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The map label for this gene is bkdA1 [H]

Identifier: 78065831

GI number: 78065831

Start: 1315143

End: 1316375

Strand: Direct

Name: bkdA1 [H]

Synonym: Bcep18194_A4360

Alternate gene names: 78065831

Gene position: 1315143-1316375 (Clockwise)

Preceding gene: 78065830

Following gene: 78065832

Centisome position: 35.6

GC content: 67.56

Gene sequence:

>1233_bases
ATGAGCCTGTCAGAGCCATTGCGTCTGCATGTGCCGGAGCCCACCGGGCGCCCGGGCTGCAAGACGGACTTTTCCTATCT
GCATCTATCGCCGGCCGGTGCCGTTCGCCGCCCGCCGATCGACGTAGCCGCGGCGGACACCGCCGATCTCGCCCGCAGCC
TCGTGCGCGTGCTCGACGACAGCGGCAAGGCCGTCGGCCCGTGGGCACCGGATCTCGACGATGCGCGGCTGATCGCCGGC
CTGCGCGCGATGCTCAAGACCCGCATTTTCGACGCGCGCATGATGATCGCGCAGCGTCAGAAGAAAATCTCCTTCTACAT
GTTGAGCCTCGGCGAAGAGGCGATCGGCACCGCGCACGCGATGGCGCTGCGCGACGGTGACATGTGCTTCCCGACCTACC
GCCAGCAGAGCATCCTGATCGCGCGCGACGTATCGCTCGAGCGAATGATCTGCCAGCTGATGTCGAACGAAGGCGACCCG
CTGAAAGGCCGCCAGCTCCCCGTGATGTACTCGGACCGCGAAGCCGGCTTTTTCTCCATTTCCGGCAACCTCGCGACGCA
GTTCATCCAGGCGGTCGGCTGGGCGATGGCGTCGGCGATCAAGGGCGACACGAAGATCGCGTCCGCGTGGATCGGCGACG
GCGCGACGGCCGAATCCGACTTCCACACCGCGCTCACGTTCGCGCACGTGTACCGCGCGCCGGTCGTGCTGAACGTCGTC
AACAACCAGTGGGCGATCTCGACGTTCCAGGCGATCGCGGGCGGCGAAGGCACGACCTTCGCCGGTCGCGGCGTCGGCTG
CGGGATCGCGTCGCTGCGCGTCGACGGCAACGACTTCCTCGCGATCTACGCGGCGTCGAGCTGGGCGGCCGAACGCGCGC
GCCGCAACCTTGGCCCGACGCTGATCGAGTGGGTGACCTACCGTGCGGGCGCGCACTCGACGTCGGACGATCCGACCAAG
TACCGGCCGAGCGACGACTGGTCCCATTTCCCGCTCGGCGATCCGATCGAGCGCTTCAAGCGCCACCTGATCGTCAAGGG
CATCTGGTCCGACGGCGCGCACGAAGCGTTGACGGCCGAGCTCGAGGCCGAGGTGATCGCCGCGCAGAAGGAAGCGGAGA
AATACGGCACGCTGGCCGACGACCGGATTCCGTCGCCGGCGTCGATGTTCGACGACGTGTACAAGGAGCTGCCCGCGCAC
CTGCGCCGTCAGCGCCAGGAACTGGGAGCGTGA

Upstream 100 bases:

>100_bases
AGATTGACGTGCCTATCCGCACGCCAGTCAGCGCGCAGGCCGGCAACCGGTCGCGCGTTCCTAATCAGCGTGAGACACAA
TCGAGCGTGGAGACGACACG

Downstream 100 bases:

>100_bases
TCATGGCGCAACAAGAGACAGGCACTGCAACGCAGCCGATGACGATGATCCAGGCGCTGCGCTCGGCGATGGACGTGATG
CTCGGGCGCGACAGCGACGT

Product: branched-chain alpha-keto acid dehydrogenase E1 component

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSLSEPLRLHVPEPTGRPGCKTDFSYLHLSPAGAVRRPPIDVAAADTADLARSLVRVLDDSGKAVGPWAPDLDDARLIAG
LRAMLKTRIFDARMMIAQRQKKISFYMLSLGEEAIGTAHAMALRDGDMCFPTYRQQSILIARDVSLERMICQLMSNEGDP
LKGRQLPVMYSDREAGFFSISGNLATQFIQAVGWAMASAIKGDTKIASAWIGDGATAESDFHTALTFAHVYRAPVVLNVV
NNQWAISTFQAIAGGEGTTFAGRGVGCGIASLRVDGNDFLAIYAASSWAAERARRNLGPTLIEWVTYRAGAHSTSDDPTK
YRPSDDWSHFPLGDPIERFKRHLIVKGIWSDGAHEALTAELEAEVIAAQKEAEKYGTLADDRIPSPASMFDDVYKELPAH
LRRQRQELGA

Sequences:

