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The map label for this gene is hemD [H]

Identifier: 78189474

GI number: 78189474

Start: 1987848

End: 1988591

Strand: Reverse

Name: hemD [H]

Synonym: Cag_1514

Alternate gene names: 78189474

Gene position: 1988591-1987848 (Counterclockwise)

Preceding gene: 78189475

Following gene: 78189472

Centisome position: 77.31

GC content: 45.03

Gene sequence:

>744_bases
ATGAAAAGCGTTCTTGTTACTCGCCCAAAAGATCAAGCAGCTTCGTTTGTAGAACAACTTGCAGCATATGGTTTGCTCTC
GGTGGTGTTCCCCACCATCGAGATCAAGCCTGTTGGTGGTTGGTTAGTGCCAACAATGGCACAATTTGATGGTGTTTTTT
TTACCAGCCCCAACAGTGTTCATGCGTTTATGGCACAACTGCTTCAAGAAGCTCCTCAAGAGTTGGCAGCATTGCAACGT
TTAAAGGTGTGGGCAGTTGGCAAAACCACATCGGCTGATCTTGCTGCACATGGCGTTACTACACAGCCTGTTCCTAAAAT
TGCTGACGCTGTTACCTTAATGGAGGAAATTGGCGATGAGGCAATTAACAATAAGAGCTTCCTTTTTTTACGAGGTAGTC
TTTCGCTTGGTGTTATTCCCGATGTTATTAGCAAGCGAGGTGGGCGCTGCATTGAGCTAACCGTTTACGAAAACGTACCT
CCTCCACTTGAAGCAAGCGCCGAAGTAAAAGCTATGCTTCAAGATGGAAAGCTTGATTGCCTCTCTTTTACCAGTCCTTC
AACGGCAATTAATTTTTTTGAAGCCATTGGCACTACTGCTATTCCTGATGGCGTAAAAGTTGCCGCAATTGGTACCACTA
CCGCCAAGGCGCTTGAAAAACTTGGAGTACGCGTTGATATTATACCTGAATACTTTGATGGACCCTCTTTTGCAAAAGCT
ATTGCAGAAGCCTTAAAGGGGTAA

Upstream 100 bases:

>100_bases
CCTCGCCAGAACAAGCTGAAGAGGCTGGTATTGCTTTAGCTGAAGAGCTTTTAAAGCAAGGTGCGGATGCTATTTTGTCG
CAAATTCGTAAAACTTGCTA

Downstream 100 bases:

>100_bases
AGCCTCTCTTTTTTTGTTCCTCGCCAAATAACGCGTGAGCTGCATTTGGCGCTTTGGAGCAACCTCTCACAACAACCCTC
GTTCTCGAAAGCTATACCAC

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKSVLVTRPKDQAASFVEQLAAYGLLSVVFPTIEIKPVGGWLVPTMAQFDGVFFTSPNSVHAFMAQLLQEAPQELAALQR
LKVWAVGKTTSADLAAHGVTTQPVPKIADAVTLMEEIGDEAINNKSFLFLRGSLSLGVIPDVISKRGGRCIELTVYENVP
PPLEASAEVKAMLQDGKLDCLSFTSPSTAINFFEAIGTTAIPDGVKVAAIGTTTAKALEKLGVRVDIIPEYFDGPSFAKA
IAEALKG

Sequences:

>Translated_247_residues
MKSVLVTRPKDQAASFVEQLAAYGLLSVVFPTIEIKPVGGWLVPTMAQFDGVFFTSPNSVHAFMAQLLQEAPQELAALQR
LKVWAVGKTTSADLAAHGVTTQPVPKIADAVTLMEEIGDEAINNKSFLFLRGSLSLGVIPDVISKRGGRCIELTVYENVP
PPLEASAEVKAMLQDGKLDCLSFTSPSTAINFFEAIGTTAIPDGVKVAAIGTTTAKALEKLGVRVDIIPEYFDGPSFAKA
IAEALKG
>Mature_247_residues
MKSVLVTRPKDQAASFVEQLAAYGLLSVVFPTIEIKPVGGWLVPTMAQFDGVFFTSPNSVHAFMAQLLQEAPQELAALQR
LKVWAVGKTTSADLAAHGVTTQPVPKIADAVTLMEEIGDEAINNKSFLFLRGSLSLGVIPDVISKRGGRCIELTVYENVP
PPLEASAEVKAMLQDGKLDCLSFTSPSTAINFFEAIGTTAIPDGVKVAAIGTTTAKALEKLGVRVDIIPEYFDGPSFAKA
IAEALKG

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 26219; Mature: 26219

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVLVTRPKDQAASFVEQLAAYGLLSVVFPTIEIKPVGGWLVPTMAQFDGVFFTSPNSV
CCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCEEEECCCHH
HAFMAQLLQEAPQELAALQRLKVWAVGKTTSADLAAHGVTTQPVPKIADAVTLMEEIGDE
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AINNKSFLFLRGSLSLGVIPDVISKRGGRCIELTVYENVPPPLEASAEVKAMLQDGKLDC
HCCCCEEEEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCEEE
LSFTSPSTAINFFEAIGTTAIPDGVKVAAIGTTTAKALEKLGVRVDIIPEYFDGPSFAKA
EECCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHCCEEEECCCCCCCHHHHHH
IAEALKG
HHHHHCC
>Mature Secondary Structure
MKSVLVTRPKDQAASFVEQLAAYGLLSVVFPTIEIKPVGGWLVPTMAQFDGVFFTSPNSV
CCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCEEEECCCHH
HAFMAQLLQEAPQELAALQRLKVWAVGKTTSADLAAHGVTTQPVPKIADAVTLMEEIGDE
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AINNKSFLFLRGSLSLGVIPDVISKRGGRCIELTVYENVPPPLEASAEVKAMLQDGKLDC
HCCCCEEEEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCEEE
LSFTSPSTAINFFEAIGTTAIPDGVKVAAIGTTTAKALEKLGVRVDIIPEYFDGPSFAKA
EECCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHCCEEEECCCCCCCHHHHHH
IAEALKG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]