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The map label for this gene is phoR [H]

Identifier: 78065920

GI number: 78065920

Start: 1407649

End: 1408968

Strand: Direct

Name: phoR [H]

Synonym: Bcep18194_A4449

Alternate gene names: 78065920

Gene position: 1407649-1408968 (Clockwise)

Preceding gene: 78065919

Following gene: 78065922

Centisome position: 38.11

GC content: 64.77

Gene sequence:

>1320_bases
ATGAACATCATCTGGGCGCGCTTTCTGGTGTCGCTCGTGCTGCTCGTGCTGATCGGCGTATTGGTCGGCGTCTTCGCCGG
CCCGACCGCGGGCCTCGTGTTCGTGGTCGTGATGCTGGTCGCGCAGGGCTTTTTCAGCACCTTTCATACGCAGCGTCTGT
GGCGCCTGCTCGATGCACCGGTCTATGGCGAGGTGCCGAGCGCGCCGGGCATCTGGGGTGAAATCTACTATCGTCTGCAC
AAGCTCGCGAAGCAGTGGCATGCGCAGGTGCGTCAGGTCGAGCAGCAGCATTCGCGCTTCATCCAGGCGATCCAGGCATC
GCCGAACGGCGTCGCGATGCTCGACGACCATGACCAGATCGAGTGGTGCAATTCGATCGCCGAGGTGCATTTCGGCCTCG
ACGCGAAGCGCGACCTGCGCCAGCACATCACCAACCTGGTGCGCCATCCCGAGTTCGTCCGCTATCTGAACGCGCAGCAT
TACGACGAGACGCTCGTGATGCGCGGCATGGGCGACTCGCGGCAGAACGTGCTGGAAGTGCAGGTGTTTCCGTACGGCGA
GAATCGCAAGCTGCTGCTCACGCAGGACATCACCGAGCTCGAGCGGACCGACGCGATGCGGCGCGACTTCGTCGCGAACG
TGTCGCACGAATTGAAGACGCCGCTCACCGTGCTGTCGGGGTTCCTCGAGACGATGCGCGAGCTGCCGCTGAACGAGGAA
GACCGTGCGCGCTATCTCGACATGATGGAGCAGCAGGCCTCGCGGATGCGGCACATCGTGACCGACCTGCTGGTGCTCGC
GAAGCTCGAGGGCGAGAGCAAGCCGCCGCTCGATCGCGCGATCGACATGCGTGCCGTGTTCGACCATCTGAAGGAGGACG
CGCAGACACTGTCGAACGGGCATCACGACATCGCGTTCACGATCGACGAGACGCTTGGCGTCACCGGCGCGCAGACGGAG
CTGTTCAGCGCATTCGCGAATCTCGTTACCAACGCGATCCGCTATACGCCGGAAGGCGGCAAGATCGTCGTGACGTGGCG
GCGCGAAGGTGCGCAGGGCGTGTTTTCCGTCACGGACAGCGGCTTCGGGATTCCGGCCGCCGACCTGCCGCGGCTCACTG
AACGCTTCTACCGCGTCGATCGCAGCCGTTCGCGCGACACGGGCGGCACGGGGCTCGGCCTTGCGATCGTCAAGCACGTG
CTGCAGCGTCATGACGCGCACCTGTACGTGCAAAGCGAGGAAGGGCGCGGCAGCACGTTCACCGCGCGGTTCCCGGGCTC
GCGCATCATCGCGATCCGGCCGGCCGCATACGAGGCATGA

Upstream 100 bases:

>100_bases
GACCGTGCGCGGCAGCGGCTACCGGCTCGCCAAGCACGCGTAACGTATCCACGCATGCCGTGTGCCACGGCATGCCGTTC
ATTCTTTCGGGCGCTGAATC

Downstream 100 bases:

>100_bases
TCGCGTAACGGCATCCGTCGCTCGTTCGGCGAGCGGCGGCATGCTGGATCCGCAATAAAAAAGCGCAGCCCGCGGGCTGC
GCTTTTTTTGTGAGCGACGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNSIAEVHFGLDAKRDLRQHITNLVRHPEFVRYLNAQH
YDETLVMRGMGDSRQNVLEVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRAVFDHLKEDAQTLSNGHHDIAFTIDETLGVTGAQTE
LFSAFANLVTNAIRYTPEGGKIVVTWRREGAQGVFSVTDSGFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAHLYVQSEEGRGSTFTARFPGSRIIAIRPAAYEA

Sequences:

>Translated_439_residues
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNSIAEVHFGLDAKRDLRQHITNLVRHPEFVRYLNAQH
YDETLVMRGMGDSRQNVLEVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRAVFDHLKEDAQTLSNGHHDIAFTIDETLGVTGAQTE
LFSAFANLVTNAIRYTPEGGKIVVTWRREGAQGVFSVTDSGFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAHLYVQSEEGRGSTFTARFPGSRIIAIRPAAYEA
>Mature_439_residues
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNSIAEVHFGLDAKRDLRQHITNLVRHPEFVRYLNAQH
YDETLVMRGMGDSRQNVLEVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRAVFDHLKEDAQTLSNGHHDIAFTIDETLGVTGAQTE
LFSAFANLVTNAIRYTPEGGKIVVTWRREGAQGVFSVTDSGFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAHLYVQSEEGRGSTFTARFPGSRIIAIRPAAYEA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=366, Percent_Identity=39.8907103825137, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI145693157, Length=342, Percent_Identity=28.3625730994152, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI48994928, Length=358, Percent_Identity=27.3743016759777, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788393, Length=259, Percent_Identity=28.957528957529, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786783, Length=255, Percent_Identity=31.7647058823529, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=32.034632034632, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=32.4074074074074, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=30.6122448979592, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=28.8888888888889, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=387, Percent_Identity=22.9974160206718, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=26, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=24.5059288537549, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=28.6324786324786, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=248, Percent_Identity=27.8225806451613, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789403, Length=225, Percent_Identity=28.4444444444444, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=26.7241379310345, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=24.8908296943231, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49637; Mature: 49637

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNSIAEVHFGLDAKRDLRQHITNLVRHPEFVRYLNAQHYDETLVMRGMGDSRQNVLEV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHEECCCCCCCCEEEE
QVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
EEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCH
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRAVFDHLKEDAQTLSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
HHDIAFTIDETLGVTGAQTELFSAFANLVTNAIRYTPEGGKIVVTWRREGAQGVFSVTDS
CCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCEEEECCC
GFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAHLYVQSEEGRGSTF
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEE
TARFPGSRIIAIRPAAYEA
EEECCCCEEEEECCCCCCC
>Mature Secondary Structure
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNSIAEVHFGLDAKRDLRQHITNLVRHPEFVRYLNAQHYDETLVMRGMGDSRQNVLEV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHEECCCCCCCCEEEE
QVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
EEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCH
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRAVFDHLKEDAQTLSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
HHDIAFTIDETLGVTGAQTELFSAFANLVTNAIRYTPEGGKIVVTWRREGAQGVFSVTDS
CCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCEEEECCC
GFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAHLYVQSEEGRGSTF
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEE
TARFPGSRIIAIRPAAYEA
EEECCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]