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The map label for this gene is parE [H]

Identifier: 78067168

GI number: 78067168

Start: 2807512

End: 2809494

Strand: Reverse

Name: parE [H]

Synonym: Bcep18194_A5699

Alternate gene names: 78067168

Gene position: 2809494-2807512 (Counterclockwise)

Preceding gene: 78067169

Following gene: 78067167

Centisome position: 76.05

GC content: 65.76

Gene sequence:

>1983_bases
ATGTCAACGAAGAAACCCAGCGCGGCCTATAGCGAAGCATCGATCAAGGTGCTCAAGGGTCTCGAGCCGGTCAAGCAGCG
GCCCGGCATGTACACCCGTACCGAGAATCCGCTGCACATCATCCAGGAAGTCATCGACAACGCGTCCGACGAGGCGCTCG
GCGGCTACGGCAAGCAGATCACGGTCACGCTGCACGCCGACCAGTCGGTCTCGGTCGAAGACGACGGCCGCGGCATCCCG
TTCGGCATGCACCCGGAAGAGGGTGTGCCGGTCGTCGAGATCGTATTCACGCGCCTGCACGCGGGCGGCAAGTTCGACAA
GGCCGCGGGCGGCGCCTACACGTTCTCGGGCGGTCTGCACGGCGTCGGCGTGTCGGTGACGAACGCGCTGGCCACGCGCC
TCGACGTGACGGTCTGGCGCGACGGCAAGATCGCGGAGCTCGGCTTCGCCGAAGGCGATGTCGTGAAACCGCTCGCGACG
CAGGGTGCTGGCCGCGGCGAGAAGAAATCCGGCACGCGCGTGCAGGTGTGGCCGAATCCGAAGTACTTCGATTCGCCGAA
CCTGCCGCTCGGCGAACTGCAACGCCTCTTGCGCTCCAAGGCCGTGCTGCTGCCGGGCGTCGAGGTCGTGCTCGTCAACG
AGAAGTCGGGCGAGCGCCAGACGTGGAAATATGAAGACGGCCTGCGCGGCTACCTGCTCGACGAAATGAACGGCAGCGAG
CTGCTGATCCCGCTGTTCGAAGGCGAGCGTTTCGCCGATTCGCGTTCGGGCGACGACACCTTCGCCGAAGGCGAGGGCGC
GTCGTGGGTCGTCGCATGGAGCGAGGAAGGTTCGCTCGTGCGCGAGTCGTACGTGAACCTGATCCCGACGCCGGCCGGCG
GCACGCACGAATCCGGCCTGCGCGACGGCCTCTACCAGGCGGTGAAAAGCTTCGTCGAACTGCACAACCTGCAGCCGAAG
GGCGTGAAGCTGCTCGCGGAAGACGTGTTCGCGCGCGTGTCGTTCGTGCTGTCCGCGAAGGTGCTCGATCCGCAGTTCCA
GGGGCAGATCAAGGAACGCCTGAACAGCCGCGACGCGGTCAAGCTCGTGTCGTCGTTCTCGCGTCCGGCGCTCGAACTGT
GGCTGAACCAGCACGTCGAGCACGGCAAGAAGCTCGCCGAACTCGTGATCAAGCAGGCGCAGGCGCGTACGCGTGCGGGC
CAGAAGGTCGAGAAGCGCAAGAGCTCGGGCGTCGCGGTGCTGCCCGGCAAGCTGACCGACTGCGAGACGGAAGATATCGC
GCGCAACGAACTGTTCCTCGTCGAGGGCGATTCGGCAGGCGGCTCCGCGAAGATGGGCCGCGACAAGGAATACCAGGCGA
TCCTGCCGCTGCGCGGCAAGGTGCTGAACACGTGGGAAACCGAGCGCGACCGCCTGTTCGCGAACAACGAGGTGCACGAC
ATCTCGGTCGCGATCGGCGTCGATCCGCACAGCCCCGATGAAAGCGTCGACCTGTCGAACCTGCGCTACGGCAAGATCTG
CATCCTGTCGGACGCGGACGTCGACGGCTCGCACATCCAGGTGCTGCTGCTCACGCTGTTCTTCAAGCATTTCCCGCAAC
TGATCGAGCGCGGCCATGTGTGCGTCGCCCGCCCGCCGTTGTTCCGCGTCGACGCGCCCGCGCGCGGCAAGAAGGCTGCG
CAGAAGCTCTATGCGCTCGACGACGGCGAACTCGAAGCGATCCTCGACAAGCTGCGCAAGGACGGCGTGCGCGAGACGCA
ATGGAGCATCAGCCGCTTCAAGGGTCTCGGCGAAATGAGCGCCGAGCAGCTGTGGGATACGACGATGAACCCCGACACGC
GGCGTCTGATGCCGGTGAAGCTCGGCGAGCTCGACTACGAGGCGACCGTCGCACGCATGACGATGCTGATGGGCAAGGGC
GAGGCAGCCGCGCGGCGCGGCTGGCTCGAGGAAAAGGGCAACGACGTCGAAGCGGACATCTAA

Upstream 100 bases:

>100_bases
TTGTTTCGATTCGCTTTTTTACGGAACTCAACGTTTTGTCCACGACGTTATCCACACGAGGTGTGGACAACGTCCCGATG
AATGATGAAATTCAGCGCCT

Downstream 100 bases:

>100_bases
GCCGAACACCTGCGCGGCCGGGCCTGACGCCCGGCCCGGCCTCACGCCACTTACGAATACGGAATTCAGATGGACGACAA
CACTTCCGATCTCTTCGCCA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSTKKPSAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGKQITVTLHADQSVSVEDDGRGIP
FGMHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALATRLDVTVWRDGKIAELGFAEGDVVKPLAT
QGAGRGEKKSGTRVQVWPNPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKSGERQTWKYEDGLRGYLLDEMNGSE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFSRPALELWLNQHVEHGKKLAELVIKQAQARTRAG
QKVEKRKSSGVAVLPGKLTDCETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHSPDESVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHVCVARPPLFRVDAPARGKKAA
QKLYALDDGELEAILDKLRKDGVRETQWSISRFKGLGEMSAEQLWDTTMNPDTRRLMPVKLGELDYEATVARMTMLMGKG
EAAARRGWLEEKGNDVEADI

Sequences:

>Translated_660_residues
MSTKKPSAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGKQITVTLHADQSVSVEDDGRGIP
FGMHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALATRLDVTVWRDGKIAELGFAEGDVVKPLAT
QGAGRGEKKSGTRVQVWPNPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKSGERQTWKYEDGLRGYLLDEMNGSE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFSRPALELWLNQHVEHGKKLAELVIKQAQARTRAG
QKVEKRKSSGVAVLPGKLTDCETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHSPDESVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHVCVARPPLFRVDAPARGKKAA
QKLYALDDGELEAILDKLRKDGVRETQWSISRFKGLGEMSAEQLWDTTMNPDTRRLMPVKLGELDYEATVARMTMLMGKG
EAAARRGWLEEKGNDVEADI
>Mature_659_residues
STKKPSAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGKQITVTLHADQSVSVEDDGRGIPF
GMHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALATRLDVTVWRDGKIAELGFAEGDVVKPLATQ
GAGRGEKKSGTRVQVWPNPKYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKSGERQTWKYEDGLRGYLLDEMNGSEL
LIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPKG
VKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFSRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQ
KVEKRKSSGVAVLPGKLTDCETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHDI
SVAIGVDPHSPDESVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHVCVARPPLFRVDAPARGKKAAQ
KLYALDDGELEAILDKLRKDGVRETQWSISRFKGLGEMSAEQLWDTTMNPDTRRLMPVKLGELDYEATVARMTMLMGKGE
AAARRGWLEEKGNDVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=644, Percent_Identity=23.7577639751553, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI19913406, Length=648, Percent_Identity=23.6111111111111, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1789408, Length=655, Percent_Identity=50.2290076335878, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=659, Percent_Identity=36.7223065250379, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17535065, Length=648, Percent_Identity=23.9197530864198, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI212645845, Length=617, Percent_Identity=24.1491085899514, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=213, Percent_Identity=29.5774647887324, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=656, Percent_Identity=25.4573170731707, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI17136538, Length=663, Percent_Identity=25.3393665158371, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72496; Mature: 72365

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKKPSAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGKQI
CCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEE
TVTLHADQSVSVEDDGRGIPFGMHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLH
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
GVGVSVTNALATRLDVTVWRDGKIAELGFAEGDVVKPLATQGAGRGEKKSGTRVQVWPNP
CCCHHHHHHHHHHEEEEEECCCCEEECCCCCCCCCCHHHHCCCCCCCCCCCCEEEECCCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKSGERQTWKYEDGLRGYLLDEMNGSE
CCCCCCCCCHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCEECCCCCCEEEEECCCCCE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGL
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHH
RDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KLVSSFSRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQKVEKRKSSGVAVLPGKLTD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
CETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
CCCHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEEE
ISVAIGVDPHSPDESVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHV
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
CVARPPLFRVDAPARGKKAAQKLYALDDGELEAILDKLRKDGVRETQWSISRFKGLGEMS
EEECCCCEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
AEQLWDTTMNPDTRRLMPVKLGELDYEATVARMTMLMGKGEAAARRGWLEEKGNDVEADI
HHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCCHHHCCCCCCCCC
>Mature Secondary Structure 
STKKPSAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGYGKQI
CCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEE
TVTLHADQSVSVEDDGRGIPFGMHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLH
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
GVGVSVTNALATRLDVTVWRDGKIAELGFAEGDVVKPLATQGAGRGEKKSGTRVQVWPNP
CCCHHHHHHHHHHEEEEEECCCCEEECCCCCCCCCCHHHHCCCCCCCCCCCCEEEECCCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVVLVNEKSGERQTWKYEDGLRGYLLDEMNGSE
CCCCCCCCCHHHHHHHHHHCCEECCCEEEEEEECCCCCCCCEECCCCCCEEEEECCCCCE
LLIPLFEGERFADSRSGDDTFAEGEGASWVVAWSEEGSLVRESYVNLIPTPAGGTHESGL
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHH
RDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KLVSSFSRPALELWLNQHVEHGKKLAELVIKQAQARTRAGQKVEKRKSSGVAVLPGKLTD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
CETEDIARNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
CCCHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEEE
ISVAIGVDPHSPDESVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHV
EEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
CVARPPLFRVDAPARGKKAAQKLYALDDGELEAILDKLRKDGVRETQWSISRFKGLGEMS
EEECCCCEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
AEQLWDTTMNPDTRRLMPVKLGELDYEATVARMTMLMGKGEAAARRGWLEEKGNDVEADI
HHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]