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The map label for this gene is mdtG [H]

Identifier: 78066338

GI number: 78066338

Start: 1886905

End: 1888161

Strand: Direct

Name: mdtG [H]

Synonym: Bcep18194_A4868

Alternate gene names: 78066338

Gene position: 1886905-1888161 (Clockwise)

Preceding gene: 78066337

Following gene: 78066339

Centisome position: 51.08

GC content: 69.53

Gene sequence:

>1257_bases
ATGAGCACGATCTCGCATGCCCCCGCTGCGGCACTGGCCGAACGGCCCGTCGCCAGCTACGCCGAACGCAACACGCGCTA
CTGGCGGCGCAATCTCGCCGTGTGCGTGTTCGGCTCGTTCACGACGCTCGTCAGCCTGAGCATGCTGCTGCCGTTCCTGC
CGCTGTACGTGCGACAACTCGGCGTCGATGCACAGTCGGCCGTGATCCAGTGGTCGGGCATCGCGTTCGGCGCGACGTTT
CTCGGCACGGCCGTTACCGCGCCGCTGTGGGGCCGCCTCGCGGACCGCTTCGGTCGCAAGCCGATGCTCGTGCGCGCAGC
GATCGGCATGGCGATCGTGATGTCGCTGATCGGCGTCGCGCACAACGTGGTCGAACTCGTCGCGCTGCGGCTGCTTGCCG
GGCTCGTCGGCGGCTACGCGTCGGCGTCGACTGTAATGGTCGGCACGCAGGCACCGCGCGAGCGCGCGGGCTGGGCGCTC
GGCATCCTGTCGACCGGTGCGCTTGCGGGCAACCTGGTCGGGCCGCTCGTCGGCGGGTTGCTGCCGGACTGGCTCGGCAT
TCGCGGCACGTTCTTTGCCGGTGGCGCGATGATCGCCGTCGCCGCGCTGTTGACGATCTTCGTCGTGAAGGAAGACTTCC
ACGCGGGCACCGATGCGAGAACGCGCACCTCGAGCGCCGCGGCCGGCACGCCGCACCGCACGAATCGCGCGGCGGTTGCC
GCACTGCTGGTGACGGCGATGATGGTGCTGCTCGCGAACATGTCGATCGAGCCGATCATCACCGTGTATATCGGCGGCCT
CGGCGTGGGCGGCGACCACCTCGCGCGCATCGCCGGCGTCGTGATGGCATGTTCGGCATTCGGCAGCATGCTGACCGCCG
CACGGCTCGGCGCACTGGCCGACCGGATCGGCAGCTGGAACGTGATCATCGGCTGCCTGTTGCTGACCGCGCTCGCGATG
GTGCCGCAGGCGTTCGTCACGCACTGGTGGCAGCTTGCCGCGCTGCGCGGGTTGATGGGCATGACGCTCGCGGGGTTGCT
GCCGTCGATCGGCAAGCTCGTGCGGCAATCGGTCGACGAGCGCGCGACCGGGCAGATGCTCGGCTACCTGCAGTCCGCGC
AGTTCAGCGGACAGGTGATCGGCCCGGTGATCGGCGGACAGATCGGCGTCGCGCTCGGGCTGCATTCGGTGTTCTTCGTG
ACCGGTGCGCTGCTGGCGGTTTGCGCGGGGCTCGCGCACTGGGCACGCGGCCGATAG

Upstream 100 bases:

>100_bases
TGTCCGGCATCGGCATTGCCCGTTTCGCATGTGTGCCGTCATCGGCAATCTTCGTCACGCCGGGGCTTCCCGCACCGCTG
ACCGCGACAGGGAGCGCGCA

Downstream 100 bases:

>100_bases
CGGCTGGCCGGCGGATCGCGGGCTGGCGTAGGATGGGCGCAGATGCGGTGTCGCGCCGGGCAGCGGCGACGACACACACC
GGCGCGACAGTTGCAGACAC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSTISHAPAAALAERPVASYAERNTRYWRRNLAVCVFGSFTTLVSLSMLLPFLPLYVRQLGVDAQSAVIQWSGIAFGATF
LGTAVTAPLWGRLADRFGRKPMLVRAAIGMAIVMSLIGVAHNVVELVALRLLAGLVGGYASASTVMVGTQAPRERAGWAL
GILSTGALAGNLVGPLVGGLLPDWLGIRGTFFAGGAMIAVAALLTIFVVKEDFHAGTDARTRTSSAAAGTPHRTNRAAVA
ALLVTAMMVLLANMSIEPIITVYIGGLGVGGDHLARIAGVVMACSAFGSMLTAARLGALADRIGSWNVIIGCLLLTALAM
VPQAFVTHWWQLAALRGLMGMTLAGLLPSIGKLVRQSVDERATGQMLGYLQSAQFSGQVIGPVIGGQIGVALGLHSVFFV
TGALLAVCAGLAHWARGR

Sequences:

>Translated_418_residues
MSTISHAPAAALAERPVASYAERNTRYWRRNLAVCVFGSFTTLVSLSMLLPFLPLYVRQLGVDAQSAVIQWSGIAFGATF
LGTAVTAPLWGRLADRFGRKPMLVRAAIGMAIVMSLIGVAHNVVELVALRLLAGLVGGYASASTVMVGTQAPRERAGWAL
GILSTGALAGNLVGPLVGGLLPDWLGIRGTFFAGGAMIAVAALLTIFVVKEDFHAGTDARTRTSSAAAGTPHRTNRAAVA
ALLVTAMMVLLANMSIEPIITVYIGGLGVGGDHLARIAGVVMACSAFGSMLTAARLGALADRIGSWNVIIGCLLLTALAM
VPQAFVTHWWQLAALRGLMGMTLAGLLPSIGKLVRQSVDERATGQMLGYLQSAQFSGQVIGPVIGGQIGVALGLHSVFFV
TGALLAVCAGLAHWARGR
>Mature_417_residues
STISHAPAAALAERPVASYAERNTRYWRRNLAVCVFGSFTTLVSLSMLLPFLPLYVRQLGVDAQSAVIQWSGIAFGATFL
GTAVTAPLWGRLADRFGRKPMLVRAAIGMAIVMSLIGVAHNVVELVALRLLAGLVGGYASASTVMVGTQAPRERAGWALG
ILSTGALAGNLVGPLVGGLLPDWLGIRGTFFAGGAMIAVAALLTIFVVKEDFHAGTDARTRTSSAAAGTPHRTNRAAVAA
LLVTAMMVLLANMSIEPIITVYIGGLGVGGDHLARIAGVVMACSAFGSMLTAARLGALADRIGSWNVIIGCLLLTALAMV
PQAFVTHWWQLAALRGLMGMTLAGLLPSIGKLVRQSVDERATGQMLGYLQSAQFSGQVIGPVIGGQIGVALGLHSVFFVT
GALLAVCAGLAHWARGR

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=384, Percent_Identity=39.0625, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI87082404, Length=338, Percent_Identity=22.7810650887574, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319871, Length=147, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43379; Mature: 43248

Theoretical pI: Translated: 11.21; Mature: 11.21

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTISHAPAAALAERPVASYAERNTRYWRRNLAVCVFGSFTTLVSLSMLLPFLPLYVRQL
CCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHH
GVDAQSAVIQWSGIAFGATFLGTAVTAPLWGRLADRFGRKPMLVRAAIGMAIVMSLIGVA
CCCHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
HNVVELVALRLLAGLVGGYASASTVMVGTQAPRERAGWALGILSTGALAGNLVGPLVGGL
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHCCEEEHHHHHHHHHHHHHHHHHHHH
LPDWLGIRGTFFAGGAMIAVAALLTIFVVKEDFHAGTDARTRTSSAAAGTPHRTNRAAVA
HHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
ALLVTAMMVLLANMSIEPIITVYIGGLGVGGDHLARIAGVVMACSAFGSMLTAARLGALA
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRIGSWNVIIGCLLLTALAMVPQAFVTHWWQLAALRGLMGMTLAGLLPSIGKLVRQSVDE
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RATGQMLGYLQSAQFSGQVIGPVIGGQIGVALGLHSVFFVTGALLAVCAGLAHWARGR
HHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STISHAPAAALAERPVASYAERNTRYWRRNLAVCVFGSFTTLVSLSMLLPFLPLYVRQL
CCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHH
GVDAQSAVIQWSGIAFGATFLGTAVTAPLWGRLADRFGRKPMLVRAAIGMAIVMSLIGVA
CCCHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
HNVVELVALRLLAGLVGGYASASTVMVGTQAPRERAGWALGILSTGALAGNLVGPLVGGL
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHCCEEEHHHHHHHHHHHHHHHHHHHH
LPDWLGIRGTFFAGGAMIAVAALLTIFVVKEDFHAGTDARTRTSSAAAGTPHRTNRAAVA
HHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
ALLVTAMMVLLANMSIEPIITVYIGGLGVGGDHLARIAGVVMACSAFGSMLTAARLGALA
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRIGSWNVIIGCLLLTALAMVPQAFVTHWWQLAALRGLMGMTLAGLLPSIGKLVRQSVDE
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RATGQMLGYLQSAQFSGQVIGPVIGGQIGVALGLHSVFFVTGALLAVCAGLAHWARGR
HHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA