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The map label for this gene is mucB [H]

Identifier: 78065713

GI number: 78065713

Start: 1174708

End: 1175760

Strand: Direct

Name: mucB [H]

Synonym: Bcep18194_A4241

Alternate gene names: 78065713

Gene position: 1174708-1175760 (Clockwise)

Preceding gene: 78065712

Following gene: 78065714

Centisome position: 31.8

GC content: 67.14

Gene sequence:

>1053_bases
ATGCGGACATTGCAGTTGAATCACGCCATCTCCGGATGGAAGCGGCTGCCGGCCCTCCTGCTTTGCGCAGCCGCCCTGTT
GTCCGTTCAATCCCTTCCTGCCCGCGCCCAGCAACCGGACGATCCCGTCGCGACCCGCAAGGGTGCCGCCGACTGGCTCG
ACCGTGTCCAGCAAGCGGCGCAGCAGCAGAGCTACGAAGGCACGTTCGTCTACCAGCGCGGCGGGTATGTGCAGTCGTCG
CGCATCGCGCACGTCGCGTCCCGCGACGGCGAGTTCGAGCGCATCGAGACGCTCGACGGCAAGCCGCGCAAGCTGCTGCG
CCATAACGACGAGCTGTACACGTTTGTGCCCGAGCGCAAGCTGTGCGTGGTCGAGCGCCGTCAGACGCGCGACTCGTTCC
CCGCGCTGCTCGGCGCGAGCGGCGAGCACGTGATGTCCGTCTACGACGCGAAGTCGCTCGGCAAGGACCGCGTGGCGGGG
ATCGACGCGCAGGTCGTCGAGCTCGTGCCGAAGGATGCGTACCGCTTCACGTACAAGCTGTGGGCTGACGCGCGCACGGG
GCTGCTGCTGCGCTCGCAGACGCTCGATGCGAACGATCACGTGCTCGAGCAGATTGCGTTCTCGCAATTGCAGACGGGCG
GCGCAAGCGGCGACAAGGCCGCGATCGCGGCCGGCATGCGCAACCTGAGCGGCTGGACGGTCGTGCGCCCGCCGGTCGCG
ACGGTCGACATGGAAGCGCAGGGCTGGCAGCTCGCCCCGAGCGTGGCCGGTTTCCAGAAGATTCGTGAAGTGCGCCGGCC
GATGGCCGCGCGCGACGCGGGCGAGCCGCCGATCCCGGTCGATCAGGCCGTCTTCACCGACGGTCTCGCGACGATCTCGG
TTTTCATCGAGCCGGCTGAAAAGAATACGCGCAAGGAAGGCGCGGGCAGCACCGGTGCAACGAACGTTCTCGTGAAGCGC
CGCGGCGACTACTGGATCACCGTGCTCGGCGAAGTGCCGCCGGCTACGTTGCAGCAGTTCGCGTCTGCCATAGAATACAA
GGCTTCCAAGTAA

Upstream 100 bases:

>100_bases
ACCTTGAAGCGCACCAGCAATTCGCACAGCAGCCCGTCGTCACGGGTTCGATGCCGCTGATCCGCGCTGCCGTGACCACC
ACGCCAGGCCAATAAACCCG

Downstream 100 bases:

>100_bases
CGCTACGGCTTCCGACATGATGAAACTCACGCTGCGCAAATGGCTCGCGGCGGCGGCGCTGTCTGCCTGCCTGCCGCTCG
TGCCGCATACCGCGTTCGCG

Product: sigma E regulatory protein, MucB/RseB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPARAQQPDDPVATRKGAADWLDRVQQAAQQQSYEGTFVYQRGGYVQSS
RIAHVASRDGEFERIETLDGKPRKLLRHNDELYTFVPERKLCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAG
IDAQVVELVPKDAYRFTYKLWADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
TVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGEPPIPVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATNVLVKR
RGDYWITVLGEVPPATLQQFASAIEYKASK

Sequences:

>Translated_350_residues
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPARAQQPDDPVATRKGAADWLDRVQQAAQQQSYEGTFVYQRGGYVQSS
RIAHVASRDGEFERIETLDGKPRKLLRHNDELYTFVPERKLCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAG
IDAQVVELVPKDAYRFTYKLWADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
TVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGEPPIPVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATNVLVKR
RGDYWITVLGEVPPATLQQFASAIEYKASK
>Mature_350_residues
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPARAQQPDDPVATRKGAADWLDRVQQAAQQQSYEGTFVYQRGGYVQSS
RIAHVASRDGEFERIETLDGKPRKLLRHNDELYTFVPERKLCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAG
IDAQVVELVPKDAYRFTYKLWADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
TVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGEPPIPVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATNVLVKR
RGDYWITVLGEVPPATLQQFASAIEYKASK

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=304, Percent_Identity=25.9868421052632, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 38367; Mature: 38367

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPARAQQPDDPVATRKGAADWLDRVQQAA
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHH
QQQSYEGTFVYQRGGYVQSSRIAHVASRDGEFERIETLDGKPRKLLRHNDELYTFVPERK
HHCCCCCEEEEECCCEECCCHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCEEEECCCCC
LCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAGIDAQVVELVPKDAYRFTYKL
EEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHCCCCHHHEEEEE
WADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
ECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCE
TVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGEPPIPVDQAVFTDGLATISVFIEPAE
EEECCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHCCCEEEEEEEECCH
KNTRKEGAGSTGATNVLVKRRGDYWITVLGEVPPATLQQFASAIEYKASK
HCCHHCCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPARAQQPDDPVATRKGAADWLDRVQQAA
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHH
QQQSYEGTFVYQRGGYVQSSRIAHVASRDGEFERIETLDGKPRKLLRHNDELYTFVPERK
HHCCCCCEEEEECCCEECCCHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCEEEECCCCC
LCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAGIDAQVVELVPKDAYRFTYKL
EEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHCCCCHHHEEEEE
WADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
ECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCE
TVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGEPPIPVDQAVFTDGLATISVFIEPAE
EEECCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHCCCEEEEEEEECCH
KNTRKEGAGSTGATNVLVKRRGDYWITVLGEVPPATLQQFASAIEYKASK
HCCHHCCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]