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The map label for this gene is ffh [H]

Identifier: 78065151

GI number: 78065151

Start: 561084

End: 562451

Strand: Reverse

Name: ffh [H]

Synonym: Bcep18194_A3675

Alternate gene names: 78065151

Gene position: 562451-561084 (Counterclockwise)

Preceding gene: 78065158

Following gene: 78065150

Centisome position: 15.23

GC content: 66.23

Gene sequence:

>1368_bases
ATGCTCGACAATCTCACTCAACGGATGGCGCGCGTCGTCAAGACGCTGCGCGGCGAGGCCCGGCTTACCGAGGCGAACAC
GCAGGAGATGCTCCGCGAGGTGCGTCTCGCCCTGCTGGAGGCCGACGTTTCGCTGCCGGTCGTCCGCGAATTCATCGCCA
AGGTCAAGGAAAAGGCGCTCGGCGAAGAAGTGATCAGCAGCCTGTCGCCGGGTCAGGCGCTGGTCGGCGTGGTCCAGAAG
GAACTGACCGCCGTGATCGGCGGCGACTACGAAGGCAAGGCCGCCGAGCTGAACCTCGCGGTCACGCCGCCCGCGGTGAT
CCTGATGGCCGGCCTGCAGGGTGCGGGCAAGACCACGACCGCCGGCAAGCTCGCGAAGCTGCTGCGCGAGAAGTACAAGA
AGAAGGTGCTGACCGTGTCGTGCGACGTGTATCGCCCGGCCGCAATCATGCAGCTGAAAACGGTGAGCGAACAGGTCGGC
GCCGACTTCTTCCCGTCCACGCCGGACCAGAAACCCGTCGACATCGCGATCGCGGCCGTCGACTGGGCGAAGCGCCACTA
CCATGACGTGCTGATCGTCGACACGGCCGGCCGCCTCGGCATCGACGAAGTGATGATGCAGGAAATCGCCGCGCTGCACG
GCACGCTGAAGCCGGCCGAAACGCTGTTCGTCGTCGACGCGATGCTCGGCCAGGACGCGGTCAACACCGCGAAGGCGTTC
AACGACACGCTGCCGCTCACCGGCGTCGTGCTGACCAAGCTCGACGGCGACTCGCGCGGCGGTGCCGCGCTGTCGGTGCG
TCACGTCACGGGCAAGCCGATCAAGTTCGTCGGTGTCGCCGAGAAGCTCGACGGCCTCGAGGTGTTCCACCCCGACCGGA
TGGCGAACCGGATCCTCGGCATGGGCGACATCCTCGCGCTCGTCGAGGAGGCGCAGCGCGGCGTCGACGTGCAGGCCGCG
CAGAAGCTCGCCGACAAGGTCAAGAAAGGCGGCGACTTCGACCTGAACGATTTCCGCGCGCAGATCTCCCAGATGAAGAA
CATGGGCGGCCTGTCGTCGCTGATGGACAAGCTGCCTGCGCAGTTCCAGCAGGCGGCGGCCGGCGCCGACATGGGCCAGG
CCGAGAAGTCGATCCGCCGGATGGAGGGCATCATCAGCTCGATGACGCCGGCCGAGCGCGCGAAACCCGAGATCATCAAG
GCGACGCGCAAGCGCCGCATTGCAGCCGGCGCGGGCGTGCCGGTGCAGGAAGTCAACCGGATGCTGAACCAGTACGACCA
GATGCGTACGATGATGAAGAAGCTGAAGGGCGGCAACATGCAGAAGATGATGCGCGGCCTGAAGGGCATGATGCCCGGCA
TGCGCTGA

Upstream 100 bases:

>100_bases
ACAATATCCATGTTCGAAGTTTACACTAGGCCCCCTTCCCGCGACGGCTCCCTTTGTTCGGTTCCGCCGCGCCTTCGGGC
CCCACTGTCCATCGCTCCCC

Downstream 100 bases:

>100_bases
TTCCGCCCATCGGCCGGCGCGCGGGTTTTTGCTGTAGCGCGCGCCGTCCGTTCTGCTTCATTCTTATTTGTATACCGACT
GCCCGCCAGAACACATGAAC

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVSLPVVREFIAKVKEKALGEEVISSLSPGQALVGVVQK
ELTAVIGGDYEGKAAELNLAVTPPAVILMAGLQGAGKTTTAGKLAKLLREKYKKKVLTVSCDVYRPAAIMQLKTVSEQVG
ADFFPSTPDQKPVDIAIAAVDWAKRHYHDVLIVDTAGRLGIDEVMMQEIAALHGTLKPAETLFVVDAMLGQDAVNTAKAF
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEVFHPDRMANRILGMGDILALVEEAQRGVDVQAA
QKLADKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPAQFQQAAAGADMGQAEKSIRRMEGIISSMTPAERAKPEIIK
ATRKRRIAAGAGVPVQEVNRMLNQYDQMRTMMKKLKGGNMQKMMRGLKGMMPGMR

Sequences:

>Translated_455_residues
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVSLPVVREFIAKVKEKALGEEVISSLSPGQALVGVVQK
ELTAVIGGDYEGKAAELNLAVTPPAVILMAGLQGAGKTTTAGKLAKLLREKYKKKVLTVSCDVYRPAAIMQLKTVSEQVG
ADFFPSTPDQKPVDIAIAAVDWAKRHYHDVLIVDTAGRLGIDEVMMQEIAALHGTLKPAETLFVVDAMLGQDAVNTAKAF
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEVFHPDRMANRILGMGDILALVEEAQRGVDVQAA
QKLADKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPAQFQQAAAGADMGQAEKSIRRMEGIISSMTPAERAKPEIIK
ATRKRRIAAGAGVPVQEVNRMLNQYDQMRTMMKKLKGGNMQKMMRGLKGMMPGMR
>Mature_455_residues
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVSLPVVREFIAKVKEKALGEEVISSLSPGQALVGVVQK
ELTAVIGGDYEGKAAELNLAVTPPAVILMAGLQGAGKTTTAGKLAKLLREKYKKKVLTVSCDVYRPAAIMQLKTVSEQVG
ADFFPSTPDQKPVDIAIAAVDWAKRHYHDVLIVDTAGRLGIDEVMMQEIAALHGTLKPAETLFVVDAMLGQDAVNTAKAF
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEVFHPDRMANRILGMGDILALVEEAQRGVDVQAA
QKLADKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPAQFQQAAAGADMGQAEKSIRRMEGIISSMTPAERAKPEIIK
ATRKRRIAAGAGVPVQEVNRMLNQYDQMRTMMKKLKGGNMQKMMRGLKGMMPGMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=458, Percent_Identity=30.5676855895196, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI226371618, Length=397, Percent_Identity=30.7304785894207, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=33.9393939393939, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI23308697, Length=202, Percent_Identity=32.1782178217822, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI295424842, Length=202, Percent_Identity=32.1782178217822, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=63.9380530973451, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1789874, Length=278, Percent_Identity=33.4532374100719, Blast_Score=132, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=461, Percent_Identity=29.2841648590022, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=202, Percent_Identity=34.1584158415842, Blast_Score=96, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=451, Percent_Identity=31.0421286031042, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI17647949, Length=445, Percent_Identity=30.7865168539326, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24641198, Length=271, Percent_Identity=28.4132841328413, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49254; Mature: 49254

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVSLPVVREFIAKVKEKAL
CCCHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVISSLSPGQALVGVVQKELTAVIGGDYEGKAAELNLAVTPPAVILMAGLQGAGKTTT
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCH
AGKLAKLLREKYKKKVLTVSCDVYRPAAIMQLKTVSEQVGADFFPSTPDQKPVDIAIAAV
HHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHH
DWAKRHYHDVLIVDTAGRLGIDEVMMQEIAALHGTLKPAETLFVVDAMLGQDAVNTAKAF
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHH
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEVFHPDRMANRILG
CCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHC
MGDILALVEEAQRGVDVQAAQKLADKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
QFQQAAAGADMGQAEKSIRRMEGIISSMTPAERAKPEIIKATRKRRIAAGAGVPVQEVNR
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
MLNQYDQMRTMMKKLKGGNMQKMMRGLKGMMPGMR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVSLPVVREFIAKVKEKAL
CCCHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVISSLSPGQALVGVVQKELTAVIGGDYEGKAAELNLAVTPPAVILMAGLQGAGKTTT
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCH
AGKLAKLLREKYKKKVLTVSCDVYRPAAIMQLKTVSEQVGADFFPSTPDQKPVDIAIAAV
HHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHH
DWAKRHYHDVLIVDTAGRLGIDEVMMQEIAALHGTLKPAETLFVVDAMLGQDAVNTAKAF
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHH
NDTLPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEVFHPDRMANRILG
CCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHC
MGDILALVEEAQRGVDVQAAQKLADKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
QFQQAAAGADMGQAEKSIRRMEGIISSMTPAERAKPEIIKATRKRRIAAGAGVPVQEVNR
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
MLNQYDQMRTMMKKLKGGNMQKMMRGLKGMMPGMR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]