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The map label for this gene is accB [H]

Identifier: 78065164

GI number: 78065164

Start: 576600

End: 577070

Strand: Reverse

Name: accB [H]

Synonym: Bcep18194_A3688

Alternate gene names: 78065164

Gene position: 577070-576600 (Counterclockwise)

Preceding gene: 78065165

Following gene: 78065163

Centisome position: 15.62

GC content: 65.61

Gene sequence:

>471_bases
ATGGATCTTCGTAAGCTGAAAACTCTGATCGACCTCGTTTCCGAATCCGGCATCTCCGAGCTGGAAGTGACGGAAGGCGA
AGGCAAGGTGCGCATCGTCAAGAACGCGCCGCCGGTCTACGTGCAGCCGACGGCTGGGTATGCCCCGCAAGTCAGCGCGC
CCGCTCCGGTCGCGCTGCCGACCGAAGGCGCTGCCGCGCCGGCCGCAGGCGGCGCAGCCGCTCCGGCGGTCCCGCAGGGC
CACGTCGTGACGTCGCCGATGGTCGGCACGTTCTATCGCGCACCGTCGCCGGGCGCGGACCCGTTCGTCCAGGTGGGCGA
CACGGTCAAGGAGGGCCAGACGATCTGCATCATCGAAGCGATGAAGCTGCTCAACGAGATCGAGTCGGACAAGGCCGGCG
TGATCAAGGAAATCCTCGTCGAGAACGGCCAGGCCGTCGAATACGGTCAGCCGCTTTTCGTGATCGGCTAA

Upstream 100 bases:

>100_bases
GCTGGACAAGCTGCAAGGCACGTCGCGCGGCTGATTTCGCGATCTAGATTCAGCGCCGGCCCCTAACCGGCGCTTTCACG
TATTGAAAGGGGAATTCCCG

Downstream 100 bases:

>100_bases
GTCCGCCGCGCGGCCTCCGGGCCGCGCGCCGCCGATGCCCGCCAGGCGCCGTTCGCGCGCCCCTCGAAGAGACGAATACT
CGCTATGTTTGAAAAAATCC

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MDLRKLKTLIDLVSESGISELEVTEGEGKVRIVKNAPPVYVQPTAGYAPQVSAPAPVALPTEGAAAPAAGGAAAPAVPQG
HVVTSPMVGTFYRAPSPGADPFVQVGDTVKEGQTICIIEAMKLLNEIESDKAGVIKEILVENGQAVEYGQPLFVIG

Sequences:

>Translated_156_residues
MDLRKLKTLIDLVSESGISELEVTEGEGKVRIVKNAPPVYVQPTAGYAPQVSAPAPVALPTEGAAAPAAGGAAAPAVPQG
HVVTSPMVGTFYRAPSPGADPFVQVGDTVKEGQTICIIEAMKLLNEIESDKAGVIKEILVENGQAVEYGQPLFVIG
>Mature_156_residues
MDLRKLKTLIDLVSESGISELEVTEGEGKVRIVKNAPPVYVQPTAGYAPQVSAPAPVALPTEGAAAPAAGGAAAPAVPQG
HVVTSPMVGTFYRAPSPGADPFVQVGDTVKEGQTICIIEAMKLLNEIESDKAGVIKEILVENGQAVEYGQPLFVIG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=163, Percent_Identity=52.1472392638037, Blast_Score=155, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 16090; Mature: 16090

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRKLKTLIDLVSESGISELEVTEGEGKVRIVKNAPPVYVQPTAGYAPQVSAPAPVALP
CCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCEEEC
TEGAAAPAAGGAAAPAVPQGHVVTSPMVGTFYRAPSPGADPFVQVGDTVKEGQTICIIEA
CCCCCCCCCCCCCCCCCCCCCEECCCCCHHEECCCCCCCCCCEECCCCCCCCCEEEHHHH
MKLLNEIESDKAGVIKEILVENGQAVEYGQPLFVIG
HHHHHHHCCCCHHHHHHHHHCCCCEEECCCEEEEEC
>Mature Secondary Structure
MDLRKLKTLIDLVSESGISELEVTEGEGKVRIVKNAPPVYVQPTAGYAPQVSAPAPVALP
CCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCEEEC
TEGAAAPAAGGAAAPAVPQGHVVTSPMVGTFYRAPSPGADPFVQVGDTVKEGQTICIIEA
CCCCCCCCCCCCCCCCCCCCCEECCCCCHHEECCCCCCCCCCEECCCCCCCCCEEEHHHH
MKLLNEIESDKAGVIKEILVENGQAVEYGQPLFVIG
HHHHHHHCCCCHHHHHHHHHCCCCEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]