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The map label for this gene is hisS

Identifier: 78189428

GI number: 78189428

Start: 1932884

End: 1934161

Strand: Reverse

Name: hisS

Synonym: Cag_1467

Alternate gene names: 78189428

Gene position: 1934161-1932884 (Counterclockwise)

Preceding gene: 78189429

Following gene: 78189427

Centisome position: 75.2

GC content: 48.28

Gene sequence:

>1278_bases
ATGTCAAGTTTTCAGTGCGTAAAAGGTACTCGCGATATTTTGCCCGACGAGAGCCTTCTTTGGTCGTTTGTGTCATCCCA
TTTTCATCATGTAGCGTCGCTTTACGGATTTCGTGAAATTCGAACGCCAATGTTTGAATACACCGATCTGTTCCAGCGAG
GTATTGGTGCCACCACCGATATTGTGGGCAAGGAGATGTTTTCATTTCAGCCCGATCCAGCAGGGCGCTCTATAACGCTT
CGTCCTGAAATGACGGCAGGCGTTATGCGTGCTGCTCTGCAAAACAATTTGTTGGCACAAGCTCCTCTCCACAAGCTTTT
TTATATAGGGGAACTGTTTCGCAAAGAGCGTCCACAAGCAGGACGCCAACGGCAGTTTAACCAATGTGGCGCTGAGCTGC
TTGGTGTTTCATCGCCTGCGGCAGTAGCTGAGGTGATGTCGCTGATGATGCACTTTTTTGGCGCACTTGGCTTAACGGGT
TTAACGCTCAAGGTTAATACGCTTGGCAATGCCGAAGAGCGACTTGCTTATCGTGAAGCCTTGCAAGCCTACTTTGCACC
TCATCGCGCAATGCTTGATGCATCATCGCAAGAGCGGCTCGAAAAAAATCCTTTGCGTATTCTTGATTCTAAAAATCCTG
CTTTACAAGAGCTGATTGCGGCTGCTCCTCGTTTGTACGATTATTTGCAAGAGGCGTCGTTGCGTGATTTTGAAAAGGTG
CTTTTTTATTTAACCGAGCGAAGAATTTCTTACACGATTGATTACCGCTTAGTGCGCGGTCTTGATTATTACTGCCATAC
TGCGTTTGAAGTTACCAGCAATGAGCTTGGTGCACAAGATGCCATTGGCGGTGGTGGTCGTTACGATGCGTTAGCGCGTG
AGCTTGGCAGTGCAACTGATATTCCAGCCGTTGGTTTTGCTGTTGGCATGGAGCGGTTGCTTATTGTGTTGGAAAAGCAA
GGATTGCTGGGTAATCGCCATGCGCGTCCACCTCGCTTGTATGTGGTGGTTCAGCAGCAAGAGATGCTCGATCACGCTTT
GCAGCTTGTGTGGCGTTTGCGCAACGGTGGTATTCGTAGTGAGCTTGATTTAGCGGGACGTAGCATGAAAGCGCAAATGC
GTGAAGCCAATAAGCTTGGCGCTCTGTATGCGCTTTTTGTAGGTGCTTCGGAATGTGCAAGTGGCAAATATGGCTTAAAA
AATCTTGCAACATCGGAGCAAACCGATCTCTCCATAGAGGCAGTTATGCAGTTGCTGCACGATCATGTAACCGAGTAA

Upstream 100 bases:

>100_bases
AGAGGTACGCCACAAGCTTTTGCAGCTTCGTACCCCAGCCGAGGTTATTGCGCTTTTTAAGGAGGAGGAGAAAGATTTTC
CTGAGATTTAAATCAACTGT

Downstream 100 bases:

>100_bases
AGGGGAGCGTGTGTATGGCAACGCATCATGTGCTACTCTATGGCAAAGAGGGATGTTGTTTGTGTGAAAAAGCTTTTGAT
GCTTTGCAACGTTTGCAGCA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSSFQCVKGTRDILPDESLLWSFVSSHFHHVASLYGFREIRTPMFEYTDLFQRGIGATTDIVGKEMFSFQPDPAGRSITL
RPEMTAGVMRAALQNNLLAQAPLHKLFYIGELFRKERPQAGRQRQFNQCGAELLGVSSPAAVAEVMSLMMHFFGALGLTG
LTLKVNTLGNAEERLAYREALQAYFAPHRAMLDASSQERLEKNPLRILDSKNPALQELIAAAPRLYDYLQEASLRDFEKV
LFYLTERRISYTIDYRLVRGLDYYCHTAFEVTSNELGAQDAIGGGGRYDALARELGSATDIPAVGFAVGMERLLIVLEKQ
GLLGNRHARPPRLYVVVQQQEMLDHALQLVWRLRNGGIRSELDLAGRSMKAQMREANKLGALYALFVGASECASGKYGLK
NLATSEQTDLSIEAVMQLLHDHVTE

Sequences:

