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The map label for this gene is aphA [H]

Identifier: 78065863

GI number: 78065863

Start: 1351443

End: 1352465

Strand: Direct

Name: aphA [H]

Synonym: Bcep18194_A4392

Alternate gene names: 78065863

Gene position: 1351443-1352465 (Clockwise)

Preceding gene: 78065862

Following gene: 78065864

Centisome position: 36.58

GC content: 69.7

Gene sequence:

>1023_bases
ATGAAAACCTATTTCCATCCCGAGCAGTTGCTGCACCATCCGCGCAGCTACCTGTCGCGTGGCCAGATGCGTGAGCCGCA
GGAAGTGCCCGAGCGCGCGGCGCGACTCGTCGCGGCCGTCCGGTCGCTCGACTTCGACGTGCGCGAGCCGGCCGACCGCG
GCACCGCGCCGATCGCGGCCGTGCACGACATGAACTACCTGCGCTTCCTGGAAGAAGCGCACCGCGACTGGAAGCAGATG
CCCGACGACTGGGGCGACGAAGTAATGTCGAACGTGTTCGTGCGCGACCCGAACCCGCTGCGCGGCGTGCTTGCGAAAGC
CGCGCGCTACCTTGCCGACGGCAGTTGCCCGGTCGATGCGAACACGTGGCGTGCCGCGTACTGGTCCGCGCAGGGCGCGC
TGGCGGCCGCGGCCGACGTCAACGACGGCGCACGCGAGGCGTACGCGCTGTGCCGGCCGCCCGGCCATCACGCACGCCGT
GACGCGGCCGGCGGCTTCTGCTACCTGAACAATGCGGCGATCGCCGCGCAGTCGCTGCTCGGCCGCCACCGCCGGGTCGC
GATCCTCGACACCGACATGCATCACGGGCAGGGCGTGCAGGAGATCTTCTACGGCCGCGACGACGTGCTGTACGTGTCGA
TCCACGGCGATCCGACCAACTTCTACCCGGTCGTCGCGGGCTACGAGGAAGAGACGGGCACCGGGGCCGGCGACGGGTTC
AACCTCAACCTGCCGATGCCGCACGGCGCGCCGGAGTCGGCGTTCTTCGAGCGGCTCGACGGTGCACTGCGCGCGCTCGC
GCGGTTCCAGCCCGACGCACTCGTGCTCGCGCTCGGCTTCGATATCTACAAGGACGATCCGCAATCGCAGGTGGCCGTCA
CGACCGACGGCTTCGGGCGGCTCGGCGGCGCGATCGGCGCACTCGGGTTGCCGACGGTGATCGTGCAAGAAGGCGGCTAT
CACCTCGACAGCCTCGACGCGAACGCGCGTGCGTTTTTCGGCGGATTCGCCGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
GCGGGTATTGCAGCGGGCGTTGCCGCGGCGGCCACCACGCAGGATGCGTGACGCGGAAAACCGATCAATCGGCATAACGA
AAAACCGACGAGGGCGAACG

Downstream 100 bases:

>100_bases
CCGGCGCGGCGGGGCCCGATCGCATGCGTGCGGACTCAAGATTTCCGCGCGCATGCCGATAATTCGCGCATATGCTGGAT
GGATGCACGAAGGAGGGCCG

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAAVHDMNYLRFLEEAHRDWKQM
PDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVDANTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQSLLGRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGTGAGDGF
NLNLPMPHGAPESAFFERLDGALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGRLGGAIGALGLPTVIVQEGGY
HLDSLDANARAFFGGFAAAR

Sequences:

>Translated_340_residues
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAAVHDMNYLRFLEEAHRDWKQM
PDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVDANTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQSLLGRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGTGAGDGF
NLNLPMPHGAPESAFFERLDGALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGRLGGAIGALGLPTVIVQEGGY
HLDSLDANARAFFGGFAAAR
>Mature_340_residues
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAAVHDMNYLRFLEEAHRDWKQM
PDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVDANTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQSLLGRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGTGAGDGF
NLNLPMPHGAPESAFFERLDGALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGRLGGAIGALGLPTVIVQEGGY
HLDSLDANARAFFGGFAAAR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=240, Percent_Identity=34.1666666666667, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI20070354, Length=216, Percent_Identity=37.037037037037, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI17158039, Length=250, Percent_Identity=33.2, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI30795204, Length=245, Percent_Identity=33.469387755102, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI30795202, Length=245, Percent_Identity=33.469387755102, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI169234807, Length=261, Percent_Identity=34.0996168582375, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI148539870, Length=261, Percent_Identity=34.0996168582375, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI8923769, Length=309, Percent_Identity=25.8899676375405, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI153085395, Length=264, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13128860, Length=230, Percent_Identity=27.8260869565217, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI262073088, Length=213, Percent_Identity=31.924882629108, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI13128862, Length=263, Percent_Identity=27.3764258555133, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI293336691, Length=225, Percent_Identity=27.5555555555556, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI226529806, Length=216, Percent_Identity=34.7222222222222, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI62750347, Length=202, Percent_Identity=36.6336633663366, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI62750349, Length=202, Percent_Identity=36.6336633663366, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262073092, Length=259, Percent_Identity=23.5521235521236, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=198, Percent_Identity=39.8989898989899, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17540332, Length=198, Percent_Identity=39.8989898989899, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193206283, Length=198, Percent_Identity=39.8989898989899, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508561, Length=308, Percent_Identity=29.2207792207792, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17537347, Length=228, Percent_Identity=33.7719298245614, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17561978, Length=238, Percent_Identity=29.8319327731092, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17534739, Length=210, Percent_Identity=30.952380952381, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI193209491, Length=226, Percent_Identity=32.3008849557522, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25154022, Length=208, Percent_Identity=27.8846153846154, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25154020, Length=208, Percent_Identity=27.8846153846154, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=217, Percent_Identity=35.9447004608295, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6323999, Length=249, Percent_Identity=27.3092369477912, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6321244, Length=206, Percent_Identity=28.1553398058252, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325325, Length=154, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281360801, Length=265, Percent_Identity=35.8490566037736, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI281360799, Length=265, Percent_Identity=35.8490566037736, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24641720, Length=265, Percent_Identity=35.8490566037736, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281360899, Length=313, Percent_Identity=30.0319488817891, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24642142, Length=313, Percent_Identity=30.0319488817891, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24642146, Length=313, Percent_Identity=30.0319488817891, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24642144, Length=313, Percent_Identity=30.0319488817891, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24644244, Length=269, Percent_Identity=29.7397769516729, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24657891, Length=233, Percent_Identity=30.9012875536481, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37117; Mature: 37117

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAA
CCCCCCHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEH
VHDMNYLRFLEEAHRDWKQMPDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVDA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
NTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARRDAAGGFCYLNNAAIAAQSLL
CCCHHHEECCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHCCCCCEEEECCHHHHHHHHH
GRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGTGAGDGF
CCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCE
NLNLPMPHGAPESAFFERLDGALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGR
EEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEEECCCHH
LGGAIGALGLPTVIVQEGGYHLDSLDANARAFFGGFAAAR
HHHHHHHCCCCEEEEECCCCEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAA
CCCCCCHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEH
VHDMNYLRFLEEAHRDWKQMPDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVDA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
NTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARRDAAGGFCYLNNAAIAAQSLL
CCCHHHEECCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHCCCCCEEEECCHHHHHHHHH
GRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGTGAGDGF
CCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCE
NLNLPMPHGAPESAFFERLDGALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGR
EEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEEECCCHH
LGGAIGALGLPTVIVQEGGYHLDSLDANARAFFGGFAAAR
HHHHHHHCCCCEEEEECCCCEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]