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The map label for this gene is accC [H]

Identifier: 78065163

GI number: 78065163

Start: 575148

End: 576515

Strand: Reverse

Name: accC [H]

Synonym: Bcep18194_A3687

Alternate gene names: 78065163

Gene position: 576515-575148 (Counterclockwise)

Preceding gene: 78065164

Following gene: 78065162

Centisome position: 15.61

GC content: 63.23

Gene sequence:

>1368_bases
ATGTTTGAAAAAATCCTCATTGCCAATCGCGGTGAAATCGCGCTGCGCATCCAGCGTGCGTGCCGCGAGCTCGGCGTCAA
GACGGTGGTCGTCTACTCGGAAGCCGACAAGGAAGCCAAGTACGTCCGCCTCGCGGACGAAGCCGTCTGTATCGGCCCGG
CCCAGTCGAACCTGAGCTACCTGAACATGCCGGCGCTGATCAGCGCCGCGGAAGTCACCGATGCCGAGGCGATCCACCCC
GGCTACGGCTTCCTGTCGGAGAATGCCGATTTCGCGGAACGCGTCGAGCAGTCGGGCTTCACGTTCATCGGCCCGCGCCC
GGAAACGATCCGCATGATGGGTGACAAGGTCACCGCGAAGCAGACGATGATCAAGACCGGCGTGCCTTGCGTACCGGGCT
CGGAAGGCGCGTTGCCGGACGATCCGAAAGAGATCGTCAAGATTGCGCGCGCGATCGGCTATCCGGTCATCATCAAGGCG
GCAGGCGGCGGTGGCGGGCGCGGGATGCGCGTCGTGCACACCGAGGCCGCGCTCGTCAACGCGGTCAACATGACCCGCGA
GGAAGCCGGCCGTGCGTTCGGCAACCCGCAGGTGTACATGGAGAAGTTCCTCGAGAACCCGCGCCACATCGAAATCCAGG
TGCTGTCCGACGCGTACAAGAACGCGATCTGGCTCGGCGAGCGCGATTGCTCGATGCAGCGCCGCCACCAGAAGGTGATC
GAGGAAGCGCCGGCACCCGGCATTCCGCGCCGCCTGATCGACCGCATCGGCGACCGCTGCGCGGACGCCTGCAAGAAGAT
GGGCTACCTCGGCGCGGGCACGTTCGAATTCCTGTACGAGAACAACGAGTTCTACTTCATCGAGATGAACACGCGCGTGC
AGGTCGAGCACCCGGTATCGGAGCTGATCACGGGCGTCGACATCGTGCAGGAACAGATCCGCATCGCGGCCGGCGAGAAG
CTCACGCTGCGCCAGCGCGACATTGAATTCCGCGGACATGCGATCGAATGCCGGATCAACGCAGAAGATCCGTTCAAGTT
CACGCCGTCGCCGGGCCGGATCACGTCGTGGCATACGCCGGGCGGTCCTGGCGTGCGCGTCGATTCGCACGCCTACAATG
GCTATTTCGTGCCGCCGAACTATGATTCGATGATCGGCAAGCTGATCACCTACGGCGCGACGCGCGAGCAGGCAATCAGC
CGGATGCGCATCGCGCTGTCGGAAATGGTCGTCGAAGGCATTCAGACCAACATCCCGCTGCACCGCGAGCTGATGATCGA
TTCGAAGTTCGTCGAAGGCGGCACCAGCATCCACTACCTCGAAAACCGGCTCGCCCAGAAGCAGCAGGTCGCACCGGAAG
AAGCGTAA

Upstream 100 bases:

>100_bases
TTTCGTGATCGGCTAAGTCCGCCGCGCGGCCTCCGGGCCGCGCGCCGCCGATGCCCGCCAGGCGCCGTTCGCGCGCCCCT
CGAAGAGACGAATACTCGCT

Downstream 100 bases:

>100_bases
GCATGAGCTATCGCGAACTCGTCGTCGAACTGGCCCGTGAGCATGCGGAGGCACTGTCCGACGCGCTGCTCGAACTCGGC
GCGCTGTCGGTGTCCGTGGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAQSNLSYLNMPALISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFTFIGPRPETIRMMGDKVTAKQTMIKTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAYKNAIWLGERDCSMQRRHQKVI
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVSELITGVDIVQEQIRIAAGEK
LTLRQRDIEFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAIS
RMRIALSEMVVEGIQTNIPLHRELMIDSKFVEGGTSIHYLENRLAQKQQVAPEEA

Sequences:

>Translated_455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAQSNLSYLNMPALISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFTFIGPRPETIRMMGDKVTAKQTMIKTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAYKNAIWLGERDCSMQRRHQKVI
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVSELITGVDIVQEQIRIAAGEK
LTLRQRDIEFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAIS
RMRIALSEMVVEGIQTNIPLHRELMIDSKFVEGGTSIHYLENRLAQKQQVAPEEA
>Mature_455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAQSNLSYLNMPALISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFTFIGPRPETIRMMGDKVTAKQTMIKTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAYKNAIWLGERDCSMQRRHQKVI
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVSELITGVDIVQEQIRIAAGEK
LTLRQRDIEFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAIS
RMRIALSEMVVEGIQTNIPLHRELMIDSKFVEGGTSIHYLENRLAQKQQVAPEEA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=48.314606741573, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=48.314606741573, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=48.314606741573, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=47.5, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=44.543429844098, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=44.543429844098, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=44.543429844098, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI38679977, Length=519, Percent_Identity=31.0211946050096, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI38679967, Length=519, Percent_Identity=31.0211946050096, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI38679960, Length=519, Percent_Identity=31.0211946050096, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI38679971, Length=519, Percent_Identity=31.0211946050096, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI38679974, Length=519, Percent_Identity=31.0211946050096, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI134142062, Length=519, Percent_Identity=30.4431599229287, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=66.369710467706, Blast_Score=600, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.0496613995485, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71987519, Length=455, Percent_Identity=45.0549450549451, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=42.9530201342282, Blast_Score=339, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=29.4354838709677, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=515, Percent_Identity=27.7669902912621, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=515, Percent_Identity=27.7669902912621, Blast_Score=188, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=41.123595505618, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6319695, Length=459, Percent_Identity=44.880174291939, Blast_Score=345, Evalue=6e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=459, Percent_Identity=45.5337690631808, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6324343, Length=523, Percent_Identity=30.019120458891, Blast_Score=223, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=480, Percent_Identity=31.6666666666667, Blast_Score=222, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24651757, Length=433, Percent_Identity=45.7274826789838, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24651759, Length=396, Percent_Identity=44.6969696969697, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI161076407, Length=513, Percent_Identity=29.2397660818713, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586460, Length=513, Percent_Identity=29.2397660818713, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161076409, Length=513, Percent_Identity=29.2397660818713, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586458, Length=513, Percent_Identity=29.2397660818713, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50526; Mature: 50526

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAQSNLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCEEEECCCCCCCCE
LNMPALISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFTFIGPRPETIRMMGDKVTAK
ECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEHHCCCCHHHH
QTMIKTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAYKNAIWLGERDCSMQRRHQKVI
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECHHHHCEEEECCCCHHHHHHHHHHH
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVS
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
ELITGVDIVQEQIRIAAGEKLTLRQRDIEFRGHAIECRINAEDPFKFTPSPGRITSWHTP
HHHHHHHHHHHHHHHHCCCEEEEEECCCEECCCEEEEEECCCCCCEECCCCCCEEECCCC
GGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAISRMRIALSEMVVEGIQTNIPL
CCCCEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HRELMIDSKFVEGGTSIHYLENRLAQKQQVAPEEA
HHHHEECCHHHCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVRLADEAVCIGPAQSNLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCEEEECCCCCCCCE
LNMPALISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFTFIGPRPETIRMMGDKVTAK
ECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEHHCCCCHHHH
QTMIKTGVPCVPGSEGALPDDPKEIVKIARAIGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDAYKNAIWLGERDCSMQRRHQKVI
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECHHHHCEEEECCCCHHHHHHHHHHH
EEAPAPGIPRRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVS
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
ELITGVDIVQEQIRIAAGEKLTLRQRDIEFRGHAIECRINAEDPFKFTPSPGRITSWHTP
HHHHHHHHHHHHHHHHCCCEEEEEECCCEECCCEEEEEECCCCCCEECCCCCCEEECCCC
GGPGVRVDSHAYNGYFVPPNYDSMIGKLITYGATREQAISRMRIALSEMVVEGIQTNIPL
CCCCEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
HRELMIDSKFVEGGTSIHYLENRLAQKQQVAPEEA
HHHHEECCHHHCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]