>Translated_425_residues
MSSFQCVKGTRDILPDESLLWSFVSSHFHHVASLYGFREIRTPMFEYTDLFQRGIGATTDIVGKEMFSFQPDPAGRSITL
RPEMTAGVMRAALQNNLLAQAPLHKLFYIGELFRKERPQAGRQRQFNQCGAELLGVSSPAAVAEVMSLMMHFFGALGLTG
LTLKVNTLGNAEERLAYREALQAYFAPHRAMLDASSQERLEKNPLRILDSKNPALQELIAAAPRLYDYLQEASLRDFEKV
LFYLTERRISYTIDYRLVRGLDYYCHTAFEVTSNELGAQDAIGGGGRYDALARELGSATDIPAVGFAVGMERLLIVLEKQ
GLLGNRHARPPRLYVVVQQQEMLDHALQLVWRLRNGGIRSELDLAGRSMKAQMREANKLGALYALFVGASECASGKYGLK
NLATSEQTDLSIEAVMQLLHDHVTE
>Mature_424_residues
SSFQCVKGTRDILPDESLLWSFVSSHFHHVASLYGFREIRTPMFEYTDLFQRGIGATTDIVGKEMFSFQPDPAGRSITLR
PEMTAGVMRAALQNNLLAQAPLHKLFYIGELFRKERPQAGRQRQFNQCGAELLGVSSPAAVAEVMSLMMHFFGALGLTGL
TLKVNTLGNAEERLAYREALQAYFAPHRAMLDASSQERLEKNPLRILDSKNPALQELIAAAPRLYDYLQEASLRDFEKVL
FYLTERRISYTIDYRLVRGLDYYCHTAFEVTSNELGAQDAIGGGGRYDALARELGSATDIPAVGFAVGMERLLIVLEKQG
LLGNRHARPPRLYVVVQQQEMLDHALQLVWRLRNGGIRSELDLAGRSMKAQMREANKLGALYALFVGASECASGKYGLKN
LATSEQTDLSIEAVMQLLHDHVTE

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=461, Percent_Identity=24.295010845987, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1788861, Length=418, Percent_Identity=41.3875598086124, Blast_Score=309, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI71993693, Length=471, Percent_Identity=24.8407643312102, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71993686, Length=470, Percent_Identity=24.468085106383, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643061, Length=476, Percent_Identity=22.4789915966387, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24643059, Length=491, Percent_Identity=22.6069246435845, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_CHLCH (Q3AQK2)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379766.1
- HSSP:   Q02147
- ProteinModelPortal:   Q3AQK2
- SMR:   Q3AQK2
- STRING:   Q3AQK2
- GeneID:   3746436
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1467
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BioCyc:   CCHL340177:CAG_1467-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 47486; Mature: 47355

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFQCVKGTRDILPDESLLWSFVSSHFHHVASLYGFREIRTPMFEYTDLFQRGIGATTD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHH
IVGKEMFSFQPDPAGRSITLRPEMTAGVMRAALQNNLLAQAPLHKLFYIGELFRKERPQA
HHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
GRQRQFNQCGAELLGVSSPAAVAEVMSLMMHFFGALGLTGLTLKVNTLGNAEERLAYREA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
LQAYFAPHRAMLDASSQERLEKNPLRILDSKNPALQELIAAAPRLYDYLQEASLRDFEKV
HHHHHHHHHHHHCCCHHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFYLTERRISYTIDYRLVRGLDYYCHTAFEVTSNELGAQDAIGGGGRYDALARELGSATD
HHHHHHHHHEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCC
IPAVGFAVGMERLLIVLEKQGLLGNRHARPPRLYVVVQQQEMLDHALQLVWRLRNGGIRS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCC
ELDLAGRSMKAQMREANKLGALYALFVGASECASGKYGLKNLATSEQTDLSIEAVMQLLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHH
DHVTE
HHCCC
>Mature Secondary Structure 
SSFQCVKGTRDILPDESLLWSFVSSHFHHVASLYGFREIRTPMFEYTDLFQRGIGATTD
CCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHH
IVGKEMFSFQPDPAGRSITLRPEMTAGVMRAALQNNLLAQAPLHKLFYIGELFRKERPQA
HHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
GRQRQFNQCGAELLGVSSPAAVAEVMSLMMHFFGALGLTGLTLKVNTLGNAEERLAYREA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
LQAYFAPHRAMLDASSQERLEKNPLRILDSKNPALQELIAAAPRLYDYLQEASLRDFEKV
HHHHHHHHHHHHCCCHHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFYLTERRISYTIDYRLVRGLDYYCHTAFEVTSNELGAQDAIGGGGRYDALARELGSATD
HHHHHHHHHEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCC
IPAVGFAVGMERLLIVLEKQGLLGNRHARPPRLYVVVQQQEMLDHALQLVWRLRNGGIRS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCC
ELDLAGRSMKAQMREANKLGALYALFVGASECASGKYGLKNLATSEQTDLSIEAVMQLLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHH
DHVTE
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA