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The map label for this gene is hisD

Identifier: 78189255

GI number: 78189255

Start: 1754009

End: 1755295

Strand: Reverse

Name: hisD

Synonym: Cag_1289

Alternate gene names: 78189255

Gene position: 1755295-1754009 (Counterclockwise)

Preceding gene: 78189259

Following gene: 78189254

Centisome position: 68.24

GC content: 48.87

Gene sequence:

>1287_bases
GTGTTACCACTTTATCGTTTTCCGCAAGAGGCTTCGGCGTTACAAGAGCGTTTAGTGCGCCATGTTTCTTTTGATGAGGC
TGCCCATAAGGCGGTTGATGAAATTCTTGCGAAGGTGCGCCAACAGGGCGACCGTGCGGTGCTTAATTATACTGAGCAGT
TTCAAGGTGTGCGTTTAACTTCCATGCAGGTTGATGAAGAGGCTATTGAGATGGCGTATCGCCATGCTGATCCTTCGCTG
ATTGCTACGTTGCATGAAGCCTATGCTAATATTGTGCGTTTTCATGAGCATGAGGTGGAGCGTAGCTTTTTTTATGAAGC
TGAAGGTGGCGTGTTGCTTGGGCAAAGGGTTCGCCCTATGGAACGTGCAATGCTCTATGTTCCAGGCGGCAAAGCTGCAT
ATCCCTCTTCGCTTTTGATGAATGCTGCACCTGCAAAAGTGGCTGGTGTTTGTGAGATTGCTGTAACCACGCCATGCGAT
GCAACGGGGGTGGTTAATCCAACAATTTTAGCAGCAGCAAAGGTTGCGGGTATTTCTTCCATTTATAAGATAGGAGGAGC
GCAAGCTGTTGCGGCGTTTGCGTATGGCACCGAGTCCATTCCAAAGGTTGATATTATCACCGGTCCAGGTAACAAGTATG
TAGCGCTTGCTAAAAAGCAGGTTTTTGGTCATGTTGCTATTGATAGCATTGCTGGTCCATCTGAAGTGGTAATTATTGCT
GACGAGTCGGCACATGCGGAGTTTGTGGCGTTAGATATGTTTGCGCAAGCTGAACACGACCCTGATGCTTCGGCGGTTTT
AATTACTACCTCCGAAAGCTTTGCTCAAGCGGTGCAGCAAGCGGTGGCTTCGCTGTTACCCACTATGCTTCGCCACGAAA
CCATTGCAAGCTCTTTGTTGCACAATGGCGCAATGGTGTTAGTGCCATCTTTGGACGATGCGTGCGCTGTTTCCGATATG
TTAGCGCCCGAACATCTTGAATTGCATGTAGTGCAACCGTGGGATATTCTCCCTAAGCTCAAACATGCAGGCGCAATTTT
TATGGGGAGTTATTCATGCGAAACTATTGGCGACTACTTTGCAGGACCTAATCACACCTTGCCAACAAGCGGCACGGCGC
GCTTTTTCTCGCCGCTGTCGGTGCGCGATTTTGTAAAGCATACCTCCATTATTTCCTACTCGCCTGAGCAGTTGCGCTCT
AAAGGGGCACAAATTGCCGCGTTTGCTGATGCTGAAGGATTGCAAGCTCATGCTGAAGCGGTTCGTGTGCGCTTAAAAAC
CTTATAG

Upstream 100 bases:

>100_bases
AGCTGGTAAGGTAGCTAATGGAACATCATTTTCAAATGATACGAAAATTCCTATTCCTGCCATGTTTTACCTCTTTTCAT
AGCAAAATTCTCCATTTTCC

Downstream 100 bases:

>100_bases
TGGCGTTTTCTCATGCAGGTTGCTGATTTTGATTATCACCTTCCCGAAGAGCGGATTGCAAAATATCCGCCTTTGGAGCG
AGGTTCTACTCGTCTTTTAG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLPLYRFPQEASALQERLVRHVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQGVRLTSMQVDEEAIEMAYRHADPSL
IATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQRVRPMERAMLYVPGGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCD
ATGVVNPTILAAAKVAGISSIYKIGGAQAVAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVAIDSIAGPSEVVIIA
DESAHAEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHETIASSLLHNGAMVLVPSLDDACAVSDM
LAPEHLELHVVQPWDILPKLKHAGAIFMGSYSCETIGDYFAGPNHTLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRS
KGAQIAAFADAEGLQAHAEAVRVRLKTL

Sequences:

>Translated_428_residues
MLPLYRFPQEASALQERLVRHVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQGVRLTSMQVDEEAIEMAYRHADPSL
IATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQRVRPMERAMLYVPGGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCD
ATGVVNPTILAAAKVAGISSIYKIGGAQAVAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVAIDSIAGPSEVVIIA
DESAHAEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHETIASSLLHNGAMVLVPSLDDACAVSDM
LAPEHLELHVVQPWDILPKLKHAGAIFMGSYSCETIGDYFAGPNHTLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRS
KGAQIAAFADAEGLQAHAEAVRVRLKTL
>Mature_428_residues
MLPLYRFPQEASALQERLVRHVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQGVRLTSMQVDEEAIEMAYRHADPSL
IATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQRVRPMERAMLYVPGGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCD
ATGVVNPTILAAAKVAGISSIYKIGGAQAVAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVAIDSIAGPSEVVIIA
DESAHAEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHETIASSLLHNGAMVLVPSLDDACAVSDM
LAPEHLELHVVQPWDILPKLKHAGAIFMGSYSCETIGDYFAGPNHTLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRS
KGAQIAAFADAEGLQAHAEAVRVRLKTL

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=423, Percent_Identity=36.4066193853428, Blast_Score=254, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6319819, Length=424, Percent_Identity=37.0283018867925, Blast_Score=261, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_CHLCH (Q3AR25)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379593.1
- ProteinModelPortal:   Q3AR25
- SMR:   Q3AR25
- STRING:   Q3AR25
- GeneID:   3747438
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1289
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- ProtClustDB:   PRK00877
- BioCyc:   CCHL340177:CAG_1289-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46058; Mature: 46058

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 324-324 ACT_SITE 325-325 BINDING 126-126 BINDING 188-188 BINDING 211-211 BINDING 234-234 BINDING 256-256 BINDING 259-259 BINDING 325-325 BINDING 358-358 BINDING 412-412 BINDING 417-417

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLYRFPQEASALQERLVRHVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQGVRLT
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCEEEE
SMQVDEEAIEMAYRHADPSLIATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQRVRPM
EEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCCCH
ERAMLYVPGGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCDATGVVNPTILAAAKVAGISS
HHEEEECCCCCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
IYKIGGAQAVAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVAIDSIAGPSEVVIIA
HHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEE
DESAHAEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHETIASSLL
CCCCCCEEEEEEHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HNGAMVLVPSLDDACAVSDMLAPEHLELHVVQPWDILPKLKHAGAIFMGSYSCETIGDYF
HCCCEEEEECCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCEEEEECCCHHHHHHHC
AGPNHTLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRSKGAQIAAFADAEGLQAHAEA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCHHHHHHH
VRVRLKTL
HHHHHCCC
>Mature Secondary Structure
MLPLYRFPQEASALQERLVRHVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQGVRLT
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCEEEE
SMQVDEEAIEMAYRHADPSLIATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQRVRPM
EEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCCCH
ERAMLYVPGGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCDATGVVNPTILAAAKVAGISS
HHEEEECCCCCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
IYKIGGAQAVAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVAIDSIAGPSEVVIIA
HHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEE
DESAHAEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHETIASSLL
CCCCCCEEEEEEHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HNGAMVLVPSLDDACAVSDMLAPEHLELHVVQPWDILPKLKHAGAIFMGSYSCETIGDYF
HCCCEEEEECCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCEEEEECCCHHHHHHHC
AGPNHTLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRSKGAQIAAFADAEGLQAHAEA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCHHHHHHH
VRVRLKTL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA