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The map label for this gene is mrdA [H]

Identifier: 78067933

GI number: 78067933

Start: 3630348

End: 3632633

Strand: Direct

Name: mrdA [H]

Synonym: Bcep18194_A6464

Alternate gene names: 78067933

Gene position: 3630348-3632633 (Clockwise)

Preceding gene: 78067932

Following gene: 78067934

Centisome position: 98.27

GC content: 68.07

Gene sequence:

>2286_bases
ATGACCGAATTCAACGACACCCAACAGCAGCTCTCGAAGTTCCGCCTGCGCGTCGCGGCGGCGGGCGTGTTCGTGTTCGT
CTGCTTCGGGCTGCTCGCGAGCCGTTTCTTCTACCTGCAGTTGATGCAGCACGGCAAATACGCGCTGCAGGCCGAGGAAA
ACCGCATCTCCGTCGCGCCGATCGTGCCGAACCGCGGGATCATCACCGACCGCAACGGCGTGATCCTCGCGAAGAACTAT
TCGGCCTATACGCTCGAGATCACGCCGTCGAAGCTCGACGACACGCTCGACAACACGATCGACAAGCTGTCCGAGATCAT
CCCGATCGACGCGCGCGACCGCCGCCGCTTCAAGAAGCTGCAGGAAGACTCGAAGAACTTCGAGAGCCTGCCGATCCGCA
CCCGGCTCACCGACGCCGAAGTCGCGCGCTTCACCGCGCAGCGCTTCCGCTTCCCCGGCGTCGACGTGCGCGCGCGGCTG
TTCCGGCAATATCCGCTCGGCACGACGGCCGCGCACGTGATCGGCTACATCGGCCGGATCTCGAAGCGCGACCAGGATCG
CATCGACGCGATGAGCGACGACAACGACAGCGATCAGGAAAACTACGATCCGCGCCGCGACGCGAACAACTACAAGGGCA
CCGACTACATCGGCAAGATCGGCGTCGAGCAGAGCTACGAGACCGAGCTGCACGGGCTGACGGGCTTCGAGGAAGTCGAG
GTGACGGCCGGCGGCCGGCCGGTACGCACGCTGTCGCGCACGCAGGCGACGCCCGGCAACAACCTCGTGCTGTCGCTCGA
CATCGGGCTGCAGCAGGTCGCCGAGCAGGCGTTCGCCGGCAAGCGCGGCGCGCTGGTCGCGATCGAGCCGAAGACGGGCG
ACGTGCTCGCGTTCGTGTCGTCGCCGAGCTTCGACCCGAACTCGTTCGTCGACGGCATCGACCAGCAGACCTGGGACGAG
CTGAACAACTCGACCGACAAGCCGCTCCTGAACCGCCCGCTGCACGGCACCTACCCGCCCGGCTCGACGTACAAGCCGTT
CATGGCGCTCGCCGGCCTGACGCTCGGCAAGCGCACGCCGGGCTGGGGCTTCCAGGATCCCGGCTACTTCACGTTCGGCG
GCCACACGTTCCGCAACGACGTGCGCTCGGGCCAGGGCTGGGTCGACATGAACAAGGCGATCATGGTGTCGAACGACACC
TACTTCTACATGCTCGCGCGCGATCTCGGCGTGAACTCGATCGCGAACTTCATGAAGCCGTTCGGCTTCGGCCAGATCAC
CGGGATCGACATCCAGGGCGAAGCGCGCGGGATCCTGCCGTCGACCGACTGGAAGAAGAAGGCGTTCAAGAAGGCCGCGC
AGCAGAAGTGGTTCGACGGCGAGACGATCAGCCTCGGGATCGGCCAGGGCTACAACTCGTTCACGATCCTGCAGCTCGCG
CACGCGACCGCGACGCTCGCGAACAACGGCGTCGTGATGAAGCCTCACCTCGTGAAGGAAGTCGAGGATCCGATCTCGCG
CGGGCGCCACCTGACCGTGCCGAAGGAAAGCGAAGTGATCCCGCTCAAGCAGGCCGACATCGACGTCGTGAAGCGCGGGA
TGGAGAACGTGATCGAGAACCCGTCCGGCACCGCGTACAAGGTGTTCCGCGGCGCGCCGTACCTCGCCGCCGGCAAGACC
GGTACCGCACAGGTGTTCTCGCTGCAAGGCTCCAACTACAAGGGCCACCTGCTCGCCGAGCACCTGCGCGACCACGCGCT
GTTCATCGCGTACGCGCCGGTCGACCATCCGCAGATCGCCGTCGCGCTGGTCGTCGAGAACGGCGGCTGGGGGGCGCAGG
CCGCCGGCCCGATCGCGCGCCGCGTGCTCGACTTCTACCTCATCGACCGCCAGAAACCGGAGAACGAGGCCGCGGCCGTG
GCTGCCGCGGCGTCGGCGACCGAACCGATCAACGCGCCGGTGATCGGCGACGCGAACAAGCCTGCTGGCGTCGCGGCTGG
CTTCACGGCGCTGCCGCAGCCGGTCGTGCCGACCGCGGCCAGCGCGGCGGAAGCGGCATCGGCCGCAGCGGCCTCCGAAG
CGTCGGCTGCCGCCGCCGCGAGCGCTGCCACGGCGGCCAATGCCAGTGCCGCTGCGCCAAGGGCCGCGAGCCTGCCGCCG
ATCCGGCGCCCGCACCGGCCACGCCGGCCCGCCAGCGACGCGCAGCCGCTCGTCGCCACGCCGCGCGACGACAATCACCG
TGCCACGGCCCCCGCGAAGGCGGCGGACGCCGGCACCGCTCATTAA

Upstream 100 bases:

>100_bases
TTGAATACCCGCCGCCTCCACGCCCGCCGCGCGCCGCGCTTCGGGGCGGCACCTCGCCCGCGCCCGCTCGGCGCGCGCGG
GCCAGATCGCTCCTAATCGC

Downstream 100 bases:

>100_bases
CGGAGAAAGGCATGCAATTCGACAAGCGCGCCTGGCTCGACAAGATCAAGCAGATGTTCGCGGGCTTCGACCGCCCGCTC
GCCCTCATCGTGTTCCTGCT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 761; Mature: 760

Protein sequence:

>761_residues
MTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNGVILAKNY
SAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARL
FRQYPLGTTAAHVIGYIGRISKRDQDRIDAMSDDNDSDQENYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSTDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVNSIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANNGVVMKPHLVKEVEDPISRGRHLTVPKESEVIPLKQADIDVVKRGMENVIENPSGTAYKVFRGAPYLAAGKT
GTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIAVALVVENGGWGAQAAGPIARRVLDFYLIDRQKPENEAAAV
AAAASATEPINAPVIGDANKPAGVAAGFTALPQPVVPTAASAAEAASAAAASEASAAAAASAATAANASAAAPRAASLPP
IRRPHRPRRPASDAQPLVATPRDDNHRATAPAKAADAGTAH

Sequences:

>Translated_761_residues
MTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNGVILAKNY
SAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARL
FRQYPLGTTAAHVIGYIGRISKRDQDRIDAMSDDNDSDQENYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSTDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVNSIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANNGVVMKPHLVKEVEDPISRGRHLTVPKESEVIPLKQADIDVVKRGMENVIENPSGTAYKVFRGAPYLAAGKT
GTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIAVALVVENGGWGAQAAGPIARRVLDFYLIDRQKPENEAAAV
AAAASATEPINAPVIGDANKPAGVAAGFTALPQPVVPTAASAAEAASAAAASEASAAAAASAATAANASAAAPRAASLPP
IRRPHRPRRPASDAQPLVATPRDDNHRATAPAKAADAGTAH
>Mature_760_residues
TEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNGVILAKNYS
AYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARLF
RQYPLGTTAAHVIGYIGRISKRDQDRIDAMSDDNDSDQENYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVEV
TAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDEL
NNSTDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTY
FYMLARDLGVNSIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLAH
ATATLANNGVVMKPHLVKEVEDPISRGRHLTVPKESEVIPLKQADIDVVKRGMENVIENPSGTAYKVFRGAPYLAAGKTG
TAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIAVALVVENGGWGAQAAGPIARRVLDFYLIDRQKPENEAAAVA
AAASATEPINAPVIGDANKPAGVAAGFTALPQPVVPTAASAAEAASAAAASEASAAAAASAATAANASAAAPRAASLPPI
RRPHRPRRPASDAQPLVATPRDDNHRATAPAKAADAGTAH

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=648, Percent_Identity=39.5061728395062, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1786272, Length=629, Percent_Identity=23.2114467408585, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 82341; Mature: 82209

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVILAKNYSAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARLFRQYPLGTTAAHVIGYIGRI
HHHCCCHHCCCCEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDDNDSDQENYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCHHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSTDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTP
CCCCCCHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVNSIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEECCCCHHHHHHHHCC
FGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANNGVVMKPHLVKEVEDPISRGRHLTVPKESEVIPLKQADIDVVKRGMENVIEN
HHHHHHCCCCEEECCHHHHHHHHHHHCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHCC
PSGTAYKVFRGAPYLAAGKTGTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCEE
VALVVENGGWGAQAAGPIARRVLDFYLIDRQKPENEAAAVAAAASATEPINAPVIGDANK
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEECCCCC
PAGVAAGFTALPQPVVPTAASAAEAASAAAASEASAAAAASAATAANASAAAPRAASLPP
CCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
IRRPHRPRRPASDAQPLVATPRDDNHRATAPAKAADAGTAH
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVILAKNYSAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARLFRQYPLGTTAAHVIGYIGRI
HHHCCCHHCCCCEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDDNDSDQENYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCHHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSTDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTP
CCCCCCHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVNSIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEECCCCHHHHHHHHCC
FGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANNGVVMKPHLVKEVEDPISRGRHLTVPKESEVIPLKQADIDVVKRGMENVIEN
HHHHHHCCCCEEECCHHHHHHHHHHHCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHCC
PSGTAYKVFRGAPYLAAGKTGTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCEE
VALVVENGGWGAQAAGPIARRVLDFYLIDRQKPENEAAAVAAAASATEPINAPVIGDANK
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEECCCCC
PAGVAAGFTALPQPVVPTAASAAEAASAAAASEASAAAAASAATAANASAAAPRAASLPP
CCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
IRRPHRPRRPASDAQPLVATPRDDNHRATAPAKAADAGTAH
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]