Click here to switch to the map view.

The map label for this gene is macA [H]

Identifier: 78188536

GI number: 78188536

Start: 661582

End: 662664

Strand: Reverse

Name: macA [H]

Synonym: Cag_0558

Alternate gene names: 78188536

Gene position: 662664-661582 (Counterclockwise)

Preceding gene: 78188540

Following gene: 78188533

Centisome position: 25.76

GC content: 48.48

Gene sequence:

>1083_bases
ATGAAATCATTTCAGAAATTTCTACCTCGCTATTCCATTGCTCTTGTTGTGCTCTTTAGCGCAACGGTGCTTTTTTTGCT
TACTCGTGCCAATACGGTTGATGTTGAAGTAGGTGAAGTTTCCCCATCTGATTTAGTGCAAGCAATTTATGCAACAGGTT
TTGTGGAAGCCGATACGGTGGCTGAGCTTCATACCGAAGCATCAGGTCGAGTAATTGCCGTAGGTGCATTGGAGGGAGAG
CAGGTTCGTGCTGGGCAAACCATTGTGCAACTTGATGCCACCCGTGCTCAGCTTGCCGTGCGTGAAGCGCGTGCCGCATT
AGCGGAGCAACAAGCCATAGTGAACGATAATCGGTTGCGTTTTGCGCGTCGTCAAGCGCTTTTTCGTGAAGGGGCAATTT
CGCGTCAAGAGTTAGAGGAATCGGAGCGAAGCCGTTTGCAATCGGAAGAGTTGTTGCAACAGCGCCAACTGCAAATTGGC
ATGAAGGCAGAGGAGGCACGCAAAAGCTCCATTTTAGCTCCATTTTCAGGCACCCTCACCTTGCAAAGCCTCAAAGTAGG
CGATTACGCGCCAGCCAATACCTTAGTTGCGCAAGTGGTTGATAGCAATGGTTTTATGGTAGTTGTGGAGGTTGATGAGC
TTGATATGCCTCGCTTACGAGTTGGGCAAGCGGCAACGGTGGCGTTTGATGCTTTGCCCGATAAACGCTATAAAGCGGTG
GTAAGCCGTTTAGTGCCACACACCGATCGCATTACAAAAACTTCGCGCCTTTATTTAACGCTTCAGGAGTTGCCAGCCTC
CATTCAAGAAGGGATGACGGCAACAGCCAACATTGTCTATAATGTTCGCCCACAAGCTTTGTTAGTGCGCAAAAATGCCC
TTGTTGATGAGCAGCGCAAAAGTTACGTATGGAAAATTGAGAAAGGCGCTTTGAAAAAGGTAGAGGTGGAGCTTGGCGCA
AGCGATATTAGTTTTGTGGAAGTGCTGCGTGGCGTGCGTGCAGGCGATAAGGTGGTGCTCTCTCCCGCTAAAACTTTACG
CGATGGCATGGAGGCAAAAATTACCTCTATAAAAAAATTGTAA

Upstream 100 bases:

>100_bases
CCAAAGATTGATAAAAATATGGAAAATGCAAGGTCGGAATGGATAAAAAGTGCAAATCGTGTAACTTCCGCCTTCCTAAC
GTTTTAACAAGCATTACTTC

Downstream 100 bases:

>100_bases
GAGAAATTTTTTCATAGACTTACAAAATCGGCATGGCACTTTCTTGGGTACCACGCCGATTTTTGTTTATCGAATTGAAT
TACCCTTTAGCTTGTTTACG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKSFQKFLPRYSIALVVLFSATVLFLLTRANTVDVEVGEVSPSDLVQAIYATGFVEADTVAELHTEASGRVIAVGALEGE
QVRAGQTIVQLDATRAQLAVREARAALAEQQAIVNDNRLRFARRQALFREGAISRQELEESERSRLQSEELLQQRQLQIG
MKAEEARKSSILAPFSGTLTLQSLKVGDYAPANTLVAQVVDSNGFMVVVEVDELDMPRLRVGQAATVAFDALPDKRYKAV
VSRLVPHTDRITKTSRLYLTLQELPASIQEGMTATANIVYNVRPQALLVRKNALVDEQRKSYVWKIEKGALKKVEVELGA
SDISFVEVLRGVRAGDKVVLSPAKTLRDGMEAKITSIKKL

Sequences:

>Translated_360_residues
MKSFQKFLPRYSIALVVLFSATVLFLLTRANTVDVEVGEVSPSDLVQAIYATGFVEADTVAELHTEASGRVIAVGALEGE
QVRAGQTIVQLDATRAQLAVREARAALAEQQAIVNDNRLRFARRQALFREGAISRQELEESERSRLQSEELLQQRQLQIG
MKAEEARKSSILAPFSGTLTLQSLKVGDYAPANTLVAQVVDSNGFMVVVEVDELDMPRLRVGQAATVAFDALPDKRYKAV
VSRLVPHTDRITKTSRLYLTLQELPASIQEGMTATANIVYNVRPQALLVRKNALVDEQRKSYVWKIEKGALKKVEVELGA
SDISFVEVLRGVRAGDKVVLSPAKTLRDGMEAKITSIKKL
>Mature_360_residues
MKSFQKFLPRYSIALVVLFSATVLFLLTRANTVDVEVGEVSPSDLVQAIYATGFVEADTVAELHTEASGRVIAVGALEGE
QVRAGQTIVQLDATRAQLAVREARAALAEQQAIVNDNRLRFARRQALFREGAISRQELEESERSRLQSEELLQQRQLQIG
MKAEEARKSSILAPFSGTLTLQSLKVGDYAPANTLVAQVVDSNGFMVVVEVDELDMPRLRVGQAATVAFDALPDKRYKAV
VSRLVPHTDRITKTSRLYLTLQELPASIQEGMTATANIVYNVRPQALLVRKNALVDEQRKSYVWKIEKGALKKVEVELGA
SDISFVEVLRGVRAGDKVVLSPAKTLRDGMEAKITSIKKL

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=377, Percent_Identity=25.4641909814324, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082036, Length=323, Percent_Identity=21.9814241486068, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39661; Mature: 39661

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFQKFLPRYSIALVVLFSATVLFLLTRANTVDVEVGEVSPSDLVQAIYATGFVEADTV
CCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHH
AELHTEASGRVIAVGALEGEQVRAGQTIVQLDATRAQLAVREARAALAEQQAIVNDNRLR
HHHHHCCCCCEEEEEECCCCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHH
FARRQALFREGAISRQELEESERSRLQSEELLQQRQLQIGMKAEEARKSSILAPFSGTLT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCEECCCCCCEE
LQSLKVGDYAPANTLVAQVVDSNGFMVVVEVDELDMPRLRVGQAATVAFDALPDKRYKAV
EEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCHHCCCHHEEEEECCCCHHHHHH
VSRLVPHTDRITKTSRLYLTLQELPASIQEGMTATANIVYNVRPQALLVRKNALVDEQRK
HHHHCCCCHHHCCCHHEEEEHHHHHHHHHCCCCEEEEEEEECCCCEEEEEHHHHHHHHHH
SYVWKIEKGALKKVEVELGASDISFVEVLRGVRAGDKVVLSPAKTLRDGMEAKITSIKKL
HEEEEECCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MKSFQKFLPRYSIALVVLFSATVLFLLTRANTVDVEVGEVSPSDLVQAIYATGFVEADTV
CCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHH
AELHTEASGRVIAVGALEGEQVRAGQTIVQLDATRAQLAVREARAALAEQQAIVNDNRLR
HHHHHCCCCCEEEEEECCCCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHH
FARRQALFREGAISRQELEESERSRLQSEELLQQRQLQIGMKAEEARKSSILAPFSGTLT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCEECCCCCCEE
LQSLKVGDYAPANTLVAQVVDSNGFMVVVEVDELDMPRLRVGQAATVAFDALPDKRYKAV
EEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCHHCCCHHEEEEECCCCHHHHHH
VSRLVPHTDRITKTSRLYLTLQELPASIQEGMTATANIVYNVRPQALLVRKNALVDEQRK
HHHHCCCCHHHCCCHHEEEEHHHHHHHHHCCCCEEEEEEEECCCCEEEEEHHHHHHHHHH
SYVWKIEKGALKKVEVELGASDISFVEVLRGVRAGDKVVLSPAKTLRDGMEAKITSIKKL
HEEEEECCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]