Click here to switch to the map view.

The map label for this gene is hemB [H]

Identifier: 78189480

GI number: 78189480

Start: 1995864

End: 1996850

Strand: Reverse

Name: hemB [H]

Synonym: Cag_1520

Alternate gene names: 78189480

Gene position: 1996850-1995864 (Counterclockwise)

Preceding gene: 78189481

Following gene: 78189479

Centisome position: 77.64

GC content: 48.02

Gene sequence:

>987_bases
ATGAGCCAACTTAACTTGCTCAATATCATCCAGCGTCCTCGCCGCCTGCGCAAAAGTGCGGCAATTCGTAACCTTGTGCA
AGAGCACTCCCTTACGGTGAATGACCTTGTGTATCCTCTGTTTGTGTGTCCTGGCACCAACGTTGTGCAAGAGGTTGGCT
CTATGCCTGGCAGCTTCCGCTACTCCATTGATAACGCCGTTAAAGAGTGCCAAGAATTATGGGATCTCGGTATTCAGTGC
ATTGACCTTTTTGGCATTCCCGAAGTGAAGAATGATGAGGGCAGCGAAGCTTACAACGACAATGGCATTATCCAAAATGC
TATCCGTGCCATTAAAGCTCAAGTGCCCGATATGTGCATTATGACCGATGTGGCGCTTGACCCCTTCACCAACTTTGGGC
ACGACGGTTTAGTACGCGACGGCATTATTCTTAATGATGAAACCGTGGAAGTGCTCTGCAAAATGGCAGTTTCGCACGCT
AACGCTGGTGCCGATTTTGTTTCCCCCAGCGATATGATGGATGGTCGCATTGGTGCCATTCGCGAAGCGCTTGATGATGA
AGATTTTATTGACGTTGGTATTCTTTCCTATGCGGCTAAATATGCTTCAAGCTTCTACGGTCCATTCCGCGATGCACTCA
ACTCCGCTCCGCAGTTTGGTGATAAAACCACTTACCAGATGAATCCCGGTAACACCGACGAGGCAATGAAGGAAATTCAG
ATTGACATTGAAGAGGGTGCCGATATTGTTATGGTAAAGCCCGGCTTAGCTTATCTCGATATTGTTCGCCGCACCAAAGA
GCGCTTTGATGTGCCTGTGGCTATTTATCACGTTTCGGGTGAATATGCTATGGTAAAAGCAGCAGCCGCGCGTGGCTGGA
TTGATGAGCAGCGTGTTATGATGGAATCATTGCTTTGCATGAAGCGTGCAGGTGGCGACTTAATTTTCACTTACTATGCA
AAAGAGGCGGCAAAAATTCTCCGCTAA

Upstream 100 bases:

>100_bases
AAAAGCATCTTCACGAAGTGCGCTGATTTTTGTATGTTTGCACCTTTTATAACGGGCATCCAACGTTTAGCAGATTCCTT
AACATTTAACGTTTTGACCT

Downstream 100 bases:

>100_bases
ACTTTCGTACCTATTCAAGCCGTTGCGGATATTTCATTTTTTAAAAGGGGAATGAAACCGCAGCGGCTTTTTTTATTGCA
TAGCAAAGTTCCCCAACTCA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSQLNLLNIIQRPRRLRKSAAIRNLVQEHSLTVNDLVYPLFVCPGTNVVQEVGSMPGSFRYSIDNAVKECQELWDLGIQC
IDLFGIPEVKNDEGSEAYNDNGIIQNAIRAIKAQVPDMCIMTDVALDPFTNFGHDGLVRDGIILNDETVEVLCKMAVSHA
NAGADFVSPSDMMDGRIGAIREALDDEDFIDVGILSYAAKYASSFYGPFRDALNSAPQFGDKTTYQMNPGNTDEAMKEIQ
IDIEEGADIVMVKPGLAYLDIVRRTKERFDVPVAIYHVSGEYAMVKAAAARGWIDEQRVMMESLLCMKRAGGDLIFTYYA
KEAAKILR

Sequences:

>Translated_328_residues
MSQLNLLNIIQRPRRLRKSAAIRNLVQEHSLTVNDLVYPLFVCPGTNVVQEVGSMPGSFRYSIDNAVKECQELWDLGIQC
IDLFGIPEVKNDEGSEAYNDNGIIQNAIRAIKAQVPDMCIMTDVALDPFTNFGHDGLVRDGIILNDETVEVLCKMAVSHA
NAGADFVSPSDMMDGRIGAIREALDDEDFIDVGILSYAAKYASSFYGPFRDALNSAPQFGDKTTYQMNPGNTDEAMKEIQ
IDIEEGADIVMVKPGLAYLDIVRRTKERFDVPVAIYHVSGEYAMVKAAAARGWIDEQRVMMESLLCMKRAGGDLIFTYYA
KEAAKILR
>Mature_327_residues
SQLNLLNIIQRPRRLRKSAAIRNLVQEHSLTVNDLVYPLFVCPGTNVVQEVGSMPGSFRYSIDNAVKECQELWDLGIQCI
DLFGIPEVKNDEGSEAYNDNGIIQNAIRAIKAQVPDMCIMTDVALDPFTNFGHDGLVRDGIILNDETVEVLCKMAVSHAN
AGADFVSPSDMMDGRIGAIREALDDEDFIDVGILSYAAKYASSFYGPFRDALNSAPQFGDKTTYQMNPGNTDEAMKEIQI
DIEEGADIVMVKPGLAYLDIVRRTKERFDVPVAIYHVSGEYAMVKAAAARGWIDEQRVMMESLLCMKRAGGDLIFTYYAK
EAAKILR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=304, Percent_Identity=39.8026315789474, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI87081728, Length=325, Percent_Identity=47.0769230769231, Blast_Score=287, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=39.0879478827362, Blast_Score=205, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21358291, Length=305, Percent_Identity=39.0163934426229, Blast_Score=231, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36396; Mature: 36265

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLNLLNIIQRPRRLRKSAAIRNLVQEHSLTVNDLVYPLFVCPGTNVVQEVGSMPGSFR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHCCCCCEE
YSIDNAVKECQELWDLGIQCIDLFGIPEVKNDEGSEAYNDNGIIQNAIRAIKAQVPDMCI
EHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
MTDVALDPFTNFGHDGLVRDGIILNDETVEVLCKMAVSHANAGADFVSPSDMMDGRIGAI
HHHHHHCCCCCCCCCCCEECCEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHH
REALDDEDFIDVGILSYAAKYASSFYGPFRDALNSAPQFGDKTTYQMNPGNTDEAMKEIQ
HHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
IDIEEGADIVMVKPGLAYLDIVRRTKERFDVPVAIYHVSGEYAMVKAAAARGWIDEQRVM
EECCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCHHHHHHH
MESLLCMKRAGGDLIFTYYAKEAAKILR
HHHHHHHHHCCCCEEEEHHHHHHHHHCC
>Mature Secondary Structure 
SQLNLLNIIQRPRRLRKSAAIRNLVQEHSLTVNDLVYPLFVCPGTNVVQEVGSMPGSFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHCCCCCEE
YSIDNAVKECQELWDLGIQCIDLFGIPEVKNDEGSEAYNDNGIIQNAIRAIKAQVPDMCI
EHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
MTDVALDPFTNFGHDGLVRDGIILNDETVEVLCKMAVSHANAGADFVSPSDMMDGRIGAI
HHHHHHCCCCCCCCCCCEECCEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHH
REALDDEDFIDVGILSYAAKYASSFYGPFRDALNSAPQFGDKTTYQMNPGNTDEAMKEIQ
HHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
IDIEEGADIVMVKPGLAYLDIVRRTKERFDVPVAIYHVSGEYAMVKAAAARGWIDEQRVM
EECCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCHHHHHHH
MESLLCMKRAGGDLIFTYYAKEAAKILR
HHHHHHHHHCCCCEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]