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The map label for this gene is lysA [H]

Identifier: 78189076

GI number: 78189076

Start: 1497068

End: 1498324

Strand: Reverse

Name: lysA [H]

Synonym: Cag_1109

Alternate gene names: 78189076

Gene position: 1498324-1497068 (Counterclockwise)

Preceding gene: 78189081

Following gene: 78189074

Centisome position: 58.25

GC content: 46.06

Gene sequence:

>1257_bases
GTGCTACAGAGTACTTATTTTTCTTACTGTAATGGTGCCTTGCTTTGCGATGGTGTGCCGCTTCAAACCTTAGCAGAGCA
GTACGGAACGCCTCTTTATGTAACAAGCGAGCGAAGCCTTATTGAGAGTTATGAGGCGTTTGAGCGTGCCTTTCAGCCAT
TACATCACTTTACTTGTTATTCGGTTAAAGCGAATTATAACCTTAGTGTTATTAAAACTTTTGCGGCGCTTGGTTGCGGG
TGCGATGTAAATTCAGGCGGTGAATTGTATCGTTCGTTGCAAGCTGGTGTGGCGCCTGACCAAATAATTTTTGCCGGAGT
TGGTAAAAAATATGAAGAAATTGCGTATGCTCTCGAGTCGGGAGTTTTAATGTTGAAGGCGGAATCGGTTTCGGAGCTTC
ATGTTATTAATCGCATTGCGGCTGAGCAGGGTAAAATTGCCTCAATTGCGTTGCGTATTAATCCAAACGTAACGGCTGAA
ACGCATCCTTACATTACCACAGGTGATAGCAAAGAGAAGTTTGGTATTGATGAAGCTGATTTAGCAGATCTTTTTGCTTT
GATTCGTCAGTTGCCACATGTGCGCTTAATTGGGCTTGATATGCACATTGGCTCACAAATTTTTGATCCTGAGTATTATG
TAGCAGCAACCACAAAACTTCTTGCTCTTTTCAATTTGTCGAAATCAATGGGGTTTGCTCTTGAGTACCTTGATATTGGT
GGTGGCTTTCCTGTAACCTATACCGACACAAAGCATGCTACGCCAATTGAGCGCTTTGCTGAAAAGTTAGTTCCACTGTT
GCAGCCACTTGGGGTAACGGTAATTTTTGAACCTGGACGCTATTTGGTGGCAAATGCGTCGGTATTGCTTACGCGTATTT
TGTACCGCAAGCGTAACCATGTTGGCAAGGAGTTTTTTGTGGTTGATGCTGGTTTAACCGAGCTGATTCGTCCAGCGCTT
TACCAATCGCACCATGAGGTGCAAGCGGTGCAGCGCCAAGAGGCATCTGTGATTGCCGATGTGGTTGGTCCAGTATGTGA
GTCAAGCGACTTTTTTGCTCGCCAGCGTGAGCTTGATGCGGTGCCTGAAGGTGGTTTGCTTGCGGTGATGTCGTGCGGGG
CGTATGCTTCGGTTATGGGTAGCAATTACAATGGGCGTTTGCGTCCAGCCGAGGTAATGGTGCGCCGTAATGGTGAGGTT
GTGCTTACGCGCCGTCGCGAAAGCTTTGAGCAGTTAATTCAGAATGAAGTGCTGTAA

Upstream 100 bases:

>100_bases
GAAACATGTATTTTACAAAATTCTAACCATCCGTAAGACTTTTTTAACCAAGGTCAATCATTACAGAACAAGGTGATTGC
CTATTTTTCTTGATATCAAC

Downstream 100 bases:

>100_bases
TTCACTATTGAGCTGGCGCTTAACATTCGCTGATGTTGGGTGCTGAGTAGAGTGTAGTGGCAGCATAAAACAGAAAACCC
CGTTTTTCTCTATAGGAAGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MLQSTYFSYCNGALLCDGVPLQTLAEQYGTPLYVTSERSLIESYEAFERAFQPLHHFTCYSVKANYNLSVIKTFAALGCG
CDVNSGGELYRSLQAGVAPDQIIFAGVGKKYEEIAYALESGVLMLKAESVSELHVINRIAAEQGKIASIALRINPNVTAE
THPYITTGDSKEKFGIDEADLADLFALIRQLPHVRLIGLDMHIGSQIFDPEYYVAATTKLLALFNLSKSMGFALEYLDIG
GGFPVTYTDTKHATPIERFAEKLVPLLQPLGVTVIFEPGRYLVANASVLLTRILYRKRNHVGKEFFVVDAGLTELIRPAL
YQSHHEVQAVQRQEASVIADVVGPVCESSDFFARQRELDAVPEGGLLAVMSCGAYASVMGSNYNGRLRPAEVMVRRNGEV
VLTRRRESFEQLIQNEVL

Sequences:

>Translated_418_residues
MLQSTYFSYCNGALLCDGVPLQTLAEQYGTPLYVTSERSLIESYEAFERAFQPLHHFTCYSVKANYNLSVIKTFAALGCG
CDVNSGGELYRSLQAGVAPDQIIFAGVGKKYEEIAYALESGVLMLKAESVSELHVINRIAAEQGKIASIALRINPNVTAE
THPYITTGDSKEKFGIDEADLADLFALIRQLPHVRLIGLDMHIGSQIFDPEYYVAATTKLLALFNLSKSMGFALEYLDIG
GGFPVTYTDTKHATPIERFAEKLVPLLQPLGVTVIFEPGRYLVANASVLLTRILYRKRNHVGKEFFVVDAGLTELIRPAL
YQSHHEVQAVQRQEASVIADVVGPVCESSDFFARQRELDAVPEGGLLAVMSCGAYASVMGSNYNGRLRPAEVMVRRNGEV
VLTRRRESFEQLIQNEVL
>Mature_418_residues
MLQSTYFSYCNGALLCDGVPLQTLAEQYGTPLYVTSERSLIESYEAFERAFQPLHHFTCYSVKANYNLSVIKTFAALGCG
CDVNSGGELYRSLQAGVAPDQIIFAGVGKKYEEIAYALESGVLMLKAESVSELHVINRIAAEQGKIASIALRINPNVTAE
THPYITTGDSKEKFGIDEADLADLFALIRQLPHVRLIGLDMHIGSQIFDPEYYVAATTKLLALFNLSKSMGFALEYLDIG
GGFPVTYTDTKHATPIERFAEKLVPLLQPLGVTVIFEPGRYLVANASVLLTRILYRKRNHVGKEFFVVDAGLTELIRPAL
YQSHHEVQAVQRQEASVIADVVGPVCESSDFFARQRELDAVPEGGLLAVMSCGAYASVMGSNYNGRLRPAEVMVRRNGEV
VLTRRRESFEQLIQNEVL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=358, Percent_Identity=29.0502793296089, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI22538418, Length=354, Percent_Identity=25.7062146892655, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI21361583, Length=354, Percent_Identity=25.7062146892655, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI16506287, Length=373, Percent_Identity=23.3243967828418, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=30.5882352941176, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17562780, Length=400, Percent_Identity=23.25, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6322664, Length=362, Percent_Identity=25.6906077348066, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24586472, Length=340, Percent_Identity=27.6470588235294, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24586474, Length=342, Percent_Identity=26.9005847953216, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46149; Mature: 46149

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSTYFSYCNGALLCDGVPLQTLAEQYGTPLYVTSERSLIESYEAFERAFQPLHHFTCY
CCCCCHHHHCCCEEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEE
SVKANYNLSVIKTFAALGCGCDVNSGGELYRSLQAGVAPDQIIFAGVGKKYEEIAYALES
EEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHC
GVLMLKAESVSELHVINRIAAEQGKIASIALRINPNVTAETHPYITTGDSKEKFGIDEAD
CEEEEEECCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEECCCCCHHCCCCHHH
LADLFALIRQLPHVRLIGLDMHIGSQIFDPEYYVAATTKLLALFNLSKSMGFALEYLDIG
HHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECC
GGFPVTYTDTKHATPIERFAEKLVPLLQPLGVTVIFEPGRYLVANASVLLTRILYRKRNH
CCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHC
VGKEFFVVDAGLTELIRPALYQSHHEVQAVQRQEASVIADVVGPVCESSDFFARQRELDA
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
VPEGGLLAVMSCGAYASVMGSNYNGRLRPAEVMVRRNGEVVLTRRRESFEQLIQNEVL
CCCCCEEEEEECCHHHHHHCCCCCCCCCHHHHHEECCCCEEEEECHHHHHHHHHHCCC
>Mature Secondary Structure
MLQSTYFSYCNGALLCDGVPLQTLAEQYGTPLYVTSERSLIESYEAFERAFQPLHHFTCY
CCCCCHHHHCCCEEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEE
SVKANYNLSVIKTFAALGCGCDVNSGGELYRSLQAGVAPDQIIFAGVGKKYEEIAYALES
EEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHC
GVLMLKAESVSELHVINRIAAEQGKIASIALRINPNVTAETHPYITTGDSKEKFGIDEAD
CEEEEEECCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEECCCCCHHCCCCHHH
LADLFALIRQLPHVRLIGLDMHIGSQIFDPEYYVAATTKLLALFNLSKSMGFALEYLDIG
HHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECC
GGFPVTYTDTKHATPIERFAEKLVPLLQPLGVTVIFEPGRYLVANASVLLTRILYRKRNH
CCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHC
VGKEFFVVDAGLTELIRPALYQSHHEVQAVQRQEASVIADVVGPVCESSDFFARQRELDA
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
VPEGGLLAVMSCGAYASVMGSNYNGRLRPAEVMVRRNGEVVLTRRRESFEQLIQNEVL
CCCCCEEEEEECCHHHHHHCCCCCCCCCHHHHHEECCCCEEEEECHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]