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The map label for this gene is acsA [H]

Identifier: 78066989

GI number: 78066989

Start: 2614145

End: 2616127

Strand: Reverse

Name: acsA [H]

Synonym: Bcep18194_A5520

Alternate gene names: 78066989

Gene position: 2616127-2614145 (Counterclockwise)

Preceding gene: 78066999

Following gene: 78066988

Centisome position: 70.82

GC content: 66.41

Gene sequence:

>1983_bases
ATGTCTGCGATTGAATCGGTTCTTCACGAAACCCGTCAGTTTGCGCCGCCCGCGGCGCTCGAACAGGCGGCGACCATTTC
CGGCATGCCGGCCTACCGTGCGCTCGCCGCCGAGGCCGAGAACGATTACGAAGGATTCTGGGCGCGTCTCGCGCGCGAGG
GTCTTGCGTGGCACAAGCCGTTCACGAAAGTGCTCGACGAGTCCAACGCGCCGTTCTACAAGTGGTTCGAGGACGGCGAG
CTGAACGCGTCGTACAACTGCCTCGACCGTCACGTCGAAGCCGGCAACGGCGAGCGCGTCGCGGTGATCTTCGAAGCCGA
CGACGGTACCGTCACGCGCGTCACCTATGCAGATCTCCTCGCGCGCGTATCGCGTTTCGCGAATGCATTGAAGAAGCGCG
GGATCGGCAAGGGCGACCGCGTCGTCATCTATATCCCGATGTCGATCGAAGGCATCGTCGCGATGCAGGCCTGCGCGCGC
ATCGGCGCGACGCACTCGGTCGTGTTCGGCGGCTTCTCCGCGAAGTCGTTGAACGAGCGGCTCGTCGACGTCGGCGCAAC
GGCGCTCATCACGGCCGACGAACAGGCGCGCGGCGGCAAGACGCTGCCGCTGAAGAGCATCGCGGATGAAGCGATCGCGC
TGGGCGGCTGCGAAGCCGTGAAGAGCGTGATCGTCTATCGCCGCACCGGCGGCAAGATCGACTGGCACGCCGAGCGCGAC
CTGTGGATGCACGAACTGACGGCCGGCGAATCGGACCAGTGCGAGCCGGAATGGGTCGGCGCCGAGCATCCGCTGTTCAT
CCTGTATACGTCGGGCTCGACCGGCAAGCCGAAGGGCGTGCAGCACAGCACGGGCGGCTACCTGCTGTGGGCCGCGCAGA
CGATGAAGTGGACCTTCGACTGGAAGCCCACCGACGTGTTCTGGTGCACGGCCGACATCGGCTGGGTCACGGGCCACACG
TACATCACGTACGGCCCGCTCGCATGCGGCGGCACGCAGGTCGTGTTCGAAGGCGTGCCGACCTACCCGGACGCCGGCCG
CTTCTGGAAGATGATCGGCGACCACAAGGTCACCGTGTTCTACACCGCGCCGACCGCGATCCGTTCGCTGATCAAGGCGG
CCGAGGCCGACGACAAGGTGCATCCGAAGAGCTACGACCTGTCGAGCCTGCGCATCATCGGCACCGTCGGCGAGCCGATC
AATCCGGAAGCATGGATGTGGTATCACAAGCACGTCGGCCAGGAGCGCTGCCCGATCGTCGACACGTGGTGGCAGACCGA
GACGGGCGGCCACATGATCACGCCGCTGCCGGGCGCGACGCCGACCGTGCCCGGTTCGTGCACGCTGCCGTTGCCCGGCA
TCATGGCCGCGGTGGTCGATGAAACCGGCCAGGACGTGCCGAACGGGCAGGGCGGCATCCTCGTCGTCAAGCGTCCGTGG
CCCGCGATGATCCGCACGATCTGGGGCGACCCGGAGCGTTTCAAGAAGAGTTACTACCCCGAGGAACTCGGCGGGCGGCT
GTATCTGGCCGGCGACGGCACCGTGCGCGACAAGGACACCGGCTACTTCACGATCATGGGCCGGATCGACGATGTGCTGA
ACGTGTCGGGCCACCGGCTCGGCACGATGGAAATCGAATCGGCGCTGGTCTCGCACGAACTCGTGGCCGAGGCGGCTGTG
GTCGGCCGTCCGGACGATACGACGGGCGAGGCGGTGGTCGCGTTCGTGGTGCTGAAGCGTTCGCGTCCGGAAGGCGAGGA
AGCAGCGGCGCTGGCGAAGACGCTGCGCGACTGGGTCGGCAAGCAGATCGGGCCGATCGCGAAGCCGAAGGACATCCGCT
TCGGCGACAACCTGCCGAAGACCCGCTCGGGCAAGATCATGCGGCGCCTGCTGCGTTCGCTCGCGAAGGGTGAAGCGATC
ACGCAGGACACGTCCACGCTCGAGAACCCGGCCATCCTCGATCAGCTCGCCGAAGTGCGCTGA

Upstream 100 bases:

>100_bases
CGGGTGGTAGGAGACAGCGGCGCGCTTGCGCCGGCCAAGACGCGCGGTGCGCACGATCGCGCCGCCATGCAGAGGATTCA
TGTTCACCAAGGGGTAGTCG

Downstream 100 bases:

>100_bases
TCGGTACCGGTTGCGCATCTCGCGCACGAGCCCCTGCGCGGCAATCCCGATTGCCCGCGCAGGGGCTTTTTGTTACATAA
CGGCATGACCGTTCCGACCC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSAIESVLHETRQFAPPAALEQAATISGMPAYRALAAEAENDYEGFWARLAREGLAWHKPFTKVLDESNAPFYKWFEDGE
LNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACAR
IGATHSVVFGGFSAKSLNERLVDVGATALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERD
LWMHELTAGESDQCEPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWVTGHT
YITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPI
NPEAWMWYHKHVGQERCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
PAMIRTIWGDPERFKKSYYPEELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAV
VGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAI
TQDTSTLENPAILDQLAEVR

Sequences:

>Translated_660_residues
MSAIESVLHETRQFAPPAALEQAATISGMPAYRALAAEAENDYEGFWARLAREGLAWHKPFTKVLDESNAPFYKWFEDGE
LNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACAR
IGATHSVVFGGFSAKSLNERLVDVGATALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERD
LWMHELTAGESDQCEPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWVTGHT
YITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPI
NPEAWMWYHKHVGQERCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
PAMIRTIWGDPERFKKSYYPEELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAV
VGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAI
TQDTSTLENPAILDQLAEVR
>Mature_659_residues
SAIESVLHETRQFAPPAALEQAATISGMPAYRALAAEAENDYEGFWARLAREGLAWHKPFTKVLDESNAPFYKWFEDGEL
NASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACARI
GATHSVVFGGFSAKSLNERLVDVGATALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERDL
WMHELTAGESDQCEPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWVTGHTY
ITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPIN
PEAWMWYHKHVGQERCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPWP
AMIRTIWGDPERFKKSYYPEELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAVV
GRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAIT
QDTSTLENPAILDQLAEVR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=683, Percent_Identity=47.7306002928258, Blast_Score=611, Evalue=1e-175,
Organism=Homo sapiens, GI253970489, Length=696, Percent_Identity=46.8390804597701, Blast_Score=606, Evalue=1e-173,
Organism=Homo sapiens, GI28416953, Length=635, Percent_Identity=46.2992125984252, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI13375727, Length=636, Percent_Identity=37.5786163522013, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI42544132, Length=532, Percent_Identity=29.6992481203008, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI122937307, Length=601, Percent_Identity=29.1181364392679, Blast_Score=181, Evalue=3e-45,
Organism=Homo sapiens, GI31982927, Length=655, Percent_Identity=25.8015267175572, Blast_Score=181, Evalue=3e-45,
Organism=Homo sapiens, GI38505220, Length=535, Percent_Identity=29.7196261682243, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI58082049, Length=527, Percent_Identity=28.4629981024668, Blast_Score=153, Evalue=6e-37,
Organism=Homo sapiens, GI115511026, Length=594, Percent_Identity=26.7676767676768, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI157311624, Length=507, Percent_Identity=27.810650887574, Blast_Score=143, Evalue=7e-34,
Organism=Homo sapiens, GI157311622, Length=507, Percent_Identity=27.810650887574, Blast_Score=143, Evalue=7e-34,
Organism=Homo sapiens, GI187761345, Length=397, Percent_Identity=27.455919395466, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI187761343, Length=397, Percent_Identity=27.455919395466, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI195947378, Length=420, Percent_Identity=24.5238095238095, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI42544134, Length=324, Percent_Identity=26.5432098765432, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790505, Length=632, Percent_Identity=51.8987341772152, Blast_Score=646, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=627, Percent_Identity=39.7129186602871, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788107, Length=559, Percent_Identity=26.4758497316637, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI145693145, Length=538, Percent_Identity=23.7918215613383, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1786810, Length=557, Percent_Identity=21.903052064632, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982997, Length=666, Percent_Identity=44.5945945945946, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71983001, Length=666, Percent_Identity=44.7447447447448, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17569507, Length=677, Percent_Identity=24.2245199409158, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17558820, Length=540, Percent_Identity=25, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994694, Length=578, Percent_Identity=24.9134948096886, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71994690, Length=578, Percent_Identity=25.2595155709343, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=578, Percent_Identity=24.9134948096886, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=415, Percent_Identity=24.8192771084337, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17557194, Length=568, Percent_Identity=24.1197183098592, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=580, Percent_Identity=24.4827586206897, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=534, Percent_Identity=21.7228464419476, Blast_Score=86, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=48.3670295489891, Blast_Score=577, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319264, Length=665, Percent_Identity=46.3157894736842, Blast_Score=546, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6319699, Length=554, Percent_Identity=23.1046931407942, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667955, Length=673, Percent_Identity=46.8053491827637, Blast_Score=587, Evalue=1e-168,
Organism=Drosophila melanogaster, GI62472339, Length=560, Percent_Identity=50.1785714285714, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24667959, Length=529, Percent_Identity=49.3383742911153, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI21355225, Length=645, Percent_Identity=34.8837209302326, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI21355181, Length=521, Percent_Identity=24.7600767754319, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581924, Length=551, Percent_Identity=24.3194192377495, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72196; Mature: 72065

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIESVLHETRQFAPPAALEQAATISGMPAYRALAAEAENDYEGFWARLAREGLAWHKP
CHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCHHCCC
FTKVLDESNAPFYKWFEDGELNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLL
HHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACARIGATHSVVFGGFSAKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LVDVGATALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERD
HHHCCCEEEEECCHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHEEEECCCCEEEEECCCC
LWMHELTAGESDQCEPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFD
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEEEC
WKPTDVFWCTADIGWVTGHTYITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVF
CCCCEEEEEECCCCEEECCEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEE
YTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPINPEAWMWYHKHVGQERCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEHHHHHCCCCCCCEE
DTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFKKSYYPEELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHCCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSHELVAEAAVVGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHCCCCCCHHHHHHHHHHHHHHH
KQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILDQLAEVR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SAIESVLHETRQFAPPAALEQAATISGMPAYRALAAEAENDYEGFWARLAREGLAWHKP
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCHHCCC
FTKVLDESNAPFYKWFEDGELNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLL
HHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACARIGATHSVVFGGFSAKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LVDVGATALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERD
HHHCCCEEEEECCHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHEEEECCCCEEEEECCCC
LWMHELTAGESDQCEPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFD
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEEEC
WKPTDVFWCTADIGWVTGHTYITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVF
CCCCEEEEEECCCCEEECCEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEE
YTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPINPEAWMWYHKHVGQERCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEHHHHHCCCCCCCEE
DTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFKKSYYPEELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHCCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSHELVAEAAVVGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHCCCCCCHHHHHHHHHHHHHHH
KQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILDQLAEVR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA