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The map label for this gene is pyrD [H]

Identifier: 78189739

GI number: 78189739

Start: 2301364

End: 2302305

Strand: Reverse

Name: pyrD [H]

Synonym: Cag_1783

Alternate gene names: 78189739

Gene position: 2302305-2301364 (Counterclockwise)

Preceding gene: 78189740

Following gene: 78189738

Centisome position: 89.51

GC content: 48.2

Gene sequence:

>942_bases
ATGACTCTCCAAACCTCCTCTCCCACCACTGCCACCGCTCTCTCTCTTGGACGCGGGCTTGAGCTTACTTCTCCCGTTTT
ACTTGCTTCGGGCACTGTGTCGTATGGTGAAGAAATTAGCCAACTCTGCAACCTTTCGCGCATTGGTGGCATAGTTACCA
AAGCAATTTCGCTTGAACCACGCGCAGGCAATCCACCGCAACGCATTGCCGAAACCCCGTCGGGCATGATTAATGCCATC
GGTTTAGCAAACGTGGGCGTTGAGCGCTTTATTGCCGATAAGGTGCCATTTCTACGTCAGCTCAACACCGCAGTGATTGT
TAACATTGCAGGACGCTCCATTGACGATTATTGCGAAGTTGTCTCCCGCCTTGATGGCGTTGAAGGGCTTGATGGGTACG
AAATAAATCTCTCCTGCCCCAACGTTAAAGGAGAGTGCATGATTATGGGTGTAAGTAGCGAGATGACCTATGAAATTGTG
TCGGCGCTACGCAGCATTACGCCACGCCATTTAATGATTAAGCTGACGCCAAACGTAACCTCCATTAGCACTATTGCCCT
TGCGGCTGAAAAAGCTGGAGCCGACTCGTTGTCGCTTATTAACACCGTTGTTGGCATGGCAGTTAATTACAAAACGCGCA
AACCGCTCTTAAAAAACGTTACGGGAGGACTTTCTGGACCAGCAATTAAGCCCATTGCATTAGCAAAAGTGTGGGAAGTC
TATCAAGCGGTTTCCATTCCAATTGTAGGAATGGGAGGCATTGCAAGTTTTGAAGATGCTATGGAATTTCTGCTTGTTGG
TGCACGAGCAATCCAAATTGGCACCATGAATTTTGTTTATCCCGACATTAGCGAAAAAATTGCAGTGGCGCTTGAAGCAC
ATTTTGCGGCACCAAACGCCATGCCACTCCGCGATTATTGCGGAAGTTTACAGGTAGAATAA

Upstream 100 bases:

>100_bases
ACGTTAGCAAGTAGTTGCACTTGAACCATTGCCGTAGCGGGCTTTTCTCTTTTTTTATAATAGAGATAAAGCCCGCTTCT
GCTTTTTCTTATTCATATCC

Downstream 100 bases:

>100_bases
ATTATTCAGAATAGGATAAATCCTTATTGAACAACTCTTTAACAGCTATTATATATGCGAATTGGAATAGGAATTGATGT
ACACCCCTTTGCCGCTGGAC

Product: dihydroorotate dehydrogenase 1

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTLQTSSPTTATALSLGRGLELTSPVLLASGTVSYGEEISQLCNLSRIGGIVTKAISLEPRAGNPPQRIAETPSGMINAI
GLANVGVERFIADKVPFLRQLNTAVIVNIAGRSIDDYCEVVSRLDGVEGLDGYEINLSCPNVKGECMIMGVSSEMTYEIV
SALRSITPRHLMIKLTPNVTSISTIALAAEKAGADSLSLINTVVGMAVNYKTRKPLLKNVTGGLSGPAIKPIALAKVWEV
YQAVSIPIVGMGGIASFEDAMEFLLVGARAIQIGTMNFVYPDISEKIAVALEAHFAAPNAMPLRDYCGSLQVE

Sequences:

>Translated_313_residues
MTLQTSSPTTATALSLGRGLELTSPVLLASGTVSYGEEISQLCNLSRIGGIVTKAISLEPRAGNPPQRIAETPSGMINAI
GLANVGVERFIADKVPFLRQLNTAVIVNIAGRSIDDYCEVVSRLDGVEGLDGYEINLSCPNVKGECMIMGVSSEMTYEIV
SALRSITPRHLMIKLTPNVTSISTIALAAEKAGADSLSLINTVVGMAVNYKTRKPLLKNVTGGLSGPAIKPIALAKVWEV
YQAVSIPIVGMGGIASFEDAMEFLLVGARAIQIGTMNFVYPDISEKIAVALEAHFAAPNAMPLRDYCGSLQVE
>Mature_312_residues
TLQTSSPTTATALSLGRGLELTSPVLLASGTVSYGEEISQLCNLSRIGGIVTKAISLEPRAGNPPQRIAETPSGMINAIG
LANVGVERFIADKVPFLRQLNTAVIVNIAGRSIDDYCEVVSRLDGVEGLDGYEINLSCPNVKGECMIMGVSSEMTYEIVS
ALRSITPRHLMIKLTPNVTSISTIALAAEKAGADSLSLINTVVGMAVNYKTRKPLLKNVTGGLSGPAIKPIALAKVWEVY
QAVSIPIVGMGGIASFEDAMEFLLVGARAIQIGTMNFVYPDISEKIAVALEAHFAAPNAMPLRDYCGSLQVE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=278, Percent_Identity=30.2158273381295, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI45006951, Length=298, Percent_Identity=26.8456375838926, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI87082059, Length=313, Percent_Identity=29.073482428115, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71984108, Length=168, Percent_Identity=32.7380952380952, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322633, Length=267, Percent_Identity=31.4606741573034, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24640763, Length=169, Percent_Identity=35.5029585798817, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18858217, Length=169, Percent_Identity=35.5029585798817, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281361352, Length=297, Percent_Identity=28.2828282828283, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137316, Length=297, Percent_Identity=28.2828282828283, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 33054; Mature: 32923

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQTSSPTTATALSLGRGLELTSPVLLASGTVSYGEEISQLCNLSRIGGIVTKAISLEP
CCCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHHEECCC
RAGNPPQRIAETPSGMINAIGLANVGVERFIADKVPFLRQLNTAVIVNIAGRSIDDYCEV
CCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCCHHHHHHH
VSRLDGVEGLDGYEINLSCPNVKGECMIMGVSSEMTYEIVSALRSITPRHLMIKLTPNVT
HHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCC
SISTIALAAEKAGADSLSLINTVVGMAVNYKTRKPLLKNVTGGLSGPAIKPIALAKVWEV
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCHHHHHCCCCCCCCCCHHHHHHHHHH
YQAVSIPIVGMGGIASFEDAMEFLLVGARAIQIGTMNFVYPDISEKIAVALEAHFAAPNA
HHHHCCCEEECCCCHHHHHHHHHHHHHHHHEEEECEEEECCCCHHHHHHHHHHHHCCCCC
MPLRDYCGSLQVE
CCHHHHCCCCCCC
>Mature Secondary Structure 
TLQTSSPTTATALSLGRGLELTSPVLLASGTVSYGEEISQLCNLSRIGGIVTKAISLEP
CCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHHEECCC
RAGNPPQRIAETPSGMINAIGLANVGVERFIADKVPFLRQLNTAVIVNIAGRSIDDYCEV
CCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCCHHHHHHH
VSRLDGVEGLDGYEINLSCPNVKGECMIMGVSSEMTYEIVSALRSITPRHLMIKLTPNVT
HHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCC
SISTIALAAEKAGADSLSLINTVVGMAVNYKTRKPLLKNVTGGLSGPAIKPIALAKVWEV
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCHHHHHCCCCCCCCCCHHHHHHHHHH
YQAVSIPIVGMGGIASFEDAMEFLLVGARAIQIGTMNFVYPDISEKIAVALEAHFAAPNA
HHHHCCCEEECCCCHHHHHHHHHHHHHHHHEEEECEEEECCCCHHHHHHHHHHHHCCCCC
MPLRDYCGSLQVE
CCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA