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The map label for this gene is thrS

Identifier: 78189671

GI number: 78189671

Start: 2227260

End: 2229233

Strand: Reverse

Name: thrS

Synonym: Cag_1715

Alternate gene names: 78189671

Gene position: 2229233-2227260 (Counterclockwise)

Preceding gene: 78189672

Following gene: 78189670

Centisome position: 86.67

GC content: 47.87

Gene sequence:

>1974_bases
ATGTCTGATCATAAAGAATCCACGGGTGCCATTGCCCTTACGCTTCCTGATAGAAGTGTACGCAACGTTGCAATGGGTAG
CACGGGTTACGATGTAGCGCTCTCCATTGGGCGTAAGTTAGCGCAAGATGCCCTTGCTATTAAGCTCAATGGCGTTGTTT
GCGACCTTAACACCCTTATCAATAGCGATGCGGCTATAGAAATTATCACCTTTACTTCGCCTGAGGGTCCTGAGATTTTT
TGGCATAGTTCCAGCCATTTAATGGCGCAAGCGATTGAGGAGCTTTTTGCGGGAAGTAAGTTTGGGGCTGGTCCTGCTAT
TGAGCAAGGCTTTTACTACGATGTTTCTTCGGAGCACCGTTTTCGTGAAGAGGATTTACGTGCTATTGAAGCACGTATGT
TGGAAATCAGCAAGCGCGATAGTAGTGTGCAGCGGCAGGAGATGAGCCGTGAAGAGGCTATTGCTTTTTTCACCTCCGTT
CGTAACGATCCTTATAAAGTTGAAATTCTTACCGAAACGCTAAAAAATGTAGAGCGCGTTTCGCTCTACCATCAAGGCGA
CTTTACCGACCTTTGTACGGGTCCACATTTGCCTTCTACTGGCAAAATAAAGGCGGTGTTGCTAACGAACATTTCTGCCT
CTTATTGGCGTGGTGATTCGAACCGTGAGCAAATGCAGCGTATTTATGGCATTACTTTCCCTTCGGAAAAGTTGTTGAAA
GAGCATGTTGCTCGAATTGAGGAGGCAAAGCGGCGCGACCATCGCAAGCTTGGTGCTGAGCTTGAGCTTTTCTTGCTCTC
TCCTGAAGTTGGTAGCGGCTTGCCGATGTGGTTGCCTAAAGGTGCCATTATTCGTAGTGAGTTGGAATCTTTTTTGCGCG
AGGAGCAGCGTAAACGTGGTTACGTGCCTGTTTACACGCCGCATATTGGCAACATTGAGCTATACAAGCGTTCGGGGCAC
TATCCATATTACAGCGATTCGCAATTTCCGCCACTTACCTATCACGATGAAGATGGTAAGCAGGAGCAGTATTTGCTTAA
GCCAATGAACTGCCCGCACCATCATCTTATTTATAGCTCTAAAATGCGGAGTTACCGCGATTTACCGCTTCGCTTTACGG
AGTTTGGAACGGTGTATCGCCATGAGCAATCGGGTGAATTAAATGGCTTGGCGCGTGCGCGTGGCTTTACGCAAGACGAT
TCGCACATTTATTGCCGTCCCGATCAGTTGGTGGATGAAATTTGTAGTGCTATTGAGCTGACGCAATTTGTCTTTAAAAC
GCTCGGCTTTGCTGAAGTACAAACACGCCTTTCGCTGCACGATCCTGCTAACCAAGCAAAATATGGTGGTACGGCTGAAG
TGTGGGAGCAGGCGGAAAAGGATGTTCAAGAAGCCGCTGAACGCATGGGGGTTGATTACTTTATTGGCATTGGTGAAGCA
AGTTTTTACGGTCCCAAAATTGACTTTATTGTGCGCGATGCTATTGGGCGCAAATGGCAGCTTGGCACCGTGCAGGTTGA
CTACGTTATGCCCGAGCGCTTCGATTTAACTTACGTTGGTAGCGATGGGCAAAAGCATCGTCCCGTTGTTATTCACCGTG
CGCCATTCGGCTCAATGGAGCGCTTTATTGGTTTGCTTATTGAGCACACCGCAGGGAACTTCCCGCTCTGGTTGGCACCT
GTGCAAGTTGCCGTGCTGCCTATTGCTGAAGAAAATCACGATTATGCAACCACTGTTTACCGCCGTTTGCTTGCGGCAGG
TATTCGTGCTGAACTTGATACGCGAAGCGAAAAAATTAATCGCAAAATTCGCGATGCTGAAATGAGCAAAACCCCTTGCA
TGTTGGTAATTGGTCAAAAAGAGCAAGCAAATGGTGAAGTGTCGCTTCGTCGCCATCGTCAAGGTGATGCTGGGCGCTTT
GCTACCGATGAGCTGATTGAAACGTTGAAGCAAGAGATTGCTAATCGCCAGTAA

Upstream 100 bases:

>100_bases
TGTAATTGGAGGAAACACTTACTGTATCGTGTAATTGTTTAATTTTTAACGCGATACGTATGCAACCCATAATGCTTTAC
AAGCGGTTTAATTGACTGTT

Downstream 100 bases:

