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The map label for this gene is pccB [H]

Identifier: 78189481

GI number: 78189481

Start: 1996949

End: 1998490

Strand: Reverse

Name: pccB [H]

Synonym: Cag_1521

Alternate gene names: 78189481

Gene position: 1998490-1996949 (Counterclockwise)

Preceding gene: 78189491

Following gene: 78189480

Centisome position: 77.7

GC content: 47.47

Gene sequence:

>1542_bases
ATGGAACGATTACTTGCCGAGCGCGAAAAAGCTCATCTTGGTGGTGGGCAGAAGCGCATTGATTCTCAACATAAAAAAGG
CAAACTAACCGCGCGTGAACGCCTTGAGTTATTGCTTGATGAGGGTAGCTTTGAGGAATTCGATATGTTTGTAACCCACC
GTGCTGTAGATTTTGATCTTGAAAAAGAGCACTACTTAGGGGATGGCGTTATTACAGGGCATGGCACTATTGATGGGCGC
ACCGTGTATGTGTTTGCGCAAGATTTTACGGTGTTTGGCGGTTCGCTCTCTGAAACCAACGCCTTGAAAATTTGCAAGGT
GATGGATCAAGCCATGAAAGTAGGCGCACCACTTATTGGCATTAACGATAGCGGTGGCGCACGTATTCAAGAAGGTGTAC
ACAGCTTGGCAGGATATGCCTCTATTTTTGAGCGCAACATTTTAGCCTCAGGGGTTATTCCTCAAATTTCAGTGATTTTT
GGACCTTGTGCGGGTGGTGCTGTCTATTCGCCTGCGCTTACCGATTTTGTGCTAATGGCTGATAAAACCAGCTATATGTT
TGTTACCGGTCCAAAGGTGGTGAAAACCGTGATGTGCGAAAACGTTACCGATGAAGAGCTTGGCGGCGCTATGGCTCATG
CTACCAAGTCGGGCGTTACGCACTTTGTGGCACAAAACGAGCACGAAGGCATTGAGCAAATTAAAAAGCTTTTAAGCTAC
CTTCCCCAAAGTAATCGCGAAGCGCCACCTGTTGCCCCGTGCAGCGATCGCATTGATAGGGCTGATGAAAAGCTCAATAG
CATTATTCCCGAAAAGCCTTCTCACCCTTACGATGTTAAAGAGGTCATTCACACCATTACAGACCATGGTGAATTTTTAG
AGGTGCATGAACACTATGCGCCTAACATTGTGGTGGGCTTTGCAACCTTTAACGGCATTTCAACCGGCATTGTTGCCAAT
CAGCCTTGCTGCCTTGCGGGCTGCCTCGATAACGATGCTTCGCGCAAAGCGGCTCGTTTTGTACGTTTTTGCGATGCCTT
TAATATTCCTCTTGTAACCTTAGTGGATGTGCCTGGCTTTTTGCCCGGTACTGCGCAAGAGTTTAATGGAATTATTAGCA
ATGGCGCCAAATTGCTCTTTGCTTATGGCGAAGCAACGGTGCCAAAAATCACTGTTATTTTGCGAAAAGCGTATGGCGGC
GCTTACTGCGTTATGAGTTCCAAACATTTACGGGGCGATATTAATTATGCTTGGCCTACGGCTGAAATTGCTGTTATGGG
ACCTTTAGGCGCTATTGAGGTGCTGTGCAACAAAACCCTCTGCACGCTTAAAGACCCCGAAGAGCGCGCACACTTTATTG
CCGACAATGCTGCCGAATACCGCGAAAAGTTTGCCAATCCCTACGAGGCGGCGAAATATGGCTACATAGATGACATTATT
GAGCCTCGCAACACGCGCCCGCGCATTATTCGCGCTTTGCAAATGCTTCGCACCAAGAAAGAGGAGAATCCCTATAAGAA
ACATGCCACCATGCCCTTGTAA

Upstream 100 bases:

>100_bases
TCTATTCTTTTGGGTTGCGACGGCTCTTTGCAACATCATTACATAACGGGCACTTGTTGTGCATCTGCATTTTTAAATTT
TTATCAGTAATATTTTTTTT

Downstream 100 bases:

>100_bases
AAGCATCTTCACGAAGTGCGCTGATTTTTGTATGTTTGCACCTTTTATAACGGGCATCCAACGTTTAGCAGATTCCTTAA
CATTTAACGTTTTGACCTAT

Product: methylmalonyl-CoA decarboxylase subunit alpha

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MERLLAEREKAHLGGGQKRIDSQHKKGKLTARERLELLLDEGSFEEFDMFVTHRAVDFDLEKEHYLGDGVITGHGTIDGR
TVYVFAQDFTVFGGSLSETNALKICKVMDQAMKVGAPLIGINDSGGARIQEGVHSLAGYASIFERNILASGVIPQISVIF
GPCAGGAVYSPALTDFVLMADKTSYMFVTGPKVVKTVMCENVTDEELGGAMAHATKSGVTHFVAQNEHEGIEQIKKLLSY
LPQSNREAPPVAPCSDRIDRADEKLNSIIPEKPSHPYDVKEVIHTITDHGEFLEVHEHYAPNIVVGFATFNGISTGIVAN
QPCCLAGCLDNDASRKAARFVRFCDAFNIPLVTLVDVPGFLPGTAQEFNGIISNGAKLLFAYGEATVPKITVILRKAYGG
AYCVMSSKHLRGDINYAWPTAEIAVMGPLGAIEVLCNKTLCTLKDPEERAHFIADNAAEYREKFANPYEAAKYGYIDDII
EPRNTRPRIIRALQMLRTKKEENPYKKHATMPL

Sequences:

>Translated_513_residues
MERLLAEREKAHLGGGQKRIDSQHKKGKLTARERLELLLDEGSFEEFDMFVTHRAVDFDLEKEHYLGDGVITGHGTIDGR
TVYVFAQDFTVFGGSLSETNALKICKVMDQAMKVGAPLIGINDSGGARIQEGVHSLAGYASIFERNILASGVIPQISVIF
GPCAGGAVYSPALTDFVLMADKTSYMFVTGPKVVKTVMCENVTDEELGGAMAHATKSGVTHFVAQNEHEGIEQIKKLLSY
LPQSNREAPPVAPCSDRIDRADEKLNSIIPEKPSHPYDVKEVIHTITDHGEFLEVHEHYAPNIVVGFATFNGISTGIVAN
QPCCLAGCLDNDASRKAARFVRFCDAFNIPLVTLVDVPGFLPGTAQEFNGIISNGAKLLFAYGEATVPKITVILRKAYGG
AYCVMSSKHLRGDINYAWPTAEIAVMGPLGAIEVLCNKTLCTLKDPEERAHFIADNAAEYREKFANPYEAAKYGYIDDII
EPRNTRPRIIRALQMLRTKKEENPYKKHATMPL
>Mature_513_residues
MERLLAEREKAHLGGGQKRIDSQHKKGKLTARERLELLLDEGSFEEFDMFVTHRAVDFDLEKEHYLGDGVITGHGTIDGR
TVYVFAQDFTVFGGSLSETNALKICKVMDQAMKVGAPLIGINDSGGARIQEGVHSLAGYASIFERNILASGVIPQISVIF
GPCAGGAVYSPALTDFVLMADKTSYMFVTGPKVVKTVMCENVTDEELGGAMAHATKSGVTHFVAQNEHEGIEQIKKLLSY
LPQSNREAPPVAPCSDRIDRADEKLNSIIPEKPSHPYDVKEVIHTITDHGEFLEVHEHYAPNIVVGFATFNGISTGIVAN
QPCCLAGCLDNDASRKAARFVRFCDAFNIPLVTLVDVPGFLPGTAQEFNGIISNGAKLLFAYGEATVPKITVILRKAYGG
AYCVMSSKHLRGDINYAWPTAEIAVMGPLGAIEVLCNKTLCTLKDPEERAHFIADNAAEYREKFANPYEAAKYGYIDDII
EPRNTRPRIIRALQMLRTKKEENPYKKHATMPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=514, Percent_Identity=60.1167315175097, Blast_Score=627, Evalue=1e-180,
Organism=Homo sapiens, GI295821216, Length=534, Percent_Identity=57.8651685393258, Blast_Score=615, Evalue=1e-176,
Organism=Homo sapiens, GI11545863, Length=495, Percent_Identity=33.3333333333333, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI134142062, Length=397, Percent_Identity=24.4332493702771, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI38679960, Length=389, Percent_Identity=25.706940874036, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI38679974, Length=389, Percent_Identity=25.706940874036, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679977, Length=389, Percent_Identity=25.706940874036, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679967, Length=389, Percent_Identity=25.706940874036, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679971, Length=389, Percent_Identity=25.706940874036, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788655, Length=246, Percent_Identity=28.4552845528455, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25147362, Length=506, Percent_Identity=58.8932806324111, Blast_Score=625, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI25147359, Length=506, Percent_Identity=58.8932806324111, Blast_Score=625, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17552936, Length=506, Percent_Identity=32.2134387351779, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI71997163, Length=311, Percent_Identity=25.08038585209, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24586065, Length=502, Percent_Identity=33.8645418326693, Blast_Score=231, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56294; Mature: 56294

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLLAEREKAHLGGGQKRIDSQHKKGKLTARERLELLLDEGSFEEFDMFVTHRAVDFDL
CCHHHHHHHHHHCCCCHHHHCCHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHEECCCC
EKEHYLGDGVITGHGTIDGRTVYVFAQDFTVFGGSLSETNALKICKVMDQAMKVGAPLIG
CHHHCCCCCEEECCCCCCCEEEEEEEECEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEE
INDSGGARIQEGVHSLAGYASIFERNILASGVIPQISVIFGPCAGGAVYSPALTDFVLMA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHEEEEE
DKTSYMFVTGPKVVKTVMCENVTDEELGGAMAHATKSGVTHFVAQNEHEGIEQIKKLLSY
CCCCEEEEECHHHHHHHHHCCCCHHHHCCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHH
LPQSNREAPPVAPCSDRIDRADEKLNSIIPEKPSHPYDVKEVIHTITDHGEFLEVHEHYA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCC
PNIVVGFATFNGISTGIVANQPCCLAGCLDNDASRKAARFVRFCDAFNIPLVTLVDVPGF
CCEEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCC
LPGTAQEFNGIISNGAKLLFAYGEATVPKITVILRKAYGGAYCVMSSKHLRGDINYAWPT
CCCCHHHHHHHHHCCCEEEEEECCCCCCHHEEHHHHHCCCEEEEECCHHCCCCCCEECCC
AEIAVMGPLGAIEVLCNKTLCTLKDPEERAHFIADNAAEYREKFANPYEAAKYGYIDDII
CEEEEECCCHHHHHHHCCCEEECCCHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCHHHHC
EPRNTRPRIIRALQMLRTKKEENPYKKHATMPL
CCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCC
>Mature Secondary Structure
MERLLAEREKAHLGGGQKRIDSQHKKGKLTARERLELLLDEGSFEEFDMFVTHRAVDFDL
CCHHHHHHHHHHCCCCHHHHCCHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHEECCCC
EKEHYLGDGVITGHGTIDGRTVYVFAQDFTVFGGSLSETNALKICKVMDQAMKVGAPLIG
CHHHCCCCCEEECCCCCCCEEEEEEEECEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEE
INDSGGARIQEGVHSLAGYASIFERNILASGVIPQISVIFGPCAGGAVYSPALTDFVLMA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHEEEEE
DKTSYMFVTGPKVVKTVMCENVTDEELGGAMAHATKSGVTHFVAQNEHEGIEQIKKLLSY
CCCCEEEEECHHHHHHHHHCCCCHHHHCCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHH
LPQSNREAPPVAPCSDRIDRADEKLNSIIPEKPSHPYDVKEVIHTITDHGEFLEVHEHYA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCC
PNIVVGFATFNGISTGIVANQPCCLAGCLDNDASRKAARFVRFCDAFNIPLVTLVDVPGF
CCEEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCC
LPGTAQEFNGIISNGAKLLFAYGEATVPKITVILRKAYGGAYCVMSSKHLRGDINYAWPT
CCCCHHHHHHHHHCCCEEEEEECCCCCCHHEEHHHHHCCCEEEEECCHHCCCCCCEECCC
AEIAVMGPLGAIEVLCNKTLCTLKDPEERAHFIADNAAEYREKFANPYEAAKYGYIDDII
CEEEEECCCHHHHHHHCCCEEECCCHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCHHHHC
EPRNTRPRIIRALQMLRTKKEENPYKKHATMPL
CCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]