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The map label for this gene is wecB [H]

Identifier: 78065937

GI number: 78065937

Start: 1427635

End: 1428852

Strand: Direct

Name: wecB [H]

Synonym: Bcep18194_A4466

Alternate gene names: 78065937

Gene position: 1427635-1428852 (Clockwise)

Preceding gene: 78065933

Following gene: 78065940

Centisome position: 38.65

GC content: 63.79

Gene sequence:

>1218_bases
ATGAAGAAGATTTTGCTTGTGTTCGGGACTCGGCCTGAGGCCATCAAGATGGCACCGCTGGTGCGTGCATTGAAGGCGCA
AGCGGGTGTCGACGCCAGGGTATGCGTGACCGCGCAGCATCGCGAAATGCTCGATCAGGTGCTGACGCTATTCGACATCA
AGCCCGACTACGATCTCAACGTGATGCGCCAAAGTCAGACGTTGACCGACGTGACGACCGGCATTCTGCAGGCAATCGGC
ATCGTCTTCGACGAATTGCGTCCGGACGTCGTGCTGGTACACGGCGATACGACGACCACGCTCGCGGTCAGTCTTGCTGC
GTTCTATCGCTATTTGCCTGTCGGGCACGTCGAGGCCGGCTTGCGCAGCGGCGACATCTGGTCGCCGTGGCCGGAGGAGT
TGAACCGCCGCGTGACCGACGCGGTGTCGTCGTGGCATTTCGCGCCGACCGGGCAGGCACGCGACAACCTGCTCAGCGAG
GGCGTACCGGGCGGGGCGGTCGTGTTGACGGGCAACACCGTGATCGATGCGCTGCACGAGGTCAAGCGCATGCTGGACTG
CACCGGTGCGCTGGCGGAAAAGGTCGCCGAACAGTTTCCGTTTCTCGAACCGTCGCGGCGCGTGGTGCTGATCACCGGGC
ATCGACGAGAAAGTTTCGGCGAACCGTTCCAGAATTTCTGCGACGCACTGTGCACGCTCGCGAATCGCTATCCCGACGCG
CAGTTCGTCTATCCGCTGCACATGAATCCGAACGTGCGGGAGCCGGCGCGCGCGCGGCTCGGCCACCTGTCGAATATCTA
CCTGATCGAGCCGCAGGAGTATCTGTCGTTCGTATTCCTGATGTCGCGTGCGCATTTCATCATCACCGATTCGGGCGGCA
TTCAGGAAGAAGGGCCGGCGCTGGGCAAGCCGGTACTGGTCACGCGCGAGACGACGGAGCGGCCGGAGGCGATCCAGGCG
GGCACCGCGCGGCTCGTCGGCACCGATCAGGAGCGGATCGTGTGGGAGGCGTCACGGCTGTTCGACAGCGAGAGCGCGTA
CGGGGAAATGGCGCGCGCGAGCAATCCGTATGGCGACGGTCATGCGAGCGAGCGGATCGTTCACGCGCTGATGCGCAATC
CGGGGGTACCGTCGAAGGCGACGAGCTTTTCGATGGGGGCGTCGGAGGTGCCGTTCAACCCGCTCACGCTGGGGTTGCAG
GCGTTGCGGTCGCGTTGA

Upstream 100 bases:

>100_bases
AACGTGTCGACCGCGTGCGAGTACGGGAGGTGCCGCCTGAATACATGCTTCGCGCCACGAGCAGGGTCATTCAGCGCGAA
ATGGCTCAACGAGGATAACG

Downstream 100 bases:

>100_bases
ACGTGCGATTGCATGAAGCACCTGCGCTCGGCTTCGACACCCGGTGAAGCCGACGGTGTTTCATTCATGATTCATCCGGC
ACGGACGCGCGAGACGGACG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKKILLVFGTRPEAIKMAPLVRALKAQAGVDARVCVTAQHREMLDQVLTLFDIKPDYDLNVMRQSQTLTDVTTGILQAIG
IVFDELRPDVVLVHGDTTTTLAVSLAAFYRYLPVGHVEAGLRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSE
GVPGGAVVLTGNTVIDALHEVKRMLDCTGALAEKVAEQFPFLEPSRRVVLITGHRRESFGEPFQNFCDALCTLANRYPDA
QFVYPLHMNPNVREPARARLGHLSNIYLIEPQEYLSFVFLMSRAHFIITDSGGIQEEGPALGKPVLVTRETTERPEAIQA
GTARLVGTDQERIVWEASRLFDSESAYGEMARASNPYGDGHASERIVHALMRNPGVPSKATSFSMGASEVPFNPLTLGLQ
ALRSR

