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The map label for this gene is gyaR [H]

Identifier: 78067952

GI number: 78067952

Start: 3653074

End: 3654087

Strand: Direct

Name: gyaR [H]

Synonym: Bcep18194_A6483

Alternate gene names: 78067952

Gene position: 3653074-3654087 (Clockwise)

Preceding gene: 78067950

Following gene: 78067955

Centisome position: 98.89

GC content: 64.5

Gene sequence:

>1014_bases
ATGAAAATTGCCATCCTCGACGACTACCAGGACGCCGTCCGCAAGCTGAACTGCTTCGAGATGCTTGCCGACCACGACGT
GAAGGTCTTCAACAATACGGTGCGCGGATTGGGACAACTCGCCAGCCGTCTGGCGGAAGTCGAGGCGCTCGTGCTGATTC
GCGAACGGACCCCGATTTCGTCGCAACTGCTCGCCAAGCTGCCGAACCTGCGCATGATCAGCCAGACCGGTCGCATTTCG
AGCCACATCGATCTCGAAGCCTGTACCGACCGCGGCATCGCTGTGCTCGAAGGCACGGGCTCGCCGATTGCCCCCGCCGA
ACTGACCTGGGCACTCGTGATGGCCGCCCAGCGCCGCATTCCGCAGTACGTCGCGAACCTGAAGCAGGGTGCGTGGCAAC
AGTCGGGCCTGAAGACGTCGGCGATGCCGCCGAACTTCGGCCTCGGCCAGGTGCTGCGCGGCCAGACGCTCGGCATCTGG
GGCTACGGCAAGATCGGCCGGCTTGTCGCCGGCTACGGCAAGGCATTCGGGATGAACGTGCTGATCTGGGGCCGCGAGCA
TTCGCTCGAGGCCGCGCGGGCTGACGGCTATACGGCCGCCGAAAGCCGCGAAGCGCTGTTCGAGCAGAGCGACGTGCTGT
CGCTGCACCTGCGCATGCATGACGACACGCGCGGGATCGTGAAGCAGGAAGACCTGATGCGGATGAAGCCGACGTCGCTG
CTCGTCAACACGAGCCGCGCCGAACTGCTCGAGGAAAATGCCCTGGTCAACGCGCTGTCGCACAACCGTCCGGGGATGGT
GGCGATCGACGTGTTCGAGAGCGAGCCGATCCTGCAGGGCTACAGCCTGCTGCGGATGGAAAACGTGATCTGCACGCCGC
ACATCGGCTACGTCGAGCGCGAAAGCTACGAGCTCTACTTCAGCGCGGCATTCCGGAACATCCTGGCGTTCGACCAGGGC
GACATGTCGAGCGTCGTCAATCCGGAAGCCCTGACGCCGCGCCGCGTGCGCTGA

Upstream 100 bases:

>100_bases
CAGCGGCCGACGTAGCATCATGTCGGCCCCGGCCGGGCGGGACGGGTGCGCGACGTGCGCCGCCGCCGCCGCCGCTTTCA
ACGCGCGACACCCGCTCACC

Downstream 100 bases:

>100_bases
GCGCCGCGGGCCGCGCCCGCCGCGCGGCCCCGCTTCCTGCTTCCCGTCTTCAGGCGGCCACGCGGCCGCCCGTCATCGCG
CCGACGCGCGTGAGGAAATG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPISSQLLAKLPNLRMISQTGRIS
SHIDLEACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVLIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRMHDDTRGIVKQEDLMRMKPTSL
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFRNILAFDQG
DMSSVVNPEALTPRRVR

Sequences:

>Translated_337_residues
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPISSQLLAKLPNLRMISQTGRIS
SHIDLEACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVLIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRMHDDTRGIVKQEDLMRMKPTSL
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFRNILAFDQG
DMSSVVNPEALTPRRVR
>Mature_337_residues
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPISSQLLAKLPNLRMISQTGRIS
SHIDLEACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVLIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRMHDDTRGIVKQEDLMRMKPTSL
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFRNILAFDQG
DMSSVVNPEALTPRRVR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=333, Percent_Identity=28.2282282282282, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI61743967, Length=280, Percent_Identity=31.0714285714286, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4557497, Length=280, Percent_Identity=31.0714285714286, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI145580578, Length=256, Percent_Identity=30.46875, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557499, Length=256, Percent_Identity=30.46875, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=28.0155642023346, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=32.6848249027237, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI87082289, Length=305, Percent_Identity=29.8360655737705, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1789279, Length=288, Percent_Identity=29.8611111111111, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787645, Length=264, Percent_Identity=25, Blast_Score=78, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=328, Percent_Identity=27.7439024390244, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=27.536231884058, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=27.1739130434783, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=225, Percent_Identity=28.8888888888889, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=276, Percent_Identity=25.7246376811594, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=25.6916996047431, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646446, Length=247, Percent_Identity=31.1740890688259, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646448, Length=247, Percent_Identity=31.1740890688259, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646452, Length=247, Percent_Identity=31.1740890688259, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646450, Length=247, Percent_Identity=31.1740890688259, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=31.2, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI28574286, Length=253, Percent_Identity=28.0632411067194, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=26.6891891891892, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=26.0536398467433, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=26.0536398467433, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=26.0536398467433, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=26.0536398467433, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28574284, Length=261, Percent_Identity=26.0536398467433, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=27.5471698113208, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585516, Length=230, Percent_Identity=25.6521739130435, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37394; Mature: 37394

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPIS
CEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
SQLLAKLPNLRMISQTGRISSHIDLEACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRI
HHHHHHCCCCEEECCCCCCCCCCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHCCHHCCCEE
LIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRMHDDTRGIVKQEDLMRMKPTSL
EEECCCCCCHHHHCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCE
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFSAAFRNILAFDQGDMSSVVNPEALTPRRVR
CCEEEEHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPIS
CEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
SQLLAKLPNLRMISQTGRISSHIDLEACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRI
HHHHHHCCCCEEECCCCCCCCCCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHCCHHCCCEE
LIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRMHDDTRGIVKQEDLMRMKPTSL
EEECCCCCCHHHHCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCE
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFSAAFRNILAFDQGDMSSVVNPEALTPRRVR
CCEEEEHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]