRSFFSRTASRDVVETLFATFQEQGWMYEDNERFYLTERGFLFADYIAEELLAK

Sequences:

>Translated_374_residues
MSLSLYLHIPFCRERCPYCDFYLITGTGQVEPFFAALARETAFRADELQGATISAIHIGGGTPSLVPVAMLSRWLEQLAC
YATFAPTMELALEANPEDITPALLDELQSLGVNRLSIGVQSFSIQKLTVLGRKHSATDALRVTEMALERFASVSLDLMCG
LPHETLAVWEGDLSTALALQPHHLSVYMLSIEPKTRFHWLVARGELPAPMEAEQALFYETAIHTIKLQGYQHYEVSNFCL
PNFHSRYNLASWERKPYLGFGAAAHSFIVQQNREIRQANIESLSRYLAHPENAVAFREELGCNERFTEELFLTLRLNRGL
SRSFFSRTASRDVVETLFATFQEQGWMYEDNERFYLTERGFLFADYIAEELLAK
>Mature_373_residues
SLSLYLHIPFCRERCPYCDFYLITGTGQVEPFFAALARETAFRADELQGATISAIHIGGGTPSLVPVAMLSRWLEQLACY
ATFAPTMELALEANPEDITPALLDELQSLGVNRLSIGVQSFSIQKLTVLGRKHSATDALRVTEMALERFASVSLDLMCGL
PHETLAVWEGDLSTALALQPHHLSVYMLSIEPKTRFHWLVARGELPAPMEAEQALFYETAIHTIKLQGYQHYEVSNFCLP
NFHSRYNLASWERKPYLGFGAAAHSFIVQQNREIRQANIESLSRYLAHPENAVAFREELGCNERFTEELFLTLRLNRGLS
RSFFSRTASRDVVETLFATFQEQGWMYEDNERFYLTERGFLFADYIAEELLAK

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=289, Percent_Identity=37.3702422145329, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1789325, Length=380, Percent_Identity=33.1578947368421, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87082341, Length=296, Percent_Identity=29.3918918918919, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42457; Mature: 42326

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSLYLHIPFCRERCPYCDFYLITGTGQVEPFFAALARETAFRADELQGATISAIHIGG
CCEEEEEECCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GTPSLVPVAMLSRWLEQLACYATFAPTMELALEANPEDITPALLDELQSLGVNRLSIGVQ
CCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEE
SFSIQKLTVLGRKHSATDALRVTEMALERFASVSLDLMCGLPHETLAVWEGDLSTALALQ
HEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEECCCCCEEEEEC
PHHLSVYMLSIEPKTRFHWLVARGELPAPMEAEQALFYETAIHTIKLQGYQHYEVSNFCL
CCEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHEEEEEECCCEEEECCCCCC
PNFHSRYNLASWERKPYLGFGAAAHSFIVQQNREIRQANIESLSRYLAHPENAVAFREEL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHC
GCNERFTEELFLTLRLNRGLSRSFFSRTASRDVVETLFATFQEQGWMYEDNERFYLTERG
CCCHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECC
FLFADYIAEELLAK
CCHHHHHHHHHHCC
>Mature Secondary Structure 
SLSLYLHIPFCRERCPYCDFYLITGTGQVEPFFAALARETAFRADELQGATISAIHIGG
CEEEEEECCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GTPSLVPVAMLSRWLEQLACYATFAPTMELALEANPEDITPALLDELQSLGVNRLSIGVQ
CCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEE
SFSIQKLTVLGRKHSATDALRVTEMALERFASVSLDLMCGLPHETLAVWEGDLSTALALQ
HEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEECCCCCEEEEEC
PHHLSVYMLSIEPKTRFHWLVARGELPAPMEAEQALFYETAIHTIKLQGYQHYEVSNFCL
CCEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHEEEEEECCCEEEECCCCCC
PNFHSRYNLASWERKPYLGFGAAAHSFIVQQNREIRQANIESLSRYLAHPENAVAFREEL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHC
GCNERFTEELFLTLRLNRGLSRSFFSRTASRDVVETLFATFQEQGWMYEDNERFYLTERG
CCCHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECC
FLFADYIAEELLAK
CCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]