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The map label for this gene is lpxK

Identifier: 78188152

GI number: 78188152

Start: 189581

End: 190696

Strand: Reverse

Name: lpxK

Synonym: Cag_0169

Alternate gene names: 78188152

Gene position: 190696-189581 (Counterclockwise)

Preceding gene: 78188153

Following gene: 78188150

Centisome position: 7.41

GC content: 48.84

Gene sequence:

>1116_bases
ATGAGTAATCCCCTGCGCCTTGCTTTTCGTCCTTTTGCCTTGCTCTACGAAGCAATTGTGCAAACTCGTAACCAGCTTTT
TAATCGTGCGGTATTAAGGGCATGGGAATCGCCAATGCCCGTTGTTTCTGTGGGGAATTTAAGTGCAGGAGGTACAGGAA
AAACACCAATGGTGGATTGGGTGGTGAAATATTATCTCTCAATAGGTTTTAAACCCGCAATTATTTCGCGCGGCTATAAG
CGCCAATCAAAAGGGGTGCAGCTTGTGTCGGATGGCAATAATGTGCTACTCAGTAGCCGTGAAGCGGGCGATGAAACCGC
TATGTTGGCATGGAATAACCCCGATGCAATTGTGGTTGTAGCAAGTAAGCGCAAGCAAGGGGTCAAGCTTATTACCAAAC
GCTTTGCCCAACGCCTCCCATCGGTTATTATTTTAGATGATGCTTTTCAGCACCGCCAAATAGCGCGTTCGTTGGATATT
GTGTTGGTGAATGCCGAAGAGCCATTTGTGGAAGCTGCCATGCTCCCCGAAGGGCGCTTGCGGGAGCCAAAAAAGAATTT
GTTGCGAGCAGATGTCGTGGTATTGAACAAAATTACCGACCTTGAAGCCGCAACACCATCCATTAAAGCGCTTGAGGAGA
TGGGGCGACCACTTGTTAAAGCACGCCTGAGCACCGGTGAATTAATTTGCTTTTCGGGCGATGCCACCACGCTTGACGAG
CCAGCCACCGCTCACCACCTGAACGCGTTTGCTTTTGCTGGAATTGCAAAACCTGAAAGCTTTGTAACAAGTTTGCAGCA
CGAAGGGGTAAATGTGGGAGCAACCCGCTTTGTGCGCGACCATGCACCGTACAGTGCCAAAATGTTACGAGCTATTCGCC
GCCAAGCTGAGGAGCAAGGGTTGTGCTTAATTACCACCGAAAAAGATTACTTCCGCCTGCTTGGGCAACCCGAACTCCTC
AGCATTATTACCGCTCTCCCCTGCTACTACCTTAAAATAGCCCCCGATATTTTTGACGGCAAAGCGCTTTTGCAAGAGAA
GCTAAATGCGGTTGTTCATTATGTACCAAAACCGGAGCCGCCAAAGAAAATTGAGGAACCATATCGGCGATGGTAA

Upstream 100 bases:

>100_bases
AGCAAAGTTACCATAACGCTGCACATCCTCGCTATTCCCTTATTTACAAGTGAGGAGGAATTGCGCCATTTTAGCACAAC
GCTTTCAGCCCGTTTTAGCC

Downstream 100 bases:

>100_bases
AGCTTTATCCCTTATTGGTTTGGGAAATGATGCAAAAATCATTGTTGTAGTCATTCCCGCGAAAGCGGGAATCCAGAATC
GTGCAAATAGAGTCTACTCC

Product: tetraacyldisaccharide-1-P 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSNPLRLAFRPFALLYEAIVQTRNQLFNRAVLRAWESPMPVVSVGNLSAGGTGKTPMVDWVVKYYLSIGFKPAIISRGYK
RQSKGVQLVSDGNNVLLSSREAGDETAMLAWNNPDAIVVVASKRKQGVKLITKRFAQRLPSVIILDDAFQHRQIARSLDI
VLVNAEEPFVEAAMLPEGRLREPKKNLLRADVVVLNKITDLEAATPSIKALEEMGRPLVKARLSTGELICFSGDATTLDE
PATAHHLNAFAFAGIAKPESFVTSLQHEGVNVGATRFVRDHAPYSAKMLRAIRRQAEEQGLCLITTEKDYFRLLGQPELL
SIITALPCYYLKIAPDIFDGKALLQEKLNAVVHYVPKPEPPKKIEEPYRRW

Sequences:

>Translated_371_residues
MSNPLRLAFRPFALLYEAIVQTRNQLFNRAVLRAWESPMPVVSVGNLSAGGTGKTPMVDWVVKYYLSIGFKPAIISRGYK
RQSKGVQLVSDGNNVLLSSREAGDETAMLAWNNPDAIVVVASKRKQGVKLITKRFAQRLPSVIILDDAFQHRQIARSLDI
VLVNAEEPFVEAAMLPEGRLREPKKNLLRADVVVLNKITDLEAATPSIKALEEMGRPLVKARLSTGELICFSGDATTLDE
PATAHHLNAFAFAGIAKPESFVTSLQHEGVNVGATRFVRDHAPYSAKMLRAIRRQAEEQGLCLITTEKDYFRLLGQPELL
SIITALPCYYLKIAPDIFDGKALLQEKLNAVVHYVPKPEPPKKIEEPYRRW
>Mature_370_residues
SNPLRLAFRPFALLYEAIVQTRNQLFNRAVLRAWESPMPVVSVGNLSAGGTGKTPMVDWVVKYYLSIGFKPAIISRGYKR
QSKGVQLVSDGNNVLLSSREAGDETAMLAWNNPDAIVVVASKRKQGVKLITKRFAQRLPSVIILDDAFQHRQIARSLDIV
LVNAEEPFVEAAMLPEGRLREPKKNLLRADVVVLNKITDLEAATPSIKALEEMGRPLVKARLSTGELICFSGDATTLDEP
ATAHHLNAFAFAGIAKPESFVTSLQHEGVNVGATRFVRDHAPYSAKMLRAIRRQAEEQGLCLITTEKDYFRLLGQPELLS
IITALPCYYLKIAPDIFDGKALLQEKLNAVVHYVPKPEPPKKIEEPYRRW

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=310, Percent_Identity=28.7096774193548, Blast_Score=115, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_CHLCH (Q3AU78)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_378490.1
- STRING:   Q3AU78
- GeneID:   3747734
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_0169
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   PDHAGIT
- ProtClustDB:   CLSK637887
- BioCyc:   CCHL340177:CAG_0169-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 41310; Mature: 41178

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLRLAFRPFALLYEAIVQTRNQLFNRAVLRAWESPMPVVSVGNLSAGGTGKTPMVDW
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHH
VVKYYLSIGFKPAIISRGYKRQSKGVQLVSDGNNVLLSSREAGDETAMLAWNNPDAIVVV
HHHHHHHCCCCHHHHHCCCHHHCCCEEEEECCCEEEEECCCCCCCEEEEEECCCCEEEEE
ASKRKQGVKLITKRFAQRLPSVIILDDAFQHRQIARSLDIVLVNAEEPFVEAAMLPEGRL
ECCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCC
REPKKNLLRADVVVLNKITDLEAATPSIKALEEMGRPLVKARLSTGELICFSGDATTLDE
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCC
PATAHHLNAFAFAGIAKPESFVTSLQHEGVNVGATRFVRDHAPYSAKMLRAIRRQAEEQG
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCC
LCLITTEKDYFRLLGQPELLSIITALPCYYLKIAPDIFDGKALLQEKLNAVVHYVPKPEP
EEEEECCHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHEEECCCCCC
PKKIEEPYRRW
CHHHHHHHHCC
>Mature Secondary Structure 
SNPLRLAFRPFALLYEAIVQTRNQLFNRAVLRAWESPMPVVSVGNLSAGGTGKTPMVDW
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHH
VVKYYLSIGFKPAIISRGYKRQSKGVQLVSDGNNVLLSSREAGDETAMLAWNNPDAIVVV
HHHHHHHCCCCHHHHHCCCHHHCCCEEEEECCCEEEEECCCCCCCEEEEEECCCCEEEEE
ASKRKQGVKLITKRFAQRLPSVIILDDAFQHRQIARSLDIVLVNAEEPFVEAAMLPEGRL
ECCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCC
REPKKNLLRADVVVLNKITDLEAATPSIKALEEMGRPLVKARLSTGELICFSGDATTLDE
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCC
PATAHHLNAFAFAGIAKPESFVTSLQHEGVNVGATRFVRDHAPYSAKMLRAIRRQAEEQG
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCC
LCLITTEKDYFRLLGQPELLSIITALPCYYLKIAPDIFDGKALLQEKLNAVVHYVPKPEP
EEEEECCHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHEEECCCCCC
PKKIEEPYRRW
CHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA