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The map label for this gene is glcA [H]

Identifier: 78067553

GI number: 78067553

Start: 3226349

End: 3228061

Strand: Direct

Name: glcA [H]

Synonym: Bcep18194_A6084

Alternate gene names: 78067553

Gene position: 3226349-3228061 (Clockwise)

Preceding gene: 78067552

Following gene: 78067559

Centisome position: 87.34

GC content: 69.12

Gene sequence:

>1713_bases
ATGCAGGCCTGGCATCAGATCTACACCCCGCTCGGCAGCCTCGGGCTGTCGGCGTTCGTCGCCGCAATCCCGATCATCTT
CTTTTTCGTCGCGCTGGCCGCGCTGCGGCTCAAGGGCCACGTCGCGGCGGCGATCACGCTGCTGCTGTCGCTCGGCGTCG
CGATCCTCGCGTACGGGATGCCCCTGCCGCAGGCGCTCGCGGCGGCCGGCTTCGGCGTCGCGTACGGCCTGTGGCCGATC
GCGTGGATCATCGTCGCGGCCGTGTTCCTGTACAAGATCGTCGTGAAGACCGGCCAGTTCGACATCATTCGCGCGTCCGT
GCTGTCGATCACCGACGACCAGCGCTTGCAGATGCTGCTGATCGGCTTCTCGTTCGGCGCGTTCCTCGAAGGCGCGGCCG
GTTTCGGCGCGCCCGTCGCGATCACGGCCGCGCTGCTCGTCGGCCTCGGCTTCAAGCCGCTGCACGCGGCGGGATTGTGT
CTGATTGCAAACACCGCGCCGGTCGCGTTCGGTGCGATGGGCATCCCGATCATCGTCGCCGGGCAGGTGACGGGCATCGA
CCCGTTCCATATCGGCGCGATGGCCGGCCGCCAGTTGCCGCTGCTGTCGCTCGCGGTGCCGTTCTGGCTCGTGTTCATGA
TGGACGGCCTGCGCGGCGTGCGACAGACCTGGCCGGCCGCGCTCGTCGCGGGCGGCAGCTTCGCGGTGACGCAGTACTTC
ACGTCGAACCACATCGGGCCCGAGCTGCCGGACATCACGTCGTCGCTCGTCAGCCTCGTCGCGCTCGCCGCGTTCCTGAA
GGTCTGGCAGCCGCGCACCGCGAAGCAGACGGCCGACGGCTTCGTCGCGTCGGGCGGCGGCGCCGCGCTCGCGGGCTTCG
GCGGCGCAAGCTCGGGCAACGGCTTCGGCACCGGCACGCGCCGGCAGGCGTCGCCGTACACGCTCGCGCAAACCGTGCGC
GCGTGGTCGCCGTTCCTGATCCTGACGGCCGTCGTCACCGTGTGGAGCATTGCGCCGTTCAAGGCGCTGTTCGCTGCTCA
CGGTGCACTCGCGTCGACCGTATTGAAGTTCCATGTGGCGGGGCTCGACCAGCTCGTCGTGAAGACCGCGCCGATCGCCG
TAACGCCGAAGGCGCTCGACGCGGTGCTGAAGATCGATCTCGTGTCGGCGGTGGGCAGCGCGATCCTCGTGACCGCGCTG
ATCTCGATGGCGCTGCTGCGGATGAAGCCGCGCGACGCGCTCGTCACGTTCGGCGAGACGCTGAGGGAGCTGACGCGCCC
GATCCTGTCGATCGGCCTGGTGCTCGCGTTCGCGTTCGTCGCGAACTATTCGGGGATGTCGTCGACGCTCGCGCTGATGC
TGGCTGCGACCGGCGCCGCGTTCCCGTTCTTCTCGCCGTTCCTCGGCTGGCTCGGCGTGTTCCTGACGGGCTCGGACACG
TCGTCGAACGCGCTGTTCTGCTCGCTGCAGCAGGCCACGGCCCATCAGCTCGGCGTGCCCGAGACGCTCGCGGTGGCCGC
GAACACGACCGGCGGCGTGACTGCGAAGATGATCTCGCCGCAATCGATCGCGGTCGCCTGCGCGGCGACGGGCCTCGTCG
GCAAGGAGTCCGAGCTGTTCCGCTTCACGGTGCGGCACAGCCTGCTGTTCGCAGTGATCGTCGGGTTGATCACGCTCGCG
CAGGCGTACGTGCTGCCAGGCATGGTGCCGTAA

Upstream 100 bases:

>100_bases
CGCCGCGCAGCCTGTCCGACCTGCTGCGCGCACGCGGCCAGCCCGAATAGCCGTTTCGTTTTTCAAGCCGTACCGACAAA
AACCTATGGAGGAGACATCC

Downstream 100 bases:

>100_bases
GCAGCGTACGCCCCAAAAACAAAACCCCACGCCCGGAAGAGCGTGGGGTTTTTCATTTCGCCGGTCGATCGCCCGCCGCG
GCAGGCGCTCGGTTGCGCGA

Product: L-lactate transporter

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MQAWHQIYTPLGSLGLSAFVAAIPIIFFFVALAALRLKGHVAAAITLLLSLGVAILAYGMPLPQALAAAGFGVAYGLWPI
AWIIVAAVFLYKIVVKTGQFDIIRASVLSITDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFKPLHAAGLC
LIANTAPVAFGAMGIPIIVAGQVTGIDPFHIGAMAGRQLPLLSLAVPFWLVFMMDGLRGVRQTWPAALVAGGSFAVTQYF
TSNHIGPELPDITSSLVSLVALAAFLKVWQPRTAKQTADGFVASGGGAALAGFGGASSGNGFGTGTRRQASPYTLAQTVR
AWSPFLILTAVVTVWSIAPFKALFAAHGALASTVLKFHVAGLDQLVVKTAPIAVTPKALDAVLKIDLVSAVGSAILVTAL
ISMALLRMKPRDALVTFGETLRELTRPILSIGLVLAFAFVANYSGMSSTLALMLAATGAAFPFFSPFLGWLGVFLTGSDT
SSNALFCSLQQATAHQLGVPETLAVAANTTGGVTAKMISPQSIAVACAATGLVGKESELFRFTVRHSLLFAVIVGLITLA
QAYVLPGMVP

Sequences:

>Translated_570_residues
MQAWHQIYTPLGSLGLSAFVAAIPIIFFFVALAALRLKGHVAAAITLLLSLGVAILAYGMPLPQALAAAGFGVAYGLWPI
AWIIVAAVFLYKIVVKTGQFDIIRASVLSITDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFKPLHAAGLC
LIANTAPVAFGAMGIPIIVAGQVTGIDPFHIGAMAGRQLPLLSLAVPFWLVFMMDGLRGVRQTWPAALVAGGSFAVTQYF
TSNHIGPELPDITSSLVSLVALAAFLKVWQPRTAKQTADGFVASGGGAALAGFGGASSGNGFGTGTRRQASPYTLAQTVR
AWSPFLILTAVVTVWSIAPFKALFAAHGALASTVLKFHVAGLDQLVVKTAPIAVTPKALDAVLKIDLVSAVGSAILVTAL
ISMALLRMKPRDALVTFGETLRELTRPILSIGLVLAFAFVANYSGMSSTLALMLAATGAAFPFFSPFLGWLGVFLTGSDT
SSNALFCSLQQATAHQLGVPETLAVAANTTGGVTAKMISPQSIAVACAATGLVGKESELFRFTVRHSLLFAVIVGLITLA
QAYVLPGMVP
>Mature_570_residues
MQAWHQIYTPLGSLGLSAFVAAIPIIFFFVALAALRLKGHVAAAITLLLSLGVAILAYGMPLPQALAAAGFGVAYGLWPI
AWIIVAAVFLYKIVVKTGQFDIIRASVLSITDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFKPLHAAGLC
LIANTAPVAFGAMGIPIIVAGQVTGIDPFHIGAMAGRQLPLLSLAVPFWLVFMMDGLRGVRQTWPAALVAGGSFAVTQYF
TSNHIGPELPDITSSLVSLVALAAFLKVWQPRTAKQTADGFVASGGGAALAGFGGASSGNGFGTGTRRQASPYTLAQTVR
AWSPFLILTAVVTVWSIAPFKALFAAHGALASTVLKFHVAGLDQLVVKTAPIAVTPKALDAVLKIDLVSAVGSAILVTAL
ISMALLRMKPRDALVTFGETLRELTRPILSIGLVLAFAFVANYSGMSSTLALMLAATGAAFPFFSPFLGWLGVFLTGSDT
SSNALFCSLQQATAHQLGVPETLAVAANTTGGVTAKMISPQSIAVACAATGLVGKESELFRFTVRHSLLFAVIVGLITLA
QAYVLPGMVP

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=569, Percent_Identity=68.7170474516696, Blast_Score=745, Evalue=0.0,
Organism=Escherichia coli, GI1790031, Length=570, Percent_Identity=64.0350877192982, Blast_Score=686, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 58979; Mature: 58979

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]