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The map label for this gene is pfp [H]

Identifier: 78189736

GI number: 78189736

Start: 2297911

End: 2299116

Strand: Reverse

Name: pfp [H]

Synonym: Cag_1780

Alternate gene names: 78189736

Gene position: 2299116-2297911 (Counterclockwise)

Preceding gene: 78189738

Following gene: 78189735

Centisome position: 89.39

GC content: 45.36

Gene sequence:

>1206_bases
GTGAAAAAAATTGGCATCCTTACCAGCGGTGGAGATTGCGGCGGTTTAAATGCTGTGCTAAAAGGCGCAGCCTTAATGGC
GCAGTCCAAAGGGCTTGAACTTTACATTATTCCTAACGGCTATGCAGGCTTGTACAATCTTGTGGATCAAGAGCGTATTG
TAAGGCTTGATCGCATTCGTCTTGATCAGTTCGATGCAAGTTTTGCAGGTTCTGAGGCTGGGCATTCGCGCGTTAAAATT
AAAGCTATTAGCAATCCTGAAAAGTATAACCGCATTAAAGCGGGCATGAAGAAGTTTGAGCTTGATGCCCTTATTATTAG
TGGTGGCGACGATTCGGGTAGCGTTATGGTTGACTTGAATCATCAAGGCATTCAGTGCATTCATGCGCCAAAAACCATGG
ATCTCGACTTACAAACCTACTCAGTTGGCGGCGACTCTACCATTAACCGCATTGCACAATTTGTGCACGACCTTAAAACT
ACGGGTAAAACGCACAATCGTGTGCTTGTAACCGAAGTGTTTGGGCGTTATGCAGGTCATACGGCTTTTCGTAGTGGTAT
TGCGGCTGAAGCCGATTGTATTTTAATTCCTGAAATTCCTGCTGATTGGGACGTGGTGTATGAGCATCTTAAAGAGCGCT
TTACTCGCCGCATTAAAGATAGCGACGTGCATAGTGGCACTTACACCATTGTGGTTGCTGAAGGGTTGAAAAATGCTGAT
GGCACTGATATTGTGGATGAATCGGCAGGTGTTGATGCTTTTGGGCATAAAAAGCTTGCTGGAGCTGGAAAATTTACCTG
TCAGCAAATCCAAAAGCGTATGAAAGCCGATCCTGCTATGCCTCTTTTTATGAAAGAAACCGGCATGTTTGTTGAAGGCG
TTTATGAAATTCCTGAGGTGCGCGAAATTCACCCTGGTCATTTAGTGCGTTCTGGTAACTCATCAGCTTACGACATTAAT
TTTGGTTTTGAAGCTGGAGCGGCTGCCGTACTGTTGTTGCTTGATGGCAAAACAGGTGTAACCGTTTCAAGGGTAAAGGG
GCGCAAAGTTGAATACATTGAGTCAAGCAAAGCCATTGTGCAGCGCCATGTTGACCTTGAGCAAGTTGCCTTGCATGAGT
CGCTTGGCATTTGCTTTGGGCGAGCAGCTCATGCGTATGAACCAATTTTGCGTGAGGTTGAAGGGGTGTATGATCGTATC
TATTAA

Upstream 100 bases:

>100_bases
GTATCTTAGCGGCTAACCCTGTCAGCCGAAGTATAAGTGCTGGCAAATAAAGAAATTCGGCTTTTAAATACTAACCTTTG
CACTTAAGGAGAAGAGAAGA

Downstream 100 bases:

>100_bases
TTGGTAACGCCATATTGCTTTTTCATTCCTTACTAAAGAGTAATTACTATTCAACGTTTTATGTACTGTTTATATGAACA
CTTCTGAACAAATTTGGATG

Product: phosphofructokinase

Products: NA

Alternate protein names: 6-phosphofructokinase, pyrophosphate dependent; PPi-dependent phosphofructokinase; PPi-PFK; Pyrophosphate-dependent 6-phosphofructose-1-kinase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKKIGILTSGGDCGGLNAVLKGAALMAQSKGLELYIIPNGYAGLYNLVDQERIVRLDRIRLDQFDASFAGSEAGHSRVKI
KAISNPEKYNRIKAGMKKFELDALIISGGDDSGSVMVDLNHQGIQCIHAPKTMDLDLQTYSVGGDSTINRIAQFVHDLKT
TGKTHNRVLVTEVFGRYAGHTAFRSGIAAEADCILIPEIPADWDVVYEHLKERFTRRIKDSDVHSGTYTIVVAEGLKNAD
GTDIVDESAGVDAFGHKKLAGAGKFTCQQIQKRMKADPAMPLFMKETGMFVEGVYEIPEVREIHPGHLVRSGNSSAYDIN
FGFEAGAAAVLLLLDGKTGVTVSRVKGRKVEYIESSKAIVQRHVDLEQVALHESLGICFGRAAHAYEPILREVEGVYDRI
Y

Sequences:

>Translated_401_residues
MKKIGILTSGGDCGGLNAVLKGAALMAQSKGLELYIIPNGYAGLYNLVDQERIVRLDRIRLDQFDASFAGSEAGHSRVKI
KAISNPEKYNRIKAGMKKFELDALIISGGDDSGSVMVDLNHQGIQCIHAPKTMDLDLQTYSVGGDSTINRIAQFVHDLKT
TGKTHNRVLVTEVFGRYAGHTAFRSGIAAEADCILIPEIPADWDVVYEHLKERFTRRIKDSDVHSGTYTIVVAEGLKNAD
GTDIVDESAGVDAFGHKKLAGAGKFTCQQIQKRMKADPAMPLFMKETGMFVEGVYEIPEVREIHPGHLVRSGNSSAYDIN
FGFEAGAAAVLLLLDGKTGVTVSRVKGRKVEYIESSKAIVQRHVDLEQVALHESLGICFGRAAHAYEPILREVEGVYDRI
Y
>Mature_401_residues
MKKIGILTSGGDCGGLNAVLKGAALMAQSKGLELYIIPNGYAGLYNLVDQERIVRLDRIRLDQFDASFAGSEAGHSRVKI
KAISNPEKYNRIKAGMKKFELDALIISGGDDSGSVMVDLNHQGIQCIHAPKTMDLDLQTYSVGGDSTINRIAQFVHDLKT
TGKTHNRVLVTEVFGRYAGHTAFRSGIAAEADCILIPEIPADWDVVYEHLKERFTRRIKDSDVHSGTYTIVVAEGLKNAD
GTDIVDESAGVDAFGHKKLAGAGKFTCQQIQKRMKADPAMPLFMKETGMFVEGVYEIPEVREIHPGHLVRSGNSSAYDIN
FGFEAGAAAVLLLLDGKTGVTVSRVKGRKVEYIESSKAIVQRHVDLEQVALHESLGICFGRAAHAYEPILREVEGVYDRI
Y

Specific function: Key control step of glycolysis. [C]

COG id: COG0205

COG function: function code G; 6-phosphofructokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphofructokinase family [H]

Homologues:

Organism=Homo sapiens, GI266453768, Length=363, Percent_Identity=26.1707988980716, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI266453748, Length=363, Percent_Identity=26.1707988980716, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4505749, Length=363, Percent_Identity=26.1707988980716, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI266453619, Length=363, Percent_Identity=26.1707988980716, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI48762920, Length=325, Percent_Identity=25.8461538461538, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1790350, Length=351, Percent_Identity=29.0598290598291, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17558788, Length=418, Percent_Identity=26.0765550239234, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: 3981 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 950 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012003
- InterPro:   IPR012829
- InterPro:   IPR022953
- InterPro:   IPR015912
- InterPro:   IPR000023 [H]

Pfam domain/function: PF00365 PFK [H]

EC number: =2.7.1.90 [H]

Molecular weight: Translated: 43826; Mature: 43826

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIGILTSGGDCGGLNAVLKGAALMAQSKGLELYIIPNGYAGLYNLVDQERIVRLDRIR
CCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
LDQFDASFAGSEAGHSRVKIKAISNPEKYNRIKAGMKKFELDALIISGGDDSGSVMVDLN
HHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEEEEEECCCCCCEEEEEEC
HQGIQCIHAPKTMDLDLQTYSVGGDSTINRIAQFVHDLKTTGKTHNRVLVTEVFGRYAGH
CCCEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCH
TAFRSGIAAEADCILIPEIPADWDVVYEHLKERFTRRIKDSDVHSGTYTIVVAEGLKNAD
HHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCC
GTDIVDESAGVDAFGHKKLAGAGKFTCQQIQKRMKADPAMPLFMKETGMFVEGVYEIPEV
CCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCEEEEHHCCCHHHHHHCCCCC
REIHPGHLVRSGNSSAYDINFGFEAGAAAVLLLLDGKTGVTVSRVKGRKVEYIESSKAIV
CCCCCCCEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEECCCCEEEEHHHHHHHH
QRHVDLEQVALHESLGICFGRAAHAYEPILREVEGVYDRIY
HHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIGILTSGGDCGGLNAVLKGAALMAQSKGLELYIIPNGYAGLYNLVDQERIVRLDRIR
CCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
LDQFDASFAGSEAGHSRVKIKAISNPEKYNRIKAGMKKFELDALIISGGDDSGSVMVDLN
HHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEEEEEECCCCCCEEEEEEC
HQGIQCIHAPKTMDLDLQTYSVGGDSTINRIAQFVHDLKTTGKTHNRVLVTEVFGRYAGH
CCCEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCH
TAFRSGIAAEADCILIPEIPADWDVVYEHLKERFTRRIKDSDVHSGTYTIVVAEGLKNAD
HHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCC
GTDIVDESAGVDAFGHKKLAGAGKFTCQQIQKRMKADPAMPLFMKETGMFVEGVYEIPEV
CCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCEEEEHHCCCHHHHHHCCCCC
REIHPGHLVRSGNSSAYDINFGFEAGAAAVLLLLDGKTGVTVSRVKGRKVEYIESSKAIV
CCCCCCCEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEECCCCEEEEHHHHHHHH
QRHVDLEQVALHESLGICFGRAAHAYEPILREVEGVYDRIY
HHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10913106 [H]