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The map label for this gene is tetA [H]

Identifier: 78065324

GI number: 78065324

Start: 757039

End: 758232

Strand: Reverse

Name: tetA [H]

Synonym: Bcep18194_A3850

Alternate gene names: 78065324

Gene position: 758232-757039 (Counterclockwise)

Preceding gene: 78065326

Following gene: 78065321

Centisome position: 20.53

GC content: 72.78

Gene sequence:

>1194_bases
TTGAATCCGTCCCTGATTGCCATCCTGGCCACGGTCCTGCTCGACGCGATCGGCGTCGGGATCGTGATGCCGATCCTGCC
GGGGCTGCTGCACTCGCTCGCCAGCGCAGGCAGCACCGACACCCATTACGGGATCCTGCTCGCGCTGTACGCGTTCGCGC
AGTTCCTGTGCGCGCCGCTGCTCGGCGCGCTGAGCGACCGCTTCGGCCGCAGGCCCGTCCTGCTCGTGTCGCTGGCGGGC
GCCGCGCTCGACTACCTGCTGATGGCGCTCGCGCCGACACTCGCGTGGCTTTACGTGGGGCGGCTGATCGCGGGCATCAC
CGGCGCGAACGTCGCGGTCGCGACGGCCTATGTCACCGACGTCACCGCCGAGCCCGATCGCGCACGACGCTTCGGCCAGC
TCGGCGCGATGATGGGTATCGGCTTCATCGCGGGCCCGTTGATCGGCGGCCTGCTCGGCGCGCTGCATGTGCGCGCGCCG
TTCGTCGCGGCCGCCGTGCTCAACGCGCTCAACCTTGCGCTCGTCTGGCGCGCGCTGCCGGAATCGCGGCCGCGTTCGGC
CCGCGAAGGCCATGCGGTCGGCGCGCTCAACCCGTTCGCCAGCCTGCGCCGGCTGAGCGGCGCACCGGCGCTCGCGCCGC
TGATCGGCATTTACGTGATCGTGGCGCTGGTGTCGCAGGCACCCGCGACGCTGTGGATCCTGTACGGCCAGGAGCATTTC
GGCTGGTCGACGCCGATCGCGGGGCTGTCGCTGGCAGGCTACGGCGCGTGCCACGCACTCGCGCAGGCATTCGCGATCGG
TCCGCTGATCGCCCGGCTCGGCGAGCGTCGCGCACTCGCACTGGGCCTCGCGGGCGACGCGCTCGGGCTCGCGGCGATTG
CATTCGCGACCGCCGCGTGGGTGCCGTTCGCGCTGCTGCCGCTGTTCGCGGCGGGCGGGATGACGCTGCCGGCCCTGCAG
GCGATGCTCGCGCGACAGGTCGACGATGCGCGCCAGGGCGAACTGCAAGGCGCACTCGCGAGCGTGGCGAGCCTGATCGG
CGTCGCGGGGCCGCTGGTCGTCACCGCGACCTATGCGGCGACACGCGCGACGTGGCCGGGGCTCGTCTGGGCCGCGGCCG
CGCTGCTTTATCTGCTCGTCCCGCCGTTGCTGGCCGGTGCGCGGCCAGCGGGCGCGACACGGCCGTCTGCATGA

Upstream 100 bases:

>100_bases
CCGTGTCGCGCGTCAGCCGCGCCCCTGTGTCCTTCATCTCTATCACCGATAGGGAAAGCTGTGGAATAATCGCCACTCTA
TCACCGATAGAGTCACACTC

Downstream 100 bases:

>100_bases
GCGCCGGCGGGTATCGCCACGCCCACCGCCGGATTCAATGCGCGAGCGTCACGAGATTCGCGTCGCGCACGAGTTGCCAG
CGGCCGTCGGCCTTGCGGAA

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNPSLIAILATVLLDAIGVGIVMPILPGLLHSLASAGSTDTHYGILLALYAFAQFLCAPLLGALSDRFGRRPVLLVSLAG
AALDYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHVRAP
FVAAAVLNALNLALVWRALPESRPRSAREGHAVGALNPFASLRRLSGAPALAPLIGIYVIVALVSQAPATLWILYGQEHF
GWSTPIAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAAIAFATAAWVPFALLPLFAAGGMTLPALQ
AMLARQVDDARQGELQGALASVASLIGVAGPLVVTATYAATRATWPGLVWAAAALLYLLVPPLLAGARPAGATRPSA

Sequences:

>Translated_397_residues
MNPSLIAILATVLLDAIGVGIVMPILPGLLHSLASAGSTDTHYGILLALYAFAQFLCAPLLGALSDRFGRRPVLLVSLAG
AALDYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHVRAP
FVAAAVLNALNLALVWRALPESRPRSAREGHAVGALNPFASLRRLSGAPALAPLIGIYVIVALVSQAPATLWILYGQEHF
GWSTPIAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAAIAFATAAWVPFALLPLFAAGGMTLPALQ
AMLARQVDDARQGELQGALASVASLIGVAGPLVVTATYAATRATWPGLVWAAAALLYLLVPPLLAGARPAGATRPSA
>Mature_397_residues
MNPSLIAILATVLLDAIGVGIVMPILPGLLHSLASAGSTDTHYGILLALYAFAQFLCAPLLGALSDRFGRRPVLLVSLAG
AALDYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHVRAP
FVAAAVLNALNLALVWRALPESRPRSAREGHAVGALNPFASLRRLSGAPALAPLIGIYVIVALVSQAPATLWILYGQEHF
GWSTPIAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAAIAFATAAWVPFALLPLFAAGGMTLPALQ
AMLARQVDDARQGELQGALASVASLIGVAGPLVVTATYAATRATWPGLVWAAAALLYLLVPPLLAGARPAGATRPSA

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=316, Percent_Identity=27.8481012658228, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI94721311, Length=357, Percent_Identity=28.2913165266106, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI225703104, Length=174, Percent_Identity=32.7586206896552, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI225703102, Length=174, Percent_Identity=32.7586206896552, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI217416366, Length=183, Percent_Identity=34.4262295081967, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI87081738, Length=179, Percent_Identity=31.8435754189944, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71996331, Length=321, Percent_Identity=23.3644859813084, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17551570, Length=144, Percent_Identity=29.8611111111111, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221513297, Length=358, Percent_Identity=26.8156424581006, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17738085, Length=335, Percent_Identity=24.7761194029851, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357569, Length=360, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161080926, Length=360, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161080924, Length=360, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656463, Length=360, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656468, Length=360, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40474; Mature: 40474

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSLIAILATVLLDAIGVGIVMPILPGLLHSLASAGSTDTHYGILLALYAFAQFLCAPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LGALSDRFGRRPVLLVSLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTD
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
VTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHVRAPFVAAAVLNALNLALVWRALP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ESRPRSAREGHAVGALNPFASLRRLSGAPALAPLIGIYVIVALVSQAPATLWILYGQEHF
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHC
GWSTPIAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAAIAFATAAW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
VPFALLPLFAAGGMTLPALQAMLARQVDDARQGELQGALASVASLIGVAGPLVVTATYAA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TRATWPGLVWAAAALLYLLVPPLLAGARPAGATRPSA
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNPSLIAILATVLLDAIGVGIVMPILPGLLHSLASAGSTDTHYGILLALYAFAQFLCAPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LGALSDRFGRRPVLLVSLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTD
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
VTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHVRAPFVAAAVLNALNLALVWRALP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ESRPRSAREGHAVGALNPFASLRRLSGAPALAPLIGIYVIVALVSQAPATLWILYGQEHF
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHC
GWSTPIAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAAIAFATAAW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
VPFALLPLFAAGGMTLPALQAMLARQVDDARQGELQGALASVASLIGVAGPLVVTATYAA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TRATWPGLVWAAAALLYLLVPPLLAGARPAGATRPSA
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]