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The map label for this gene is ggt [H]

Identifier: 78067692

GI number: 78067692

Start: 3381254

End: 3383131

Strand: Direct

Name: ggt [H]

Synonym: Bcep18194_A6223

Alternate gene names: 78067692

Gene position: 3381254-3383131 (Clockwise)

Preceding gene: 78067691

Following gene: 78067693

Centisome position: 91.53

GC content: 70.82

Gene sequence:

>1878_bases
ATGTTCGACCGGATTCGTCCGCATTCGCGCTCCTGGACGCTGCTCGCCGCCGTCGCGCTCGTCGCGTTCAACGCCGGCTG
CACGTCCCCGTCCACGCCGCCGTCGGGTGCAGTGGTGCCCGTCGCCGCCGCATCGGGCGCCGCCGTGCCGCTGCCCGGCT
TCCACGCGCCCGAGCTGTCGTCCGGCTGGACCGACAAGCCGGGCTGGACCTCGCAGCACTTCATGATCGCCGCCGCGAAC
CCGCTCGCGACGCAGGCCGGCTACGACATGCTGAAGGCGGGCGGCACCGCGATCGACGCGGCGATCGCGACGCAGATGGT
GCTCGCGCTCGTCGAGCCGCAATCGTCGGGAATCGGCGGCGGCGCGTTCATGCTGTACTTCGACGGCAAGGCGACACAGG
CCTACGACGGCCGCGAAACCGCACCGGCCGCCGCGACCGACCGCCTGTTCTACGGGCCGACCGGCCAGCCGATGAGCTTC
TACGAAGGTGTCGTCGGCGGGCGCTCGGTCGGCACGCCGGGTGTGCTGCGCATGCTCGACGCCGCGCACCGCGCGCACGG
CAAGCTGCCGTGGCGCCGGCTGTTCCAGCCGGCGATCCGGCTCGCCGAGCACGGCTTCACGATCAGCCCGCGGCTCGCGA
TGCTGATCGCGAACGACAAGTACCTGAAGAACGACCCGGCCGCGCGCGCGTACTTCTACAACCCGGACGGCACGCCGAAG
GCGGCCGGCACGGTGCTGAAGAACCCCGCGCTCGCGACCGTGCTGCGCCAGGTCGCCGACCGCGGCGCGAACGCGTTCTA
CAGCGGCGCGATCGCGCGCGACATCGTCACGAAGGTGCGCAAGCACCCGACCAACCCGGGCCTGCTGTCGCTCCAGGATC
TCGCGCGCTACAAGGCGAAGGTGCGCACGCCGCTGTGCGCCGACTACCGGCGCTCGGTCGTGTGCGGGATGCCGCCGCCG
TCGTCGGGCGGCCTCGCGATCGCGCAGATGCTCGGCATCCTCGAAGCGATGCCCGACTGGCAGCAGATCGGCGCGCAGAA
GCCGGTGCGCAACGACGTCGGCTTCGAGCCCACGCCGTTCGCCGCGCACCTGTTCAGCGAAGCCGGGCGCCTCGCGTATG
CGGACCGCGCGCGCTACGTGGCCGATCCCGATTTCGTGCCGCTGCCGGGCGGCAGCTGGGCAAGCCTCACCGACAAGACC
TATCTCGCGCAGCGCGCGCACCTGATCGGCGACAGCAGCATGGGCGTCGCGCAGGCCGGCACGCCGCAGGGCGCGACGCT
CGCGATGGCCGACGACCGCAGCCCCGAGCTGCCGTCGACGTCCGACATCGCGATCGTCGACCGCTACGGCCAGGCGCTGT
CGATGACAACGAGCATCGAGGACGCATTCGGTTCGCGGCTGATGGTACGCGGCTTCATGCTGAACAACCAGCTCACCGAT
TTCTCGTTCGTGTCGAACGACAACGGCCGGCCGGTCGCGAACCGCGTGCAGGCCGGCAAGCGGCCGCGCTCGGCGATGTC
GCCGGAGCTCGTGTTCGACAAGAAGACGAAGCAGGTGACGATGGTCGTCGGCTCGGCCGGCGGCCCCGCGATCATCAATC
ACGTCGCGAAGACGCTCGTGGGCGTGCTCGACTGGGGGATGACGATGCAGCAGGCGATCGCGCTGCCGAACTTCGGTTCG
ATGAACGGGCCGACGCAACTCGAACGCGGCCGCGTGTCGGACGCGCTCGCCGATGGGCTGAAGGGCCGCGGGCACGACGT
GCAGGTCGTCGAGATGAACTCGGGGCTGCAGGGGATCCAGCGGCTGAACGTGCAGGGGCAGACGGTGTGGTTCGGCGGGG
CGGATCCGCGGCGGGAAGGGATGGCGATGGGGGATTGA

Upstream 100 bases:

>100_bases
CAAGCCGCCGGCCGCGCGGCGACAATAGCGCGCCCGGGGCGGGCAGCCGCGTTGCGCCGGCACCGTCGCCTCCTTCGAAT
TCACTGCTGCCGAGGGTTCA

Downstream 100 bases:

>100_bases
GGGCGATGAGCGACAACTTTACCTATCTGGTCGATCCGGTGGTTTCGCTCGCGGAAGCCCCTGCCGCGGCGCAACGCATG
ATCGCGTGGCTGCAGGCGCA

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MFDRIRPHSRSWTLLAAVALVAFNAGCTSPSTPPSGAVVPVAAASGAAVPLPGFHAPELSSGWTDKPGWTSQHFMIAAAN
PLATQAGYDMLKAGGTAIDAAIATQMVLALVEPQSSGIGGGAFMLYFDGKATQAYDGRETAPAAATDRLFYGPTGQPMSF
YEGVVGGRSVGTPGVLRMLDAAHRAHGKLPWRRLFQPAIRLAEHGFTISPRLAMLIANDKYLKNDPAARAYFYNPDGTPK
AAGTVLKNPALATVLRQVADRGANAFYSGAIARDIVTKVRKHPTNPGLLSLQDLARYKAKVRTPLCADYRRSVVCGMPPP
SSGGLAIAQMLGILEAMPDWQQIGAQKPVRNDVGFEPTPFAAHLFSEAGRLAYADRARYVADPDFVPLPGGSWASLTDKT
YLAQRAHLIGDSSMGVAQAGTPQGATLAMADDRSPELPSTSDIAIVDRYGQALSMTTSIEDAFGSRLMVRGFMLNNQLTD
FSFVSNDNGRPVANRVQAGKRPRSAMSPELVFDKKTKQVTMVVGSAGGPAIINHVAKTLVGVLDWGMTMQQAIALPNFGS
MNGPTQLERGRVSDALADGLKGRGHDVQVVEMNSGLQGIQRLNVQGQTVWFGGADPRREGMAMGD

Sequences:

>Translated_625_residues
MFDRIRPHSRSWTLLAAVALVAFNAGCTSPSTPPSGAVVPVAAASGAAVPLPGFHAPELSSGWTDKPGWTSQHFMIAAAN
PLATQAGYDMLKAGGTAIDAAIATQMVLALVEPQSSGIGGGAFMLYFDGKATQAYDGRETAPAAATDRLFYGPTGQPMSF
YEGVVGGRSVGTPGVLRMLDAAHRAHGKLPWRRLFQPAIRLAEHGFTISPRLAMLIANDKYLKNDPAARAYFYNPDGTPK
AAGTVLKNPALATVLRQVADRGANAFYSGAIARDIVTKVRKHPTNPGLLSLQDLARYKAKVRTPLCADYRRSVVCGMPPP
SSGGLAIAQMLGILEAMPDWQQIGAQKPVRNDVGFEPTPFAAHLFSEAGRLAYADRARYVADPDFVPLPGGSWASLTDKT
YLAQRAHLIGDSSMGVAQAGTPQGATLAMADDRSPELPSTSDIAIVDRYGQALSMTTSIEDAFGSRLMVRGFMLNNQLTD
FSFVSNDNGRPVANRVQAGKRPRSAMSPELVFDKKTKQVTMVVGSAGGPAIINHVAKTLVGVLDWGMTMQQAIALPNFGS
MNGPTQLERGRVSDALADGLKGRGHDVQVVEMNSGLQGIQRLNVQGQTVWFGGADPRREGMAMGD
>Mature_625_residues
MFDRIRPHSRSWTLLAAVALVAFNAGCTSPSTPPSGAVVPVAAASGAAVPLPGFHAPELSSGWTDKPGWTSQHFMIAAAN
PLATQAGYDMLKAGGTAIDAAIATQMVLALVEPQSSGIGGGAFMLYFDGKATQAYDGRETAPAAATDRLFYGPTGQPMSF
YEGVVGGRSVGTPGVLRMLDAAHRAHGKLPWRRLFQPAIRLAEHGFTISPRLAMLIANDKYLKNDPAARAYFYNPDGTPK
AAGTVLKNPALATVLRQVADRGANAFYSGAIARDIVTKVRKHPTNPGLLSLQDLARYKAKVRTPLCADYRRSVVCGMPPP
SSGGLAIAQMLGILEAMPDWQQIGAQKPVRNDVGFEPTPFAAHLFSEAGRLAYADRARYVADPDFVPLPGGSWASLTDKT
YLAQRAHLIGDSSMGVAQAGTPQGATLAMADDRSPELPSTSDIAIVDRYGQALSMTTSIEDAFGSRLMVRGFMLNNQLTD
FSFVSNDNGRPVANRVQAGKRPRSAMSPELVFDKKTKQVTMVVGSAGGPAIINHVAKTLVGVLDWGMTMQQAIALPNFGS
MNGPTQLERGRVSDALADGLKGRGHDVQVVEMNSGLQGIQRLNVQGQTVWFGGADPRREGMAMGD

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=560, Percent_Identity=29.8214285714286, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI73915090, Length=560, Percent_Identity=29.8214285714286, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI73915096, Length=560, Percent_Identity=29.8214285714286, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI73915094, Length=560, Percent_Identity=29.8214285714286, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI113429324, Length=557, Percent_Identity=29.443447037702, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI113429326, Length=565, Percent_Identity=28.6725663716814, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI153266885, Length=579, Percent_Identity=27.979274611399, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI153266901, Length=580, Percent_Identity=27.7586206896552, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI109148539, Length=533, Percent_Identity=27.2045028142589, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI153266907, Length=576, Percent_Identity=26.7361111111111, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI30581157, Length=198, Percent_Identity=30.8080808080808, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI30581155, Length=198, Percent_Identity=30.8080808080808, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI171543825, Length=178, Percent_Identity=30.8988764044944, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789856, Length=560, Percent_Identity=34.6428571428571, Blast_Score=264, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI212646519, Length=566, Percent_Identity=31.2720848056537, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI72000294, Length=566, Percent_Identity=31.2720848056537, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193208245, Length=532, Percent_Identity=31.390977443609, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI193208247, Length=532, Percent_Identity=31.390977443609, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17542894, Length=547, Percent_Identity=30.5301645338208, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17506189, Length=567, Percent_Identity=27.8659611992945, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17564448, Length=434, Percent_Identity=26.9585253456221, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI72001497, Length=236, Percent_Identity=27.5423728813559, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI72001495, Length=236, Percent_Identity=27.5423728813559, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=232, Percent_Identity=30.6034482758621, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24642670, Length=617, Percent_Identity=30.1458670988655, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24642666, Length=617, Percent_Identity=30.1458670988655, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI161077880, Length=617, Percent_Identity=30.1458670988655, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI45551474, Length=617, Percent_Identity=30.1458670988655, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI161077878, Length=617, Percent_Identity=30.1458670988655, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI18859893, Length=557, Percent_Identity=29.802513464991, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI161077496, Length=531, Percent_Identity=26.5536723163842, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI18859741, Length=563, Percent_Identity=26.1101243339254, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 66274; Mature: 66274

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRIRPHSRSWTLLAAVALVAFNAGCTSPSTPPSGAVVPVAAASGAAVPLPGFHAPELS
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCC
SGWTDKPGWTSQHFMIAAANPLATQAGYDMLKAGGTAIDAAIATQMVLALVEPQSSGIGG
CCCCCCCCCCCCEEEEEECCCHHHHHCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GAFMLYFDGKATQAYDGRETAPAAATDRLFYGPTGQPMSFYEGVVGGRSVGTPGVLRMLD
CEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHH
AAHRAHGKLPWRRLFQPAIRLAEHGFTISPRLAMLIANDKYLKNDPAARAYFYNPDGTPK
HHHHHCCCCCHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCCCEEEEECCCCCCH
AAGTVLKNPALATVLRQVADRGANAFYSGAIARDIVTKVRKHPTNPGLLSLQDLARYKAK
HHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHH
VRTPLCADYRRSVVCGMPPPSSGGLAIAQMLGILEAMPDWQQIGAQKPVRNDVGFEPTPF
HCCCHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCH
AAHLFSEAGRLAYADRARYVADPDFVPLPGGSWASLTDKTYLAQRAHLIGDSSMGVAQAG
HHHHHHHCCCEEEHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
TPQGATLAMADDRSPELPSTSDIAIVDRYGQALSMTTSIEDAFGSRLMVRGFMLNNQLTD
CCCCCEEEEECCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHCCCEEEEEEEECCCCCC
FSFVSNDNGRPVANRVQAGKRPRSAMSPELVFDKKTKQVTMVVGSAGGPAIINHVAKTLV
EEEEECCCCCCHHHHHHCCCCCCCCCCCCEEECCCCCEEEEEEECCCCHHHHHHHHHHHH
GVLDWGMTMQQAIALPNFGSMNGPTQLERGRVSDALADGLKGRGHDVQVVEMNSGLQGIQ
HHHHHCHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCEEEEEECCCHHHHH
RLNVQGQTVWFGGADPRREGMAMGD
HHCCCCCEEEECCCCHHHCCCCCCC
>Mature Secondary Structure
MFDRIRPHSRSWTLLAAVALVAFNAGCTSPSTPPSGAVVPVAAASGAAVPLPGFHAPELS
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCC
SGWTDKPGWTSQHFMIAAANPLATQAGYDMLKAGGTAIDAAIATQMVLALVEPQSSGIGG
CCCCCCCCCCCCEEEEEECCCHHHHHCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GAFMLYFDGKATQAYDGRETAPAAATDRLFYGPTGQPMSFYEGVVGGRSVGTPGVLRMLD
CEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHH
AAHRAHGKLPWRRLFQPAIRLAEHGFTISPRLAMLIANDKYLKNDPAARAYFYNPDGTPK
HHHHHCCCCCHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCCCEEEEECCCCCCH
AAGTVLKNPALATVLRQVADRGANAFYSGAIARDIVTKVRKHPTNPGLLSLQDLARYKAK
HHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHH
VRTPLCADYRRSVVCGMPPPSSGGLAIAQMLGILEAMPDWQQIGAQKPVRNDVGFEPTPF
HCCCHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCH
AAHLFSEAGRLAYADRARYVADPDFVPLPGGSWASLTDKTYLAQRAHLIGDSSMGVAQAG
HHHHHHHCCCEEEHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
TPQGATLAMADDRSPELPSTSDIAIVDRYGQALSMTTSIEDAFGSRLMVRGFMLNNQLTD
CCCCCEEEEECCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHCCCEEEEEEEECCCCCC
FSFVSNDNGRPVANRVQAGKRPRSAMSPELVFDKKTKQVTMVVGSAGGPAIINHVAKTLV
EEEEECCCCCCHHHHHHCCCCCCCCCCCCEEECCCCCEEEEEEECCCCHHHHHHHHHHHH
GVLDWGMTMQQAIALPNFGSMNGPTQLERGRVSDALADGLKGRGHDVQVVEMNSGLQGIQ
HHHHHCHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCEEEEEECCCHHHHH
RLNVQGQTVWFGGADPRREGMAMGD
HHCCCCCEEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA