Click here to switch to the map view.

The map label for this gene is ppx [H]

Identifier: 78065922

GI number: 78065922

Start: 1411440

End: 1412954

Strand: Direct

Name: ppx [H]

Synonym: Bcep18194_A4451

Alternate gene names: 78065922

Gene position: 1411440-1412954 (Clockwise)

Preceding gene: 78065920

Following gene: 78065924

Centisome position: 38.21

GC content: 66.53

Gene sequence:

>1515_bases
ATGGTTACAACCCCCCACTTGCTGGCTGCCGTGGATCTCGGCTCGAACAGCTTCCGGCTGATCGTCGGTCGTGTCGAGGA
AACGCCGGCAGGCAGCCAGATCTATCCCGTCGACGCGTTGCGCGAGCCGGTCCGGCTGGCCGCAGGCCTGTCGAGCGACA
AGATGCTCGATCGCGCGTCGCAGGAGCGTGGCTGGGAGGCGCTCAAGCGGTTCGGCGAGCGCCTGCGCGATTTCCATCCC
GATCATGTGCGCGCGGTGGCGACCAACACGCTGCGCGTCGCGAAGAACGCGGGCGAATTTCTCGGTGAGGCCGAAGCGGC
ACTCGGTTTCCCGATCGAAGTGATTGCAGGCCGCGAAGAAGCGCGGCTGATCTATGCGGGTGCCGCGCACTCGGTGCCGG
CAAGCGCCGGCAAGCGGCTCGTCGTCGACATCGGCGGCGGCTCCACCGAATTCATCATCGGCTCGCACTACACGCCGATC
GTGATGGAGAGCCTCTATATCGGCTGCGTGAGCCACAGCCGCACGTTCTTCCCGGCCGGCAACGTCGACGAATACACGAT
GCGGCAGGCCGAACTCGCGGCCAAGCGCGAGATCCAGATCATTTCGAGCGAGTACAAGAAGGCGGGCTGGGACCAGGCGA
TCGGCTCGTCGGGCACTGCGCGTGCGCTCGCGGAGCTCGTCGAGGCGAACGGCTTCAACGATCCGGGGATCACGCACGGC
ATTTCGCGCGGCGGCCTCGAGCGGCTGAAGCGTGCGCTGATCAAGTCGGAGAACGTCAACCGGCTGAAGCTGGTCGCGCT
GAAGCCCGATCGCGTGCCGGTGCTCGCGGGCGGCCTCGCGATCATGCTCGCGGTGTTCGAGGAGCTCGGTGTCGACTACG
TCGATACGACCGACGGCGCGCTGCGTCTCGGTGTGCTGTACGACCTGCTCGGCCGGACGCAGCACGAGGACATGCGCGCG
GTGACCGTCGAGGGCTTTACGCGCCGCTACGGTGTCGATCGTGCGCAGGCCGAGCGGATCGGCGCGCTGGCGGGGCGTTT
CTTCGACGAACTCGAGGAAGCCGACGAAGAAGCGCGCGAGGAAGGGCGGATGTTCCTCGGCTGGGCGGCCGCGTTGCACG
AGATCGGTTTGTCGATCTCGCACAGCTCATATCACAAGCATTCGGCTTATATCGCGAGCAACGCGGACATGCCGGGTTTT
TCGCGCACCGACCAGGCGCGCCTCGCCGCGCTGGTGCTCGGTCACGCGGGCAAGCTCGGCAAGCTGTCGCAGGCGCGTGA
GGTCGAGTGGCCGCTACTGTTCTGCCTGCGGCTCGCGGCGCTGCTGTGCCGGCGCCGGACCGATGCCGGGCTGCCGGACA
TTTCCGTTTCGCAGATGAAGAAGGGCGGCTATGAAGTGCGCCTGCCGAGCGCATGGGTCGAGCAGAATCCGCTGACCGAC
TACAGCCTCAGCCAGGAGGCAGCCGAGTGGGAGAAGGTCGGCATCCCGTATCGCGTGGTGTATACCGGCGCGTAA

Upstream 100 bases:

>100_bases
GCAATGGCAAGCGTTCCACGCTTAAAATGTCGCCTTTGATTGATCGCCCAGGGTTGCCGCATAGGCTGCCGTGGGAGAAC
GCGCACGGAGCCCCCTTCTG

Downstream 100 bases:

>100_bases
CAGGTCAAGCGAGGTCGAAGCGAGGTCGATAGCAGGGCTGGGAGGGGGCGGGCAGCAGGAAGGCTGGGCGTCCCTCAGGC
TTGCCGCATGATCGTCCTGA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKMLDRASQERGWEALKRFGERLRDFHP
DHVRAVATNTLRVAKNAGEFLGEAEAALGFPIEVIAGREEARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPI
VMESLYIGCVSHSRTFFPAGNVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
ISRGGLERLKRALIKSENVNRLKLVALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRA
VTVEGFTRRYGVDRAQAERIGALAGRFFDELEEADEEAREEGRMFLGWAAALHEIGLSISHSSYHKHSAYIASNADMPGF
SRTDQARLAALVLGHAGKLGKLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVSQMKKGGYEVRLPSAWVEQNPLTD
YSLSQEAAEWEKVGIPYRVVYTGA

Sequences:

>Translated_504_residues
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKMLDRASQERGWEALKRFGERLRDFHP
DHVRAVATNTLRVAKNAGEFLGEAEAALGFPIEVIAGREEARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPI
VMESLYIGCVSHSRTFFPAGNVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
ISRGGLERLKRALIKSENVNRLKLVALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRA
VTVEGFTRRYGVDRAQAERIGALAGRFFDELEEADEEAREEGRMFLGWAAALHEIGLSISHSSYHKHSAYIASNADMPGF
SRTDQARLAALVLGHAGKLGKLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVSQMKKGGYEVRLPSAWVEQNPLTD
YSLSQEAAEWEKVGIPYRVVYTGA
>Mature_504_residues
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKMLDRASQERGWEALKRFGERLRDFHP
DHVRAVATNTLRVAKNAGEFLGEAEAALGFPIEVIAGREEARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPI
VMESLYIGCVSHSRTFFPAGNVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
ISRGGLERLKRALIKSENVNRLKLVALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRA
VTVEGFTRRYGVDRAQAERIGALAGRFFDELEEADEEAREEGRMFLGWAAALHEIGLSISHSSYHKHSAYIASNADMPGF
SRTDQARLAALVLGHAGKLGKLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVSQMKKGGYEVRLPSAWVEQNPLTD
YSLSQEAAEWEKVGIPYRVVYTGA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=497, Percent_Identity=38.430583501006, Blast_Score=331, Evalue=8e-92,
Organism=Escherichia coli, GI48994966, Length=497, Percent_Identity=37.4245472837022, Blast_Score=309, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 54982; Mature: 54982

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKMLDRAS
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHH
QERGWEALKRFGERLRDFHPDHVRAVATNTLRVAKNAGEFLGEAEAALGFPIEVIAGREE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPIVMESLYIGCVSHSRTFFPAG
CEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCEECCCC
NVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCHHC
ISRGGLERLKRALIKSENVNRLKLVALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGA
CCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHCCCEEECCCCH
LRLGVLYDLLGRTQHEDMRAVTVEGFTRRYGVDRAQAERIGALAGRFFDELEEADEEARE
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGRMFLGWAAALHEIGLSISHSSYHKHSAYIASNADMPGFSRTDQARLAALVLGHAGKLG
CCCEEEHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
KLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVSQMKKGGYEVRLPSAWVEQNPLTD
CCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEECCHHHHCCCCCCC
YSLSQEAAEWEKVGIPYRVVYTGA
CCCCHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKMLDRAS
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHH
QERGWEALKRFGERLRDFHPDHVRAVATNTLRVAKNAGEFLGEAEAALGFPIEVIAGREE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPIVMESLYIGCVSHSRTFFPAG
CEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCEECCCC
NVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCHHC
ISRGGLERLKRALIKSENVNRLKLVALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGA
CCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHCCCEEECCCCH
LRLGVLYDLLGRTQHEDMRAVTVEGFTRRYGVDRAQAERIGALAGRFFDELEEADEEARE
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGRMFLGWAAALHEIGLSISHSSYHKHSAYIASNADMPGFSRTDQARLAALVLGHAGKLG
CCCEEEHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
KLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVSQMKKGGYEVRLPSAWVEQNPLTD
CCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEECCHHHHCCCCCCC
YSLSQEAAEWEKVGIPYRVVYTGA
CCCCHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]