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The map label for this gene is yjcE [H]

Identifier: 78067760

GI number: 78067760

Start: 3452833

End: 3454500

Strand: Direct

Name: yjcE [H]

Synonym: Bcep18194_A6291

Alternate gene names: 78067760

Gene position: 3452833-3454500 (Clockwise)

Preceding gene: 78067754

Following gene: 78067762

Centisome position: 93.47

GC content: 68.41

Gene sequence:

>1668_bases
ATGGAAATCGTCTTCACCGTCCTGATCCTGCTGCTGACCGTCGCGCTGTCCGGCGCCGTCACGCGCATCCTGCCGTTCCA
ACTGCCGTTGCCGCTGATGCAGATCGCGTTCGGCGCGATGCTCGCGTGGCCGAAGCTGAACCTGCACGTCGCGTTCGATC
CCGAAATCTTCATGCTGCTGTTCATTCCGCCGCTGCTGTTCGCGGACGGCTGGCGGATTCCGAAGCGCGAGCTGTACCTG
CAGCGCCGCGCGATCCTGATGCTCGCATTCGGGCTCGTGTTCATGACGGTACTCGCAGTGGGCTACTTCGCGCACTGGCT
GATACCCGAGTTGCCGCTGCCGATCGCGTTCGCGCTCGCGGCCGTGCTGTCACCGACCGACGCGGTCGCGCTGTCCGGCA
TCGCCGGCAAGGGCCGGATCCCGCCGCAACTGATGCACATCCTCGAAGGCGAGGCGCTGATGAACGACGCGTCGGGCCTC
GTCGCACTGAAATTCGCGATCGCGGCCGCGCTGACGGGCATGTTCTCGCTGCGCGACGCGTCGGTCACGTTCGTGATCGT
CGCCGCCGGCGGGCTCGCGACGGGCGCGATCGTGTCGTGGGCATTCAGCGCGCTGTCGACGCGCTTCCTGAACGCCGAGC
AGGAAGGCGATCCGGCCCCCGGCATCGTGATGACGCTGCTCGTGCCGTTCGCGGCCTACCTGTTCGCCGAGCACCTCGAC
CTGTCGGGCGTGCTGGCGGCCGTGTCGGCCGGGATGATGATGAACTACACGAGCTTCTCGCGTAAAAGCACCGTCGCGTC
GCGCGTACGCGCCGAAAGCACGTGGGCGATGATCGAGTTCGTGTTCAACGGCATGGTGTTCATCATGCTCGGGCTGCAGC
TGCCGCACATCATCGGCCGCACGCTCGTCGACGCGCACCACACGAGCGACGCGCTCGTCGGCCGGATGGTCTTCAACGTC
TGCGCGATGATGCTCGCGCTGTATGCGATCCGCTTCCTGTGGGTCTGGCTGCTGCGCTGGTTCGCGAGCCGTCGCGCCGC
ACGCCAGGGCCTCACGGGCACGATGGCCGGCGTGCGCACGATCGCGGTGATGACGGTCGGCGGCGTGCGCGGCGCGGTCA
CGCTCGCCGGCGTGCTGTCGATTCCGGTCGCGCTGTCCGACGGCGTGCCGCTGCCGGGCCGCGACACGGCGATCTTCGTT
GCATCGGCCGTGATCCTCGGCTCGCTCATCGTCGCGGTGATCGGCCTGCCGCTGCTGCTGCGCGGCGTGCGTTCGTCGCG
CAGCCCGCTCGGCGACGAGGAACGCGCCGCGCGCGCCGCCGCCGCTCAGGCCGCGATCCGCGCGATCGACTCGTCGCACG
ACGCGATCTCGGTCGATCTCGACGAATCGGGCGCCGCACGCTGCGCGGATATCTCCGCACGCGTGATGGACCAGTACCGC
CGCCGCCTCGCGACGCTCGCCGAGGACGGCCCCACGCCGCGCGCGGAAGCGAAGCAGGCCGAAACGATGGAACTGCAGAT
GCGGATCGCGGCCGTGCGCGCGGAACGTTCCGCGCTTTATCGGCTGCGCAGCGAGAGCAAGATTTCCGACGAGACGCTGA
CGAAGCTGCTCCGCGAGATCGACCTGTCCGAGACCGCGCTGTCGACGCGCAAGAAAGGCATTCTCTGA

Upstream 100 bases:

>100_bases
GCACCATTTTCGTGCACACGCACCGGCCTCTCGAACGCACCCGTCACGCTGTCACGCTACACTCCGTACGATCGTTTCAT
TCCCCGTATTCGCCGTATCG

Downstream 100 bases:

>100_bases
AGGTCCGGCCGCTGCCTGTACGCAGCAGCTTGGACCCAACAAAAAACGGCGACGCTCAAGCGTCGCCGTTTTCACATCCG
ACCGCGTTCGCGTTACTTCG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MEIVFTVLILLLTVALSGAVTRILPFQLPLPLMQIAFGAMLAWPKLNLHVAFDPEIFMLLFIPPLLFADGWRIPKRELYL
QRRAILMLAFGLVFMTVLAVGYFAHWLIPELPLPIAFALAAVLSPTDAVALSGIAGKGRIPPQLMHILEGEALMNDASGL
VALKFAIAAALTGMFSLRDASVTFVIVAAGGLATGAIVSWAFSALSTRFLNAEQEGDPAPGIVMTLLVPFAAYLFAEHLD
LSGVLAAVSAGMMMNYTSFSRKSTVASRVRAESTWAMIEFVFNGMVFIMLGLQLPHIIGRTLVDAHHTSDALVGRMVFNV
CAMMLALYAIRFLWVWLLRWFASRRAARQGLTGTMAGVRTIAVMTVGGVRGAVTLAGVLSIPVALSDGVPLPGRDTAIFV
ASAVILGSLIVAVIGLPLLLRGVRSSRSPLGDEERAARAAAAQAAIRAIDSSHDAISVDLDESGAARCADISARVMDQYR
RRLATLAEDGPTPRAEAKQAETMELQMRIAAVRAERSALYRLRSESKISDETLTKLLREIDLSETALSTRKKGIL

Sequences:

>Translated_555_residues
MEIVFTVLILLLTVALSGAVTRILPFQLPLPLMQIAFGAMLAWPKLNLHVAFDPEIFMLLFIPPLLFADGWRIPKRELYL
QRRAILMLAFGLVFMTVLAVGYFAHWLIPELPLPIAFALAAVLSPTDAVALSGIAGKGRIPPQLMHILEGEALMNDASGL
VALKFAIAAALTGMFSLRDASVTFVIVAAGGLATGAIVSWAFSALSTRFLNAEQEGDPAPGIVMTLLVPFAAYLFAEHLD
LSGVLAAVSAGMMMNYTSFSRKSTVASRVRAESTWAMIEFVFNGMVFIMLGLQLPHIIGRTLVDAHHTSDALVGRMVFNV
CAMMLALYAIRFLWVWLLRWFASRRAARQGLTGTMAGVRTIAVMTVGGVRGAVTLAGVLSIPVALSDGVPLPGRDTAIFV
ASAVILGSLIVAVIGLPLLLRGVRSSRSPLGDEERAARAAAAQAAIRAIDSSHDAISVDLDESGAARCADISARVMDQYR
RRLATLAEDGPTPRAEAKQAETMELQMRIAAVRAERSALYRLRSESKISDETLTKLLREIDLSETALSTRKKGIL
>Mature_555_residues
MEIVFTVLILLLTVALSGAVTRILPFQLPLPLMQIAFGAMLAWPKLNLHVAFDPEIFMLLFIPPLLFADGWRIPKRELYL
QRRAILMLAFGLVFMTVLAVGYFAHWLIPELPLPIAFALAAVLSPTDAVALSGIAGKGRIPPQLMHILEGEALMNDASGL
VALKFAIAAALTGMFSLRDASVTFVIVAAGGLATGAIVSWAFSALSTRFLNAEQEGDPAPGIVMTLLVPFAAYLFAEHLD
LSGVLAAVSAGMMMNYTSFSRKSTVASRVRAESTWAMIEFVFNGMVFIMLGLQLPHIIGRTLVDAHHTSDALVGRMVFNV
CAMMLALYAIRFLWVWLLRWFASRRAARQGLTGTMAGVRTIAVMTVGGVRGAVTLAGVLSIPVALSDGVPLPGRDTAIFV
ASAVILGSLIVAVIGLPLLLRGVRSSRSPLGDEERAARAAAAQAAIRAIDSSHDAISVDLDESGAARCADISARVMDQYR
RRLATLAEDGPTPRAEAKQAETMELQMRIAAVRAERSALYRLRSESKISDETLTKLLREIDLSETALSTRKKGIL

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI5454070, Length=303, Percent_Identity=22.4422442244224, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI294997330, Length=280, Percent_Identity=23.5714285714286, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI110227626, Length=280, Percent_Identity=23.5714285714286, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI27734935, Length=268, Percent_Identity=23.5074626865672, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI41872703, Length=436, Percent_Identity=21.7889908256881, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI14211919, Length=262, Percent_Identity=23.6641221374046, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI148727259, Length=360, Percent_Identity=23.3333333333333, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI15529998, Length=468, Percent_Identity=21.1538461538462, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790501, Length=555, Percent_Identity=48.8288288288288, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71980847, Length=379, Percent_Identity=25.3298153034301, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71999821, Length=348, Percent_Identity=24.7126436781609, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71999817, Length=348, Percent_Identity=24.7126436781609, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71999819, Length=348, Percent_Identity=24.7126436781609, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71990932, Length=379, Percent_Identity=24.802110817942, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71993590, Length=292, Percent_Identity=26.027397260274, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71993582, Length=292, Percent_Identity=26.027397260274, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71990924, Length=380, Percent_Identity=24.4736842105263, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71987535, Length=517, Percent_Identity=22.0502901353965, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71987537, Length=517, Percent_Identity=22.0502901353965, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25150332, Length=368, Percent_Identity=22.554347826087, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320663, Length=262, Percent_Identity=22.9007633587786, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221473212, Length=448, Percent_Identity=22.0982142857143, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281364513, Length=269, Percent_Identity=24.1635687732342, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221473215, Length=269, Percent_Identity=24.1635687732342, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221473222, Length=269, Percent_Identity=24.1635687732342, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221510734, Length=343, Percent_Identity=25.3644314868805, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221510738, Length=343, Percent_Identity=25.3644314868805, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281360447, Length=255, Percent_Identity=28.2352941176471, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221510732, Length=343, Percent_Identity=25.3644314868805, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221510736, Length=343, Percent_Identity=25.3644314868805, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24585580, Length=343, Percent_Identity=25.3644314868805, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24585578, Length=343, Percent_Identity=25.3644314868805, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59734; Mature: 59734

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVFTVLILLLTVALSGAVTRILPFQLPLPLMQIAFGAMLAWPKLNLHVAFDPEIFMLL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
FIPPLLFADGWRIPKRELYLQRRAILMLAFGLVFMTVLAVGYFAHWLIPELPLPIAFALA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AVLSPTDAVALSGIAGKGRIPPQLMHILEGEALMNDASGLVALKFAIAAALTGMFSLRDA
HHHCCCHHHHCCCCCCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
SVTFVIVAAGGLATGAIVSWAFSALSTRFLNAEQEGDPAPGIVMTLLVPFAAYLFAEHLD
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
LSGVLAAVSAGMMMNYTSFSRKSTVASRVRAESTWAMIEFVFNGMVFIMLGLQLPHIIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLVDAHHTSDALVGRMVFNVCAMMLALYAIRFLWVWLLRWFASRRAARQGLTGTMAGVRT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IAVMTVGGVRGAVTLAGVLSIPVALSDGVPLPGRDTAIFVASAVILGSLIVAVIGLPLLL
HHHHEECCCHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RGVRSSRSPLGDEERAARAAAAQAAIRAIDSSHDAISVDLDESGAARCADISARVMDQYR
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
RRLATLAEDGPTPRAEAKQAETMELQMRIAAVRAERSALYRLRSESKISDETLTKLLREI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
DLSETALSTRKKGIL
CCHHHHHHHHHCCCC
>Mature Secondary Structure
MEIVFTVLILLLTVALSGAVTRILPFQLPLPLMQIAFGAMLAWPKLNLHVAFDPEIFMLL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
FIPPLLFADGWRIPKRELYLQRRAILMLAFGLVFMTVLAVGYFAHWLIPELPLPIAFALA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AVLSPTDAVALSGIAGKGRIPPQLMHILEGEALMNDASGLVALKFAIAAALTGMFSLRDA
HHHCCCHHHHCCCCCCCCCCCHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
SVTFVIVAAGGLATGAIVSWAFSALSTRFLNAEQEGDPAPGIVMTLLVPFAAYLFAEHLD
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
LSGVLAAVSAGMMMNYTSFSRKSTVASRVRAESTWAMIEFVFNGMVFIMLGLQLPHIIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLVDAHHTSDALVGRMVFNVCAMMLALYAIRFLWVWLLRWFASRRAARQGLTGTMAGVRT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IAVMTVGGVRGAVTLAGVLSIPVALSDGVPLPGRDTAIFVASAVILGSLIVAVIGLPLLL
HHHHEECCCHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RGVRSSRSPLGDEERAARAAAAQAAIRAIDSSHDAISVDLDESGAARCADISARVMDQYR
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
RRLATLAEDGPTPRAEAKQAETMELQMRIAAVRAERSALYRLRSESKISDETLTKLLREI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
DLSETALSTRKKGIL
CCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]