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The map label for this gene is ascD [H]

Identifier: 78067291

GI number: 78067291

Start: 2936646

End: 2937677

Strand: Direct

Name: ascD [H]

Synonym: Bcep18194_A5822

Alternate gene names: 78067291

Gene position: 2936646-2937677 (Clockwise)

Preceding gene: 78067289

Following gene: 78067292

Centisome position: 79.5

GC content: 65.7

Gene sequence:

>1032_bases
ATGGCATTCAACGTCACTCTCAAGCAAAGCGGCCGGCAATTCCAGGTCGAGTCGGACGAAACCGTGCTGGCGGCTGCGCT
GCGCCAGAACGTCCATCTGCCGTACGGCTGCAAGAACGGCGCGTGCGGCTCCTGCAAGGGCCAGATCGTGTCGGGCCAGA
TCGAACAGGGCCCGCACGCCGCGTCGGCACTGTCCAACGACGAACGCACGCGCGGCCTCGCGCTGCTGTGCTGCTCGAAG
GCGCAGTGCGATCTCGAAATCGACGTGCGTGAAATCGCCGGCGTCGACGGCGTGCAGGTCAAGAAGCTGCCGTGCCGGAT
CGCCGCACTCGAGCGCAAGGCCGACGACGTGATGGTCGTGAAGCTCCAGTTGCCCGCCAACGAACGCCTGCAGTATCTCG
CGGGCCAGTACGTCGAGTTCATCCTGAAGGACGGCTCGCGCCGCAGCTACTCGATGGCGAACGCGCCGCACGAGGAAGGC
CCGGTTGAGCTGCACATCCGCCACATGCCGGGCGGCAAGTTCACCGACCACGTGTTCGGTGCGATGAAGGAGCGCGACAT
CCTGCGCTTCGAAGGCCCGCTCGGCACATTCTTCCTGCGTGAAGATTCCGACAAGCCGATCGTGCTGCTCGCATCGGGCA
CGGGCTTCGCGCCGATCAAGGCGATCATCGAGCACGTGAAGCACACGGGCATCACGCGCCCGATGACGCTCTACTGGGGC
GCGCGCCGCAAGAAGGACATCTATCTCGGCGAGCTCGCCGAACAATGGGCGCGCGAGATCCCGAACTTCAAGTACGTGCC
GGTGCTCTCCGAGCCGGACGCCGGCGACCAGTGGACGGGCCGCACCGGTTTCGTCCATCGTGCGGTGATCGAGGACCTGC
CCGATCTGTCGGGCCACCAGGTGTATGCATGCGGCGCGCCGGTGATGGTCGAATCCGCACAGCGCGACTTCACGCAGCAC
CACGCACTGCCCGCCGACGAGTTCTACGCGGACTCGTTCACGAGCGCCGCCGATCTCGCGCATCCGGTCTAA

Upstream 100 bases:

>100_bases
GCGAAATCAGTAGCCACCGCTGCGCGACGCGCAACGGGTTTGCATTGTAGCTGCCGTGCTCGACATGCACGGTCCCCACA
TTTTGTTCTAGTTTGGTTCT

Downstream 100 bases:

>100_bases
CGCCTGCGCACCCGCGTACCGCACTGCGCCCCGCGATGTCACATCCGTGGCATCGCGGCGGTTTACAGTGAGGCGCGGGA
TGCCTTATGCTTGCGCACAT

Product: CDP-6-deoxy-delta-3,4-glucoseen reductase

Products: NAD(P); FMNH2; 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: CDP-6-deoxy-delta-3,4-glucoseen reductase; E3 [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MAFNVTLKQSGRQFQVESDETVLAAALRQNVHLPYGCKNGACGSCKGQIVSGQIEQGPHAASALSNDERTRGLALLCCSK
AQCDLEIDVREIAGVDGVQVKKLPCRIAALERKADDVMVVKLQLPANERLQYLAGQYVEFILKDGSRRSYSMANAPHEEG
PVELHIRHMPGGKFTDHVFGAMKERDILRFEGPLGTFFLREDSDKPIVLLASGTGFAPIKAIIEHVKHTGITRPMTLYWG
ARRKKDIYLGELAEQWAREIPNFKYVPVLSEPDAGDQWTGRTGFVHRAVIEDLPDLSGHQVYACGAPVMVESAQRDFTQH
HALPADEFYADSFTSAADLAHPV

Sequences:

>Translated_343_residues
MAFNVTLKQSGRQFQVESDETVLAAALRQNVHLPYGCKNGACGSCKGQIVSGQIEQGPHAASALSNDERTRGLALLCCSK
AQCDLEIDVREIAGVDGVQVKKLPCRIAALERKADDVMVVKLQLPANERLQYLAGQYVEFILKDGSRRSYSMANAPHEEG
PVELHIRHMPGGKFTDHVFGAMKERDILRFEGPLGTFFLREDSDKPIVLLASGTGFAPIKAIIEHVKHTGITRPMTLYWG
ARRKKDIYLGELAEQWAREIPNFKYVPVLSEPDAGDQWTGRTGFVHRAVIEDLPDLSGHQVYACGAPVMVESAQRDFTQH
HALPADEFYADSFTSAADLAHPV
>Mature_342_residues
AFNVTLKQSGRQFQVESDETVLAAALRQNVHLPYGCKNGACGSCKGQIVSGQIEQGPHAASALSNDERTRGLALLCCSKA
QCDLEIDVREIAGVDGVQVKKLPCRIAALERKADDVMVVKLQLPANERLQYLAGQYVEFILKDGSRRSYSMANAPHEEGP
VELHIRHMPGGKFTDHVFGAMKERDILRFEGPLGTFFLREDSDKPIVLLASGTGFAPIKAIIEHVKHTGITRPMTLYWGA
RRKKDIYLGELAEQWAREIPNFKYVPVLSEPDAGDQWTGRTGFVHRAVIEDLPDLSGHQVYACGAPVMVESAQRDFTQHH
ALPADEFYADSFTSAADLAHPV

Specific function: Participates in the conversion of CDP-6-deoxy-D-glycero- L-threo-4-hexulose to 3,6-dideoxy-D-glycero-D-glycero-4-hexulose together with CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) in two consecutive steps. The detailed mechanism of E3 is not

COG id: COG0543

COG function: function code HC; 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI2367314, Length=235, Percent_Identity=30.2127659574468, Blast_Score=121, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6322146, Length=174, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322699, Length=216, Percent_Identity=24.0740740740741, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323552, Length=201, Percent_Identity=27.363184079602, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.5.1.29 [C]

Molecular weight: Translated: 37838; Mature: 37706

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNVTLKQSGRQFQVESDETVLAAALRQNVHLPYGCKNGACGSCKGQIVSGQIEQGPHA
CEEEEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCH
ASALSNDERTRGLALLCCSKAQCDLEIDVREIAGVDGVQVKKLPCRIAALERKADDVMVV
HHHCCCCHHHCCEEEEEECCCCCCEEEEHHHHCCCCCCEEECCCHHHHHHHCCCCCEEEE
KLQLPANERLQYLAGQYVEFILKDGSRRSYSMANAPHEEGPVELHIRHMPGGKFTDHVFG
EEECCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEEECCCCCHHHHHHH
AMKERDILRFEGPLGTFFLREDSDKPIVLLASGTGFAPIKAIIEHVKHTGITRPMTLYWG
HHHCCCEEEEECCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEC
ARRKKDIYLGELAEQWAREIPNFKYVPVLSEPDAGDQWTGRTGFVHRAVIEDLPDLSGHQ
CCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCE
VYACGAPVMVESAQRDFTQHHALPADEFYADSFTSAADLAHPV
EEECCCCCEEHHHHHHHHHHCCCCHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
AFNVTLKQSGRQFQVESDETVLAAALRQNVHLPYGCKNGACGSCKGQIVSGQIEQGPHA
EEEEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCH
ASALSNDERTRGLALLCCSKAQCDLEIDVREIAGVDGVQVKKLPCRIAALERKADDVMVV
HHHCCCCHHHCCEEEEEECCCCCCEEEEHHHHCCCCCCEEECCCHHHHHHHCCCCCEEEE
KLQLPANERLQYLAGQYVEFILKDGSRRSYSMANAPHEEGPVELHIRHMPGGKFTDHVFG
EEECCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEEECCCCCHHHHHHH
AMKERDILRFEGPLGTFFLREDSDKPIVLLASGTGFAPIKAIIEHVKHTGITRPMTLYWG
HHHCCCEEEEECCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEC
ARRKKDIYLGELAEQWAREIPNFKYVPVLSEPDAGDQWTGRTGFVHRAVIEDLPDLSGHQ
CCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCE
VYACGAPVMVESAQRDFTQHHALPADEFYADSFTSAADLAHPV
EEECCCCCEEHHHHHHHHHHCCCCHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD(P)H2; FMN [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD(P)H2; FMN; 2 2-octaprenylphenol; O2 [C]

Specific reaction: NAD(P)H2 + FMN = NAD(P) + FMNH2 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10931327; 11586360; 12142430 [H]