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The map label for this gene is cbs [H]

Identifier: 78189592

GI number: 78189592

Start: 2132227

End: 2133600

Strand: Reverse

Name: cbs [H]

Synonym: Cag_1634

Alternate gene names: 78189592

Gene position: 2133600-2132227 (Counterclockwise)

Preceding gene: 78189594

Following gene: 78189591

Centisome position: 82.95

GC content: 47.74

Gene sequence:

>1374_bases
ATGCAACAGTACCCAACCCTTACGCTTACTACCGAAACGCCTTTACTTCAGCTTCGTCATCTTGCGCGTACTATACGTCC
AACTATTATGGCGAAGCTTGAATACATGAATTCGGCATACTCGCACCATTTTCGAGCAGCACAAGCTATTGTGCAAGCGG
CTGAAGAGCAAGAGCAAATTCATCCGGGTATGACGTTGGTTGATTGGAGCCTTGGCAGTAGCGCGATTGCACTTGCTATG
GTTGCCGTTAATCGTGGCTACAAATTGCTGTTAGCGGTGCCCGACACCATTGCAAACGAACAGCAAAACATGTTGCGTGC
CCTTGGCGCTGAGCTTATTATGACACCAGCCGATGCCCTGCCCGATGAAGCACGAAGCTGCATGATGGTTGCTCACAGCC
TTGAGCAAAGCATTCCGCACGCTTTTTTTGTAGGCATGTACGATAACCCCTTGAGCTTGCGCATTCATAGCGATATTACC
GCACCTGAATTGCTTCTCCAATGCAACAATGCCGTAACGCACGTTGTGGTGCCGCTTGGCTCAGGCGCGTTAGCATTTGG
CATGAGCCGTGCGCTGAAAGCTGCCAACCCCTCACTCCATATTATTGGGGTTGAACCCAAAGGTTCCATTTACGCCTCAC
TCTTTCAGCGGGGTGAACTTTCTGCCCCAGAGCGTTGGGATGTGGAAGAGATGGGCGCTCGCCAACCCTCCCCATTTTGG
GAACGTTCACTTTTGGATGATGTGGTGCAAATAAGCGATCACGACGCTTTTAATTGTGCGCGTGAATTGCTTCGTACAGA
GGCAATATTTGCTGGTGGAGCTTCGGGCGCCGCTATGGCAGCCGCTCTTCACCTTGCCAAGCAATGTAATGAAGATGATT
CTATTGCGGTGATGCTTACCGATTTTGGTGGTTACTCCCTCAGTCGCCTTTATTGCGACGATTGGATGCGTAAAAAAGGT
TTTTATCGCAAAGTAAAATCATCACTTGAGCAAATTACGGCTGAAGATATTTTGCAACGCAAAGCACGTCGCAACCTCAT
TTTTGCTCATCCCGAACATACGCTTGCCGAAGTGTTTGAAATGATGAAGCAAAACGATGTTTCCCAAATGCCTATTGTTT
CATACAACGCACCTATTGGCAGCATTAGCGAAAACAGGATTCTTTCTATTCTTATTGAACACGATGATGCCATGAATGCT
AAAGTGATTGGCTTTATGGAAAAACCTTTTCCCGTATGTTCGCCCGATGCCACCATTTCGGAATTATCGGCTCGCTTGCA
ACAACATGCCTCAGGCGTTCTTGTGAATATGTCGGATGGTAAGCTGCAACTCCTTACAAAATCAGATCTTATAGATGCGC
TTACCCACAAGTAA

Upstream 100 bases:

>100_bases
AATGCTTGCTACTTTCCCCCCTTGCTGTTACTTTGATGCAAAGAACCACTGCTGGTAAAATCCAGACGGCATCTTTAAAA
AATCTGTACATCATTCTACC

Downstream 100 bases:

>100_bases
ATGGCAGAATATTATCATGTTGGTTTTTTAGAAGGAATTCTTTATCTACCGCCTCATTTGTGGAGCCCTATTTTCAAGCG
CCAAAAAGGAGAACAACTCC

Product: hypothetical protein

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MQQYPTLTLTTETPLLQLRHLARTIRPTIMAKLEYMNSAYSHHFRAAQAIVQAAEEQEQIHPGMTLVDWSLGSSAIALAM
VAVNRGYKLLLAVPDTIANEQQNMLRALGAELIMTPADALPDEARSCMMVAHSLEQSIPHAFFVGMYDNPLSLRIHSDIT
APELLLQCNNAVTHVVVPLGSGALAFGMSRALKAANPSLHIIGVEPKGSIYASLFQRGELSAPERWDVEEMGARQPSPFW
ERSLLDDVVQISDHDAFNCARELLRTEAIFAGGASGAAMAAALHLAKQCNEDDSIAVMLTDFGGYSLSRLYCDDWMRKKG
FYRKVKSSLEQITAEDILQRKARRNLIFAHPEHTLAEVFEMMKQNDVSQMPIVSYNAPIGSISENRILSILIEHDDAMNA
KVIGFMEKPFPVCSPDATISELSARLQQHASGVLVNMSDGKLQLLTKSDLIDALTHK

Sequences:

>Translated_457_residues
MQQYPTLTLTTETPLLQLRHLARTIRPTIMAKLEYMNSAYSHHFRAAQAIVQAAEEQEQIHPGMTLVDWSLGSSAIALAM
VAVNRGYKLLLAVPDTIANEQQNMLRALGAELIMTPADALPDEARSCMMVAHSLEQSIPHAFFVGMYDNPLSLRIHSDIT
APELLLQCNNAVTHVVVPLGSGALAFGMSRALKAANPSLHIIGVEPKGSIYASLFQRGELSAPERWDVEEMGARQPSPFW
ERSLLDDVVQISDHDAFNCARELLRTEAIFAGGASGAAMAAALHLAKQCNEDDSIAVMLTDFGGYSLSRLYCDDWMRKKG
FYRKVKSSLEQITAEDILQRKARRNLIFAHPEHTLAEVFEMMKQNDVSQMPIVSYNAPIGSISENRILSILIEHDDAMNA
KVIGFMEKPFPVCSPDATISELSARLQQHASGVLVNMSDGKLQLLTKSDLIDALTHK
>Mature_457_residues
MQQYPTLTLTTETPLLQLRHLARTIRPTIMAKLEYMNSAYSHHFRAAQAIVQAAEEQEQIHPGMTLVDWSLGSSAIALAM
VAVNRGYKLLLAVPDTIANEQQNMLRALGAELIMTPADALPDEARSCMMVAHSLEQSIPHAFFVGMYDNPLSLRIHSDIT
APELLLQCNNAVTHVVVPLGSGALAFGMSRALKAANPSLHIIGVEPKGSIYASLFQRGELSAPERWDVEEMGARQPSPFW
ERSLLDDVVQISDHDAFNCARELLRTEAIFAGGASGAAMAAALHLAKQCNEDDSIAVMLTDFGGYSLSRLYCDDWMRKKG
FYRKVKSSLEQITAEDILQRKARRNLIFAHPEHTLAEVFEMMKQNDVSQMPIVSYNAPIGSISENRILSILIEHDDAMNA
KVIGFMEKPFPVCSPDATISELSARLQQHASGVLVNMSDGKLQLLTKSDLIDALTHK

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=397, Percent_Identity=28.2115869017632, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI295821200, Length=397, Percent_Identity=28.2115869017632, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4557415, Length=397, Percent_Identity=28.2115869017632, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=31.986531986532, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788754, Length=312, Percent_Identity=31.0897435897436, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17534315, Length=321, Percent_Identity=32.7102803738318, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562970, Length=305, Percent_Identity=34.0983606557377, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=32.6732673267327, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=34.1296928327645, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=30.188679245283, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI115535073, Length=309, Percent_Identity=30.42071197411, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17561720, Length=278, Percent_Identity=34.1726618705036, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=32.1428571428571, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321594, Length=502, Percent_Identity=26.8924302788845, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=24.4648318042813, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24643623, Length=407, Percent_Identity=28.7469287469287, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129101, Length=407, Percent_Identity=28.7469287469287, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 50407; Mature: 50407

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQYPTLTLTTETPLLQLRHLARTIRPTIMAKLEYMNSAYSHHFRAAQAIVQAAEEQEQI
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HPGMTLVDWSLGSSAIALAMVAVNRGYKLLLAVPDTIANEQQNMLRALGAELIMTPADAL
CCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCHHHEECCCCCC
PDEARSCMMVAHSLEQSIPHAFFVGMYDNPLSLRIHSDITAPELLLQCNNAVTHVVVPLG
CHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCHHHHHHHHCCCEEEEEEECC
SGALAFGMSRALKAANPSLHIIGVEPKGSIYASLFQRGELSAPERWDVEEMGARQPSPFW
CCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCHH
ERSLLDDVVQISDHDAFNCARELLRTEAIFAGGASGAAMAAALHLAKQCNEDDSIAVMLT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEE
DFGGYSLSRLYCDDWMRKKGFYRKVKSSLEQITAEDILQRKARRNLIFAHPEHTLAEVFE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHH
MMKQNDVSQMPIVSYNAPIGSISENRILSILIEHDDAMNAKVIGFMEKPFPVCSPDATIS
HHHHCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHH
ELSARLQQHASGVLVNMSDGKLQLLTKSDLIDALTHK
HHHHHHHHHCCCEEEEECCCEEEEEEHHHHHHHHHCC
>Mature Secondary Structure
MQQYPTLTLTTETPLLQLRHLARTIRPTIMAKLEYMNSAYSHHFRAAQAIVQAAEEQEQI
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HPGMTLVDWSLGSSAIALAMVAVNRGYKLLLAVPDTIANEQQNMLRALGAELIMTPADAL
CCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCHHHEECCCCCC
PDEARSCMMVAHSLEQSIPHAFFVGMYDNPLSLRIHSDITAPELLLQCNNAVTHVVVPLG
CHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCHHHHHHHHCCCEEEEEEECC
SGALAFGMSRALKAANPSLHIIGVEPKGSIYASLFQRGELSAPERWDVEEMGARQPSPFW
CCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCHH
ERSLLDDVVQISDHDAFNCARELLRTEAIFAGGASGAAMAAALHLAKQCNEDDSIAVMLT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEE
DFGGYSLSRLYCDDWMRKKGFYRKVKSSLEQITAEDILQRKARRNLIFAHPEHTLAEVFE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHH
MMKQNDVSQMPIVSYNAPIGSISENRILSILIEHDDAMNAKVIGFMEKPFPVCSPDATIS
HHHHCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHH
ELSARLQQHASGVLVNMSDGKLQLLTKSDLIDALTHK
HHHHHHHHHCCCEEEEECCCEEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]