>100_bases
AGAGTGGCAAAGAGGGCATTGTTAACAATGAATTTTGAGTGATGCCCCGCAAGTTTGATACCCGATAAACAAATTCATAA
CGAATGAAGAAACCAAAGGT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSDHKESTGAIALTLPDRSVRNVAMGSTGYDVALSIGRKLAQDALAIKLNGVVCDLNTLINSDAAIEIITFTSPEGPEIF
WHSSSHLMAQAIEELFAGSKFGAGPAIEQGFYYDVSSEHRFREEDLRAIEARMLEISKRDSSVQRQEMSREEAIAFFTSV
RNDPYKVEILTETLKNVERVSLYHQGDFTDLCTGPHLPSTGKIKAVLLTNISASYWRGDSNREQMQRIYGITFPSEKLLK
EHVARIEEAKRRDHRKLGAELELFLLSPEVGSGLPMWLPKGAIIRSELESFLREEQRKRGYVPVYTPHIGNIELYKRSGH
YPYYSDSQFPPLTYHDEDGKQEQYLLKPMNCPHHHLIYSSKMRSYRDLPLRFTEFGTVYRHEQSGELNGLARARGFTQDD
SHIYCRPDQLVDEICSAIELTQFVFKTLGFAEVQTRLSLHDPANQAKYGGTAEVWEQAEKDVQEAAERMGVDYFIGIGEA
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLTYVGSDGQKHRPVVIHRAPFGSMERFIGLLIEHTAGNFPLWLAP
VQVAVLPIAEENHDYATTVYRRLLAAGIRAELDTRSEKINRKIRDAEMSKTPCMLVIGQKEQANGEVSLRRHRQGDAGRF
ATDELIETLKQEIANRQ

Sequences:

>Translated_657_residues
MSDHKESTGAIALTLPDRSVRNVAMGSTGYDVALSIGRKLAQDALAIKLNGVVCDLNTLINSDAAIEIITFTSPEGPEIF
WHSSSHLMAQAIEELFAGSKFGAGPAIEQGFYYDVSSEHRFREEDLRAIEARMLEISKRDSSVQRQEMSREEAIAFFTSV
RNDPYKVEILTETLKNVERVSLYHQGDFTDLCTGPHLPSTGKIKAVLLTNISASYWRGDSNREQMQRIYGITFPSEKLLK
EHVARIEEAKRRDHRKLGAELELFLLSPEVGSGLPMWLPKGAIIRSELESFLREEQRKRGYVPVYTPHIGNIELYKRSGH
YPYYSDSQFPPLTYHDEDGKQEQYLLKPMNCPHHHLIYSSKMRSYRDLPLRFTEFGTVYRHEQSGELNGLARARGFTQDD
SHIYCRPDQLVDEICSAIELTQFVFKTLGFAEVQTRLSLHDPANQAKYGGTAEVWEQAEKDVQEAAERMGVDYFIGIGEA
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLTYVGSDGQKHRPVVIHRAPFGSMERFIGLLIEHTAGNFPLWLAP
VQVAVLPIAEENHDYATTVYRRLLAAGIRAELDTRSEKINRKIRDAEMSKTPCMLVIGQKEQANGEVSLRRHRQGDAGRF
ATDELIETLKQEIANRQ
>Mature_656_residues
SDHKESTGAIALTLPDRSVRNVAMGSTGYDVALSIGRKLAQDALAIKLNGVVCDLNTLINSDAAIEIITFTSPEGPEIFW
HSSSHLMAQAIEELFAGSKFGAGPAIEQGFYYDVSSEHRFREEDLRAIEARMLEISKRDSSVQRQEMSREEAIAFFTSVR
NDPYKVEILTETLKNVERVSLYHQGDFTDLCTGPHLPSTGKIKAVLLTNISASYWRGDSNREQMQRIYGITFPSEKLLKE
HVARIEEAKRRDHRKLGAELELFLLSPEVGSGLPMWLPKGAIIRSELESFLREEQRKRGYVPVYTPHIGNIELYKRSGHY
PYYSDSQFPPLTYHDEDGKQEQYLLKPMNCPHHHLIYSSKMRSYRDLPLRFTEFGTVYRHEQSGELNGLARARGFTQDDS
HIYCRPDQLVDEICSAIELTQFVFKTLGFAEVQTRLSLHDPANQAKYGGTAEVWEQAEKDVQEAAERMGVDYFIGIGEAS
FYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLTYVGSDGQKHRPVVIHRAPFGSMERFIGLLIEHTAGNFPLWLAPV
QVAVLPIAEENHDYATTVYRRLLAAGIRAELDTRSEKINRKIRDAEMSKTPCMLVIGQKEQANGEVSLRRHRQGDAGRFA
TDELIETLKQEIANRQ

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=645, Percent_Identity=39.5348837209302, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI38570111, Length=650, Percent_Identity=38.1538461538462, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI20070344, Length=654, Percent_Identity=37.3088685015291, Blast_Score=427, Evalue=1e-119,
Organism=Escherichia coli, GI1788013, Length=645, Percent_Identity=40.7751937984496, Blast_Score=520, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI71984192, Length=645, Percent_Identity=36.8992248062016, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71984184, Length=645, Percent_Identity=36.8992248062016, Blast_Score=470, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322112, Length=661, Percent_Identity=36.1573373676248, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322654, Length=383, Percent_Identity=35.509138381201, Blast_Score=254, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24583839, Length=644, Percent_Identity=39.1304347826087, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24583842, Length=644, Percent_Identity=39.1304347826087, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI28574141, Length=644, Percent_Identity=39.1304347826087, Blast_Score=482, Evalue=1e-136,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_CHLCH (Q3APV9)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_380009.1
- ProteinModelPortal:   Q3APV9
- SMR:   Q3APV9
- STRING:   Q3APV9
- GeneID:   3746981
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1715
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GRKWQLG
- ProtClustDB:   PRK00413
- BioCyc:   CCHL340177:CAG_1715-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74598; Mature: 74467

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHKESTGAIALTLPDRSVRNVAMGSTGYDVALSIGRKLAQDALAIKLNGVVCDLNTLI
CCCCCCCCCEEEEEECCCCHHHEECCCCCCHHHHHHHHHHHHCCEEEEECCEEEEHHHHH
NSDAAIEIITFTSPEGPEIFWHSSSHLMAQAIEELFAGSKFGAGPAIEQGFYYDVSSEHR
CCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCH
FREEDLRAIEARMLEISKRDSSVQRQEMSREEAIAFFTSVRNDPYKVEILTETLKNVERV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHE
SLYHQGDFTDLCTGPHLPSTGKIKAVLLTNISASYWRGDSNREQMQRIYGITFPSEKLLK
EEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCHHHHHHHHCCCCCHHHHHH
EHVARIEEAKRRDHRKLGAELELFLLSPEVGSGLPMWLPKGAIIRSELESFLREEQRKRG
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
YVPVYTPHIGNIELYKRSGHYPYYSDSQFPPLTYHDEDGKQEQYLLKPMNCPHHHLIYSS
CCEEECCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCHHEECCCCCCCHHHEEHH
KMRSYRDLPLRFTEFGTVYRHEQSGELNGLARARGFTQDDSHIYCRPDQLVDEICSAIEL
HHHHHCCCCEEEHHHCHHEEECCCCCCCHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHH
TQFVFKTLGFAEVQTRLSLHDPANQAKYGGTAEVWEQAEKDVQEAAERMGVDYFIGIGEA
HHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLTYVGSDGQKHRPVVIHRAPFGSME
CCCCCCEEEEEEHHCCCEEEECEEEEEEECCCCEEEEEECCCCCCCCCEEEEECCCCHHH
RFIGLLIEHTAGNFPLWLAPVQVAVLPIAEENHDYATTVYRRLLAAGIRAELDTRSEKIN
HHHHHHHHHCCCCCCEEEECEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RKIRDAEMSKTPCMLVIGQKEQANGEVSLRRHRQGDAGRFATDELIETLKQEIANRQ
HHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDHKESTGAIALTLPDRSVRNVAMGSTGYDVALSIGRKLAQDALAIKLNGVVCDLNTLI
CCCCCCCCEEEEEECCCCHHHEECCCCCCHHHHHHHHHHHHCCEEEEECCEEEEHHHHH
NSDAAIEIITFTSPEGPEIFWHSSSHLMAQAIEELFAGSKFGAGPAIEQGFYYDVSSEHR
CCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCH
FREEDLRAIEARMLEISKRDSSVQRQEMSREEAIAFFTSVRNDPYKVEILTETLKNVERV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHE
SLYHQGDFTDLCTGPHLPSTGKIKAVLLTNISASYWRGDSNREQMQRIYGITFPSEKLLK
EEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCHHHHHHHHCCCCCHHHHHH
EHVARIEEAKRRDHRKLGAELELFLLSPEVGSGLPMWLPKGAIIRSELESFLREEQRKRG
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
YVPVYTPHIGNIELYKRSGHYPYYSDSQFPPLTYHDEDGKQEQYLLKPMNCPHHHLIYSS
CCEEECCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCHHEECCCCCCCHHHEEHH
KMRSYRDLPLRFTEFGTVYRHEQSGELNGLARARGFTQDDSHIYCRPDQLVDEICSAIEL
HHHHHCCCCEEEHHHCHHEEECCCCCCCHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHH
TQFVFKTLGFAEVQTRLSLHDPANQAKYGGTAEVWEQAEKDVQEAAERMGVDYFIGIGEA
HHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLTYVGSDGQKHRPVVIHRAPFGSME
CCCCCCEEEEEEHHCCCEEEECEEEEEEECCCCEEEEEECCCCCCCCCEEEEECCCCHHH
RFIGLLIEHTAGNFPLWLAPVQVAVLPIAEENHDYATTVYRRLLAAGIRAELDTRSEKIN
HHHHHHHHHCCCCCCEEEECEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RKIRDAEMSKTPCMLVIGQKEQANGEVSLRRHRQGDAGRFATDELIETLKQEIANRQ
HHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA