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The map label for this gene is cobC [H]

Identifier: 78067249

GI number: 78067249

Start: 2895605

End: 2896624

Strand: Direct

Name: cobC [H]

Synonym: Bcep18194_A5780

Alternate gene names: 78067249

Gene position: 2895605-2896624 (Clockwise)

Preceding gene: 78067248

Following gene: 78067250

Centisome position: 78.38

GC content: 72.25

Gene sequence:

>1020_bases
ATGTCTGACACACACATCGCGCACGGCGGCAACCTGCATGAAGCCGCACGCCGCCACGGCATTCCGTACGACGCGTGGCT
TGACCTGTCGACCGGCATCAATCCGGTCGGCTATCCGGTCCCGCCCGTCCCGACCGACGCATGGCGCCGGCTGCCTGACG
ACGGCGACGGCCTCGCGGCCTGCGCCGCGCAGTACTACCACGCCCCCGATTCCGCACACGTGCTGCCGGTTGCCGGCAGC
CAGGCCGCGATCCGTGCGTTGCCCGCGTTGCTGCCGCCCGGCGACGCCGGTGTCGCGGCGCTCGCGTATGGCGAATACGC
GCCGGCCTTCGCGCGCCACGGCCATCGCGTCGTCGCGCTCGACATCGACGCGGATACGCTGCCTGCGACGCTGCGTCACG
TCATCGTCGGGAATCCGAATAATCCGACTGCCGAGTTCGTGCCGGCCGAGCGCCTGCTCGATTGGCACGCGCAGCTGGCG
GCGCGCGGCGGCACGCTGATCGTCGACGAGGCATTCGCCGATACGGGCGCGACGCGGTCGCTCGCGCCGCACGTCGATCG
CCCGGGCCTCGTCGTGCTGCGTTCGGTCGGCAAGTTCTTCGGGCTTGCCGGCATCCGCGCAGGCTTCGTGCTCGCGTGCC
CTGACCGGATCGTCGCGCTGCGCGACATGCTCGGTGCATGGACGGTGAGCGGCCCCGCGCGCCATGCGGTCGCCGAGGCG
TTCGCCGACCGCGCATGGCAGGCCGCCGCCCGCGAACGGCTCGCGGCCGACGGCGAGCGGCTGGCCGCCTTGCTGCGCGC
GCACGGCTTCGCGGTTCGCGCGACACCGCTCTTCAGCTGGACCGACGATCCGCGCGCCGCGGCGCTGCATGCGACACTCG
CGGCACGCGGAATCTGGACGCGGCACTTCCCGACACCATCGAGCGTACGCGTCGGTCTGCCGGGCAGCGAAGCCGAATGG
CAGCGCCTCGGCGACGCGCTCGCGCACTGCGTGCCGACGCTGCAACAGGAATCCGCATGA

Upstream 100 bases:

>100_bases
GCCGTCCACATCGTCGCCGCGCTGTCGCTCGTCACGCGCACGCTTGCCCTGTGGCTCGCGCTGCTGGTCGCAAGCGGCGC
ACTCGCCATGGCCACTCATC

Downstream 100 bases:

>100_bases
ATCCGCTCATGGTTCGCCGGCTCGCGCCAGTCGCGTTACTGGCCGCACTCGCGTACGCACCACTCGTCCGCGCCGATGTC
ACAACGCGCGACGACGCCGG

Product: putative threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSDTHIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPTDAWRRLPDDGDGLAACAAQYYHAPDSAHVLPVAGS
QAAIRALPALLPPGDAGVAALAYGEYAPAFARHGHRVVALDIDADTLPATLRHVIVGNPNNPTAEFVPAERLLDWHAQLA
ARGGTLIVDEAFADTGATRSLAPHVDRPGLVVLRSVGKFFGLAGIRAGFVLACPDRIVALRDMLGAWTVSGPARHAVAEA
FADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWTDDPRAAALHATLAARGIWTRHFPTPSSVRVGLPGSEAEW
QRLGDALAHCVPTLQQESA

Sequences:

>Translated_339_residues
MSDTHIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPTDAWRRLPDDGDGLAACAAQYYHAPDSAHVLPVAGS
QAAIRALPALLPPGDAGVAALAYGEYAPAFARHGHRVVALDIDADTLPATLRHVIVGNPNNPTAEFVPAERLLDWHAQLA
ARGGTLIVDEAFADTGATRSLAPHVDRPGLVVLRSVGKFFGLAGIRAGFVLACPDRIVALRDMLGAWTVSGPARHAVAEA
FADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWTDDPRAAALHATLAARGIWTRHFPTPSSVRVGLPGSEAEW
QRLGDALAHCVPTLQQESA
>Mature_338_residues
SDTHIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPTDAWRRLPDDGDGLAACAAQYYHAPDSAHVLPVAGSQ
AAIRALPALLPPGDAGVAALAYGEYAPAFARHGHRVVALDIDADTLPATLRHVIVGNPNNPTAEFVPAERLLDWHAQLAA
RGGTLIVDEAFADTGATRSLAPHVDRPGLVVLRSVGKFFGLAGIRAGFVLACPDRIVALRDMLGAWTVSGPARHAVAEAF
ADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWTDDPRAAALHATLAARGIWTRHFPTPSSVRVGLPGSEAEWQ
RLGDALAHCVPTLQQESA

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35863; Mature: 35732

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTHIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPTDAWRRLPDDGDGLAA
CCCCCCCCCCCHHHHHHHCCCCCHHEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHH
CAAQYYHAPDSAHVLPVAGSQAAIRALPALLPPGDAGVAALAYGEYAPAFARHGHRVVAL
HHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCCEEEEE
DIDADTLPATLRHVIVGNPNNPTAEFVPAERLLDWHAQLAARGGTLIVDEAFADTGATRS
ECCCCHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCC
LAPHVDRPGLVVLRSVGKFFGLAGIRAGFVLACPDRIVALRDMLGAWTVSGPARHAVAEA
CCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHH
FADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWTDDPRAAALHATLAARGIWT
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEE
RHFPTPSSVRVGLPGSEAEWQRLGDALAHCVPTLQQESA
ECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDTHIAHGGNLHEAARRHGIPYDAWLDLSTGINPVGYPVPPVPTDAWRRLPDDGDGLAA
CCCCCCCCCCHHHHHHHCCCCCHHEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHH
CAAQYYHAPDSAHVLPVAGSQAAIRALPALLPPGDAGVAALAYGEYAPAFARHGHRVVAL
HHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCCEEEEE
DIDADTLPATLRHVIVGNPNNPTAEFVPAERLLDWHAQLAARGGTLIVDEAFADTGATRS
ECCCCHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCC
LAPHVDRPGLVVLRSVGKFFGLAGIRAGFVLACPDRIVALRDMLGAWTVSGPARHAVAEA
CCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHH
FADRAWQAAARERLAADGERLAALLRAHGFAVRATPLFSWTDDPRAAALHATLAARGIWT
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEE
RHFPTPSSVRVGLPGSEAEWQRLGDALAHCVPTLQQESA
ECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]