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The map label for this gene is uvrD [H]

Identifier: 78066057

GI number: 78066057

Start: 1564393

End: 1566756

Strand: Direct

Name: uvrD [H]

Synonym: Bcep18194_A4586

Alternate gene names: 78066057

Gene position: 1564393-1566756 (Clockwise)

Preceding gene: 78066054

Following gene: 78066058

Centisome position: 42.35

GC content: 66.75

Gene sequence:

>2364_bases
ATGCCCGACCTGCTCGCCAATCTGAACCCCGAACAACTCGCCGCCGTCACGTTGCCGAACGAACCGGCGCTGATCCTTGC
AGGGGCGGGCAGCGGCAAGACCCGCGTGCTGATCACCCGCATCGCGTGGCTGATCAAGCAGGGCTACGCATCGCCGCCCA
CCGTGCTCGCCGTGACCTTCACGAACAAGGCCGCGCGCGAGATGATGGCGCGCCTGTCGGCGATGATGCCGATCGACACG
CGCGGGATGTGGATCGGCACGTTCCACGGCCTGTGCAACCGGATGCTGCGCACGCACTGGCGTGACGCCGGCCTGCCGCA
GACCTTCCAGATCCTCGATACGGCCGACCAGCTGTCCGCGATCAAGCGGCTGATGAAGGCGGCGAACGTCGATGATGAAA
AGTACCCGCCGAAGAACGTGCAGTACTTCATCAACAATGCGAAGGAGCAAGGGCTGCGTCCCGACAAGGTCGACGCATCC
GACAACTTCAACCGCAAGTTCGTCGAGCTGTACCAGGCATACGACCAGCAGTGCCAGCGCGAGGGCGTCGTCGATTTCCC
CGAACTGCTGCTGCGCTGCTACGAACTGCTCGCGTACAACGCGCCGCTGCGCGCGCACTACCAGGCGCGCTTCCGGCACA
TCCTCGTCGACGAGTTCCAGGACACCAACAAGCTGCAGTATGCGTGGCTCAAGATGCTCGCGGGCGGCGAGAACGCGATC
TTTGCGGTCGGCGACGACGACCAGTCGATCTACGCGTTCCGCGGCGCGAACGTCGGCAACATGCGCGACTTCGAAGACGA
ATTCCGCGTGCGCAACCTGATCAAGCTCGAGCAGAACTACCGGTCGCACGGCAACATTCTCGACGCGGCGAACCAGCTGA
TCTCGAACAACGCGCACCGTCTCGGCAAGAACCTGCGTACCGACGCCGGCCACGGCGAGCCCGTGCGCGTGTACGAGGCG
AGCACCGATTCGCAGGAAGCCGGCTGGATCGTCGAGGAGATCCGCTCGCTGATCAACACCGGGATGGCGCGTAGCGAAGT
GGCCGTCCTGTACCGCAGCAACGCGCAGTCGCGCTCGATCGAGCACACGCTGATGTCGTCCGGCATCCCGTACCGCGTGT
ACGGCGGCCTGCGCTTCTTCGAGCGCCAGGAAGTGAAGCACGCGCTCGCGTACCTGCGCCTGATCGACAACCCGAACGAC
GACACCGCGTTCGTGCGCGTCGTGAACTTCCCGACCCGCGGCATCGGCGCGCGCTCGATCGAGCAGCTGGCCGACGCCGC
GCGCCTGTACGGCTGCTCGATGGCCGCCGCGATTCCGTACGTGACGGGCAAGGCCGGCACGAGCCTCGGCGGGTTCGCGA
ACCTGGTCGCGAAGATGCGCGCCGATACGCAGCACATGAACTTGCCCGACACCGTCGAGCACATCGTGCGCGCCAGCGGT
CTCGCCGATTTCTACCAGGGCGAGCGCGAAGGCCAGGACCGTCTCGAGAACTTGCAGGAACTGGTCAACGCGGCCACCGC
GTTCATCGCCGAGGAAGGCTACGGGCTCGACACGCCGGCCCGTTCGATCCCGCTGCGCGCAGGCGCAATTGCGGCGCCCG
AGCTCGGCACCGCGACGGACGATCCGGCGGTCGACGTGCTCGATCCGGTGTCGCCTGCCGACCCGGCACAGAACCCCGAC
ACGATGACGCCGCTCGCCGGCTTCCTGTCGCATGCGTCGCTGGAGGCCGGCGACAACCAGGCGCAGGCCGGGCAGGACGC
CGTGCAACTGATGACGGTGCACGCGGCGAAGGGGCTCGAATTCTCGGCCGTGTTCATCACGGGCCTCGAGGAAGGGCTGT
TCCCGCATGAGAACAGCGTGCTCGAATCGGACGGCCTCGAGGAAGAGCGCCGGCTGATGTACGTCGCGATCACGCGCGCG
AAGGAGCGGCTCTACCTGTCGTTCGCGCAGAGCCGGATGCTGCACGGCCAGACGCGCTACAACGTGCGCTCGCGTTTCTT
CGACGAACTGCCCGAACACGTGCTCAAGTGGCTGACGCCGAAGGTCGAGGCCGGTTCGCGCTGGGGCGGTCGGTCGGACA
ACGCCGGGTACGGGCGCGACTGGTTCGCGCGGCCGGGTGGCGGCAGTCGCGAGCAGATCGTCGATCCGGCCGTATCCGCG
CCGTTGCCCGCGTTCGCGAACAAGCAGCGCGCGGCCGATGCCGGTTTCCGGGTCGGCCAGCAGGTGTTCCACACCAAGTT
CGGCGAAGGCACGGTCACCGCGCTCGAGGGCAACGGCACCGATGCGAAGGCGCAGGTGAAATTCAAGCGGCACGGCGAGA
AGTGGCTCGCGCTGGCGGTCGCGAAACTGCAGGCGGTGGAATGA

Upstream 100 bases:

>100_bases
CGCGCGCTTGCGACGTGCTGTCGAACGGATCGGGAACAGCATCGCGCGGCCGACTTATAATGTCGGGTCCGCATTTTTCT
CGCCCGTTCGCTGCCGCTCC

Downstream 100 bases:

>100_bases
TGAGCATCGACATGATGGGTACGGTTTCGACGCGTCCGCTCGGCATTCTGGCTGCGCTGCCCGAGGAACTCGGCGACCTG
ATCGCCACGATGCGCGCCGA

Product: ATP-dependent DNA helicase UvrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 787; Mature: 786

Protein sequence:

>787_residues
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIKQGYASPPTVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDAS
DNFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAI
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEA
STDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSIEHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFVRVVNFPTRGIGARSIEQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLVAKMRADTQHMNLPDTVEHIVRASG
LADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATDDPAVDVLDPVSPADPAQNPD
TMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDPAVSA
PLPAFANKQRAADAGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Sequences:

>Translated_787_residues
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIKQGYASPPTVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDAS
DNFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAI
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEA
STDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSIEHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFVRVVNFPTRGIGARSIEQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLVAKMRADTQHMNLPDTVEHIVRASG
LADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATDDPAVDVLDPVSPADPAQNPD
TMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDPAVSA
PLPAFANKQRAADAGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAVAKLQAVE
>Mature_786_residues
PDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIKQGYASPPTVLAVTFTNKAAREMMARLSAMMPIDTR
GMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDASD
NFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAIF
AVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEAS
TDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSIEHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDD
TAFVRVVNFPTRGIGARSIEQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLVAKMRADTQHMNLPDTVEHIVRASGL
ADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATDDPAVDVLDPVSPADPAQNPDT
MTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAK
ERLYLSFAQSRMLHGQTRYNVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDPAVSAP
LPAFANKQRAADAGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=792, Percent_Identity=44.1919191919192, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=685, Percent_Identity=35.1824817518248, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=28.8235294117647, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=761, Percent_Identity=27.9894875164258, Blast_Score=217, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6324477, Length=719, Percent_Identity=23.2267037552156, Blast_Score=110, Evalue=6e-25,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 87058; Mature: 86927

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIKQGYASPPTVLAVTF
CCCCCCCCCHHHEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDASDNFNRKFVELYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHR
EEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEASTDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSI
HHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHH
EHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFVRVVNFPTRGIGARSI
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHH
EQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLVAKMRADTQHMNLPDTVEHIVRASG
HHHHHHHHHHCCHHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
LADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATD
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DPAVDVLDPVSPADPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
FSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEECHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDPAVSA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHCC
PLPAFANKQRAADAGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAV
CCCHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEHHHCCHHHHHHHH
AKLQAVE
HHHHHCC
>Mature Secondary Structure 
PDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIKQGYASPPTVLAVTF
CCCCCCCCHHHEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDASDNFNRKFVELYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHR
EEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEASTDSQEAGWIVEEIRSLINTGMARSEVAVLYRSNAQSRSI
HHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHH
EHTLMSSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFVRVVNFPTRGIGARSI
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHH
EQLADAARLYGCSMAAAIPYVTGKAGTSLGGFANLVAKMRADTQHMNLPDTVEHIVRASG
HHHHHHHHHHCCHHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
LADFYQGEREGQDRLENLQELVNAATAFIAEEGYGLDTPARSIPLRAGAIAAPELGTATD
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DPAVDVLDPVSPADPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
FSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEECHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NVRSRFFDELPEHVLKWLTPKVEAGSRWGGRSDNAGYGRDWFARPGGGSREQIVDPAVSA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHCC
PLPAFANKQRAADAGFRVGQQVFHTKFGEGTVTALEGNGTDAKAQVKFKRHGEKWLALAV
CCCHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEHHHCCHHHHHHHH
AKLQAVE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]