>Translated_410_residues
MSLSEPLRLHVPEPTGRPGCKTDFSYLHLSPAGAVRRPPIDVAAADTADLARSLVRVLDDSGKAVGPWAPDLDDARLIAG
LRAMLKTRIFDARMMIAQRQKKISFYMLSLGEEAIGTAHAMALRDGDMCFPTYRQQSILIARDVSLERMICQLMSNEGDP
LKGRQLPVMYSDREAGFFSISGNLATQFIQAVGWAMASAIKGDTKIASAWIGDGATAESDFHTALTFAHVYRAPVVLNVV
NNQWAISTFQAIAGGEGTTFAGRGVGCGIASLRVDGNDFLAIYAASSWAAERARRNLGPTLIEWVTYRAGAHSTSDDPTK
YRPSDDWSHFPLGDPIERFKRHLIVKGIWSDGAHEALTAELEAEVIAAQKEAEKYGTLADDRIPSPASMFDDVYKELPAH
LRRQRQELGA
>Mature_409_residues
SLSEPLRLHVPEPTGRPGCKTDFSYLHLSPAGAVRRPPIDVAAADTADLARSLVRVLDDSGKAVGPWAPDLDDARLIAGL
RAMLKTRIFDARMMIAQRQKKISFYMLSLGEEAIGTAHAMALRDGDMCFPTYRQQSILIARDVSLERMICQLMSNEGDPL
KGRQLPVMYSDREAGFFSISGNLATQFIQAVGWAMASAIKGDTKIASAWIGDGATAESDFHTALTFAHVYRAPVVLNVVN
NQWAISTFQAIAGGEGTTFAGRGVGCGIASLRVDGNDFLAIYAASSWAAERARRNLGPTLIEWVTYRAGAHSTSDDPTKY
RPSDDWSHFPLGDPIERFKRHLIVKGIWSDGAHEALTAELEAEVIAAQKEAEKYGTLADDRIPSPASMFDDVYKELPAHL
RRQRQELGA

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=357, Percent_Identity=37.2549019607843, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI258645172, Length=358, Percent_Identity=37.1508379888268, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI4885543, Length=302, Percent_Identity=25.8278145695364, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI291084742, Length=287, Percent_Identity=26.1324041811847, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4505685, Length=287, Percent_Identity=26.1324041811847, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI291084744, Length=262, Percent_Identity=25.9541984732824, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI86563355, Length=393, Percent_Identity=36.3867684478371, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI86563357, Length=393, Percent_Identity=36.3867684478371, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17536047, Length=305, Percent_Identity=26.5573770491803, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32564172, Length=305, Percent_Identity=26.5573770491803, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321026, Length=378, Percent_Identity=30.1587301587302, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355903, Length=363, Percent_Identity=35.2617079889807, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24639748, Length=314, Percent_Identity=26.7515923566879, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639740, Length=263, Percent_Identity=27.3764258555133, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639746, Length=263, Percent_Identity=27.3764258555133, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639744, Length=263, Percent_Identity=27.3764258555133, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571106, Length=263, Percent_Identity=27.3764258555133, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR022593 [H]

Pfam domain/function: PF00676 E1_dh; PF12573 OxoDH_E1alpha_N [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 44806; Mature: 44675

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSEPLRLHVPEPTGRPGCKTDFSYLHLSPAGAVRRPPIDVAAADTADLARSLVRVLDD
CCCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHCC
SGKAVGPWAPDLDDARLIAGLRAMLKTRIFDARMMIAQRQKKISFYMLSLGEEAIGTAHA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHH
MALRDGDMCFPTYRQQSILIARDVSLERMICQLMSNEGDPLKGRQLPVMYSDREAGFFSI
EEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCEEEE
SGNLATQFIQAVGWAMASAIKGDTKIASAWIGDGATAESDFHTALTFAHVYRAPVVLNVV
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
NNQWAISTFQAIAGGEGTTFAGRGVGCGIASLRVDGNDFLAIYAASSWAAERARRNLGPT
CCCCHHHHHHHHCCCCCCEECCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHCCCHH
LIEWVTYRAGAHSTSDDPTKYRPSDDWSHFPLGDPIERFKRHLIVKGIWSDGAHEALTAE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCCCHHHHHHH
LEAEVIAAQKEAEKYGTLADDRIPSPASMFDDVYKELPAHLRRQRQELGA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLSEPLRLHVPEPTGRPGCKTDFSYLHLSPAGAVRRPPIDVAAADTADLARSLVRVLDD
CCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHCC
SGKAVGPWAPDLDDARLIAGLRAMLKTRIFDARMMIAQRQKKISFYMLSLGEEAIGTAHA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHH
MALRDGDMCFPTYRQQSILIARDVSLERMICQLMSNEGDPLKGRQLPVMYSDREAGFFSI
EEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCEEEE
SGNLATQFIQAVGWAMASAIKGDTKIASAWIGDGATAESDFHTALTFAHVYRAPVVLNVV
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
NNQWAISTFQAIAGGEGTTFAGRGVGCGIASLRVDGNDFLAIYAASSWAAERARRNLGPT
CCCCHHHHHHHHCCCCCCEECCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHCCCHH
LIEWVTYRAGAHSTSDDPTKYRPSDDWSHFPLGDPIERFKRHLIVKGIWSDGAHEALTAE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCCCHHHHHHH
LEAEVIAAQKEAEKYGTLADDRIPSPASMFDDVYKELPAHLRRQRQELGA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]