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The map label for this gene is comA [H]

Identifier: 78066886

GI number: 78066886

Start: 2484297

End: 2486789

Strand: Reverse

Name: comA [H]

Synonym: Bcep18194_A5417

Alternate gene names: 78066886

Gene position: 2486789-2484297 (Counterclockwise)

Preceding gene: 78066887

Following gene: 78066885

Centisome position: 67.32

GC content: 72.32

Gene sequence:

>2493_bases
ATGCGCGTGTGGTGGATCGCGTTCGCGCTCGGCGTGGTCGTGCTGCAGCGGCAGGCGGCGTTGCCGGGTGCGCTCGCATG
GACGATCGGTGCAGCCGTGCTCGCAGGCTGCGTGGTGCTCGGCACGTGGAGCATGCGTGGCCGGCGCACGCGTACGACCG
TCGCGTTCGGATGGATGCTGTGCGCGCTCGCGGCCTGTGACGTCGGGTTTGGCTATGCAGCTGCGCGGGCCGAATGGCGG
CTGGGCGACAACCTGCCCGTCGAGTGGGAAGGGCGCGACATCGTCGTCACCGGCGTGATCCGGGGGCTGCCCGTGGTCGA
CGAGACAGGCGCGCGGTTGCTGTTCGCGGTCGAGTCGAACGATGCGGGGCTGGCCCGCTTTCCGCCGTTGATCCGGCTGT
CGTGGCGTGCATATGGCGCATCGGCGACACGCGATCCACTGCCTGATTTGCGCGCCGCGCAACGCTGGCGATTCGTCGTG
CGACTGAAGCGCCCGCATGCCGAGGCCAATCCGGGTGTGCGCGACAGCGAGGCGGCGTGGCTGGCCGCCGGCATTCGCGC
GATCGGTTATGTCAGCGCGCCCCGGCGGGCGGAATTGATCGATGCGCGCGCATCGGGATGGCGTGCATCGATCGATCGGC
TGCGCGACGCGCTGCGCTCGCGTATCGGCGAGACGCTCGGCAGCGACGCCGGCCATCGCGGCATCGTCGCCGCGCTCGCG
ATCGGCGATCAGTCGGGCATCGGCGATGACGACTGGCGCGTGCTGCGCAGCACGGGTACGAGCCATCTGGTCGCAATTTC
GGGCCTGCATGTCGGGCTCGTCGGTGCGATCGCAGGCGGGCTCGTATCGATGGTCTGGCGCCGCCTGCGCTGGCGCGCAC
GGGCCGCGACGCTGATGTTGCCGGCACCGTACGCGGCCGCGCTCGCCGCGCTGGCGGCCGCGGCCGGCTACGCGGCGCTC
GCCGGCTTCAACGTGCCGGCGCAGCGCGCGTGGTGGATGATCGCGGCCGGCGGCATCGCGTACCTGGCCGGGCGCAGCGT
ACCGGCTTCCGCGGTGCTGTGCGTGGCGCTCGGTGGCGTGCTGCTTGCCGATCCGTGGGCCGTGCTGTCGGCCGGGTTCT
GGCTGTCGTTCGGGGCGGTTGTCGTGATCCTGCTGGCCGTCGCCGGCTGGCGTGCCGCGCGTGAGGCCGATGCGGAGAGC
GAGGAGGGCGAGGAGGGCGACGGCGCGGCCGGCCTGTCGAGCCGGTTGCGCGCGTGGGGTGCACGCGCCGGACGCCGTAT
TGCAGAGGCCACGCGCGTGCAGTACGCGGTGACGATCGGTCTCGCGCCGCTGACGGCCGCATGGTTCGCGCAAGTTTCCC
TGTCGGGCCCGTTCGGCAATGCGTTCGCGATTCCGTGGGTCAGTTCGGTCGTGACGCCGGTCGTGCTGGCCGGCATCGCG
TTGCCTGCGCCGCTCGATGCGTATGCGTTCCGGCTTGCGCACGCGGCGCTCGAACCGATGATGACGTTGCTCGGGCACCT
TGCCGACTGGCCGGCCGGCGTGTTCTGGCTGCGCATGCCGGACTGGCCGACGCTGGTGCTGGCCTGCGTGGGCGTCGCAT
GGGCGTTGATGCCGCGCGGCTGGCCGTTGCGCTGGGCTGCCCCGCTCACGTGGCTGCCGCTCGTCGCGCCGGCTGCCGAT
GCGCCGCCGCCGGGCGGCTTCCGGCTGACCGTTCTCGACGTCGGGCAGGGCGCGTCGGTGCTGGTGGAGACCGCGCGGCG
AACCTTGCTGTTCGACGCCGGGCCGGGTGCGGAGTCGACCCACGCCGGCGCACGGATCGTCGCGCCGGCGTTGCGTGCAC
GCGGCATCGCGGTGATCGATTCGCTCGTGCTCAGTCACGCGGATGCCGATCACGCGGGCGGCGCATCGGCCGTCTATGCC
GTTGCCGACGTGCGTCAGCTGCTGGCCGGCATTGCGCCGGGCAGCCGGCTGTGGCGCGATGCGGCCGCCGCCGGCGTCAC
CGATCAGCTGCCGTGCGCGGCCGGGCAGCGCTGGACCTGGGACGGCGTCACGTTCACGATGCTGTGGCCGCCGGGCGGCC
CGGGCACGGGCTCGTCGAACGGGCAGTCGTGCGTGCTGCGCATCGACGCGGGCGAGACGTCCGCGCTGCTGACGGGCGAC
GTCGACGCGCGCGGCGAACGCCGGCTCGTGGACGCGGCGCGCGACGCGCTGGCCGCACAGATCCTGGTCGTTCCGCACCA
CGGCAGCCGCACGTCGTCGGTTGAGCCTTTCCTCGATTCGGTCGGGCCGCGCGTTGCGGTATTTCCTGTAGGCTATCGCA
ATCGATTCGGACATCCGCACCGGACGGTTCTCGCCCGTTACGAGGCGCGCGGGATCCCGCTGCCGCGCACCGATCGCGAC
GGCGCCGTGCGGTTCGACGTCGCGCCGGCTAACGGCGGGTTTGCCTTCGAGCGTCATCGCGACGTTCGGCGACGGTACTG
GATGGATCGATGA

Upstream 100 bases:

>100_bases
CGCGCTCGCCGCGCTGCCGCGACTCGCACTTTCGTCCGCATAATCGTTGCCGGAAGGCGCCGCATGCTCAAGGGCGGTGC
CGGGTCGACGAGGAGGGGCG

Downstream 100 bases:

>100_bases
GCGCGGCGAGAGCCCGCGTATCAGGAAACAAGGCCCGGGACCCGCGCACAATACCGAAGCGTGAGCCCGGCAGAACGCGA
AGCATAAGACCGGAGTGAGC

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 830; Mature: 830

Protein sequence:

>830_residues
MRVWWIAFALGVVVLQRQAALPGALAWTIGAAVLAGCVVLGTWSMRGRRTRTTVAFGWMLCALAACDVGFGYAAARAEWR
LGDNLPVEWEGRDIVVTGVIRGLPVVDETGARLLFAVESNDAGLARFPPLIRLSWRAYGASATRDPLPDLRAAQRWRFVV
RLKRPHAEANPGVRDSEAAWLAAGIRAIGYVSAPRRAELIDARASGWRASIDRLRDALRSRIGETLGSDAGHRGIVAALA
IGDQSGIGDDDWRVLRSTGTSHLVAISGLHVGLVGAIAGGLVSMVWRRLRWRARAATLMLPAPYAAALAALAAAAGYAAL
AGFNVPAQRAWWMIAAGGIAYLAGRSVPASAVLCVALGGVLLADPWAVLSAGFWLSFGAVVVILLAVAGWRAAREADAES
EEGEEGDGAAGLSSRLRAWGARAGRRIAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIA
LPAPLDAYAFRLAHAALEPMMTLLGHLADWPAGVFWLRMPDWPTLVLACVGVAWALMPRGWPLRWAAPLTWLPLVAPAAD
APPPGGFRLTVLDVGQGASVLVETARRTLLFDAGPGAESTHAGARIVAPALRARGIAVIDSLVLSHADADHAGGASAVYA
VADVRQLLAGIAPGSRLWRDAAAAGVTDQLPCAAGQRWTWDGVTFTMLWPPGGPGTGSSNGQSCVLRIDAGETSALLTGD
VDARGERRLVDAARDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPHRTVLARYEARGIPLPRTDRD
GAVRFDVAPANGGFAFERHRDVRRRYWMDR

Sequences:

>Translated_830_residues
MRVWWIAFALGVVVLQRQAALPGALAWTIGAAVLAGCVVLGTWSMRGRRTRTTVAFGWMLCALAACDVGFGYAAARAEWR
LGDNLPVEWEGRDIVVTGVIRGLPVVDETGARLLFAVESNDAGLARFPPLIRLSWRAYGASATRDPLPDLRAAQRWRFVV
RLKRPHAEANPGVRDSEAAWLAAGIRAIGYVSAPRRAELIDARASGWRASIDRLRDALRSRIGETLGSDAGHRGIVAALA
IGDQSGIGDDDWRVLRSTGTSHLVAISGLHVGLVGAIAGGLVSMVWRRLRWRARAATLMLPAPYAAALAALAAAAGYAAL
AGFNVPAQRAWWMIAAGGIAYLAGRSVPASAVLCVALGGVLLADPWAVLSAGFWLSFGAVVVILLAVAGWRAAREADAES
EEGEEGDGAAGLSSRLRAWGARAGRRIAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIA
LPAPLDAYAFRLAHAALEPMMTLLGHLADWPAGVFWLRMPDWPTLVLACVGVAWALMPRGWPLRWAAPLTWLPLVAPAAD
APPPGGFRLTVLDVGQGASVLVETARRTLLFDAGPGAESTHAGARIVAPALRARGIAVIDSLVLSHADADHAGGASAVYA
VADVRQLLAGIAPGSRLWRDAAAAGVTDQLPCAAGQRWTWDGVTFTMLWPPGGPGTGSSNGQSCVLRIDAGETSALLTGD
VDARGERRLVDAARDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPHRTVLARYEARGIPLPRTDRD
GAVRFDVAPANGGFAFERHRDVRRRYWMDR
>Mature_830_residues
MRVWWIAFALGVVVLQRQAALPGALAWTIGAAVLAGCVVLGTWSMRGRRTRTTVAFGWMLCALAACDVGFGYAAARAEWR
LGDNLPVEWEGRDIVVTGVIRGLPVVDETGARLLFAVESNDAGLARFPPLIRLSWRAYGASATRDPLPDLRAAQRWRFVV
RLKRPHAEANPGVRDSEAAWLAAGIRAIGYVSAPRRAELIDARASGWRASIDRLRDALRSRIGETLGSDAGHRGIVAALA
IGDQSGIGDDDWRVLRSTGTSHLVAISGLHVGLVGAIAGGLVSMVWRRLRWRARAATLMLPAPYAAALAALAAAAGYAAL
AGFNVPAQRAWWMIAAGGIAYLAGRSVPASAVLCVALGGVLLADPWAVLSAGFWLSFGAVVVILLAVAGWRAAREADAES
EEGEEGDGAAGLSSRLRAWGARAGRRIAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIA
LPAPLDAYAFRLAHAALEPMMTLLGHLADWPAGVFWLRMPDWPTLVLACVGVAWALMPRGWPLRWAAPLTWLPLVAPAAD
APPPGGFRLTVLDVGQGASVLVETARRTLLFDAGPGAESTHAGARIVAPALRARGIAVIDSLVLSHADADHAGGASAVYA
VADVRQLLAGIAPGSRLWRDAAAAGVTDQLPCAAGQRWTWDGVTFTMLWPPGGPGTGSSNGQSCVLRIDAGETSALLTGD
VDARGERRLVDAARDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPHRTVLARYEARGIPLPRTDRD
GAVRFDVAPANGGFAFERHRDVRRRYWMDR

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=690, Percent_Identity=26.0869565217391, Blast_Score=190, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 87849; Mature: 87849

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVWWIAFALGVVVLQRQAALPGALAWTIGAAVLAGCVVLGTWSMRGRRTRTTVAFGWML
CEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
CALAACDVGFGYAAARAEWRLGDNLPVEWEGRDIVVTGVIRGLPVVDETGARLLFAVESN
HHHHHHHCCCCHHHHCCCEECCCCCCEEECCCEEEEEEHHCCCCCEECCCCEEEEEEECC
DAGLARFPPLIRLSWRAYGASATRDPLPDLRAAQRWRFVVRLKRPHAEANPGVRDSEAAW
CCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHEEEEEEEECCCCCCCCCCCCCCHHH
LAAGIRAIGYVSAPRRAELIDARASGWRASIDRLRDALRSRIGETLGSDAGHRGIVAALA
HHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
IGDQSGIGDDDWRVLRSTGTSHLVAISGLHVGLVGAIAGGLVSMVWRRLRWRARAATLML
ECCCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
PAPYAAALAALAAAAGYAALAGFNVPAQRAWWMIAAGGIAYLAGRSVPASAVLCVALGGV
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCHHEECCCCCCHHHHHHHHHCCH
LLADPWAVLSAGFWLSFGAVVVILLAVAGWRAAREADAESEEGEEGDGAAGLSSRLRAWG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
ARAGRRIAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIA
HHHHHHHHHHHHEEEEEEECCHHHHHHHHHEEEECCCCCCEEEHHHHHHHHHHHHHHHHC
LPAPLDAYAFRLAHAALEPMMTLLGHLADWPAGVFWLRMPDWPTLVLACVGVAWALMPRG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
WPLRWAAPLTWLPLVAPAADAPPPGGFRLTVLDVGQGASVLVETARRTLLFDAGPGAEST
CCCEECCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHEEEEECCCCCCCC
HAGARIVAPALRARGIAVIDSLVLSHADADHAGGASAVYAVADVRQLLAGIAPGSRLWRD
CCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
AAAAGVTDQLPCAAGQRWTWDGVTFTMLWPPGGPGTGSSNGQSCVLRIDAGETSALLTGD
HHHCCCCCCCCCCCCCCEEECCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEEECC
VDARGERRLVDAARDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPH
CCCCCCHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHCCCCEEEEEECCHHHCCCCCH
RTVLARYEARGIPLPRTDRDGAVRFDVAPANGGFAFERHRDVRRRYWMDR
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVWWIAFALGVVVLQRQAALPGALAWTIGAAVLAGCVVLGTWSMRGRRTRTTVAFGWML
CEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
CALAACDVGFGYAAARAEWRLGDNLPVEWEGRDIVVTGVIRGLPVVDETGARLLFAVESN
HHHHHHHCCCCHHHHCCCEECCCCCCEEECCCEEEEEEHHCCCCCEECCCCEEEEEEECC
DAGLARFPPLIRLSWRAYGASATRDPLPDLRAAQRWRFVVRLKRPHAEANPGVRDSEAAW
CCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHEEEEEEEECCCCCCCCCCCCCCHHH
LAAGIRAIGYVSAPRRAELIDARASGWRASIDRLRDALRSRIGETLGSDAGHRGIVAALA
HHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
IGDQSGIGDDDWRVLRSTGTSHLVAISGLHVGLVGAIAGGLVSMVWRRLRWRARAATLML
ECCCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
PAPYAAALAALAAAAGYAALAGFNVPAQRAWWMIAAGGIAYLAGRSVPASAVLCVALGGV
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCHHEECCCCCCHHHHHHHHHCCH
LLADPWAVLSAGFWLSFGAVVVILLAVAGWRAAREADAESEEGEEGDGAAGLSSRLRAWG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
ARAGRRIAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIA
HHHHHHHHHHHHEEEEEEECCHHHHHHHHHEEEECCCCCCEEEHHHHHHHHHHHHHHHHC
LPAPLDAYAFRLAHAALEPMMTLLGHLADWPAGVFWLRMPDWPTLVLACVGVAWALMPRG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
WPLRWAAPLTWLPLVAPAADAPPPGGFRLTVLDVGQGASVLVETARRTLLFDAGPGAEST
CCCEECCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHEEEEECCCCCCCC
HAGARIVAPALRARGIAVIDSLVLSHADADHAGGASAVYAVADVRQLLAGIAPGSRLWRD
CCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
AAAAGVTDQLPCAAGQRWTWDGVTFTMLWPPGGPGTGSSNGQSCVLRIDAGETSALLTGD
HHHCCCCCCCCCCCCCCEEECCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEEECC
VDARGERRLVDAARDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPH
CCCCCCHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHCCCCEEEEEECCHHHCCCCCH
RTVLARYEARGIPLPRTDRDGAVRFDVAPANGGFAFERHRDVRRRYWMDR
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]