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The map label for this gene is bkdA2 [H]

Identifier: 78065832

GI number: 78065832

Start: 1316378

End: 1317418

Strand: Direct

Name: bkdA2 [H]

Synonym: Bcep18194_A4361

Alternate gene names: 78065832

Gene position: 1316378-1317418 (Clockwise)

Preceding gene: 78065831

Following gene: 78065833

Centisome position: 35.63

GC content: 66.67

Gene sequence:

>1041_bases
ATGGCGCAACAAGAGACAGGCACTGCAACGCAGCCGATGACGATGATCCAGGCGCTGCGCTCGGCGATGGACGTGATGCT
CGGGCGCGACAGCGACGTGGTCGTGTTCGGGCAGGACGTCGGTTATTTCGGCGGGGTATTCCGCTGTACCGAAGGACTGC
AGAACAAATACGGCAAGTCGCGCGTGTTCGATGCGCCGATCTCGGAAAGCGGGATCGTCGGCGCGGCGGTGGGGATGGGC
GCATACGGGCTGCGCCCGGTGTGCGAGATCCAGTTCGCCGACTATTTCTATCCGGCATCCGACCAGATCGTGTCGGAAGG
CGCGCGGCTGCGCTATCGCTCGGCCGGCCAGTTCATCGCGCCGATGACGATCCGCATGCCCTGCGGCGGCGGCATCTACG
GCGGCCAGACGCACAGCCAGAGCCCGGAGGCGATGTTCACGCAGGTGTGCGGGCTGCGCACGGTGATGCCGTCGAATCCG
TACGACGCGAAGGGGTTGCTGATTGCATCGATCGAGAACGACGATCCGGTGATCTTCCTCGAACCGAAACGGCTGTACAA
CGGGCCGTTCGACGGCCATCACGACCGGCCGGTCACGTCGTGGCTCAAGCATCCGGCCAGCGCGGTGCCCGAGGGCTACT
ACACGGTGCCGCTCGATACGGCCGCCGTGGTGCGGCCCGGCAACGACGTGACGGTGCTGACCTACGGCACGACGGTACAC
GTGTCGCTCGCCGCGGCCGAGGAGACGGGCATCGATGCGGAGGTGATCGACCTGCGCACGCTGTGGCCGCTCGACCTCGA
CACGATCGTCGCGTCGGTGCGCAAGACCGGCCGCTGCGTCGTGGTGCACGAGGCGACGCGCACCTGCGGTTATGGTGCGG
AACTGGTAGCGCTGGTCCAGGAACATTGCTTCTACCACCTCGAGGCGCCGGTCGAGCGCACGACGGGCTGGGATACGCCG
TATCCGCATGCGCAGGAGTGGGCGTACTTTCCGGGCCCGGCCCGGGTCGGTGAAGCGTTGCGACGCGTGATGGAGGCGTG
A

Upstream 100 bases:

>100_bases
CCGACGACCGGATTCCGTCGCCGGCGTCGATGTTCGACGACGTGTACAAGGAGCTGCCCGCGCACCTGCGCCGTCAGCGC
CAGGAACTGGGAGCGTGATC

Downstream 100 bases:

>100_bases
GATGGGGATTCATGTCATCAAGATGCCGGATATCGGCGAAGGGATTGCCGAGGTCGAGCTGGTGGCCTGGCACGTGGAAG
TCGGGCAGACGATCAAGGAA

Product: branched-chain alpha-keto acid dehydrogenase E1 component

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MAQQETGTATQPMTMIQALRSAMDVMLGRDSDVVVFGQDVGYFGGVFRCTEGLQNKYGKSRVFDAPISESGIVGAAVGMG
AYGLRPVCEIQFADYFYPASDQIVSEGARLRYRSAGQFIAPMTIRMPCGGGIYGGQTHSQSPEAMFTQVCGLRTVMPSNP
YDAKGLLIASIENDDPVIFLEPKRLYNGPFDGHHDRPVTSWLKHPASAVPEGYYTVPLDTAAVVRPGNDVTVLTYGTTVH
VSLAAAEETGIDAEVIDLRTLWPLDLDTIVASVRKTGRCVVVHEATRTCGYGAELVALVQEHCFYHLEAPVERTTGWDTP
YPHAQEWAYFPGPARVGEALRRVMEA

Sequences:

>Translated_346_residues
MAQQETGTATQPMTMIQALRSAMDVMLGRDSDVVVFGQDVGYFGGVFRCTEGLQNKYGKSRVFDAPISESGIVGAAVGMG
AYGLRPVCEIQFADYFYPASDQIVSEGARLRYRSAGQFIAPMTIRMPCGGGIYGGQTHSQSPEAMFTQVCGLRTVMPSNP
YDAKGLLIASIENDDPVIFLEPKRLYNGPFDGHHDRPVTSWLKHPASAVPEGYYTVPLDTAAVVRPGNDVTVLTYGTTVH
VSLAAAEETGIDAEVIDLRTLWPLDLDTIVASVRKTGRCVVVHEATRTCGYGAELVALVQEHCFYHLEAPVERTTGWDTP
YPHAQEWAYFPGPARVGEALRRVMEA
>Mature_345_residues
AQQETGTATQPMTMIQALRSAMDVMLGRDSDVVVFGQDVGYFGGVFRCTEGLQNKYGKSRVFDAPISESGIVGAAVGMGA
YGLRPVCEIQFADYFYPASDQIVSEGARLRYRSAGQFIAPMTIRMPCGGGIYGGQTHSQSPEAMFTQVCGLRTVMPSNPY
DAKGLLIASIENDDPVIFLEPKRLYNGPFDGHHDRPVTSWLKHPASAVPEGYYTVPLDTAAVVRPGNDVTVLTYGTTVHV
SLAAAEETGIDAEVIDLRTLWPLDLDTIVASVRKTGRCVVVHEATRTCGYGAELVALVQEHCFYHLEAPVERTTGWDTPY
PHAQEWAYFPGPARVGEALRRVMEA

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=341, Percent_Identity=46.3343108504399, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI34101272, Length=341, Percent_Identity=46.3343108504399, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI156564403, Length=324, Percent_Identity=35.1851851851852, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI291084858, Length=324, Percent_Identity=33.9506172839506, Blast_Score=176, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17506935, Length=335, Percent_Identity=45.0746268656716, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17538422, Length=343, Percent_Identity=37.6093294460641, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6319698, Length=344, Percent_Identity=35.4651162790698, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI160714832, Length=338, Percent_Identity=45.5621301775148, Blast_Score=297, Evalue=8e-81,
Organism=Drosophila melanogaster, GI160714828, Length=338, Percent_Identity=45.5621301775148, Blast_Score=297, Evalue=8e-81,
Organism=Drosophila melanogaster, GI21358145, Length=325, Percent_Identity=39.0769230769231, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24650940, Length=325, Percent_Identity=39.0769230769231, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24650943, Length=97, Percent_Identity=41.2371134020619, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650945, Length=97, Percent_Identity=41.2371134020619, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI160714826, Length=67, Percent_Identity=46.2686567164179, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 37677; Mature: 37546

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQETGTATQPMTMIQALRSAMDVMLGRDSDVVVFGQDVGYFGGVFRCTEGLQNKYGKS
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
RVFDAPISESGIVGAAVGMGAYGLRPVCEIQFADYFYPASDQIVSEGARLRYRSAGQFIA
EEEECCCCCCCCEEHHHCCCCCCCCCEEEEEEECEECCCCHHHHHCCCCEEEECCCCEEC
PMTIRMPCGGGIYGGQTHSQSPEAMFTQVCGLRTVMPSNPYDAKGLLIASIENDDPVIFL
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCEEEEEECCCCCEEEE
EPKRLYNGPFDGHHDRPVTSWLKHPASAVPEGYYTVPLDTAAVVRPGNDVTVLTYGTTVH
CCHHHHCCCCCCCCCCCHHHHHHCCHHHCCCCEEEEECCCEEEEECCCCEEEEEECCEEE
VSLAAAEETGIDAEVIDLRTLWPLDLDTIVASVRKTGRCVVVHEATRTCGYGAELVALVQ
EEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHH
EHCFYHLEAPVERTTGWDTPYPHAQEWAYFPGPARVGEALRRVMEA
HHHEEEECCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQQETGTATQPMTMIQALRSAMDVMLGRDSDVVVFGQDVGYFGGVFRCTEGLQNKYGKS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
RVFDAPISESGIVGAAVGMGAYGLRPVCEIQFADYFYPASDQIVSEGARLRYRSAGQFIA
EEEECCCCCCCCEEHHHCCCCCCCCCEEEEEEECEECCCCHHHHHCCCCEEEECCCCEEC
PMTIRMPCGGGIYGGQTHSQSPEAMFTQVCGLRTVMPSNPYDAKGLLIASIENDDPVIFL
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCEEEEEECCCCCEEEE
EPKRLYNGPFDGHHDRPVTSWLKHPASAVPEGYYTVPLDTAAVVRPGNDVTVLTYGTTVH
CCHHHHCCCCCCCCCCCHHHHHHCCHHHCCCCEEEEECCCEEEEECCCCEEEEEECCEEE
VSLAAAEETGIDAEVIDLRTLWPLDLDTIVASVRKTGRCVVVHEATRTCGYGAELVALVQ
EEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHH
EHCFYHLEAPVERTTGWDTPYPHAQEWAYFPGPARVGEALRRVMEA
HHHEEEECCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3416875; 10426958 [H]