Sequences:

>Translated_405_residues
MKKILLVFGTRPEAIKMAPLVRALKAQAGVDARVCVTAQHREMLDQVLTLFDIKPDYDLNVMRQSQTLTDVTTGILQAIG
IVFDELRPDVVLVHGDTTTTLAVSLAAFYRYLPVGHVEAGLRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSE
GVPGGAVVLTGNTVIDALHEVKRMLDCTGALAEKVAEQFPFLEPSRRVVLITGHRRESFGEPFQNFCDALCTLANRYPDA
QFVYPLHMNPNVREPARARLGHLSNIYLIEPQEYLSFVFLMSRAHFIITDSGGIQEEGPALGKPVLVTRETTERPEAIQA
GTARLVGTDQERIVWEASRLFDSESAYGEMARASNPYGDGHASERIVHALMRNPGVPSKATSFSMGASEVPFNPLTLGLQ
ALRSR
>Mature_405_residues
MKKILLVFGTRPEAIKMAPLVRALKAQAGVDARVCVTAQHREMLDQVLTLFDIKPDYDLNVMRQSQTLTDVTTGILQAIG
IVFDELRPDVVLVHGDTTTTLAVSLAAFYRYLPVGHVEAGLRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSE
GVPGGAVVLTGNTVIDALHEVKRMLDCTGALAEKVAEQFPFLEPSRRVVLITGHRRESFGEPFQNFCDALCTLANRYPDA
QFVYPLHMNPNVREPARARLGHLSNIYLIEPQEYLSFVFLMSRAHFIITDSGGIQEEGPALGKPVLVTRETTERPEAIQA
GTARLVGTDQERIVWEASRLFDSESAYGEMARASNPYGDGHASERIVHALMRNPGVPSKATSFSMGASEVPFNPLTLGLQ
ALRSR

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=371, Percent_Identity=59.5687331536388, Blast_Score=446, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 44674; Mature: 44674

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILLVFGTRPEAIKMAPLVRALKAQAGVDARVCVTAQHREMLDQVLTLFDIKPDYDLN
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCH
VMRQSQTLTDVTTGILQAIGIVFDELRPDVVLVHGDTTTTLAVSLAAFYRYLPVGHVEAG
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHC
LRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSEGVPGGAVVLTGNTVIDALHE
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHH
VKRMLDCTGALAEKVAEQFPFLEPSRRVVLITGHRRESFGEPFQNFCDALCTLANRYPDA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHCCCHHHHHHHHHHHHHHCCCCC
QFVYPLHMNPNVREPARARLGHLSNIYLIEPQEYLSFVFLMSRAHFIITDSGGIQEEGPA
EEEEEEECCCCCCCHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
LGKPVLVTRETTERPEAIQAGTARLVGTDQERIVWEASRLFDSESAYGEMARASNPYGDG
CCCCEEEECCCCCCCHHHHCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
HASERIVHALMRNPGVPSKATSFSMGASEVPFNPLTLGLQALRSR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKKILLVFGTRPEAIKMAPLVRALKAQAGVDARVCVTAQHREMLDQVLTLFDIKPDYDLN
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCH
VMRQSQTLTDVTTGILQAIGIVFDELRPDVVLVHGDTTTTLAVSLAAFYRYLPVGHVEAG
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHC
LRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSEGVPGGAVVLTGNTVIDALHE
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHH
VKRMLDCTGALAEKVAEQFPFLEPSRRVVLITGHRRESFGEPFQNFCDALCTLANRYPDA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHCCCHHHHHHHHHHHHHHCCCCC
QFVYPLHMNPNVREPARARLGHLSNIYLIEPQEYLSFVFLMSRAHFIITDSGGIQEEGPA
EEEEEEECCCCCCCHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
LGKPVLVTRETTERPEAIQAGTARLVGTDQERIVWEASRLFDSESAYGEMARASNPYGDG
CCCCEEEECCCCCCCHHHHCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
HASERIVHALMRNPGVPSKATSFSMGASEVPFNPLTLGLQALRSR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]